CN105535465A - 一种治疗心律失常的中药制剂及其制备方法 - Google Patents
一种治疗心律失常的中药制剂及其制备方法 Download PDFInfo
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Abstract
本发明提供一种治疗心律失常的中药制剂,其有效成份的原料组成为:川乌、玉竹、鹿衔草、桂枝、甘松、茯神、龙齿、桑寄生、大青叶、石菖蒲、黄芩、陈皮、天花粉、酸枣仁、红花、细辛。本发明药物所选药材配伍相宜,符合中医药学和现代医药学理论,并具有清心燥湿、活血理气、养血柔肝,宁心安神,益气复脉之功效。对治疗心律失常具有显著疗效,见效较快,治愈后不复发,安全无毒副作用,成本较低,能够达到标本兼治的目的,具有临床推广价值。
Description
技术领域
本发明涉及本发明属于医用药物领域,具体地说,涉及一种治疗心律失常的中药制剂及其制备方法。
背景技术
心律失常是由于心脏激动的起源或传导异常所致的心律或心率的改变。在心血管系统疾病中,心律失常是最为严重的病症之一,不但可加重原有心脏疾病,如加快心力衰竭的进展,而且还可导致患者突然死亡,严重威胁人类健康。常见的心律失常有窦性心动过速、窦性心动过缓、窦性心律不齐、过早搏动、阵发性心动过速、心房颤动、房室传导阻滞等。
中医认为心律失常的主动病因有:心虚胆怯、心血不足、阴虚火旺、心阳不振、水饮凌心、瘀血阻络等。当发生心律失常时,心房和心室收缩程序改变,能使心排血量下降30%左右,引起病人心虚、胸闷、无力等症状;心律不齐较严重可致窦性停博、窦房阻滞和心动过缓,出现心动过速综合症;心律不齐可导致猝死:发生猝死最多的原因是心律失常,其中以室性心动过速、室颤及传导阻滞引起瘁死的发生率最高。心律不齐是中老年人常见症,往往引起头晕、胸闷、胸痛、气急、多汗、颜面苍白、四肢发冷、抽搐、昏迷等症状,还会影响正常的工作学习。
目前临床上常用的抗心律失常药以西药为主,常用的抗快速心律失常药物分为四大类,包括通道阻滞剂、β受体阻滞剂。对于缓慢性心律失常,一般选用增强自律性和加速传导的药物。在剂量不当或长期用药时可诱发传导阻滞及心衰,具有10%左右的发病概率。虽然抗心律失常药物能减少心律失常发作,但仍存在很大的局限性。
中医药在治疗心律失常上显示了一定优势,体现在整合调节方面,可以多途径、多环节、多靶点阻断心律失常发生;且中医药具有副作用少、费用低、依从性好、疗效明显等临床优势,因此,研制一种有效的改善心律失常症状的中药药剂具有重要的意义。
发明内容
本发明提出了一种治疗心律失常的中药制剂,该药剂能有效的对心律失常症状进行治疗,其具体的技术方案如下:
一种治疗心律失常的中药制剂,它由以下重量份配比的中药原料制作而成:
川乌:16~38份;玉竹:10~38份;鹿衔草:12~39份;桂枝:14~28份;
甘松:13~36份;茯神:11~33份;龙齿:11~33份;桑寄生:10~32份;
大青叶:9~31份;石菖蒲:9~31份;黄芩:6~28份;陈皮:5~27份;
天花粉:5~28份;酸枣仁:4~24份;红花:3~17份;细辛:3~17份。
优选地,它由以下重量份的中药原料制作而成:
川乌:25份;玉竹:22份;鹿衔草:25份;桂枝:22份;
甘松:24份;茯神:22份;龙齿:20份;桑寄生:25份;
大青叶:20份;石菖蒲:22份;黄芩:15份;陈皮:12份;
天花粉:15份;酸枣仁:16份;红花:12份;细辛:10份。
一种治疗心律失常的药物的制备方法,包括以下工艺步骤:
1)将川乌、桂枝、甘松、茯神、桑寄生、石菖蒲、黄芩、陈皮、天花粉、红花、细辛洗净,放入容器内,第一次加入9~11倍量的蒸馏水,浸泡3~4.5小时后,武火煮沸1~1.5小时,小火煎煮3.5~4.5小时,提取汁液;第二次加入5~8倍量蒸馏水,煮沸0.5~小时,提取汁液;第三次加入3~4倍量蒸馏水,煮沸0.5小时,提取汁液;合并三次提取液,过滤,得滤液,浓缩成65℃下相对密度为1.08~1.15的稠膏,备用;
2)取龙齿刷净,在坩埚内煅红透,取出,放凉,研末,过200目细粉,水飞过,晒干备用;
3)将酸枣仁放入容器内,进行粉碎处理,研末,过180目细粉,备用;
4)将大青叶放入武火内,表面烧至黑色,取出,晾干,研末,过180目细粉,备用;
5)将玉竹、鹿衔草浸入3~4倍量的60%的乙醇溶液浸泡1.5~2小时,加热提取3.5小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.11~1.16的稠膏,备用;
6)将上述步骤1)~5)所制得的稠膏以及细粉混合,制成片剂,即得所述的治疗心律失常的药物。
本发明所用各药用原料的药理学研究现状如下:
川乌:药性辛;苦;热;归心;肝;脾;肾经;功效祛风除湿;温经;散寒止痛;主治风寒湿痹;关节疼痛;肢体麻木;半身不遂;头风头痛;心腹冷痛;寒疝作痛;跌打瘀痛;阴疽肿毒;《主治秘要》云,川乌其用有六:除寒一也;去心下坚痞二也;温养脏腑三也;治诸风四也;破聚滞气五也;感寒腹痛六也。
玉竹:药性甘;平;归肺;胃经;滋阴润肺;养胃生津;主治燥咳;劳嗽;热病阴液耗伤之咽干口渴;内热消渴;阴虚外感;头昏眩晕;筋脉挛痛;《日华子本草》:除烦闷,止渴,润心肺,补五劳七伤,虚损,腰脚疼痛,天行热狂。《本草拾遗》:主聪明,调血气,令人强壮。
鹿衔草:药性甘;苦;性温。归肝、肾经;补肾强骨;祛风除湿;肾虚腰痛;风湿痹痛;筋骨痿软;新久咳嗽;吐血;衄血;崩漏;
桂枝:药性辛;甘;性温;归膀胱;心;肺经;功效散寒解表;温通经脉;通阳化气;主治风寒表证;寒湿痹痛;四肢厥冷;经闭痛经;癥瘕结块;胸痹;心悸;痰饮;小便不利;《素问·阴阳应象大论》曰,味厚则泄,气厚则发热,辛以散结,甘可补虚。故能调和腠理,下气散逆,止痛除烦,此桂枝其用也。盖其用之道有六:曰和营,曰通阳,曰利水,曰下气,曰行痰,曰补中。其功之最大,施之最广,无如桂枝汤,则和营其首功也。
甘松:药性味辛;甘;性温;归脾;胃经;功效理气止痛;醒脾健胃;主治脘腹胀痛;不思饮食;《本草正义》:甘松,近东瀛医家谓此药善通经络,专治转筋,为霍乱转筋必需之药。颐自定霍乱药酒方,用伊打和酒精,浸取浓汁,合姜、附、萸、连诸味,治真寒霍乱、转筋入腹危急重症,极有捷效,知此物温运,活络通经,无出其右。此固向来治药物学者之所未知者也。
茯神:药性甘;淡;性平;归心;脾经;功效宁心;安神;利水;主治惊悸;健忘;健忘失眠;惊痫;小便不利;
《药品化义》:茯神,其体沉重,重可去怯,其性温补。补可去弱。戴人曰,心本热,虚则寒。如心气虚怯,神不守舍,惊悸怔忡,魂魄恍惚,劳怯健忘,俱宜温养心神,非此不能也。
龙齿:药性涩;甘;凉;归心;肝经;功效镇惊安神;清热除烦;主治惊痫;癫狂;心悸怔忡;失眠多梦;身热心烦;《药性论》:镇心,安魂魄。
桑寄生:药性苦;甘;性平;归经肝;肾经;功效补肝肾;强筋骨;祛风湿;安胎;主治腰膝酸痛;筋骨痿弱;肢体偏枯;风湿痹痛;头错目眩;胎动不安,崩漏下血;《日华子本草》:助筋骨,益血脉。
