CN104147431A - Medicament for treating chronic urethritis and preparation method thereof - Google Patents
Medicament for treating chronic urethritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicament for treating chronic urethritis and a preparation method thereof. The medicament is prepared from raw materials comprising main ingredients and auxiliary materials, wherein the main ingredients comprise the following raw materials by weight: cyathocline lyrata, christia obcordata, achnatherum splendens, willow, clematis, licorice, araceae aglaonema modestum, seed of Chinese waxgourd, cranberry leaf, tuckahoe, alisma, the rhizome of large-headed atractylodes, herba lophatheri, fresh rehmannia root and malva verticillata; the auxiliary materials comprise the following raw materials by weight: acanthopanax root, habenaria petelotii, cowpea shell, Chinese rose and daphne odera. The medicament disclosed by the invention is a modern Chinese medicine adopting a composition method taking the functions of clearing away heat and toxic materials, eliminating damp and treating stranguria as the principal things, and taking the functions of tonifying kidney, strengthening the foundation, promoting blood circulation to remove blood stasis, strengthening the body resistance to eliminate pathogenic factors, and improving immunity of the organism as supplements, is free of toxic and side effect, and can be used for treating the chronic urethritis with effective recurrence prevention, obvious curative effect and stable function.
Description
Technical field
The present invention relates to traditional Chinese medical science pharmaceutical technology field, especially relate to a kind of medicament for the treatment of chronic urethritis and preparation method thereof.
Background technology
Urethritis refers to the inflammation of urethral mucosa, is a kind of commonly encountered diseases, is divided into clinically acute and chronic, nonspecific urethritis and gonococcal urethritis.Wherein, chronic urethritis, men and women can fall ill.Many and the prostatitis of male exists simultaneously; Female urethra is short, and pathogenic bacteria is more easily invaded.This disease is a kind of commonly encountered diseases, frequently-occurring disease, and sickness rate accounts for the 30%--45% left and right in crowd.Most in the steady mode of attacking, fall ill, minority acute attack transfers chronic process to later, after being ill common sympton have urethra uncomfortable, scorching hot, the pain of itching.What have has a small amount of limpid secretions, frequent micturition, and nocturia increases, and hypogastric region is uncomfortable, pubis place pain.Male still has the symptom of scrotum testis discomfort.
The symptom of chronic urethritis does not have acute urethritis so remarkable, and urethral secretions reduces, and only has pruritus or the sense of ant row, and it is remarkable that the stimulation disease of urinating has not resembled acute stage, and some patients were can be asymptomatic.Chronic urethritis is to be relatively difficult to thoroughly radical cure, its main cause is that some people obtained after acute urethritis, abuses outside antibiotic medicine, and it is rear invalid or the state of an illness is temporarily controlled to take, drink or eat seafood etc. after stimulus object and recur, bring double burden usually to patient's economy and spirit.
Chronic urethritis obtains after being ill, and while urinating, urethra has burning pain, frequent micturition and urgent micturition, so that dysuria, the broad ectrum antibiotic that use are controlled the state of an illness more clinically, but abuse of antibiotics induced renal damage not only also easily causes dysbacteriosis, and urethritis repeatedly.Chronic urethritis obtains answers continuous use after being ill, and the raw drug resistance of Western medicine life-time service fecund does not have good resistancing action to urethritis pathogenic bacterium, only relies on western medicine very easily to recur, prognosis weak effect.
So be badly in need of developing a kind of safe without toxic side effect, and the herbal mixture that is difficult for after curing recurring is thoroughly cured chronic urethritis.
Summary of the invention
For the problem of above-mentioned proposition, the technical problem that the present invention solves is just to provide a kind of evident in efficacy, and after curing, is difficult for recurring, acting on stable chronic urethritis nursing medicament and preparation method thereof.
Technical scheme of the present invention is: a kind of medicament for the treatment of chronic urethritis, its crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: cup chrysanthemum 80-140 part, Herba Christiae Obcordatae 55-85 part, Caulis Achnatheri Splendentis 20-40 part, Folium Salicis Babylonicae 36-56 part, red autumnal leaves Radix clematidis floridae 27-45 part, soil Radix Glycyrrhizae 34-50 part, great Ye Rohdea japonica Roth 28-42 part, Semen Benincasae 60-84 part, Folium Vaccinii vitis-idaeae 35-65 part, Poria 60-80 part, Rhizoma Alismatis 26-40 part, Rhizoma Atractylodis Macrocephalae 50-75 part, Herba Lophatheri 35-60 part, fresh Rhizoma Phragmitis 76-100 part, Semen Abutili 30-50 part, described adjuvant by weight component meter is comprised of following crude drug: Radix Et Caulis Acanthopanacis Senticosi 26-48 part, Habenria petelotii Gagnep. 25-65 part, Pericarpium Vignae sinensis 12-60 part, Flos Rosae Chinensis 10-30 part, Radix Buddlejae Butterflybush 15-35 part.
