CN105521437A - Spider and emei pueraria flower hemorrhoid-treating gel and preparation method thereof - Google Patents

Spider and emei pueraria flower hemorrhoid-treating gel and preparation method thereof Download PDF

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CN105521437A
CN105521437A CN201610018485.6A CN201610018485A CN105521437A CN 105521437 A CN105521437 A CN 105521437A CN 201610018485 A CN201610018485 A CN 201610018485A CN 105521437 A CN105521437 A CN 105521437A
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parts
radix
herba
gel
hemorrhoid
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隋妍蕾
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

The invention discloses a spider and emei pueraria flower hemorrhoid-treating gel and a preparation method thereof, and relates to the technical field of medicine. The spider and emei pueraria flower hemorrhoid-treating gel includes main materials and adjuvant materials, wherein the main materials are prepared into traditional Chinese medicinal powder from the following traditional Chinese medicinal raw materials: root of smalleaf desmodium, spider, twelve stamen melastoma herb, herb or root of Chlorophytum comosum (Thunb.) Baker., emei pueraria flower, fortune paulownia root, folium hibisci mutabilis, cutch, root of common lamiophlomis, cortex moutan, mylabris, root and leaf of psychotria asiatica L., rhizome of ligusticum wallichii, fructus gardeniae, herba violae, caulis lonicerae, rhizoma curcumae longae, folium isatidis, twig of vaccinium laetum diels, all-grass of lecomte mazus, peppermint, radix notoginseng, hedgehog hide and radix bupleuri; and the adjuvant materials consist of the following ingredients: adrenobazonum, vitamin E, rutin, 6-aminocaproic acid and p-carboxybenzylamine. Compared with an existing medicine, the gel disclosed by the invention is short in treatment course, rapid to take effect, significant in effect and not easy for reoccurrence; and the gel, on treating hemorrhoids, is universal and has a good treatment effect on the hemorrhoids caused by various reasons; and upon clinical verification, the gel is rapid to take effect, safe and free from side effects.

Description

A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel and preparation method thereof
Technical field
The present invention relates to medical art, specifically relate to a kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel and preparation method thereof.
Background technology
Hemorrhoid are bottom anal orifice and rectal intestine and a kind of chronic disease of the vein group of the venous plexus generation varicose of anal mucosa and one or more softnesses of being formed.Usually continue firmly when defecation, cause intravenous pressure herein repeatedly to raise, vein will enlargement.Hemorrhoid are a kind of commonly encountered diseases, frequently-occurring disease, just have saying of " ten people nine hemorrhoid " from ancient times, and hemorrhoid are agglomerates that the displacement of anus pad pathologic hypertrophy and crissum veins beneath the skin clump stasis of blood stream are formed.The sickness rate of hemorrhoid is very high, and after the treatment of hemorrhoid patients underwent operative or other therapies are treated, relapse rate is also higher, and therefore, hemorrhoid become the nightmare of Most patients.Though there is the medicine of multiple treatment hemorrhoid to see in prior art, mostly there is the defects such as cost is high, therapeutic process is painful, not easily healing, easily recurrence.Having blood in stool, deviating from and the symptoms such as pain appears because of hemorrhoid in many patients, has had a strong impact on life, working and learning, so there is the exploitation of the hemorrhoid treating medicine of good result to have great importance.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel with general applicability and preparation method thereof, has good therapeutic effect for the hemorrhoid caused by a variety of causes, and instant effect, safety have no side effect.
Technical scheme of the present invention is:
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel, comprise major ingredient and adjuvant, described major ingredient is made up of monarch drug and ministerial drug, and described monarch drug is prepared from by following raw material of Chinese medicine: Radix desmodiik microphylli, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae; Described ministerial drug is prepared from by following raw material of Chinese medicine: Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Cortex Moutan, Mylabris, Red Psychotria Leaf, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Violae, Caulis Lonicerae, Rhizoma Curcumae Longae, Folium Isatidis, Herba Vaccinii Bracteati, Mazus japonicus, Herba Menthae, Radix Notoginseng, Corium Erinacei Seu Hemiechianus, Radix Bupleuri; Adjuvant consists of the following composition: carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid.
