CN105535096A - Traditional Chinese medicine composition for treating suppurative otitis meadia as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating suppurative otitis meadia as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating the suppurative otitis meadia as well as a preparation method and application thereof, belonging to the field of treatment of the suppurative otitis meadia by traditional Chinese medicines. The invention discloses the traditional Chinese medicine composition for treating the suppurative otitis meadia first, and the traditional Chinese medicine composition is prepared from olivary nucleus, sticktight, herb of viscid germander, herba ecliptae and triquetrous tadehagi herb. On the basis of the traditional Chinese medicine composition, the better efficacies of clearing away heat and toxic materials, and eliminating stasis to subdue swelling are achieved due to the addition of the raw medicinal materials, namely the seed of Chinese dodder and malaytea scurfpea fruit. Clinical effect results prove that the raw medicinal materials, namely the olivary nucleus, the sticktight, the herb of viscid germander, the herba ecliptae and the triquetrous tadehagi herb have a remarkable synergistic effect with the seed of Chinese dodder and the malaytea scurfpea fruit, such that the curing rate and the total effective rate of treatment of the suppurative otitis meadia can be remarkably improved, and the curative effect is exact. The traditional Chinese medicine disclosed by the invention is reasonable in compatibility; the preparation method is simple and can be applied to prepare medicines for treating the suppurative otitis meadia.
Description
Technical field
The present invention relates to the Chinese medicine composition of therapeutic purulent otitis media, also relate to the preparation method of described Chinese medicine composition, and its preparation therapeutic purulent otitis media medicine in application.
Background technology
Suppurative otitis media is the suppurative inflammation of middle ear mucosa, is apt to occur in child, be also children's's hearing loss commonly encountered diseases because of.Acute suppurative otitis media infects by suppurative bacterium the otitis media caused, its symptom mainly otalgia, suppurate, for childhood period common infectious disease, sickness rate is high, easily recurs, complication and sequela many.Infection control, adequate drainage, removing the cause of disease is its Therapeutic Principle.If the acute suppurative otitis media course of disease was more than 6 ~ 8 weeks, pathological changes is invaded and middle ear mucosa, periosteum or deeply reach sclerotin and cause irreversible damage to be called chronic suppurative otitis media.Chronic suppurative otitis media refers to middle-ear mucosa, periosteum or deeply reaches the chronic suppurative inflammation of sclerotin, comparatively common clinically, often be interrupted with in ear or persistence is suppurated, the perforation of ear drum, auditory dysesthesia for main clinical manifestation, the complication outside intracranial, cranium can be caused time serious.
The medicine of existing therapeutic purulent otitis media all in various degree also exist that cure rate is low, the defect such as slow curative effect, side effect are large.Therefore, a kind of Chinese medicine composition suppurative otitis media to definite therapeutic effect is newly developed, by significant and using value.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of Chinese medicine composition of therapeutic purulent otitis media, and cure rate and the total effective rate of this traditional Chinese medicine composition for treating suppurative otitis media are high, determined curative effect;
Another technical problem to be solved by this invention is to provide a kind of preparation method of described Chinese medicine composition.
For solving the problems of the technologies described above, the technical solution used in the present invention is:
First the present invention discloses a kind of Chinese medicine composition of therapeutic purulent otitis media, comprises following component: Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri); The weight portion of each component is: Nux Canarii albi 30-50 part, Herba Bidentis Bipinnatae 25-40 part, Herba Teucrii Viscidi 20-35 part, Herba Ecliptae 15-25 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part; Preferably, the weight portion of each component is: Nux Canarii albi 45 parts, Herba Bidentis Bipinnatae 32 parts, Herba Teucrii Viscidi 30 parts, Herba Ecliptae 21 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts.
Nux Canarii albi is the pit of olive subject plant Fructus Canarii albi.Nature and flavor: " detailed outline ": " sweet puckery, temperature, nontoxic." function cures mainly: disappear all fishbone fishbones, treats for stomachache, hernia, discharging fresh blood stool.