Further, a kind of medicament for the treatment of chronic urethritis, its crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: cup chrysanthemum 100-120 part, Herba Christiae Obcordatae 65-75 part, Caulis Achnatheri Splendentis 25-35 part, Folium Salicis Babylonicae 40-52 part, red autumnal leaves Radix clematidis floridae 30-42 part, soil Radix Glycyrrhizae 38-46 part, great Ye Rohdea japonica Roth 30-40 part, Semen Benincasae 64-80 part, Folium Vaccinii vitis-idaeae 45-55 part, Poria 65-75 part, Rhizoma Alismatis 30-35 part, Rhizoma Atractylodis Macrocephalae 55-70 part, Herba Lophatheri 40-55 part, fresh Rhizoma Phragmitis 86-90 part, Semen Abutili 35-45 part, described adjuvant by weight component meter is comprised of following crude drug: Radix Et Caulis Acanthopanacis Senticosi 26-48 part, Habenria petelotii Gagnep. 35-55 part, Pericarpium Vignae sinensis 22-50 part, Flos Rosae Chinensis 15-25 part, Radix Buddlejae Butterflybush 20-30 part.
A preparation method for the treatment of the medicament of chronic urethritis, comprises the steps:
Step 1: take a glass chrysanthemum, Semen Benincasae, Flos Rosae Chinensis in described ratio, toast at 220～280 ℃ 25～35 minutes, be ground into coarse powder after cooling, further pulverize, cross 150 mesh sieves, the fine powder amount that enable pass is crossed 150 mesh sieves at least reaches 55%, collect by the fine powder 1 of 150 mesh sieves, standby;
Step 2: can not drop into multi-function extractor by the coarse powder of 150 mesh sieves and extract twice, the amount of overstriking grain weight for the first time 8-12 water boiling and extraction 2-3 hour doubly, the amount of overstriking grain weight for the second time 6-9 water boiling and extraction 2-3 hour doubly, merge extracted twice liquid, filter, filtrate heating is condensed into extractum, put into after 85 ℃ of oven dry of baking box, room temperature is cooling, grinds to form fine powder 2, standby;
Step 3: take fresh fresh Rhizoma Phragmitis, Folium Salicis Babylonicae, great Ye Rohdea japonica Roth and drying Herba Christiae Obcordatae, Caulis Achnatheri Splendentis, red autumnal leaves Radix clematidis floridae, native Radix Glycyrrhizae, great Ye Rohdea japonica Roth, Folium Vaccinii vitis-idaeae, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lophatheri, fresh Rhizoma Phragmitis, Semen Abutili, Radix Et Caulis Acanthopanacis Senticosi, Habenria petelotii Gagnep., Pericarpium Vignae sinensis, Radix Buddlejae Butterflybush in described ratio, add with respect to mixing medicine gross weight 4-6 water soaking 8-14 hour doubly, after big fire is boiled, use slow fire instead and continue to decoct extraction 40-60 minute, extract altogether 3 times, merge extractive liquid, filters, filtrate heating concentrates to obtain extractum a, and medicinal residues are standby;
Step 4: the medicinal residues of step 3 are added to 60-90% soak with ethanol 1.5-3 hour, extract twice, each 1.5-2.5 hour, merge extractive liquid,, 100-180 order filters, getting the 3000-4000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 4000-6000 through the molecular weight that dams, the extractum b that when ultrafiltrate concentrating under reduced pressure obtains 85 ℃, relative density is 1.26;
Step 5: extractum a and extractum b are mixed, be dried to powder 3 with spray dryer;
Step 6: the powder 1 that step 1 is made, the powder 2 that step 2 makes, the powder 3 that step 5 makes mix, obtains chronic urethritis nursing medicament of the present invention.
Further, described a kind of preparation method for the treatment of the medicament of chronic urethritis, also can add various pharmaceutic adjuvant well known in the art, preparation process is routinely made the acceptable any conventional dosage form of pharmaceutics, and described dosage form comprises: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, solution.
Wherein, the preparation method of described sugar coated tablet is: in the mixed-powder of described step 6, add 5-9 part microcrystalline Cellulose, the pregelatinized Starch of 140-260 part, after tabletting, re-use sugar-coat material and wrap a glace, obtain sugar coated tablet.Microcrystalline Cellulose can be directly used in dry powder sheeting, and as drug excipient, implant, disintegrating agent, pregelatinized Starch can be used as diluent and filler, and described sugar-coat material is: syrup, rubber cement, Pulvis Talci, white beeswax.