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel comprises major ingredient and adjuvant, and described monarch drug is prepared from by the raw material of Chinese medicine of following weight portion: Radix desmodiik microphylli 60 ~ 110 parts, Uroctea compatilis Koch. 50 ~ 100 parts, Herba Melastomatis Dodecandri 45 ~ 85 parts, Herba Chlorophyti Comosi 40 ~ 70 parts, Flos Puerariae Omeiensis 35 ~ 65 parts, Radix paulowniae 30 ~ 60 parts, described ministerial drug is prepared from by the raw material of Chinese medicine of following weight portion: Folium Hibisci Mutabilis 15 ~ 20 parts, 1 ~ 3 part, catechu, Radix Lamiophlomidis Rotatae 1 ~ 2 part, Cortex Moutan 10 ~ 20 parts, Mylabris 1 ~ 3 part, Red Psychotria Leaf 20 ~ 25 parts, Rhizoma Chuanxiong 8 ~ 10 parts, Fructus Gardeniae 5 ~ 8 parts, Herba Violae 18 ~ 20 parts, Caulis Lonicerae 14 ~ 17 parts, 12 ~ 15 parts, Rhizoma Curcumae Longae, Folium Isatidis 15 ~ 17 parts, Herba Vaccinii Bracteati 20 ~ 25 parts, Mazus japonicus 2 ~ 5 parts, Herba Menthae 2 ~ 5 parts, Radix Notoginseng 5 ~ 10 parts, Corium Erinacei Seu Hemiechianus 5 ~ 10 parts, Radix Bupleuri 10 ~ 20 parts, described adjuvant consists of the following composition: carbazochrome salicylate 0.01 ~ 0.1 part, vitamin E2 ~ 5 part, rutosids 0.5 ~ 1.5 part, 6-aminocaprolc acid 0.2 ~ 0.5 part, para-amino-methyl-benzoic acid 1 ~ 2 part.
Described adjuvant also comprises Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.).Rhizoma Bolbostematis: [function cures mainly] eliminating stagnation poison, subduing inflammation.Control acute mastitis, scrofula sucutaneous nodule, sore swollen toxin and snakeworm poison.Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.): [function cures mainly] puts scabies, impetigo, tinea alba, impetigo, erysipelas.
The weight portion of described Rhizoma Bolbostematis and Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is respectively: Rhizoma Bolbostematis 5 ~ 10 parts, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) 3 ~ 6 parts.
Wherein, the pharmacologically active of individual medicine is as follows:
Radix desmodiik microphylli: sweet in the mouth, property is put down.Return Liver Channel, urinary bladder channel, large intestine channel.Clearing away heat-damp and promoting diuresis, hemostasis, dredging collateral.To harness the Yellow River subcutaneous ulcer, dysentery, urine leaching pain, rheumatalgia, spitting of blood, metrorrhagia, leucorrhea, hemorrhoid, traumatic injury.
Uroctea compatilis Koch.: salty in the mouth, hardship, cold in nature.Return lung meridian, liver, large intestine channel." Japan hanako materia medica ": " controlling children's tells inverse.Apply fistula skin ulcer."
Herba Melastomatis Dodecandri: sweet in the mouth, puckery, property is put down.Return liver,kidney,spleen, lung four warp." east, Fujian book on Chinese herbal medicine ": " control dysmenorrhea, metrorrhagia and leukorrhagia, dysentery, hemorrhoid complicated by anal fistula, rubella, hernia."
Herba Chlorophyti Comosi: sweet-bitter flavor, property is put down." Fujian traditional herbal medicine ": " eliminating carbuncle detoxifies, and moves back scorching detumescence.Control furuncle swelling toxin, swelling and pain of hemorrhoid."
Flos Puerariae Omeiensis: property is put down, acrid in the mouth is bitter.Control hemorrhoid, alcoholic intoxication.