大青叶:药性苦;寒;归经肝;心;胃;脾经;功效清热解毒;凉血消斑;主治热病高热烦渴;神昏;斑疹;吐血;衄血;黄疸;泻痢;《本草经疏》:甄权云大青味甘,能去大热,治温疫寒热。盖大寒兼苦,其能解散邪热明矣。
石菖蒲:药性味辛;苦;性微温;归经心;肝;脾经;功效化痰开窍;化湿行气;祛风利痹;消肿止痛;主治热病神昏;痰厥;健忘;耳鸣;耳聋;脘腹胀痛;噤口痢;风湿痹痛;跌打损伤;痈疽疥癣;《纲目》:菖蒲气温,心气不足者用之,虚则补其母也。肝苦急,以辛补之是矣。
黄芩:药性味苦;性寒;归经归肺;心;肝;胆;大肠经;功效清热泻火;燥湿解毒;止血;安胎;;
主治肺热咳嗽;热病高热神昏;肝火头痛;目赤肿痛;湿热黄疸;泻痢;热淋;吐衄血;崩漏;胎热不安;痈肿疔疮;《主治秘诀》云,黄苓其用有九:泻肺经热,一一也;夏月须用,二也;上焦及皮肤凤热,三也:去诸热,四也;妇人产后,养阻退阳,五也;利胸中气,六也;消隔上痰,七也;除上焦热及脾湿,八也;安胎,九也;
陈皮:苦、辛,温。归肺、脾经;功效辛散通温,气味芳香,长于理气,能入脾肺,故既能行散肺气壅遏,又能行气宽中,用于肺气拥滞、胸膈痞满及脾胃气滞、脘腹胀满等症;
天花粉:药性味甘;微苦;性微寒;归经归肺;胃经;功效清热生津;润肺化痰;消肿排浓;主治热病口渴;消渴多饮;肺热燥咳;疮疡肿毒;《本草汇言》:天花粉,退五脏郁热,如心火盛而舌干口燥,肺火盛而咽肿喉痹,脾火盛而口舌齿肿,痰火盛而咳嗽不宁。
酸枣仁:药性甘;平;归经心;脾;肝;胆经;功效宁心安神;养肝;敛汗;主治虚烦不眠;惊悸怔忡;体虚自汗、盗汗;《药品化义》:酸枣仁,仁主补,皮益心血,其气炒香,化为微温,藉香以透心气,得温以助心神。
红花:药性味辛;性温;归经归心;肚经;功效活血能经;祛瘀止痛;主治经闭;痛经;产后瘀阻腹痛;胞痹心痛癥瘕积聚;跌打损伤;关节疼痛;中风偏竣;斑疹;《本草汇言》:红花,破血、行血、和血、调血之药也。
细辛:药性辛;温;小毒;归经肺;肾;心;肝;胆;脾经;功效散寒祛风;止痛;温肺化饮;通窍;主治风寒表证;头痛,牙痛;风湿痹痛;痰饮咳喘;鼻塞;鼻渊;口疮;《本草正义》:细辛,芳香最烈,故善开结气,宣泄郁滞,而能上达巅顶,通利耳目,旁达百骸,无微不至,内之宣络脉而疏通百节,外之行孔窍而直透肌肤。
本发明与现有技术相比,具有以下有益效果:
本发明药物所选药材配伍相宜,符合中医药学和现代医药学理论,并具有清心燥湿、活血理气、养血柔肝,宁心安神,益气复脉之功效。对治疗心律失常具有显著疗效,见效较快,治愈后不复发,安全无毒副作用,成本较低,能够达到标本兼治的目的,具有临床推广价值。
具体实施方式
下面结合实施例对本发明的一种治疗心律失常的中药制剂及其制备方法作进一步详细的说明。
实施例1
本发明药物有效成分的原料组成及重量为:
川乌:16克;玉竹:10克;鹿衔草:12克;桂枝:14克;
甘松:13克;茯神:11克;龙齿:11克;桑寄生:10克;
大青叶:9克;石菖蒲:9克;黄芩:6克;陈皮:5克;
天花粉:5克;酸枣仁:4克;红花:3克;细辛:3克。
一种治疗心律失常的药物的制备方法,包括以下工艺步骤:
(1)将甘蓝和玳瑁洗净,切碎,放入容器内,绞汁,滤杂质,留汁液备用;
(2)将百合、当归、碧桃干、红门兰、苦瓜、龙骨、合欢皮、芥子、昙花、梨皮和南酸枣洗净,放入容器内,加入8~10倍量的蒸馏水,浸泡5~6小时后,煮沸3~4小时,提取;再次加入6~8倍量蒸馏水,煮沸2~3小时,提取;最后,加入4~6倍量蒸馏水,加热煮沸1~2小时,提取;合并三次提取液,过滤,得滤液,浓缩成60℃下相对密度为1.10~1.13的稠膏,备用;