Herba Bidentis Bipinnatae is the herb of feverfew Herba Bidentis Bipinnatae.Nature and flavor: 1. supplement to the Herbal: " bitter in the mouth is flat, nontoxic." 2. " Quanzhou book on Chinese herbal medicine ": " is warm in nature, and bitter in the mouth is nontoxic." function cures mainly: heat clearing away, removing toxic substances, dissipating blood stasis, detumescence.Treating malaria disease, diarrhoea, dysentery, hepatitis, acute nephritis, stomachache, dysphagic, acute appendicitis, laryngopharynx swelling and pain, traumatic injury, snake bite and insect sting.
Herba Teucrii Viscidi is the herb of labiate Herba Teucrii Viscidi.Nature and flavor are pungent, cool.Function cures mainly: cool the blood dissipate blood stasis, subduing swelling and detoxicating.Control haematemesis, discharging fresh blood stool, traumatic injury, carbuncle, hemorrhoid, erysipelas.
Herba Ecliptae, another name Herba Ecliptae is the dry aerial parts of feverfew Eclipta prostrata EcliptaprostrataL..Nature and flavor are sweet, sour, cold.Return kidney, Liver Channel.Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Herba Desmodii Triquetri (Herba Tadehagi Triquetri), is pulse family beggar-ticks plant gourd tea Desmodiumtriquetrum (L.) DC., is used as medicine with Herb.Property mildly bitter flavor, puckery, cool.Function cures mainly: heat-clearing and toxic substances removing, and removing food stagnancy dampness removing, parasite killing is anticorrosion.For preventing heatstroke, cold, fever, laryngopharynx swelling and pain, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, Fructus Ananadis comosi is poisoning, children's's scleroderma.
The Chinese medicine composition of Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) compatibility is had certain curative effect to suppurative otitis media by the present invention.When following crude drug is added on the basis of drug composition in the present invention, there is effect of better heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling: Semen Cuscutae and Fructus Psoraleae; The weight portion of each component is: Semen Cuscutae 25-45 part, Fructus Psoraleae 20-30 part; Preferably, the weight portion of each component is: Semen Cuscutae 35 parts, Fructus Psoraleae 27 parts.
Semen Cuscutae is the dry mature seed of convolvulus cuscuta plant CuscutachinensisLam..Nature and flavor are sweet, temperature.Return liver,kidney,spleen warp.Function cures mainly: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.
Fructus Psoraleae is the dry mature fruit of legumes psoraleae PsoraleacorylifoliaL..Nature and flavor are pungent, bitter, temperature.Return kidney, spleen channel.Function cures mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal.For impotence and seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
The result of Clinical efficacy comparison proves, the Chinese medicine composition of Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri) compatibility is had certain therapeutic effect to suppurative otitis media by the present invention, and cure rate is 72%, and effective percentage is 8%, and total effective rate reaches 80%.And on the basis of above-mentioned Chinese medicine composition, add Semen Cuscutae and Fructus Psoraleae, significantly improve the therapeutic effect of suppurative otitis media, cure rate reaches 98%, and total effective rate reaches 100%; Its cure rate and total effective rate improve more than 20 percentage points and 16 percentage points than other Chinese medicine composition groups respectively, and do not occur any untoward reaction in the treatment, follow up a case by regular visits to more afterwards, have no recurrence.Above result proves, has obvious synergistic function, the determined curative effect of therapeutic purulent otitis media between crude drug Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Semen Cuscutae, Fructus Psoraleae.
Following crude drug is added further in the basis stating Chinese medicine composition on the invention, there is better heat clearing and damp drying, effect of eliminating fire and detoxication: Herba Saxifragae, Rhizoma Coptidis and Radix Ophiopogonis; The weight portion of each component is: Herba Saxifragae 20-35 part, Rhizoma Coptidis 20-30 part, Radix Ophiopogonis 15-25 part; Preferably, the weight portion of each component is: Herba Saxifragae 33 parts, Rhizoma Coptidis 25 parts, Radix Ophiopogonis 20 parts.
Herba Saxifragae is the herb of saxifragaceae plant Herba Saxifragae SaxifragastoloniferaMeerb. [S.sarmentosaL.f.].Nature and flavor bitter, acrid, cold.Slightly poisonous.Function cures mainly: heat-clearing and toxic substances removing.For fever of children, cough and asthma; Otitis media is controlled in external, and auricle festers, furuncle, furuncle and phyma, eczema.