Radix paulowniae: cold in nature, bitter in the mouth." Chongqing medical herbs ": " except rheumatism, bowel relieving gastric heat poison, for rheumatism foot pain, discharging fresh blood stool, hemorrhoid."
Carbazochrome salicylate: the permeability that can reduce blood capillary, promotes that impaired blood capillary pipe end bounces back and stops blooding.Be mainly used in capillary permeability increase caused by hemorrhage, as hemorrhage in essential purpura, retinal hemorrhage, chronic pulmonary, gastrointestinal hemorrhage, epistaxis, spitting of blood, hematuria, hemorrhoid hemorrhage, metrorrhagia, cerebral hemorrhage etc.To bleed profusely and arterial hemorrhage curative effect poor.
The preparation method of major ingredient is as follows:
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 2 ~ 5 minutes, germicidal wavelength is between 240nm ~ 270nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:4 ~ 1:6, soak 1 ~ 2 hour;
(3) make in extraction vessel, to be warmed up to 90 DEG C ~ 95 DEG C, and reflux, extract, 2.5 ~ 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 60 ~ 70 orders, then supersonic jet mill to 60 ~ 70 μm are adopted, again with nanon ball-mill grinding 3.5 ~ 4 hours, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3 ~ 4 times of weight, soak time 3 ~ 4 hours, Corium Erinacei Seu Hemiechianus after soaking, at 50 ~ 55 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 300 ~ 400 revs/min, grind 20 ~ 25 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient.
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel process for preparing, comprises the steps,
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 2 ~ 5 minutes, germicidal wavelength is between 240nm ~ 270nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:4 ~ 1:6, soak 1 ~ 2 hour;
(3) make in extraction vessel, to be warmed up to 90 DEG C ~ 95 DEG C, and reflux, extract, 2.5 ~ 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 60 ~ 70 orders, then supersonic jet mill to 60 ~ 70 μm are adopted, again with nanon ball-mill grinding 3.5 ~ 4 hours, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3 ~ 4 times of weight, soak time 3 ~ 4 hours, Corium Erinacei Seu Hemiechianus after soaking, at 50 ~ 55 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 300 ~ 400 revs/min, grind 20 ~ 25 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient;
(7) described adjuvant carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid and Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is added, carry out co-grinding, stirring, join again in gel-type vehicle, described gel-type vehicle is aqueous gel substrate, is formulated according to the weight ratio of 8:3:2:1:1 by water, propylene glycol, cellulose derivative, tragakanta and starch; Adding distil water again, mixing, leaves standstill, is prepared into gel preparation, namely obtains described Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel.
Beneficial effect of the present invention is embodied in: Chinese-western medicine preparation of the present invention preparation is simple, and raw material is easy to get, and ingredient is clear and definite, stable in properties, be convenient to the foundation of pharmaceutical preparation quality control, is applicable to industrialized mass production, has good potential applicability in clinical practice.By updating supplement in clinical treatment for many years, adjustment prescription and dose plus-minus, repeatedly verify compatibility, make Chinese medicine composition prescription of the present invention science more, meet the traditional theory of Chinese medicine completely, the specially good effect good recipe for the treatment of hemorrhoid, anal fistula, the various each phase hemorrhoid of refractory multiple, cure rate reaches more than 99%, compared with existing medicine, short treating period, instant effect, Be very effective, not easily recurs.What the present invention treated hemorrhoid has general applicability, has good therapeutic effect for the hemorrhoid caused by a variety of causes, and through clinical verification, instant effect, safety have no side effect.
Operation instruction: usage and consumption: every day 3 ~ 5 times, after affected part cleans up, be applied in affected part 12nd is a course for the treatment of.Points for attention: avoid tobacco and wine to stimulate, eat pungent stimulation food less.
