CN105532490B - The multi-functional non-human primate cognitive function test cage of touch screen - Google Patents
The multi-functional non-human primate cognitive function test cage of touch screen Download PDFInfo
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- CN105532490B CN105532490B CN201610076775.6A CN201610076775A CN105532490B CN 105532490 B CN105532490 B CN 105532490B CN 201610076775 A CN201610076775 A CN 201610076775A CN 105532490 B CN105532490 B CN 105532490B
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- 238000012360 testing method Methods 0.000 title claims abstract description 35
- 230000003920 cognitive function Effects 0.000 title claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- 238000012546 transfer Methods 0.000 claims abstract description 17
- 230000006698 induction Effects 0.000 claims abstract description 5
- 238000012544 monitoring process Methods 0.000 claims description 5
- 210000004556 brain Anatomy 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 abstract description 17
- 230000006870 function Effects 0.000 abstract description 6
- 241001465754 Metazoa Species 0.000 abstract description 5
- 238000002474 experimental method Methods 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 abstract description 4
- 241000282553 Macaca Species 0.000 description 12
- 235000013305 food Nutrition 0.000 description 8
- 238000012549 training Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 238000010171 animal model Methods 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 239000003651 drinking water Substances 0.000 description 3
- 235000020188 drinking water Nutrition 0.000 description 3
- 235000015203 fruit juice Nutrition 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000003925 brain function Effects 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 241000282560 Macaca mulatta Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 230000007177 brain activity Effects 0.000 description 1
- 230000003930 cognitive ability Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/03—Housing for domestic or laboratory animals
- A01K1/031—Cages for laboratory animals; Cages for measuring metabolism of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/0005—Stable partitions
- A01K1/0017—Gates, doors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K1/00—Housing animals; Equipment therefor
- A01K1/02—Pigsties; Dog-kennels; Rabbit-hutches or the like
- A01K1/035—Devices for use in keeping domestic animals, e.g. fittings in housings or dog beds
- A01K1/0356—Feeding or drinking devices associated with cages
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Housing For Livestock And Birds (AREA)
- Testing Of Devices, Machine Parts, Or Other Structures Thereof (AREA)
Abstract
The multi-functional non-human primate cognitive function test cage of touch screen belongs to animal experiment device technical field.Including a test-cage and a transfer cage.An infrared induction touch screen coupled with computer is fastened on the rear facade that test-cage can be moved forward and backward, top surface is equipped with watch window and moveable camera, rear locking position can be moved up and down before being located at touch screen touch surface to water nozzle, lattice-shaped subjacent is equipped with the dropping tray that can be pushed into and pull out from test-cage side elevation, and the preceding facade of lattice-shaped sets the test cage door that can be pushed into and pull out from test-cage side together.It shifts cage and has steamboat and watch window, preceding facade is the plug-type transfer cage door that can be docked with test cage door after opening together.The present apparatus not only can flexibly, conveniently, intelligently, efficiently, accurately carry out non-human primate based on modern computer technology and train and test, and not need separately to be equipped with corresponding monkey cage, and utility function is more, acquisition cost and use cost are low.
Description
Technical field
The invention belongs to animal experiment device technical fields, and in particular to one kind is for recognizing non-human primate
The device of aptitude tests.
Background technique
In Neurobiology field, it is often necessary to Behavior test is carried out to experimental animal, by allowing experimental animal to complete
Certain behaviouristics normal form assesses its cognitive ability and brain function, and then discloses the rule of brain activity.Inhuman spirit
Long class animal, such as macaque have the nervous system of advanced complexity, can complete a variety of as a kind of high-grade experimental animal
Complicated behaviouristics task；By completing these behaviouristics tasks to carry out it higher brain and cognitive function evaluation to be nerve
One very important research means of biology.