(3)将芭蕉叶放入武火内,表面烧至黑色,取出,晾干,研末,过200目细粉,备用;
(4)将马蹄根放入容器内,进行粉碎处理,研末,过180目细粉,备用;
(5)将葡萄洗净,浸入3倍量的60%的乙醇溶液浸泡1~2小时,加热提取3小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.12~1.15的稠膏,备用;
(6)将上述步骤(1)~(5)所制得的汁液、稠膏以及细粉混合,制成片剂,每片0.5~0.8克,即得本发明所述的治疗心律失常的药物。
用法用量:口服即可,每日2次,早晚各1次,每次2片,饭后温开水送服;7天为1个疗程,2~3个疗程即可见到显著效果,病情严重者酌增用量。
实施例2
本发明药物有效成分的原料组成及重量为:
川乌:38克;玉竹:38克;鹿衔草:39克;桂枝:28克;
甘松:36克;茯神:33克;龙齿:33克;桑寄生:32克;
大青叶:31克;石菖蒲:31克;黄芩:28克;陈皮:27克;
天花粉:28克;酸枣仁:24克;红花:17克;细辛:17克。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
实施例3
本发明药物有效成分的原料组成及重量为:
川乌:25份;玉竹:22份;鹿衔草:25份;桂枝:22份;
甘松:24份;茯神:22份;龙齿:20份;桑寄生:25份;
大青叶:20份;石菖蒲:22份;黄芩:15份;陈皮:12份;
天花粉:15份;酸枣仁:16份;红花:12份;细辛:10份。
本实施例的药物制备方法工艺步骤及用法用量与实施例1相同。
临床资料:
1、病例选择:
作为治疗心律失常的药物,选择确诊的心律失常患者190例临床观察,病人随机分成治疗组和对照组两组,治疗组85例,其中男性37例,女性48例,年龄38~71岁,平均年龄54.5岁,平均病程3.5年;对照组85例,其中男性38例,女性47例,年龄41~70岁,平均年龄53.5岁,平均病程3年。
治疗组和对照组两组病例的病程、症状轻重程度基本一致,无显著差异,具有可比性。
2、药物选择:
治疗组服用本发明药物,口服即可,每日2次,早晚各1次,每次2片,每片0.5g,饭后温开水送服;7天为1个疗程,连续服务2~3个疗程。
对照组注射氟卡尼,静脉滴注,成人每千克体重2mg于15分钟滴完;儿童每千克体重2mg于10分钟内滴完,疗程视病情而定。
3、疗效判定:
(1)治愈:临床症状全部消失,心电图检查恢复正常。
(2)显效:临床症状明显改善,心电图检查明显好转。
(3)有效:临床症状有所改善,心电图检查有所好转。
(4)无效:通过治疗后临床症状无减轻或加重。
4、结果:
例数 | 治愈 | 显效 | 有效 | 无效 | 治愈率 | 总有效率 | |
治疗组 | 85 | 49 | 20 | 12 | 4 | 57.6% | 95.3% |
对照组 | 85 | 35 | 15 | 17 | 18 | 41.1% | 78.8% |
以上结果显示,治疗组的治愈率和总有效率明显高于对照组。
典型病例举例:
1、唐某,男,49岁,四川宜宾人。患者过度劳累后突感心胸不适,胸闷气短、心慌。来我院就诊,吸气时心律明显高于呼气,经心电图检查为窦性心律不齐,服用本发明药物治疗,服用1个疗程后,症状明显减轻,服用第2个疗程后,症状消失,心电图正常,半年后随访无复发。