Wherein, the preparation method of described hard capsule is: in the mixed-powder of described step 6, add the pregelatinized Starch of 150-250 part, 3-8 part mannitol, 2-6 part magnesium stearate, 0.5-0.6 part alginic acid, make hard capsule.Wherein pregelatinized Starch is as filler, and mannitol is as diluent, and magnesium stearate is as lubricant, and alginic acid is as disintegrating agent, and hard capsule is produced simpler, and adjuvant is less, can reduce between adjuvant and medicine and interact.
Wherein, the preparation method of described granule is: in the mixed-powder of described step 6, add 30-60 part lactose, 100-140 part starch slurry, 4-6 part Polyethylene Glycol, granulation agent.Wherein, lactose is as filler, and starch slurry is as binding agent, and Polyethylene Glycol is as lubricant.
Medicine character is discussed:
Cup chrysanthemum: [nature and flavor] hardship, cool.[function cures mainly] heat-clearing and toxic substances removing, anti-inflammation hemostasia, dehumidifying diuresis, parasite killing.Cure mainly acute gastroenteritis, heatstroke, cystitis, urethritis, pharyngolaryngitis, stomatitis, spits blood, epistaxis.
Herba Christiae Obcordatae: [nature and flavor] micro-hardship, cool.[function cures mainly] herb: clearing away heat-damp and promoting diuresis, diuresis leukorrhagia stopping.For conjunctivitis, dysuria, cystitis, urethritis, chronic nephritis, mastitis, stranguria caused by urinary stone, leucorrhea; Scabies is controlled in external, traumatic injury, venom.
Caulis Achnatheri Splendentis: [nature and flavor] are sweet, light is flat.[function cures mainly] diuresis heat clearing away.Cure mainly urethritis.1 liang of Caulis Achnatheri Splendentis basal part of stem, is decocted in water for oral dose.
Folium Salicis Babylonicae: [nature and flavor] hardship, cold, nontoxic.[function cures mainly] heat clearing away; Removing toxic substances; Diuresis; Suppressing the hyperactive liver; Pain relieving; Rash.Main chronic tracheitis; Urethritis; Cystitis; Vesical calculus; Nebulousurine; Hypertension; Swollen ulcer drug; Burn and scald; Arthralgia; Toothache; Acute diseases such as cholera and sunstroke rash; Skin pruritus.
Red autumnal leaves Radix clematidis floridae: [nature and flavor] are bitter, puckery, cool.[function cures mainly] dehumidifying diuresis, blood-cleaning detoxifying.Dispelling the wind and dampness pathogens arthralgia, traumatic injury, urethritis, cystitis, has blood in stool, and oral ulcer, under Placenta Hominis difficulty.Also can control the diseases such as galactostasis, menoxenia.
Soil Radix Glycyrrhizae: [nature and flavor] < < Simao, Yunnan Chinese herbal medicine selects > >: " rattan, sweetness and bitterness, flat." [function cures mainly] < < Simao, Yunnan Chinese herbal medicine selects > >: " rattan: promoting urination to remove dampness, relieving cough and reducing sputum.Control nephritis, cystitis, urethritis, cough, beriberi edema."
Great Ye Rohdea japonica Roth: [nature and flavor] pungent, micro-hardship, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For dog bite, venom, laryngopharynx swelling and pain, urethritis, enteritis, cough due to lung-heat.Carbuncle pyogenic infections from tumour or sore, pediatric proctoptosis are controlled in external.
Semen Benincasae: [nature and flavor] are sweet, cold.[function cures mainly] removing heat from the lung and dissipating phlegm; Eliminating carbuncle evacuation of pus; Dampness removing.Main phlegm-heat cough; Lung abscess; Intestinal carbuncle; Nebulousurine; Leukorrhagia; Foot gas; Edema; Stranguria.
Folium Vaccinii vitis-idaeae: [nature and flavor] are bitter, puckery, temperature.Slightly poisonous.[function cures mainly] diuresis, removing toxic substances, for urethritis, cystitis.
Poria: [nature and flavor] are sweet, light is flat.GUIXIN, spleen, kidney channel.Swelling is full, dysuria with harnessing the river for [function cures mainly] promoting diuresis to eliminate damp pathogen, and normal and Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae are equal to use.
Rhizoma Alismatis: [nature and flavor]: sweet, cold.[function cures mainly] < < detailed outline > > tri-is loose in vain: control and emit damp cholera, dysuria, dizzy taking fluids profusely: Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, each three money of Poria.
The Rhizoma Atractylodis Macrocephalae: [nature and flavor] bitter in the mouth; Sweet; Warm in nature.[function cures mainly] invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Diuresis.