Rhizoma Coptidis is the dry rhizome of ranunculaceae plant Rhizoma Coptidis CoptischinensisFranch., Coptis deltoidea C.Y.Cheng et Hsiao CoptisdeltoideaC.Y.ChengetHsiao or Coptis Teeta Wall CoptisteetaWall..Nature and flavor are bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Radix Ophiopogonis is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf) Ophiopogonjaponicus (Thunb.) Ker-Gawl..Nature and flavor are sweet, and micro-hardship, is slightly cold.GUIXIN, lung, stomach warp.Function cures mainly: YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Clinical practice result shows, the present invention adds Herba Saxifragae, Rhizoma Coptidis and the Chinese medicine composition of Radix Ophiopogonis further, and the cure rate for the treatment of chronic suppurative otitis media reaches 99.2%.
The invention also discloses a kind of method preparing described Chinese medicine composition, comprise the following steps: take each component according to described weight portion, pulverize, mix homogeneously, to obtain final product.The present invention is not particularly limited described pulverizing, can adjust according to actual needs, as a reference, is crushed to 100-300 order.
Chinese medicine composition of the present invention can be applied to the medicine preparing therapeutic purulent otitis media, treatment on effective dose described Chinese medicine composition basis on add suitable adjuvant or carrier.Wherein, the dosage form of described medicine is oral formulations, comprising: powder, tablet, electuary, pill, Emulsion, granule, soft capsule, hard capsule or microcapsule.Therapeutic purulent otitis media of the present invention comprises: acute suppurative otitis media and chronic suppurative otitis media.
Adjuvant of the present invention or carrier refer to adjuvant or the carrier of pharmaceutical field routine, such as: diluent, agent of bursting apart, lubricant, excipient, binding agent, fluidizer, filler, surfactant etc.; In addition, other adjuvant can also be added in the composition, as flavouring agent and sweeting agent.Described diluent can be that one or more increase the composition of tablet weight and volume, and conventional diluent comprises lactose, starch, pregelatinized Starch, microcrystalline Cellulose, sorbitol, mannitol and inorganic calcium salt etc.Described disintegrating agent can be crospolyvinylpyrrolidone (with gross weight than being 2-6%), one or more mixture in cross-linking sodium carboxymethyl cellulose (with gross weight than being 2-6%), alginic acid (with gross weight than being 2-5%), microcrystalline Cellulose (with gross weight than being 5-15%).Described lubricant comprises stearic acid, sodium stearate, magnesium stearate, calcium stearate, Polyethylene Glycol, Pulvis Talci, one or more mixture in hydrogenated vegetable oil.The amount ranges (with gross weight ratio) of lubricant is generally 0.25-0.75%.Described binding agent can be the composition that one or more are conducive to granulating, can be starch slurry (10-30%, with binding agent gross weight ratio), hydroxypropyl emthylcellulose (2-5%, with binding agent gross weight ratio), polyvinylpyrrolidone (2-20%, with binding agent gross weight ratio).Described fluidizer can for one or more mixture in micropowder silica gel, Pulvis Talci, magnesium trisilicate.The composition that described surfactant can improve wettability for one or more and increase drug-eluting, such as sodium lauryl sulphate (usual range is 0.2-6%, with gross weight ratio).
The present invention's each taste crude drug used can be bought at pharmacy and obtain.
The usage of Chinese medicine composition of the present invention and consumption: dosage depends on the factor such as age, health status of concrete dosage form, patient.As guidance, usage and dosage: powder, boiled water is taken after mixing it with water, each 3-5g, 2 times on the one, within 3 days, is a course for the treatment of.