Detailed description of the invention
Embodiment one
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel comprises major ingredient and adjuvant, described major ingredient is made up of monarch drug and ministerial drug, and described monarch drug is prepared from by the raw material of Chinese medicine of following weight portion: Radix desmodiik microphylli 60 parts, Uroctea compatilis Koch. 50 parts, Herba Melastomatis Dodecandri 45, Herba Chlorophyti Comosi 40, Flos Puerariae Omeiensis 35, Radix paulowniae 30; Described ministerial drug is prepared from by the raw material of Chinese medicine of following weight portion: Folium Hibisci Mutabilis 15 parts, 1 part, catechu, Radix Lamiophlomidis Rotatae 1 part, Cortex Moutan 10 parts, Mylabris 1 part, Red Psychotria Leaf 20 parts, Rhizoma Chuanxiong 8 parts, Fructus Gardeniae 5 parts, Herba Violae 18 parts, Caulis Lonicerae 14 parts, 12 parts, Rhizoma Curcumae Longae, Folium Isatidis 15 parts, Herba Vaccinii Bracteati 20 parts, Mazus japonicus 2 parts, Herba Menthae 2 parts, Radix Notoginseng 5 parts, Corium Erinacei Seu Hemiechianus 5 parts, Radix Bupleuri 10 parts; Described adjuvant consists of the following composition: carbazochrome salicylate 0.01 part, vitamin E2 part, rutosids 0.5 part, 6-aminocaprolc acid 0.2 part, para-amino-methyl-benzoic acid 1 part, Rhizoma Bolbostematis 5 parts, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) 3 parts.
The preparation method of composition of this surgical hemorrhoid treatment, comprises the steps,
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 2 minutes, germicidal wavelength is between 240;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:4, soak 1 hour;
(3) make in extraction vessel, to be warmed up to 90 DEG C, and reflux, extract, 2.5 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 60 orders, then supersonic jet mill to 60 μm is adopted, 3.5 hours are ground again with nanon ball-mill, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3 times of weight, soak time 3 hours, Corium Erinacei Seu Hemiechianus after soaking, at 50 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 300 revs/min, grind 20 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient;
(7) described adjuvant carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid and Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is added, carry out co-grinding, stirring, join again in gel-type vehicle, described gel-type vehicle is aqueous gel substrate, is formulated according to the weight ratio of 8:3:2:1:1 by water, propylene glycol, cellulose derivative, tragakanta and starch; Adding distil water again, mixing, leaves standstill, is prepared into gel preparation, namely obtains described Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel.
Embodiment two
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel comprises major ingredient and adjuvant, described major ingredient is made up of monarch drug and ministerial drug, and described monarch drug is prepared from by the raw material of Chinese medicine of following weight portion: Radix desmodiik microphylli 85 parts, Uroctea compatilis Koch. 75 parts, Herba Melastomatis Dodecandri 65 parts, Herba Chlorophyti Comosi 55 parts, Flos Puerariae Omeiensis 50 parts, Radix paulowniae 45 parts; Described ministerial drug is prepared from by the raw material of Chinese medicine of following weight portion: Folium Hibisci Mutabilis 17 parts, 2 parts, catechu, Radix Lamiophlomidis Rotatae 1.5 parts, Cortex Moutan 15 parts, Mylabris 2 parts, Red Psychotria Leaf 22 parts, Rhizoma Chuanxiong 9 parts, Fructus Gardeniae 6 parts, Herba Violae 19 parts, Caulis Lonicerae 15 parts, 13 parts, Rhizoma Curcumae Longae, Folium Isatidis 16 parts, Herba Vaccinii Bracteati 22 parts, Mazus japonicus 3 parts, Herba Menthae 4 parts, Radix Notoginseng 7 parts, Corium Erinacei Seu Hemiechianus 7 parts, Radix Bupleuri 15 parts; Described adjuvant consists of the following composition: carbazochrome salicylate 0.05 part, vitamin E 3 parts, rutosids 1 part, 6-aminocaprolc acid 0.3 part, para-amino-methyl-benzoic acid 1.5 parts, Rhizoma Bolbostematis 7 parts, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) 4 parts.