Herba Lophatheri: [nature and flavor] sweet in the mouth, light, cold in nature; GUIXIN, lung, stomach, urinary bladder channel.[function cures mainly] body gently oozes and lets out, and has clearing heat and relieving fidgetness, the effect of inducing diuresis for treating stranguria syndrome.< < detailed outline > >: go dysphoria with smothery sensation, diuresis, relieving restlessness is quenched the thirst, children's's pox poison, outer disease is vicious.
Fresh Rhizoma Phragmitis: [nature and flavor] nature and flavor: sweet, cold.[function cures mainly] clearing away heat and promoting production of body fluid, relieving restlessness, preventing or arresting vomiting, diuresis.Rhizoma Phragmitis eliminating heat from the lung, the energy diuresis of holding concurrently, can go out from urine by heat conduction poison.
Semen Abutili: [nature and flavor] Herb: sweet, cool.[function cures mainly] < < Compendium of Materia Medica > > says: " the sliding key of certain herbaceous plants with big flowers dish, energy profit two just." diuresis, hemostasis, QI invigorating hidroschesis.
Radix Et Caulis Acanthopanacis Senticosi: [nature and flavor] mildly bitter flavor; Pungent; Warm in nature.[return through] returns spleen; Kidney; Heart channel.[function cures mainly] replenishing kidney, strengthening waist; Benefiting vital QI for tranquillizing; Promoting blood circulation to remove obstruction in the collateral.Main kidney deficiency and bodily weakness; Soreness of the waist and knees; Children's's walking retardation in children; Insufficiency of the spleen weak; Deficiency of vital energy edema; Inappetence; Insomnia and dreamful sleep; Forgetful; Thoracic obstruction pain; Anemofrigid-damp arthralgia; Treating swelling and pain by traumatic injury.
Habenria petelotii Gagnep.: [nature and flavor] sweet, micro-hardship, flat.[function cures mainly] the kidney invigorating lung heat clearing.Nourishing YIN and moistening the lung, tonify deficiency benefit is damaged.Main lumbago due to renal deficiency; Sexual impotence; Bed-wetting; Hernia; Cough due to lung-heat.
Pericarpium Vignae sinensis: [nature and flavor] are sweet; Flat.[function cures mainly] kidney and spleen invigorating; Inducing diuresis to remove edema; Analgesia; Removing toxic substances.Main lumbago; Nephritis; Cholecystitis; Herpes zoster; Acute mastitis.
Flos Rosae Chinensis: [nature and flavor] are sweet, temperature.[function cures mainly] blood stasis dispelling that restores menstrual flow and invigorates blood circulation, hemostasis and pain-relieving, eliminating carbuncle poison.
Radix Buddlejae Butterflybush: [nature and flavor] are warm in nature, acrid in the mouth is bitter.[function cures mainly] promoting blood circulation and detumescence, removing toxic substances dysentery relieving.
Beneficial effect of the present invention is presented as: medicament of the present invention is with heat-clearing and toxic substances removing, dampness removing is treating stranguria is main, be aided with reinforcing kidney and strengthening resistance, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, the modern Chinese medicine of the method that raising immunity of organisms is prescription, have no side effect, be used for treating chronic urethritis, not only evident in efficacy, and can effectively prevent recurrence, act on more stable.
The specific embodiment
Embodiment 1:
A kind of medicament for the treatment of chronic urethritis, its crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: 80 parts of cup chrysanthemums, 55 parts of Herba Christiae Obcordataes, 20 parts of Caulis Achnatheri Splendentiss, 36 parts of Folium Salicis Babylonicaves, 27 parts of red autumnal leaves Radix clematidis floridaes, 34 parts, soil Radix Glycyrrhizae, 28 parts of great Ye Rohdea japonica Roth, 60 parts of Semen Benincasaes, 35 parts of Folium Vaccinii vitis-idaeaes, 60 parts, Poria, 26 parts of Rhizoma Alismatis, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 35 parts of Herba Lophatheris, 76 parts of fresh Rhizoma Phragmitis, 30 parts of Semen Abutili, described adjuvant by weight component meter is comprised of following crude drug: 26 parts of Radix Et Caulis Acanthopanacis Senticosis, 25 parts of Habenria petelotii Gagnep., 12 parts of Pericarpium Vignae sinensiss, 10 parts of Flos Rosae Chinensiss, 15 parts of Radix Buddlejae Butterflybushs.
