CN104545798A - Rat and mouse pelma pain threshold detector - Google Patents
Rat and mouse pelma pain threshold detector Download PDFInfo
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- CN104545798A CN104545798A CN201310470984.5A CN201310470984A CN104545798A CN 104545798 A CN104545798 A CN 104545798A CN 201310470984 A CN201310470984 A CN 201310470984A CN 104545798 A CN104545798 A CN 104545798A
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- rat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
- A61B5/1104—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb induced by stimuli or drugs
- A61B5/1105—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb induced by stimuli or drugs of laboratory animals, e.g. activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4824—Touch or pain perception evaluation
- A61B5/4827—Touch or pain perception evaluation assessing touch sensitivity, e.g. for evaluation of pain threshold
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
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- Pathology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Clinical Laboratory Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Oral & Maxillofacial Surgery (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a rat and mouse pelma pain threshold detector. The rat and mouse pelma pain threshold detector comprises a fixing support, a shell and a controller. A fixing plate is arranged at the top of the fixing support. A fixing groove is formed in the fixing plate. A fixing net is installed in the fixing groove. A transparent rat/mouse box is arranged on the fixing plate. A base plate is arranged at the lower portion of the fixing support, and the shell is installed on the base plate. A telescoping mechanism is installed at the bottom of the shell. A needle base is installed at the upper end of the telescoping mechanism, and a needle is installed on the needle base. A connecting plate is horizontally arranged in the shell. A laser positioning instrument and a camera are installed on the connecting plate. The connecting plate is provided with holes matching the needle correspondingly. A sliding plate is installed at the bottom end of the shell, a handle is fixedly installed on the sliding plate, and a button is arranged on the handle. The rat and mouse pelma pain threshold detector has the beneficial effects that the needle can be controlled by the controller to upwards stimulate the pelma of a rat or mouse, and the rat or mouse breaks away from the needle after feeling pains; and comprehensive and accurate results are obtained through the controller according to the length of the length of time the needle stays in the bodies of the animals and the pressure applied by the bodies of the animals to the needle, and mistakes possibly caused by using a macroscopic observation method are avoided.
Description
Technical field
The present invention relates to a kind of animal detecting instrument device, specifically a kind of large mice vola tenderness instrument.
Background technology
New analgesic, must first through animal experiment for before clinical, and particularly the experiment of large mice is carried out testing or verifying.Therefore, the twinge test analysis of large mice has very important Practical significance, and it by behavioral competence, motor function and the perception after the large mice medication of observation, can evaluate the drug effect of new drug exactly.And in twinge test, important step is carried out in the twinge analysis of syringe needle to large mice.And the sensitivity that the existing test to animal twinge is reacted twinge by direct visual perception animal mostly, there is no relevant device to animal twinge reaction and make detailed comprehensive analysis, thus be also difficult to draw conclusion accurately.
Summary of the invention
For solving the problem, the object of this invention is to provide a kind of large mice vola tenderness instrument, it more accurately can objectively draw the conclusion that twinge is tested.
The present invention for achieving the above object, is achieved through the following technical solutions: comprise fixed mount, housing and controller, and the top of fixed mount is fixing head, holddown groove offered by fixing head, install fixed network in holddown groove, fixing head is arranged transparent Mus case, transparent Mus case is positioned at above fixed network; Fixed mount bottom is provided with base plate, holder housing on base plate; Housing bottom installs telescoping mechanism, and needle stand is installed in telescoping mechanism upper end, and syringe needle installed by needle stand, and syringe needle is corresponding up and down with one of them mesh of fixed network; Be horizontally disposed with connecting plate in housing, connecting plate installed laser orientation instru-ment and photographic head, connecting plate is offered the hole with syringe needle corresponding matching; Sliding panel is installed in housing bottom, and sliding panel fixedly mounts handle, handle arranges button, button is connected with controller by wire; Display installed by controller, and controller is connected with telescoping mechanism, laser orientation instru-ment and photographic head respectively.
For realizing object of the present invention further, can also by the following technical solutions: two spacing press strips installed by described fixing head, and the both sides of fixed network pushed down respectively by two spacing press strips; Described housing upper end arranges lamina tecti, and lamina tecti offers through hole, and lamina tecti is stretched out by through hole in the upper end of syringe needle; Arrange baffle plate in described transparent Mus case, transparent Mus case interior separation is multiple individual cavities by baffle plate, and the transparent Mus case on each individual cavities top all arranges cover plate; Install light compensating lamp in described housing, light compensating lamp is connected with controller.
The invention has the advantages that: it is furnished with telescoping mechanism, telescoping mechanism arranges syringe needle.Syringe needle can be controlled the vola of upwards stimulation in rats or mice by controller, rat or mice are experienced twinge and depart from syringe needle, according to measuring syringe needle, the length of the time of staying and the pressure size of animal to syringe needle draw comprehensive and accurate result to controller in animal body, the result drawn than traditional observation method of naked eye is more accurate, avoids the mistake that observation method of naked eye may occur.The present invention also makes animal test under without constraint, glitch-free free state, completely eliminates all objective factors of the interference threshold of pain, the threshold of pain of animal can be displayed truly.