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel process for preparing, comprises the steps,
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 3 minutes, germicidal wavelength is between 250nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:5, soak 1.5 hours;
(3) make in extraction vessel, to be warmed up to 93 DEG C, and reflux, extract, 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 65 orders, then supersonic jet mill to 65 μm is adopted, 3.5 hours are ground again with nanon ball-mill, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3.5 times of weight, soak time 3.5 hours, Corium Erinacei Seu Hemiechianus after soaking, at 53 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 3050 revs/min, grind 23 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient;
(7) described adjuvant carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid and Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is added, carry out co-grinding, stirring, join again in gel-type vehicle, described gel-type vehicle is aqueous gel substrate, is formulated according to the weight ratio of 8:3:2:1:1 by water, propylene glycol, cellulose derivative, tragakanta and starch; Adding distil water again, mixing, leaves standstill, is prepared into gel preparation, namely obtains described Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel.
Embodiment three
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel comprises major ingredient and adjuvant, described major ingredient is made up of monarch drug and ministerial drug, and described monarch drug is prepared from by the raw material of Chinese medicine of following weight portion: Radix desmodiik microphylli 110 parts, Uroctea compatilis Koch. 100 parts, Herba Melastomatis Dodecandri 85 parts, Herba Chlorophyti Comosi 70 parts, Flos Puerariae Omeiensis 65 parts, Radix paulowniae 60 parts; Described ministerial drug is prepared from by the raw material of Chinese medicine of following weight portion: Folium Hibisci Mutabilis 20 parts, 3 parts, catechu, Radix Lamiophlomidis Rotatae 2 parts, Cortex Moutan 20 parts, Mylabris 3 parts, Red Psychotria Leaf 25 parts, Rhizoma Chuanxiong 10 parts, Fructus Gardeniae 8 parts, Herba Violae 20 parts, Caulis Lonicerae 17 parts, 15 parts, Rhizoma Curcumae Longae, Folium Isatidis 17 parts, Herba Vaccinii Bracteati 25 parts, Mazus japonicus 5 parts, Herba Menthae 5 parts, Radix Notoginseng 10 parts, Corium Erinacei Seu Hemiechianus 10 parts, Radix Bupleuri 20 parts; Adjuvant consists of the following composition: carbazochrome salicylate 0.1 part, vitamin E 5 parts, rutosids 1.5 parts, 6-aminocaprolc acid 0.5 part, para-amino-methyl-benzoic acid 2 parts.
Adjuvant also comprises Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.).The weight portion of Rhizoma Bolbostematis and Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is respectively: Rhizoma Bolbostematis 10 parts, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) 6 parts.
A kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel process for preparing, comprises the steps,
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 5 minutes, germicidal wavelength is between 270nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:6, soak 2 hours;
(3) make in extraction vessel, to be warmed up to 95 DEG C, and reflux, extract, 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) get the Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri, after pretreatment, insert pulverizer and be crushed to 70 orders, then supersonic jet mill to 70 μm is adopted, grind 4 hours with nanon ball-mill again, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 4 times of weight, soak time 4 hours, Corium Erinacei Seu Hemiechianus after soaking, at 55 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 400 revs/min, grind 25 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient;
(7) described adjuvant carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid and Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is added, carry out co-grinding, stirring, join again in gel-type vehicle, described gel-type vehicle is aqueous gel substrate, is formulated according to the weight ratio of 8:3:2:1:1 by water, propylene glycol, cellulose derivative, tragakanta and starch; Adding distil water again, mixing, leaves standstill, is prepared into gel preparation, namely obtains described Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel.
Clinical practice typical case:
Lee, female, 30 years old, disease opinion drew blood, had petechia, many places, was diagnosed as external hemorrhoid, infection, according to every 3 times, 6 days courses for the treatment of, without hemorrhage, had no recurrence.
Wang, man, long-term sitting work state, external hemorrhoid: anus edge skin fold projection, obviously, have tenderness, during defecation, pain increases the weight of for red and swollen heat pain, edema, hyperemia, and have a small amount of secretions, use after 10 days, red and swollen heat pain, edema, congestive symptom disappear, pain with no pressure, defecation is normal, foreign secretions.