Its preparation technology is as follows:
Step 1: take a glass chrysanthemum, Semen Benincasae, Flos Rosae Chinensis in described ratio, toast at 220 ℃ 25 minutes, be ground into coarse powder after cooling, further pulverize, cross 150 mesh sieves, the fine powder amount that enable pass is crossed 150 mesh sieves at least reaches 55%, collect by the fine powder 1 of 150 mesh sieves, standby;
Step 2: can not drop into multi-function extractor by the coarse powder of 150 mesh sieves and extract twice, the water boiling and extraction that the amount of overstriking grain weight is for the first time 8 times 2 hours, the water boiling and extraction that the amount of overstriking grain weight is for the second time 6 times 2 hours, merge extracted twice liquid, filter, filtrate heating is condensed into extractum, put into after 85 ℃ of oven dry of baking box, room temperature is cooling, grinds to form fine powder 2, standby;
Step 3: take fresh fresh Rhizoma Phragmitis, Folium Salicis Babylonicae, great Ye Rohdea japonica Roth and drying Herba Christiae Obcordatae, Caulis Achnatheri Splendentis, red autumnal leaves Radix clematidis floridae, native Radix Glycyrrhizae, great Ye Rohdea japonica Roth, Folium Vaccinii vitis-idaeae, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lophatheri, fresh Rhizoma Phragmitis, Semen Abutili, Radix Et Caulis Acanthopanacis Senticosi, Habenria petelotii Gagnep., Pericarpium Vignae sinensis, Radix Buddlejae Butterflybush in described ratio, add with respect to the water soaking 8 hours that mixes 4 times of medicine gross weights, after big fire is boiled, use slow fire instead and continue to decoct extraction 40 minutes, extract altogether 3 times, merge extractive liquid, filters, filtrate heating concentrates to obtain extractum a, and medicinal residues are standby;
Step 4: the medicinal residues of step 3 are added to 60% soak with ethanol 1.5 hours, extract twice, each 1.5 hours, merge extractive liquid,, 100 orders filter, getting 3000 revs/min of supernatant after centrifugal, is 4000 ultrafiltration post ultrafiltration through the molecular weight that dams, the extractum b that when ultrafiltrate concentrating under reduced pressure obtains 85 ℃, relative density is 1.26;
Step 5: extractum a and extractum b are mixed, be dried to powder 3 with spray dryer;
Step 6: the powder 1 that step 1 is made, the powder 2 that step 2 makes, the powder 3 that step 5 makes mix, and add 5 parts of microcrystalline Cellulose, 140 parts of pregelatinized Starch, after tabletting, re-use sugar-coat material and wrap a glace, obtain sugar coated tablet.Microcrystalline Cellulose can be directly used in dry powder sheeting, and as drug excipient, implant, disintegrating agent, pregelatinized Starch can be used as diluent and filler, and described sugar-coat material is: syrup, rubber cement, Pulvis Talci, white beeswax.
Embodiment 2:
A kind of medicament for the treatment of chronic urethritis, its crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: 110 parts of cup chrysanthemums, 70 parts of Herba Christiae Obcordataes, 30 parts of Caulis Achnatheri Splendentiss, 46 parts of Folium Salicis Babylonicaves, 36 parts of red autumnal leaves Radix clematidis floridaes, 42 parts, soil Radix Glycyrrhizae, 35 parts of great Ye Rohdea japonica Roth, 72 parts of Semen Benincasaes, 50 parts of Folium Vaccinii vitis-idaeaes, 70 parts, Poria, 33 parts of Rhizoma Alismatis, 62.5 parts of the Rhizoma Atractylodis Macrocephalaes, 47.5 parts of Herba Lophatheris, 88 parts of fresh Rhizoma Phragmitis, 40 parts of Semen Abutili, described adjuvant by weight component meter is comprised of following crude drug: 37 parts of Radix Et Caulis Acanthopanacis Senticosis, 45 parts of Habenria petelotii Gagnep., 36 parts of Pericarpium Vignae sinensiss, 20 parts of Flos Rosae Chinensiss, 25 parts of Radix Buddlejae Butterflybushs.