Based on Neuropsychology, forefathers have had developed the behaviouristics normal form of a set of assessment macaque higher brain, in conjunction with
Food reward completes a series of task by macaque, when by evaluating difficulty, accuracy, the completion sequence of completion task, reacting,
The data such as interval time are come higher brains and cognitive functions such as learning and memory, decision, the reasonings of evaluating macaque.It is domestic at present right
Device as shown in Figure 1 is used mostly in the Behavior test of macaque, that is, using based on the WGTA system developed the eighties
Test method needs experimenter to operate equipment one to one and macaque is trained and is tested, and process is extremely cumbersome, time-consuming
Inefficiency；More trained closely related with operator with test, experimental result is highly susceptible to experimenter's influence；
Each food reward is given by experimenter, can not accurate quantification；The operating process of different experimenters can not be completely
Unanimously, have the shortcomings that artificial data error and poor repeatability.Furthermore it is mostly directly trained and tests in monkey house, be tested Mi
Interference of the monkey vulnerable to other macaques.This Behavior test system by manpower has been unable to satisfy present more macaques, more
The requirement of experiment of business, accurate repeatable measurement.
Occurs a kind of " monkey CANTAB touch screen cognitive system " (model 8095 from imported from America on the market recently
Type/8905 types), the recognition tests for non-human primate.It has central controller, stimulating module and animal response
Module can connect keyboard, monitor and mouse.Software includes CANTAB test application program and the more matchmakers of basic Whisker
Body application software.CANTAB application program includes a series of test execution function, user can directly by touch screen into
Row setting and operation.System has food award and liquid to award software module function.80950 types are to carry out food prize to rhesus macaque
Reward experiment, 89051 types are to carry out liquid award experiment, and the two is also applied for awarding other non-human primates.
80951 have the suction pipe of special designing, carry out liquid award with graduated peristaltic pump by one.Hardware includes: a frame
The touch screen panel of shell protection, fixing response lever, food dispenser, a bracket.Diagonal line response region is one anti-
Infrared touch panel of the type with LCD monitor is splashed, a signal lamp, the food dispenser with pallet and a response thick stick are next to
Bar.All components are mounted in stainless steel cabinet.The device is disadvantageous in that:
1, its hardware is only the box-like equipment with touch screen, and when use must be equipped with corresponding cage；Furthermore from it is great (about
25kg), it is adjusted at a distance from monkey cage and height, it is also necessary to be equipped with corresponding liftable mobile platform.
It 2, is to be rewarded by feeding to give macaque, the food given needs special shaped and hardness
Biscuit particulate, otherwise its automatic foodstuff delivering system can break down, and the manufacture difficulty of feeding food is larger, and costly (price is about
For 2800 yuans/kilogram).
3, lack some utility functions, such as water supply system is unable to adjust position, do not prevent macaque from accidentally touching touch screen
Design, the camera etc. that subject animal is not monitored.
4, expensive, 15 to 20 ten thousand RMB.
Summary of the invention
The purpose of the present invention is to provide a kind of multi-functional non-human primate cognitive function test cage of touch screen, the equipment
Compared to the prior art, not only can based on modern computer technology flexibly, conveniently, intelligently, efficiently, accurately carry out non-human primates
Zoology training and test, and do not need separately to be equipped with corresponding monkey cage, and utility function is more, acquisition cost and use cost are low.
The structure of apparatus of the present invention:
Including a test-cage and a transfer cage；
Test-cage bottom is equipped with longitudinal rear facade track, can be moved forward and backward and after the rear facade of locking position is installed on this
On facade track；An infrared induction touch screen electrically connected with computer, the touch surface direction of the touch screen are fastened on facade afterwards
Inside test-cage；The camera frame that the top surface of test-cage is equipped with closed transparent observing window and monitoring camera can be allowed mobile；
Waterworks include as the stepper motor of injector push-rod power, the electronic controller of stepper motor, water inlet pipe and connection
To the hose of water nozzle and syringe outlet；Be respectively provided on two side elevations of test-cage one it is vertical to water nozzle beam track,
Water supply in front of touch screen touch surface is tight-lipped to be fixed in on water nozzle crossbeam, can moving up and down the horizontal to water nozzle of rear locking position
Girder span branch is at two on water nozzle beam track；Test-cage lattice-shaped subjacent, which is equipped with, to be pushed into and draw from test-cage side elevation
Dropping tray out；The preceding facade of test-cage lattice-shaped sets the test cage door that can be pushed into and pull out from test-cage side together；
It shifts cage and has steamboat and watch window, what can be docked with test cage door after facade is opened before transfer cage for one pushes away
Pull-type transfer cage door.