Technical solution of the present invention compared with prior art, has following beneficial effect:
The compatibility of Chinese medicine composition of the present invention is reasonable, between crude drug Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Semen Cuscutae, Fructus Psoraleae, there is obvious synergistic function, cure rate and the total effective rate of therapeutic purulent otitis media can be significantly improved, determined curative effect.Crude drug Herba Saxifragae, Rhizoma Coptidis and Radix Ophiopogonis are added further in the basis stating Chinese medicine composition on the invention, there is better heat clearing and damp drying, effect of eliminating fire and detoxication.The preparation method of Chinese medicine composition of the present invention is simple, has no side effect, has a good application prospect.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.It should be understood that described embodiment is only exemplary, any restriction is not formed to scope of the present invention.It will be understood by those skilled in the art that and can modify to the details of technical solution of the present invention and form or replace down without departing from the spirit and scope of the present invention, but these amendments or replacement all fall into protection scope of the present invention.
Embodiment 1 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 30, Herba Bidentis Bipinnatae 25, Herba Teucrii Viscidi 20, Herba Ecliptae 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, be crushed to 100 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 2 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 50 parts, Herba Bidentis Bipinnatae 40 parts, Herba Teucrii Viscidi 35 parts, Herba Ecliptae 25 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 20 parts, be crushed to 300 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 3 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 45, Herba Bidentis Bipinnatae 32, Herba Teucrii Viscidi 30, Herba Ecliptae 21, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18, be crushed to 250 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 4 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 30, Herba Bidentis Bipinnatae 25, Herba Teucrii Viscidi 20, Herba Ecliptae 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Semen Cuscutae 25, Fructus Psoraleae 20, be crushed to 100 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 5 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 50, Herba Bidentis Bipinnatae 40, Herba Teucrii Viscidi 35, Herba Ecliptae 25, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 20, Semen Cuscutae 45, Fructus Psoraleae 30, be crushed to 300 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 6 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 45, Herba Bidentis Bipinnatae 32, Herba Teucrii Viscidi 30, Herba Ecliptae 21, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18, Semen Cuscutae 35, Fructus Psoraleae 27, be crushed to 250 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 7 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 30, Herba Bidentis Bipinnatae 25, Herba Teucrii Viscidi 20, Herba Ecliptae 15, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10, Semen Cuscutae 25, Fructus Psoraleae 20, Herba Saxifragae 20, Rhizoma Coptidis 20, Radix Ophiopogonis 15, be crushed to 100 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 8 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 50, Herba Bidentis Bipinnatae 40, Herba Teucrii Viscidi 35, Herba Ecliptae 25, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 20, Semen Cuscutae 45, Fructus Psoraleae 30, Herba Saxifragae 35, Rhizoma Coptidis 30, Radix Ophiopogonis 25, be crushed to 300 orders, mix homogeneously, obtain final product according to following ratio.
Embodiment 9 Chinese medicine composition
Each component (g) is taken: Nux Canarii albi 45, Herba Bidentis Bipinnatae 32, Herba Teucrii Viscidi 30, Herba Ecliptae 21, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18, Semen Cuscutae 35, Fructus Psoraleae 27, Herba Saxifragae 33, Rhizoma Coptidis 25, Radix Ophiopogonis 20, be crushed to 250 orders, mix homogeneously, obtain final product according to following ratio.
The preparation of embodiment 10 granule
Chinese medicine composition prepared by Example 33 grams, mix with 5 grams of microcrystalline Cellulose, 3 grams of lactose, 1 gram of cross-linking sodium carboxymethyl cellulose, with 3% polyvidone ethanol (50% concentration) for binding agent soft material, cross 40 mesh sieves to granulate, 60 DEG C of dryings, cross 30 mesh sieve granulate, obtain granule.
The preparation of embodiment 11 tablet
Chinese medicine composition 100g prepared by Example 6, adds mannitol 25g, sucrose 25g, with 5% polyvidone ethanol wet granulation, 24 mesh sieves are granulated, drying 4 hours under 60 DEG C of conditions, and 20 mesh sieve granulate, add magnesium stearate 0.5g, be mixed evenly, tabletting, make 1000.Every sheet is containing crude drug 100mg.
The preparation of embodiment 12 pill
Chinese medicine composition 100g prepared by Example 9, mixes with 35g microcrystalline Cellulose, adds water and make plain ball as binding agent.