Its preparation technology is as follows:
Step 1: take a glass chrysanthemum, Semen Benincasae, Flos Rosae Chinensis in described ratio, toast at 250 ℃ 30 minutes, be ground into coarse powder after cooling, further pulverize, cross 150 mesh sieves, the fine powder amount that enable pass is crossed 150 mesh sieves at least reaches 55%, collect by the fine powder 1 of 150 mesh sieves, standby;
Step 2: can not drop into multi-function extractor by the coarse powder of 150 mesh sieves and extract twice, the water boiling and extraction that the amount of overstriking grain weight is for the first time 10 times 2.5 hours, the water boiling and extraction that the amount of overstriking grain weight is for the second time 7.5 times 2.5 hours, merge extracted twice liquid, filter, filtrate heating is condensed into extractum, put into after 85 ℃ of oven dry of baking box, room temperature is cooling, grinds to form fine powder 2, standby;
Step 3: take fresh fresh Rhizoma Phragmitis, Folium Salicis Babylonicae, great Ye Rohdea japonica Roth and drying Herba Christiae Obcordatae, Caulis Achnatheri Splendentis, red autumnal leaves Radix clematidis floridae, native Radix Glycyrrhizae, great Ye Rohdea japonica Roth, Folium Vaccinii vitis-idaeae, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lophatheri, fresh Rhizoma Phragmitis, Semen Abutili, Radix Et Caulis Acanthopanacis Senticosi, Habenria petelotii Gagnep., Pericarpium Vignae sinensis, Radix Buddlejae Butterflybush in described ratio, add with respect to the water soaking 11 hours that mixes 5 times of medicine gross weights, after big fire is boiled, use slow fire instead and continue to decoct extraction 50 minutes, extract altogether 3 times, merge extractive liquid, filters, filtrate heating concentrates to obtain extractum a, and medicinal residues are standby;
Step 4: the medicinal residues of step 3 are added to 75% soak with ethanol 2.25 hours, extract twice, each 2.0 hours, merge extractive liquid,, 140 orders filter, getting 3500 revs/min of supernatant after centrifugal, is 5000 ultrafiltration post ultrafiltration through the molecular weight that dams, the extractum b that when ultrafiltrate concentrating under reduced pressure obtains 85 ℃, relative density is 1.26;
Step 5: extractum a and extractum b are mixed, be dried to powder 3 with spray dryer;
Step 6: the powder 1 that step 1 is made, the powder 2 that step 2 makes, the powder 3 that step 5 makes mix, and add 200 parts of pregelatinized Starch, 5.5 portions of mannitol, 4 parts of magnesium stearate, 0.55 part of alginic acid, make hard capsule.Wherein pregelatinized Starch is as filler, and mannitol is as diluent, and magnesium stearate is as lubricant, and alginic acid is as disintegrating agent, and hard capsule is produced simpler, and adjuvant is less, can reduce between adjuvant and medicine and interact.
Embodiment: 3:
A kind of medicament for the treatment of chronic urethritis, its crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: 140 parts of cup chrysanthemums, 85 parts of Herba Christiae Obcordataes, 40 parts of Caulis Achnatheri Splendentiss, 56 parts of Folium Salicis Babylonicaves, 45 parts of red autumnal leaves Radix clematidis floridaes, 50 parts, soil Radix Glycyrrhizae, 42 parts of great Ye Rohdea japonica Roth, 84 parts of Semen Benincasaes, 65 parts of Folium Vaccinii vitis-idaeaes, 80 parts, Poria, 40 parts of Rhizoma Alismatis, 75 parts of the Rhizoma Atractylodis Macrocephalaes, 60 parts of Herba Lophatheris, 100 parts of fresh Rhizoma Phragmitis, 50 parts of Semen Abutili, described adjuvant by weight component meter is comprised of following crude drug: 48 parts of Radix Et Caulis Acanthopanacis Senticosis, 65 parts of Habenria petelotii Gagnep., 60 parts of Pericarpium Vignae sinensiss, 30 parts of Flos Rosae Chinensiss, 35 parts of Radix Buddlejae Butterflybushs.
Its preparation technology is as follows:
Step 1: take a glass chrysanthemum, Semen Benincasae, Flos Rosae Chinensis in described ratio, toast at 280 ℃ 35 minutes, be ground into coarse powder after cooling, further pulverize, cross 150 mesh sieves, the fine powder amount that enable pass is crossed 150 mesh sieves at least reaches 55%, collect by the fine powder 1 of 150 mesh sieves, standby;
Step 2: can not drop into multi-function extractor by the coarse powder of 150 mesh sieves and extract twice, the water boiling and extraction that the amount of overstriking grain weight is for the first time 12 times 3 hours, the water boiling and extraction that the amount of overstriking grain weight is for the second time 9 times 3 hours, merge extracted twice liquid, filter, filtrate heating is condensed into extractum, put into after 85 ℃ of oven dry of baking box, room temperature is cooling, grinds to form fine powder 2, standby;
Step 3: take fresh fresh Rhizoma Phragmitis, Folium Salicis Babylonicae, great Ye Rohdea japonica Roth and drying Herba Christiae Obcordatae, Caulis Achnatheri Splendentis, red autumnal leaves Radix clematidis floridae, native Radix Glycyrrhizae, great Ye Rohdea japonica Roth, Folium Vaccinii vitis-idaeae, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lophatheri, fresh Rhizoma Phragmitis, Semen Abutili, Radix Et Caulis Acanthopanacis Senticosi, Habenria petelotii Gagnep., Pericarpium Vignae sinensis, Radix Buddlejae Butterflybush in described ratio, add with respect to the water soaking 14 hours that mixes 6 times of medicine gross weights, after big fire is boiled, use slow fire instead and continue to decoct extraction 60 minutes, extract altogether 3 times, merge extractive liquid, filters, filtrate heating concentrates to obtain extractum a, and medicinal residues are standby;
Step 4: the medicinal residues of step 3 are added to 90% soak with ethanol 3 hours, extract twice, each 2.5 hours, merge extractive liquid,, 180 orders filter, getting 4000 revs/min of supernatant after centrifugal, is 6000 ultrafiltration post ultrafiltration through the molecular weight that dams, the extractum b that when ultrafiltrate concentrating under reduced pressure obtains 85 ℃, relative density is 1.26;
Step 5: extractum a and extractum b are mixed, be dried to powder 3 with spray dryer;
Step 6: the powder 1 that step 1 is made, the powder 2 that step 2 makes, the powder 3 that step 5 makes mix, and add 60 parts of lactose, 140 parts of starch slurries, 6 parts of Polyethylene Glycol, granulation agent.Wherein, lactose is as filler, and starch slurry is as binding agent, and Polyethylene Glycol is as lubricant.