Syringe in waterworks, as the stepper motor of injector push-rod power, the electronic controller of stepper motor, with
And the coupling structure between them is the prior art.Test application program and multimedia application software with present apparatus cooperation are also
The prior art is known by those skilled in the art.
The use of apparatus of the present invention: the transfer cage with steamboat can be moved easily, between life cage and test-cage
Monkey is transported, the case where watch window of cage is for observing monkey in transfer cage is transported.After transhipment in place, allows and shift cage door and test
Cage door docking, pumping opens transfer cage door and test cage door, after allowing monkey to enter test-cage, inserts and closes test cage door.According to the body of monkey
Type and age adjust in test-cage to the front-rear position of water nozzle upper and lower position and touch screen, make monkey complete under the posture of natural sitting
At task and obtain drinking-water reward.The syringe equipped with drinking-water or fruit juice can be accurately pushed by computer control, is quantitatively given
Monkey drinking-water or fruit juice reward.When monkey be correctly completed touch screen task and after, clear water or fruit juice can be drunk to water nozzle.Test-cage
Watch window is for observing and monitoring monkey situation in cage, the removable monitoring screen to adjust camera of lens supporting structure, side
Just the training and test case of experimenter's remote reviewing monkey, in due course regulation experiment program.The dropping tray in training cage bottom portion needs clear
It can be extracted out from side when reason.
Beneficial effects of the present invention: it not only can flexibly, conveniently, intelligently, efficiently, accurately be carried out based on modern computer technology
Non-human primate training and test, and do not need separately to be equipped with corresponding monkey cage, and utility function is more, acquisition cost and makes
With at low cost.Specifically, the invention has the characteristics that:
1, package unit occupied area is no more than 3 square metres, saves space；Drawing and pulling type dropping tray is arranged at lower part, facilitates progress
It sweeps.
2, position can be adjusted to adapt to the macaque of all ages and classes and figure.
3, can be by computer-controlled full-automatic training and test, the condition tested every time and reward are stringent quantitative, subtract significantly
Artificial error and artificial interference are lacked, training effectiveness is greatly improved, and test result is objective.
4, remote control and surveillance technology can be used, a staff can operate multiple devices；Training, test, number
It according to record and counts by computer automatic running, greatly reduces the workload of staff, highly improve conventional efficient.
5, it is convenient to operate.Test-cage is equipped with compact and flexible transfer cage, transfer cage and most domestic macaque life cage
Matching, experimenter only need to realize transfer of the monkey between life cage and test-cage easily using transfer cage.
6, it repairs and easy to maintain.
Detailed description of the invention
Fig. 1 is the stereoscopic schematic diagram of existing device.
Fig. 2 is perspective structure schematic diagram when embodiment test-cage is docked with transfer cage.
Fig. 3 is the stereoscopic schematic diagram of embodiment.
Fig. 4 is the schematic front view of embodiment test-cage.
Fig. 5 is in embodiment to water nozzle, to water nozzle track and to water nozzle crossbeam coupling structure stereoscopic schematic diagram.