Huang, female, 38 years old, is diagnosed as internal hemorrhoid with bleeding.Ill 1 year, anus was normal at ordinary times, get angry, squat for a long time or stool time anal along routing up, stool has blood and deviates from slight blood stasis, and wipe clean for a long time, allodynic, lives very inconvenient.To use after the present invention uniform application in affected part, medication 15 days, drug withdrawal, get angry, squat for a long time or stool time, anal is along no longer deviating from, and blood stasis also atrophy is no longer deviate from, and stopped bleeding does not recur so far.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.

Claims (6)

1. a Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel, it is characterized in that, comprise major ingredient and adjuvant, described major ingredient is made up of monarch drug and ministerial drug, and described monarch drug is prepared from by following raw material of Chinese medicine: Radix desmodiik microphylli, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae; Described ministerial drug is prepared from by following raw material of Chinese medicine: Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Cortex Moutan, Mylabris, Red Psychotria Leaf, Rhizoma Chuanxiong, Fructus Gardeniae, Herba Violae, Caulis Lonicerae, Rhizoma Curcumae Longae, Folium Isatidis, Herba Vaccinii Bracteati, Mazus japonicus, Herba Menthae, Radix Notoginseng, Corium Erinacei Seu Hemiechianus, Radix Bupleuri; Described adjuvant consists of the following composition: carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid.
2. a kind of Uroctea compatilis Koch. according to claim 1 bitter Pueraria lobota hemorrhoid gel, it is characterized in that, described monarch drug is prepared from by the raw material of Chinese medicine of following weight portion: Radix desmodiik microphylli 60 ~ 110 parts, Uroctea compatilis Koch. 50 ~ 100 parts, Herba Melastomatis Dodecandri 45 ~ 85 parts, Herba Chlorophyti Comosi 40 ~ 70 parts, Flos Puerariae Omeiensis 35 ~ 65 parts, Radix paulowniae 30 ~ 60 parts, described ministerial drug is prepared from by the raw material of Chinese medicine of following weight portion: Folium Hibisci Mutabilis 15 ~ 20 parts, 1 ~ 3 part, catechu, Radix Lamiophlomidis Rotatae 1 ~ 2 part, Cortex Moutan 10 ~ 20 parts, Mylabris 1 ~ 3 part, Red Psychotria Leaf 20 ~ 25 parts, Rhizoma Chuanxiong 8 ~ 10 parts, Fructus Gardeniae 5 ~ 8 parts, Herba Violae 18 ~ 20 parts, Caulis Lonicerae 14 ~ 17 parts, 12 ~ 15 parts, Rhizoma Curcumae Longae, Folium Isatidis 15 ~ 17 parts, Herba Vaccinii Bracteati 20 ~ 25 parts, Mazus japonicus 2 ~ 5 parts, Herba Menthae 2 ~ 5 parts, Radix Notoginseng 5 ~ 10 parts, Corium Erinacei Seu Hemiechianus 5 ~ 10 parts, Radix Bupleuri 10 ~ 20 parts, described adjuvant is grouped into by the one-tenth of following lower weight portion: carbazochrome salicylate 0.01 ~ 0.1 part, vitamin E2 ~ 5 part, rutosids 0.5 ~ 1.5 part, 6-aminocaprolc acid 0.2 ~ 0.5 part, para-amino-methyl-benzoic acid 1 ~ 2 part.
3. a kind of Uroctea compatilis Koch. according to claim 1 bitter Pueraria lobota hemorrhoid gel, it is characterized in that, described adjuvant also comprises Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.).
4. a kind of Uroctea compatilis Koch. according to claim 3 bitter Pueraria lobota hemorrhoid gel, it is characterized in that, the weight portion of described Rhizoma Bolbostematis and Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) is respectively: Rhizoma Bolbostematis 5 ~ 10 parts, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.) 3 ~ 6 parts.