Clinical typical case cures case:
Sufferer one: female, 26 years old, in the time of urine, feel somewhat boiling hot, urethral orifice is a little outstanding somewhat red, paruria, frequent micturition, urgent micturition.Through Drug therapy, have no improvement for a long time, afterwards, take medicament of the present invention, symptom disappears very soon, just cures soon.
Sufferer two: female, 29 years old, urethra congestion and edema, urethra produces purulent secretion, is infected with crotch, and urine is abnormal, occurs pyuria, hematuria.Through western medicine, slightly take a turn for the better, but often outbreak repeatedly, since starting to take medicament of the present invention after one week, secretions no longer occurs, pyuria and hematuria disappearance, healing very soon, and long-time not recurrence.
Sufferer three: man, 34 years old, while urinating, there are pruritus and the sense of ant row, urethra has burning pain, and lethargy is depressed, dysuria.Adopt western medicine for half a year, during fashion, recur, take afterwards pharmaceutical treatment of the present invention, the pruritus while urinating and the sense of ant row fade away, and cure very soon, have no recurrence.
Sufferer four: man, 41 years old, urethra tingle while urinating, prodding and itching feeling, play the anterior urethra mouth of urinating for the first time morning and have rare clearly shape secretions, faint yellow, secretions amount is less, takes medicament of the present invention and treats, the sensation of pricking of urinating in a short time disappears, secretions also disappears, and after diagnosing for curing, has no recurrence in long-term.
Finally it should be noted that: above embodiment only, in order to technical scheme of the present invention to be described, is not intended to limit; Although the present invention is had been described in detail with reference to previous embodiment, those of ordinary skill in the art is to be understood that: its technical scheme that still can record previous embodiment is modified, or part technical characterictic is wherein equal to replacement; And these modifications or replacement do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. a medicament for the treatment of chronic urethritis, it is characterized in that crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: cup chrysanthemum 80-140 part, Herba Christiae Obcordatae 55-85 part, Caulis Achnatheri Splendentis 20-40 part, Folium Salicis Babylonicae 36-56 part, red autumnal leaves Radix clematidis floridae 27-45 part, soil Radix Glycyrrhizae 34-50 part, great Ye Rohdea japonica Roth 28-42 part, Semen Benincasae 60-84 part, Folium Vaccinii vitis-idaeae 35-65 part, Poria 60-80 part, Rhizoma Alismatis 26-40 part, Rhizoma Atractylodis Macrocephalae 50-75 part, Herba Lophatheri 35-60 part, fresh Rhizoma Phragmitis 76-100 part, Semen Abutili 30-50 part, described adjuvant by weight component meter is comprised of following crude drug: Radix Et Caulis Acanthopanacis Senticosi 26-48 part, Habenria petelotii Gagnep. 25-65 part, Pericarpium Vignae sinensis 12-60 part, Flos Rosae Chinensis 10-30 part, Radix Buddlejae Butterflybush 15-35 part.
2. a kind of medicament for the treatment of chronic urethritis according to claim 1, it is characterized in that crude drug comprises major ingredient and adjuvant, described major ingredient by weight component meter is comprised of following crude drug: cup chrysanthemum 100-120 part, Herba Christiae Obcordatae 65-75 part, Caulis Achnatheri Splendentis 25-35 part, Folium Salicis Babylonicae 40-52 part, red autumnal leaves Radix clematidis floridae 30-42 part, soil Radix Glycyrrhizae 38-46 part, great Ye Rohdea japonica Roth 30-40 part, Semen Benincasae 64-80 part, Folium Vaccinii vitis-idaeae 45-55 part, Poria 65-75 part, Rhizoma Alismatis 30-35 part, Rhizoma Atractylodis Macrocephalae 55-70 part, Herba Lophatheri 40-55 part, fresh Rhizoma Phragmitis 86-90 part, Semen Abutili 35-45 part, described adjuvant by weight component meter is comprised of following crude drug: Radix Et Caulis Acanthopanacis Senticosi 26-48 part, Habenria petelotii Gagnep. 35-55 part, Pericarpium Vignae sinensis 22-50 part, Flos Rosae Chinensis 15-25 part, Radix Buddlejae Butterflybush 20-30 part.