Specific embodiment
See the embodiment of Fig. 2~Fig. 5.Including a test-cage 1 and a transfer cage 2；
1 bottom of test-cage is equipped with longitudinal rear facade track (being not drawn into figure), can be moved forward and backward and locking position not
Facade 3 is installed on the rear facade track after rust steel steel plate, and square orifice is opened on rear facade, one is fastened in mouth and is electrically connected with computer
17 cun of infrared induction touch screens 4, the touch surface of touch screen 4 is towards the inside of test-cage 1.The top surface of test-cage 1 is equipped with organic
Glass window mouth 5 and the camera frame 6 that monitoring camera (being not drawn into figure) can be allowed mobile.Waterworks include as note
The stepper motor of emitter push rod power, the electronic controller of stepper motor, water inlet pipe 18, connection are to water nozzle 7 and syringe outlet
Hose.Be respectively provided on two stainless steel plate side elevations of test-cage 1 one it is vertical to water nozzle beam track 8, be located at and touch
Shield in front of 4 touch surfaces to water nozzle 7 be anchored on on water nozzle crossbeam 9, can move up and down rear locking position to water nozzle crossbeam 9 across
Branch is at two on water nozzle beam track 8.The lattice-shaped subjacent of test-cage 1 is equipped with and can be pushed into from the side elevation of test-cage 1
With the dropping tray 21 of pull-out.The preceding facade of 1 lattice-shaped of test-cage sets the test-cage that can be pushed into and pull out from 1 side of test-cage together
Door 10.Cage 2 is shifted with four steamboats 11 and watch window 12 that can only lock.The preceding facade for shifting cage 2 is after opening together
The plug-type transfer cage door 13 that can be docked with test cage door 10.14 be to hang over 1 top pocket for the punch head of test-cage for that will shift cage 2
Hook；15 be the handle for shifting cage 2, and 16 be the side handrail for shifting cage 2, and 17 be the flat stabilizer blade of test-cage 11, and 19 be water inlet
Interface, 20 be the knob of dropping tray 21, and 22 be the height adjustment fastening screw to water nozzle crossbeam 9.
Claims (3)
1. a kind of multi-functional non-human primate cognitive function test cage of touch screen, it is characterised in that:
Including a test-cage and a transfer cage；
Test-cage bottom is equipped with longitudinal rear facade track, can be moved forward and backward and the rear facade of locking position is installed on the rear facade
On track；Square orifice is opened on facade afterwards, an infrared induction touch screen electrically connected with computer, the touching of the touch screen are fastened in mouth
It touches facing towards inside test-cage；The top surface of test-cage is equipped with closed transparent observing window and can allow monitoring camera is mobile to take the photograph
As head frame；Waterworks include as the stepper motor of injector push-rod power, the electronic controller of stepper motor, water inlet pipe
With connection to the hose of water nozzle and syringe outlet；Be respectively provided on two side elevations of test-cage one it is vertical to water nozzle crossbeam
Track, water supply in front of touch screen touch surface is tight-lipped be fixed in on water nozzle crossbeam, can move up and down rear locking position to
Water nozzle crossbeam is across branch at two on water nozzle beam track；Test-cage lattice-shaped subjacent is equipped with and can push away from test-cage side elevation
The dropping tray for entering and pulling out；The preceding facade of test-cage lattice-shaped sets the test-cage that can be pushed into and pull out from test-cage side together
Door；
It shifts cage and has steamboat and watch window, can be docked with test cage door after facade is opened before transfer cage for one plug-type
Shift cage door；
Entire cognitive function test cage occupied area is no more than 3 square metres.
2. the multi-functional non-human primate cognitive function test cage of touch screen as described in claim 1, it is characterised in that: with electricity
The infrared induction touch screen that brain electrically connects is 17 cun.