The Opadry (stomach dissolution type) of Shanghai Ka Lekang (COLORCON) packaging technique company limited is selected by above-mentioned plain ball to carry out coating for coating material, coating conditions is as follows: select water to be lytic agent, coating solution concentration is 18%, coating weight gain 4%, inlet temperature 65 DEG C; Sheet bed tempertaure 43 DEG C; Atomizing pressure 2.0bar; Coating pan rotating speed 17rmp, charging flow velocity 3g/min, obtains pill.
The effect observation of test example 1 traditional Chinese medicine composition for treating suppurative otitis media
Be patient 400 people (cardinal symptom is otalgia, suppurates) of acute suppurative otitis media by clinical diagnosis, be divided into 8 groups of (each group patient no significant difference (P>0.05) in age, severity extent at random, there is comparability), use respectively following Chinese medicine composition 1-8 (unit: g):
Chinese medicine composition 1: Nux Canarii albi 45, Herba Bidentis Bipinnatae 32, Herba Teucrii Viscidi 30, Herba Ecliptae 21, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18;
Chinese medicine composition 2-8 adds following crude drug respectively on Chinese medicine composition 1 basis:
Chinese medicine composition 2: Semen Cuscutae 35, dried Alumen 27;
Chinese medicine composition 3: Semen Cuscutae 35, Moschus 27;
Chinese medicine composition 4: Spica Prunellae 35, Fructus Psoraleae 27;
Chinese medicine composition 5: Semen Cuscutae 35, Fructus Psoraleae 27;
Chinese medicine composition 6: Fructus Forsythiae 35, Fructus Psoraleae 27;
Chinese medicine composition 7: Os Draconis 35, Radix Sophorae Flavescentis 27;
Chinese medicine composition 8: Herba Taraxaci 35, Herba Patriniae 27;
The preparation method of each Chinese medicine composition is with embodiment 3.Using method is: boiled water is taken after mixing it with water, every day 2 times, each 3g.Treating 3 days is 1 course for the treatment of, and 2 courses for the treatment of terminate rear statistics curative effect.
Efficacy assessment standard:
Recovery from illness: otalgia, the malaise symptoms such as to suppurate disappear completely;
Effective: otalgia, the malaise symptoms such as to suppurate obviously are alleviated;
Invalid: above-mentioned malaise symptoms is unchanged, even increases the weight of.
The comparative result of clinical efficacy is in table 1.Total effective rate=cure rate+effective percentage.
The effect of the different traditional Chinese medicine composition for treating suppurative otitis media of table 1
Result shows, Chinese medicine composition of the present invention 1 pair of suppurative otitis media has certain therapeutic effect, and fully recover 36 people, and cure rate is 72%; Effective 4 people, effective percentage is 8%; Total effective rate reaches 80%.And use Chinese medicine composition 5 of the present invention, fully recover 49 people, and cure rate is 98%, effective 1 people, and effective percentage is 2%, and total effective rate reaches 100%; Its cure rate and total effective rate are higher than other Chinese medicine composition groups more than 20 percentage points and 16 percentage points respectively, and, there is not any untoward reaction in the treatment, within rear 1 year, follow up a case by regular visits to, do not recur.
Above result proves, Semen Cuscutae and Fructus Psoraleae are added in the basis of Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), can significantly improve cure rate and the total effective rate of therapeutic purulent otitis media.Illustrate, between crude drug Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) and Semen Cuscutae, Fructus Psoraleae, there is obvious synergistic function.
The practical application of test example 2 Chinese medicine composition of the present invention
By clinical diagnosis be chronic suppurative otitis media (main clinical manifestation be in ear be interrupted or persistence is suppurated, the perforation of ear drum, auditory dysesthesia) patient 123 people, take the embodiment of the present invention 9 Chinese medicine composition, boiled water is taken after mixing it with water, every day 2 times, each 3g.The cure rate for the treatment of 15 days is follow up a case by regular visits to after 99.2%, 3 months, has no recurrence.
Claims (10)
1. a Chinese medicine composition for therapeutic purulent otitis media, is characterized in that, comprises following component: Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae and Herba Desmodii Triquetri (Herba Tadehagi Triquetri).