5. a kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel as described in Claims 1-4 any one, it is characterized in that, the preparation method of described major ingredient is as follows:
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 2 ~ 5 minutes, germicidal wavelength is between 240nm ~ 270nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carry out evacuation in extraction vessel, in extraction vessel, inject distilled water according to the solid-liquid ratio of 1:4 ~ 1:6, soak 1 ~ 2 hour;
(3) make in extraction vessel, to be warmed up to 90 DEG C ~ 95 DEG C, and reflux, extract, 2.5 ~ 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 60 ~ 70 orders, then supersonic jet mill to 60 ~ 70 μm are adopted, again with nanon ball-mill grinding 3.5 ~ 4 hours, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3 ~ 4 times of weight, soak time 3 ~ 4 hours, Corium Erinacei Seu Hemiechianus after soaking, at 50 ~ 55 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 300 ~ 400 revs/min, grind 20 ~ 25 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient.
6. the preparation method of a kind of Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel according to any one of Claims 1 to 5, is characterized in that, comprise the steps,
(1) Radix desmodiik microphylli of formula ratio, Uroctea compatilis Koch., Herba Melastomatis Dodecandri, Herba Chlorophyti Comosi, Flos Puerariae Omeiensis, Radix paulowniae, Folium Hibisci Mutabilis, catechu, Radix Lamiophlomidis Rotatae, Red Psychotria Leaf, Fructus Gardeniae, Herba Violae, Folium Isatidis, Herba Vaccinii Bracteati, Herba Menthae is got, after each pretreatment of raw material, place in ultraviolet sterilization apparatus and sterilize, sterilizing time 2 ~ 5 minutes, germicidal wavelength is between 240nm ~ 270nm;
(2) raw material after sterilization in (1) is placed in extraction vessel under purification condition, carries out evacuation in extraction vessel, according to 1:(4 ~ 6) solid-liquid ratio in extraction vessel, inject distilled water, soak 1 ~ 2 hour;
(3) make in extraction vessel, to be warmed up to 90 DEG C ~ 95 DEG C, and reflux, extract, 2.5 ~ 3 hours, filter, obtain extracting solution, concentrate drying powdering, obtain effective ingredient I, stand-by;
(4) Cortex Moutan of formula ratio, Mylabris, Rhizoma Chuanxiong, Caulis Lonicerae, Rhizoma Curcumae Longae, Mazus japonicus, Radix Notoginseng, Radix Bupleuri is got, after pretreatment, insert pulverizer and be crushed to 60 ~ 70 orders, then supersonic jet mill to 60 ~ 70 μm are adopted, again with nanon ball-mill grinding 3.5 ~ 4 hours, obtain effective ingredient II, stand-by;
(5) get the Corium Erinacei Seu Hemiechianus of formula ratio, add the distilled water of 3 ~ 4 times of weight, soak time 3 ~ 4 hours, Corium Erinacei Seu Hemiechianus after soaking, at 50 ~ 55 DEG C, is communicated with water together, drops into grinder by soaking temperature, grinder rotating speed is set to 300 ~ 400 revs/min, grind 20 ~ 25 minutes, grinder content is released, filter, collecting medicinal liquid pours in vacuum decompressioning and concentrating tank, concentrating under reduced pressure, obtains effective ingredient III, stand-by;
(6) merge above-mentioned effective ingredient I, II, III, obtain described major ingredient;
(7) add described adjuvant carbazochrome salicylate, vitamin E, rutosids, 6-aminocaprolc acid, para-amino-methyl-benzoic acid and Rhizoma Bolbostematis, Platycladus orientalis (L.) Franco (Biota orientalis (L.) Endl.), carry out co-grinding, stirring, then join in gel-type vehicle, mixing; Adding distil water again, mixing, leaves standstill, and forms gel preparation, namely obtains described Uroctea compatilis Koch. bitter Pueraria lobota hemorrhoid gel.
CN201610018485.6A 2016-01-12 2016-01-12 Spider and emei pueraria flower hemorrhoid-treating gel and preparation method thereof Pending CN105521437A (en)

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CN114129700A (en) * 2021-11-30 2022-03-04 常德集智生物科技有限公司 A pharmaceutical composition for treating hemorrhoid, and its preparation method

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CN114129700A (en) * 2021-11-30 2022-03-04 常德集智生物科技有限公司 A pharmaceutical composition for treating hemorrhoid, and its preparation method

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