3. the multi-functional non-human primate cognitive function test cage of touch screen as described in claim 1, it is characterised in that: test
The top surface of cage sets organic glass observation window mouth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610076775.6A CN105532490B (en) | 2016-02-03 | 2016-02-03 | The multi-functional non-human primate cognitive function test cage of touch screen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201610076775.6A CN105532490B (en) | 2016-02-03 | 2016-02-03 | The multi-functional non-human primate cognitive function test cage of touch screen |
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| CN105532490A CN105532490A (en) | 2016-05-04 |
| CN105532490B true CN105532490B (en) | 2019-03-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000022057A1 (en) * | 2020-09-18 | 2022-03-18 | Tecniplast Spa | CAGE OR CAGE FOR LAYING LABORATORY ANIMALS |
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| CN106386539B (en) * | 2016-08-31 | 2019-08-30 | 广西南宁灵康赛诺科生物科技有限公司 | It is a kind of for testing the device and test method of primate laboratory animal memory function |
| CN107912326B (en) * | 2016-10-10 | 2021-03-05 | 中国科学院脑科学与智能技术卓越创新中心 | Animal behavior training method and training device |
| CN107047339A (en) * | 2017-03-29 | 2017-08-18 | 袁超 | A kind of medical experiment monkey class rearging cage |
| CN107041322A (en) * | 2017-05-02 | 2017-08-15 | 中国人民解放军军事医学科学院基础医学研究所 | Non-human primates vision and Cognitive Function Research system |
| US11172648B2 (en) * | 2018-10-24 | 2021-11-16 | Bioculture Mauritius, Ltd. | Non-human primate restraint system |
| CN110192930B (en) * | 2019-07-10 | 2024-06-21 | 南京市红山森林动物园管理处 | Compressible wild animal treatment baoding cage |
| CN111727904A (en) * | 2020-05-18 | 2020-10-02 | 中国科学院深圳先进技术研究院 | Experimental animal behavior monitoring device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1175598A (en) * | 1997-09-05 | 1999-03-23 | Takeda Chem Ind Ltd | Breeding cage for monkey and tool for catching monkey |
| JP5296475B2 (en) * | 2008-09-30 | 2013-09-25 | 三菱化学メディエンス株式会社 | Transport cage and non-human primate transport method |
| KR101574219B1 (en) * | 2014-01-13 | 2015-12-04 | 한국생명공학연구원 | Cage for transferring primate using vehicle |
| KR20150101769A (en) * | 2014-02-27 | 2015-09-04 | 이상철 | Mobile Primate Cage |
| CN204306922U (en) * | 2014-09-02 | 2015-05-06 | 北京中科灵瑞生物技术股份有限公司 | Monkey multifunctional combination type experimental cage |
| CN204274701U (en) * | 2014-09-03 | 2015-04-22 | 北京中科灵瑞生物技术股份有限公司 | monkey special type experimental cage |
| CN104472385B (en) * | 2014-11-03 | 2017-05-10 | 中国科学院深圳先进技术研究院 | Non-human primate social behavior testing device |
| CN104663490B (en) * | 2015-03-03 | 2018-10-09 | 广西南宁灵康赛诺科生物科技有限公司 | The automatic device of a set of evaluation primate laboratory animal memory function and the cognitive ability evaluation method of animal |
| CN204762732U (en) * | 2015-05-29 | 2015-11-18 | 苏州猴皇动物实验设备科技有限公司 | Monkey is water supply system for cage |
| CN204742149U (en) * | 2015-05-29 | 2015-11-11 | 苏州猴皇动物实验设备科技有限公司 | Monkey cage for animal experiments |
| CN204888305U (en) * | 2015-08-17 | 2015-12-23 | 昆明亚灵生物科技有限公司 | Multi -functional transfer cage of primate for experiments |
| CN205337166U (en) * | 2016-02-03 | 2016-06-29 | 中国科学院昆明动物研究所 | Touch-screen multifunctional non-human primate cognitive function test cage |
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2016
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000022057A1 (en) * | 2020-09-18 | 2022-03-18 | Tecniplast Spa | CAGE OR CAGE FOR LAYING LABORATORY ANIMALS |
| EP3970480A1 (en) * | 2020-09-18 | 2022-03-23 | Tecniplast S.p.A. | Cage for housing laboratory animals |
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