2、宋某,女,68岁,新疆石河子人。患者2年前出现心跳不规律、心慌伴有胸闷、每年都发作,来我院就诊,诊断为心房颤动型心律失常,医生给予本发明药物治疗,服用1个疗程后,症状有所好转,服用3个疗程后,症状全部消失,心电图检查无异常,1年后随访无复发。
3、方某,男,55岁,河北唐山人。患者时常有心悸和胸闷症状,每周发生两三次,去医院诊断患心律不齐。服用本发明药物治疗,服用1个疗程后,患者感觉浑身舒畅,胸闷减轻。继续服用2个疗程后,心悸、胸闷症状消失,1年后随访未复发。
4、林某,男,42岁,山东临沂人。患者心跳超过100次每分钟,未认真治疗,后来病情加重,严重时昏厥两次,去医院就诊,诊断为窦性心动过速,医生推荐,服用本发明药物治疗,服用1个疗程后,症状明显改善,服用第2个疗程后,心跳恢复正常,心电图检查正常,半年后随访未复发。
5、刁某,女,52岁,苏州人。患者心慌,胸闷,乏力,心律不齐,用过几种药物进行治疗,效果不佳,后服用本发明药物治疗,服用1个疗程后,病情有所稳定,服用2个疗程后,症状消失,复查各项指标均正常。
6、赵某,女,58岁,黑龙江齐齐哈尔人。患者患心律不齐3年余,有胸闷、心痛症状,吃过几种西药治疗后,有所缓解,停药后复发。经服用本发明药物治疗,服用1个疗程后,症状有所好转,心跳逐渐恢复正常,服用2个疗程后,症状全部消失,心跳恢复正常,心电图检查无异常,随访至今未复发。
Claims (3)
1.一种治疗心律失常的中药制剂,其特征在于:它由以下重量份配比的中药原料制作而成:
川乌:16~38份;玉竹:10~38份;鹿衔草:12~39份;桂枝:14~28份;
甘松:13~36份;茯神:11~33份;龙齿:11~33份;桑寄生:10~32份;
大青叶:9~31份;石菖蒲:9~31份;黄芩:6~28份;陈皮:5~27份;
天花粉:5~28份;酸枣仁:4~24份;红花:3~17份;细辛:3~17份。
2.根据权利要求1所述的一种治疗心律失常的中药制剂,其特征在于:它由以下重量份的中药原料制作而成:
川乌:25份;玉竹:22份;鹿衔草:25份;桂枝:22份;
甘松:24份;茯神:22份;龙齿:20份;桑寄生:25份;
大青叶:20份;石菖蒲:22份;黄芩:15份;陈皮:12份;
天花粉:15份;酸枣仁:16份;红花:12份;细辛:10份。
3.一种如权利要求1或2所述治疗心律失常的药物的制备方法,其特征在于:包括以下工艺步骤:
步骤一:将川乌、桂枝、甘松、茯神、桑寄生、石菖蒲、黄芩、陈皮、天花粉、红花、细辛洗净,放入容器内,第一次加入9~11倍量的蒸馏水,浸泡3~4.5小时后,武火煮沸1~1.5小时,小火煎煮3.5~4.5小时,提取汁液;第二次加入5~8倍量蒸馏水,煮沸0.5~小时,提取汁液;第三次加入3~4倍量蒸馏水,煮沸0.5小时,提取汁液;合并三次提取液,过滤,得滤液,浓缩成65℃下相对密度为1.08~1.15的稠膏,备用;
步骤二:取龙齿刷净,在坩埚内煅红透,取出,放凉,研末,过200目细粉,水飞过,晒干备用;
步骤三:将酸枣仁放入容器内,进行粉碎处理,研末,过180目细粉,备用;
步骤四:将大青叶放入武火内,表面烧至黑色,取出,晾干,研末,过180目细粉,备用;
步骤五:将玉竹、鹿衔草浸入3~4倍量的60%的乙醇溶液浸泡1.5~2小时,加热提取3.5小时,回收乙醇,滤过,得滤液,浓缩为65℃下相对密度为1.11~1.16的稠膏,备用;
步骤六:将上述步骤(1)~(5)所制得的稠膏以及细粉混合,制成片剂,即得所述的治疗心律失常的药物。
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