Accompanying drawing explanation
Fig. 1 is the structural representation of large mice vola tenderness instrument of the present invention.
Reference numeral: transparent Mus case 21 holddown groove of 1 fixed mount 2 fixing head 3 housing 4 cover plate 5 fixed network 6 syringe needle 7 spacing press strip 8 laser orientation instru-ment 9 photographic head 10 needle stand 11 light compensating lamp 12 telescoping mechanism 13 base plate 14 controller 15 screen 16 sliding panel 17 handle 18 lamina tecti 19 connecting plate 20.
Detailed description of the invention
Large mice vola tenderness instrument, comprises fixed mount 1, housing 3 and controller 14, and the top of fixed mount 1 is fixing head 2, fixing head 2 is offered holddown groove 21, install fixed network 5 in holddown groove 21, fixing head 2 is arranged transparent Mus case 20, transparent Mus case 20 is positioned at above fixed network 5; Fixed mount 1 bottom is provided with base plate 13, holder housing 3 on base plate 13; Install telescoping mechanism 12 bottom housing 3, needle stand 10 is installed in telescoping mechanism 12 upper end, and needle stand 10 is installed syringe needle 6, syringe needle 6 is corresponding up and down with one of them mesh of fixed network 5; Be horizontally disposed with connecting plate 19 in housing 3, connecting plate 19 installed laser orientation instru-ment 8 and photographic head 9, connecting plate 19 is offered the hole with syringe needle 6 corresponding matching; Sliding panel 16 is installed in housing 3 bottom, and sliding panel 16 fixedly mounts handle 17, handle 17 arranges button, button is connected with controller 14 by wire; Controller 14 is installed display 15, controller 14 is connected with telescoping mechanism 12, laser orientation instru-ment 8 and photographic head 9 respectively.Telescoping mechanism 12 is arranged syringe needle 6, make syringe needle 6 can be controlled to stab by controller 14 vola of rat or mice, until rat or mice experience twinge break away from syringe needle 6.In telescoping mechanism 12, pressure transducer is set, the pressure that pressure transducer monitored over time syringe needle 6 is subject to, when rat or mice experience twinge break away from syringe needle 6 time, the maximum pressure value that pressure transducer records just is the threshold of pain of rat or mice.Described telescoping mechanism 12 can be the existing mechanism that syringe needle 6 can be driven to be elevated such as electric pushrod or cylinder.
In order to make test result more accurate, test process is easier, the present invention arranges laser orientation instru-ment 8 and photographic head 9 in housing 3, and the position in rat or mice vola is shown by the display 15 on controller 14, and the position relationship in syringe needle 6 and rat or mice vola, thus, make tester pass through to watch display 15, just accurately can control the vola that syringe needle 6 stabs rat or mice.
During test, first rat or mice are put into transparent Mus case 20 a period of time, after rat or mice peace and quiet, laser orientation instru-ment 8 and photographic head 9 is used to determine the position of rat or mice foot and are shown by display 15, then people move immediately below syringe needle 6 to rat or mice vola according to the position of Mus foot on display 15 by handle 17, re-use button on handle 17 to control telescoping mechanism 12 by controller 14 and drive syringe needle 6 to move up to stab rat or mice vola, the pressure transducer arranged in telescoping mechanism 12 is recorded rat or mice and is experienced pressure peak when pain departs from syringe needle 6 and rat or mice and produce the time of pressure to syringe needle 6, test data is passed to controller 14 to pressure transducer so that testing crew reference.
Described fixing head 2 is installed the both sides that fixed network 5 pushed down respectively by two spacing press strips, 7, two spacing press strips 7.Arrange saddle inside fixing head 2, spacing press strip 7 coordinates the saddle on fixing head 2 fixed network 5 can be clamped, and makes fixed network 5 for convenience detach and cleaning.
For avoiding the Excreta of rat or mice to enter housing 3, described housing 3 upper end arranges lamina tecti 18, and lamina tecti 18 offers through hole, and lamina tecti 18 is stretched out by through hole in the upper end of syringe needle 6.
For increasing the quantity of test rat or mice, conveniently rat or mice are put into and take out, arrange baffle plate in described transparent Mus case 20, transparent Mus case 20 interior separation is multiple individual cavities by baffle plate, and the transparent Mus case 20 on each individual cavities top all arranges cover plate 4.This structure also makes people rat or mice can be put into transparent Mus case 20 in batches, makes rat or mice quiet successively, thus test can be carried out successively continuously, avoid test because waiting for rat or mice quiet generation time interval.
For convenience of observing animal position, install light compensating lamp 11 in described housing 3, light compensating lamp 11 is connected with controller 14.