3. a kind of preparation method for the treatment of the medicament of chronic urethritis according to claim 1 and 2, is characterized in that comprising the steps:
Step 1: take a glass chrysanthemum, Semen Benincasae, Flos Rosae Chinensis in described ratio, toast at 220～280 ℃ 25～35 minutes, be ground into coarse powder after cooling, further pulverize, cross 150 mesh sieves, the fine powder amount that enable pass is crossed 150 mesh sieves at least reaches 55%, collect by the fine powder 1 of 150 mesh sieves, standby;
Step 2: can not drop into multi-function extractor by the coarse powder of 150 mesh sieves and extract twice, the amount of overstriking grain weight for the first time 8-12 water boiling and extraction 2-3 hour doubly, the amount of overstriking grain weight for the second time 6-9 water boiling and extraction 2-3 hour doubly, merge extracted twice liquid, filter, filtrate heating is condensed into extractum, put into after 85 ℃ of oven dry of baking box, room temperature is cooling, grinds to form fine powder 2, standby;
Step 3: take fresh fresh Rhizoma Phragmitis, Folium Salicis Babylonicae, great Ye Rohdea japonica Roth and drying Herba Christiae Obcordatae, Caulis Achnatheri Splendentis, red autumnal leaves Radix clematidis floridae, native Radix Glycyrrhizae, great Ye Rohdea japonica Roth, Folium Vaccinii vitis-idaeae, Poria, Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Herba Lophatheri, fresh Rhizoma Phragmitis, Semen Abutili, Radix Et Caulis Acanthopanacis Senticosi, Habenria petelotii Gagnep., Pericarpium Vignae sinensis, Radix Buddlejae Butterflybush in described ratio, add with respect to mixing medicine gross weight 4-6 water soaking 8-14 hour doubly, after big fire is boiled, use slow fire instead and continue to decoct extraction 40-60 minute, extract altogether 3 times, merge extractive liquid, filters, filtrate heating concentrates to obtain extractum a, and medicinal residues are standby;
Step 4: the medicinal residues of step 3 are added to 60-90% soak with ethanol 1.5-3 hour, extract twice, each 1.5-2.5 hour, merge extractive liquid,, 100-180 order filters, getting the 3000-4000 rev/min of supernatant after centrifugal, is the ultrafiltration post ultrafiltration of 4000-6000 through the molecular weight that dams, the extractum b that when ultrafiltrate concentrating under reduced pressure obtains 85 ℃, relative density is 1.26;
Step 5: extractum a and extractum b are mixed, be dried to powder 3 with spray dryer;
Step 6: the powder 1 that step 1 is made, the powder 2 that step 2 makes, the powder 3 that step 5 makes mix, obtains chronic urethritis nursing medicament of the present invention.
4. a kind of preparation method for the treatment of the medicament of chronic urethritis according to claim 3, it is characterized in that also can adding various pharmaceutic adjuvant well known in the art, preparation process is routinely made the acceptable any conventional dosage form of pharmaceutics, and described dosage form comprises: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet, granule, pill, solution.
5. a kind of preparation method for the treatment of the medicament of chronic urethritis according to claim 4, the preparation method that it is characterized in that described sugar coated tablet is: in the mixed-powder of described step 6, add 5-9 part microcrystalline Cellulose, the pregelatinized Starch of 140-260 part, after tabletting, re-use sugar-coat material and wrap a glace, obtain sugar coated tablet.
6. a kind of preparation method for the treatment of the medicament of chronic urethritis according to claim 4, the preparation method that it is characterized in that described hard capsule is: in the mixed-powder of described step 6, add the pregelatinized Starch of 150-250 part, 3-8 part mannitol, 2-6 part magnesium stearate, 0.5-0.6 part alginic acid, make hard capsule.
7. a kind of preparation method for the treatment of the medicament of chronic urethritis according to claim 4, the preparation method that it is characterized in that described granule is: in the mixed-powder of described step 6, add 30-60 part lactose, 100-140 part starch slurry, 4-6 part Polyethylene Glycol, granulation agent.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106491857A (en) * | 2016-11-29 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of oral ulcer and preparation method thereof |
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2014
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Non-Patent Citations (1)
| Title |
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| 周亦农 等: "尿炎康颗粒剂治疗非淋菌性尿道炎疗效观察", 《中医药学刊》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106491857A (en) * | 2016-11-29 | 2017-03-15 | 广西大学 | A kind of treat Chinese medicine preparation of oral ulcer and preparation method thereof |
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