2. according to Chinese medicine composition according to claim 1, it is characterized in that, the weight portion of each component is: Nux Canarii albi 30-50 part, Herba Bidentis Bipinnatae 25-40 part, Herba Teucrii Viscidi 20-35 part, Herba Ecliptae 15-25 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part.
3. according to Chinese medicine composition according to claim 2, it is characterized in that, the weight portion of each component is: Nux Canarii albi 45 parts, Herba Bidentis Bipinnatae 32 parts, Herba Teucrii Viscidi 30 parts, Herba Ecliptae 21 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts.
4. a Chinese medicine composition for therapeutic purulent otitis media, is characterized in that, comprises following component: Nux Canarii albi, Herba Bidentis Bipinnatae, Herba Teucrii Viscidi, Herba Ecliptae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Semen Cuscutae and Fructus Psoraleae.
5. according to Chinese medicine composition according to claim 4, it is characterized in that, the weight portion of each component is: Nux Canarii albi 30-50 part, Herba Bidentis Bipinnatae 25-40 part, Herba Teucrii Viscidi 20-35 part, Herba Ecliptae 15-25 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 10-20 part, Semen Cuscutae 25-45 part, Fructus Psoraleae 20-30 part.
6. according to Chinese medicine composition according to claim 5, it is characterized in that, the weight portion of each component is: Nux Canarii albi 45 parts, Herba Bidentis Bipinnatae 32 parts, Herba Teucrii Viscidi 30 parts, Herba Ecliptae 21 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 18 parts, Semen Cuscutae 35 parts, Fructus Psoraleae 27 parts.
7. according to Chinese medicine composition according to claim 4, it is characterized in that, also comprise following component: Herba Saxifragae, Rhizoma Coptidis and Radix Ophiopogonis;
Preferably, the weight portion of each component is: Herba Saxifragae 20-35 part, Rhizoma Coptidis 20-30 part, Radix Ophiopogonis 15-25 part;
Preferred, the weight portion of each component is: Herba Saxifragae 33 parts, Rhizoma Coptidis 25 parts, Radix Ophiopogonis 20 parts.
8. prepare a method for claim 1 to 7 Chinese medicine composition described in any one, it is characterized in that, comprise the following steps: take each component according to described weight portion, pulverize, mix homogeneously, to obtain final product.
9. the application of claim 1 to 7 Chinese medicine composition described in any one in the medicine of the therapeutic purulent otitis media of preparation.
10. according to application according to claim 9, it is characterized in that, the dosage form of described medicine is oral formulations, comprising: powder, tablet, electuary, pill, Emulsion, granule, soft capsule, hard capsule or microcapsule.
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| CN106074895A (en) * | 2016-06-22 | 2016-11-09 | 王青青 | A kind of Chinese medicine treating acute suppurative otitis media and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2424512A1 (en) * | 2000-10-18 | 2002-04-25 | Auris Ehf. | Delivery system and method of treating or preventing otitis media |
| CN102671061A (en) * | 2012-04-20 | 2012-09-19 | 许梅 | Traditional Chinese medicine for treating chronic suppurative otitis media, as well as application and preparation method of same |
| CN104147448A (en) * | 2014-08-29 | 2014-11-19 | 蔡炜 | Orally-taken traditional Chinese medicinal composition for treating chronic otitis media |
-
2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2424512A1 (en) * | 2000-10-18 | 2002-04-25 | Auris Ehf. | Delivery system and method of treating or preventing otitis media |
| CN102671061A (en) * | 2012-04-20 | 2012-09-19 | 许梅 | Traditional Chinese medicine for treating chronic suppurative otitis media, as well as application and preparation method of same |
| CN104147448A (en) * | 2014-08-29 | 2014-11-19 | 蔡炜 | Orally-taken traditional Chinese medicinal composition for treating chronic otitis media |
Non-Patent Citations (2)
| Title |
|---|
| 黄泰康主编: "《中医疑难病方药手册》", 31 July 1997, 中国医药科技出版社 * |
| 黄泰康主编: "《五官科疾病》", 30 April 1994, 中国医药科技出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074895A (en) * | 2016-06-22 | 2016-11-09 | 王青青 | A kind of Chinese medicine treating acute suppurative otitis media and preparation method thereof |
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