Syringe needle 6 also can take off from telescoping mechanism 12 when using by large mice vola tenderness instrument of the present invention, in needle stand 10, heater or refrigerating plant can be installed, make large mice vola tenderness instrument also can carry out cold touching or hot test of touching, complete alternative vola photo-thermal twinge instrument or hot-plate instrument, when heat touches test, the temperature constant of needle stand 10 is accurate, carries out nothing isolation thermostimulation to animal vola, stimulation location is accurate, concordance good, ensure that the true effect of experiment.
Technical scheme of the present invention is not restricted in the scope of embodiment of the present invention.The technology contents of the not detailed description of the present invention is known technology.
Claims (5)
1. large mice vola tenderness instrument, it is characterized in that: comprise fixed mount (1), housing (3) and controller (14), the top of fixed mount (1) is fixing head (2), fixing head (2) is offered holddown groove (21), in holddown groove (21), fixed network (5) is installed, fixing head (2) is arranged transparent Mus case (20), transparent Mus case (20) is positioned at fixed network (5) top; Fixed mount (1) bottom is provided with base plate (13), the upper holder housing (3) of base plate (13); Telescoping mechanism (12) is installed in housing (3) bottom, and needle stand (10) is installed in telescoping mechanism (12) upper end, and needle stand (10) is installed syringe needle (6), syringe needle (6) is corresponding up and down with one of them mesh of fixed network (5); Be horizontally disposed with connecting plate (19) in housing (3), connecting plate (19) installed laser orientation instru-ment (8) and photographic head (9), connecting plate (19) is offered the hole with syringe needle (6) corresponding matching; Sliding panel (16) is installed in housing (3) bottom, and sliding panel (16) fixedly mounts handle (17), (17) arrange button to handle, and button is connected with controller (14) by wire; Controller (14) is installed display (15), controller (14) is connected with telescoping mechanism (12), laser orientation instru-ment (8) and photographic head (9) respectively.
2. large mice vola tenderness instrument according to claim 1, is characterized in that: the upper installation two spacing press strips (7) of described fixing head (2), two spacing press strips (7) push down the both sides of fixed network (5) respectively.
3. large mice vola tenderness instrument according to claim 1, it is characterized in that: described housing (3) upper end arranges lamina tecti (18), and (18) offer through hole to lamina tecti, lamina tecti (18) is stretched out by through hole in the upper end of syringe needle (6).
4. large mice vola tenderness instrument according to claim 1, it is characterized in that: in described transparent Mus case (20), baffle plate is set, transparent Mus case (20) interior separation is multiple individual cavities by baffle plate, and the transparent Mus case (20) on each individual cavities top all arranges cover plate (4).
5. large mice vola tenderness instrument according to claim 1, is characterized in that: install light compensating lamp (11) in described housing (3), light compensating lamp (11) is connected with controller (14).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470984.5A CN104545798A (en) | 2013-10-11 | 2013-10-11 | Rat and mouse pelma pain threshold detector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470984.5A CN104545798A (en) | 2013-10-11 | 2013-10-11 | Rat and mouse pelma pain threshold detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104545798A true CN104545798A (en) | 2015-04-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310470984.5A Pending CN104545798A (en) | 2013-10-11 | 2013-10-11 | Rat and mouse pelma pain threshold detector |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104545798A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167753A (en) * | 2015-10-12 | 2015-12-23 | 南京大学医学院附属鼓楼医院 | Inclined plate type mechanical pain-sensitivity determining device |
| CN107049236A (en) * | 2016-12-16 | 2017-08-18 | 北京大学 | A kind of In The Rat Sole threshold of pain measuring system |
| CN107550463A (en) * | 2017-09-20 | 2018-01-09 | 复旦大学 | One kind is used for living animal body-sensing mechanical force stimulating system |
| CN111227800A (en) * | 2020-01-21 | 2020-06-05 | 深圳市美格尔医疗技术研究院 | Hot stabbing pain tester |
| CN112043453A (en) * | 2020-09-25 | 2020-12-08 | 浙江农林大学 | Four limbs location bed is used in clinical operation of poultry animal doctor |
-
2013
- 2013-10-11 CN CN201310470984.5A patent/CN104545798A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105167753A (en) * | 2015-10-12 | 2015-12-23 | 南京大学医学院附属鼓楼医院 | Inclined plate type mechanical pain-sensitivity determining device |
| CN105167753B (en) * | 2015-10-12 | 2017-12-29 | 南京大学医学院附属鼓楼医院 | A kind of ramp type machinery pain sensitive detection device |
| CN107049236A (en) * | 2016-12-16 | 2017-08-18 | 北京大学 | A kind of In The Rat Sole threshold of pain measuring system |
| CN107550463A (en) * | 2017-09-20 | 2018-01-09 | 复旦大学 | One kind is used for living animal body-sensing mechanical force stimulating system |
| CN111227800A (en) * | 2020-01-21 | 2020-06-05 | 深圳市美格尔医疗技术研究院 | Hot stabbing pain tester |
| CN112043453A (en) * | 2020-09-25 | 2020-12-08 | 浙江农林大学 | Four limbs location bed is used in clinical operation of poultry animal doctor |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150429 |