CN105521157A - A traditional Chinese medicine compound prescription for inducing oestrus and activating blood circulation for livestock - Google Patents
A traditional Chinese medicine compound prescription for inducing oestrus and activating blood circulation for livestock Download PDFInfo
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- CN105521157A CN105521157A CN201511021416.2A CN201511021416A CN105521157A CN 105521157 A CN105521157 A CN 105521157A CN 201511021416 A CN201511021416 A CN 201511021416A CN 105521157 A CN105521157 A CN 105521157A
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- angelicae sinensis
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Classifications
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract
The invention relates to a traditional Chinese medicine compound prescription for inducing oestrus and activating blood circulation for livestock. The compound prescription is prepared from following raw material medicines by weight: 180-220 g of epimedium herb, 80-120 g of barbary wolfberry fruit, 80-120 g of Chinese angelica, 80-120 g of motherwort herb, 80-120 g of vitamin E and 80-120 g of NCG.
Description
Technical field:
The present invention relates to a kind of domestic animal to promote the sexual maturity the Chinese medicine compound of invigorating blood circulation, this Chinese medicine is prepared from by Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri, vitamin E, NCG, and this Chinese medicine has the kidney invigorating and promotes the sexual maturity, promoting blood flow to regulate menstruation.Move and Postpartum Anoestrus after being used for the treatment of the puberty of pig and cattle and sheep.
Background technology:
In large-scale cultivation process, poultry sterility and infertility not only affects sows farrowing amount, more directly affects cost of raising pigs.Female animal infertility is many because of nutritional disorder, and hormone is disorderly, and environmental stress, the reasons such as some sickness influence cause.Male animal is sterile many because of congenital defect, and excessively, prolonged illness is impairment of the kidney or is worn with agely caused in breeding.These type of poultry show as that lassitude, vigor are low, fatiguability more; Fear of cold is afraid of cold; Sexual hypofunction, to move after puberty and Postpartum Anoestrus etc.Poultry infertility directly affects the economic benefit of production, causes serious economic loss.
Theory of Chinese medical science is thought, kidney controlling essence storage.Essence is the base substance forming life, is also the material base of the various functional activity of the growth promoter vital organs of the human body.Kidney essense abundance is then hale and hearty, and vital organs of the human body function is normal, and suffer from a deficiency of the kidney, vitality weakens, and various disease will attack gradually.Because possesing deficiency more than suffering from a deficiency of the kidney, kidney essense is not filled, and menses can not, or extremely not contained on time and extremely, rushes conception vessel void, and vessels of the uterus loses supports.Therefore, treat this type of sterility and infertility, suitable warming and recuperating the kidney-YANG, nourishing the liver and kidney.
The Chinese medicine compound developed for this type of infected animal is according to instruction of Chinese Medicine theory, infertile according to the female animal caused according to insufficiency of kidney-YANG, male animal is sterile, Postpartum Anoestrus, the clinical syndrome such as to move after puberty, start with from aspects such as " warming and recuperating the kidney-YANG; nourishing the liver and kidney; the kidney invigorating is promoted the sexual maturity; promoting blood flow to regulate menstruation ", carry out with the Chinese medicine compound be made up of Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri, vitamin E, NCG.Develop after being used for the treatment of the puberty of pig and cattle and sheep and move and the herbal medicine additive of Postpartum Anoestrus.
Summary of the invention:
Herba Epimedii: acrid in the mouth is warm in nature, special invigorating kidney-YANG, the dirty deficiency and coldness of dispelling of warming the kidney.Temperature venting QI-blood, to eliminate condensation, dredge the meridian passage.Cold-damp person is partial to for rheumatic arthralgia.Pungent to moisten kidney, sweet temperature Yiyang gas, enters kidney and helps Yuanyang, is namely the kidney invigorating gas, the kidney warming then easy liver, so can bone and muscle strengthening, and easy strength.There is slow down aging, blood pressure lowering in addition, blood sugar lowering, blood fat reducing.Suppress ex vivo thrombosis, stimulate the synthesis of bone marrow DNA, improve immunity, promote bone growth, prevention of osteoporosis, antiinflammatory, antiviral, the effects such as antitumor.
Fructus Lycii: sweet, flat, return liver, kidney channel.Nourishing the liver and kidney, replenishing vital essence to improve eyesight.For the sweet flat matter profit of syndrome of yin deficiency of liver and kidney this product, flat invigorating the liver and kidney, has strengthening by means of tonics effect, and all cards of all hepatic and renal YIN deficiency all can be applied.Fructus Lycii is rich in lycium barbarum polysaccharide, and lycium barbarum polysaccharide is a kind of water soluble polysaccharide, has physiologically active, can enhancing non-specific immunity function, improves resistance against diseases.Cytophagous phagocytic function can be significantly improved, improve lymphocytic multiplication capacity.
Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Can enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation, be applicable to heart-liver blood deficiency card.Radix Angelicae Sinensis polysaccharide activates macrophage, lymphocyte etc. in hematopoieticmicroenviron-ment by direct and (or) degradation pathways, also muscular tissue can be stimulated, promote that it produces the hematopoietic regulation factor, and then promotion functions hematopoietic stem cell granular leukocyte macrophage colony becomes the proliferation and differentiation of unit (CFU-GM), stimulate proliferation of Bone Marrow CFU-GM hemopoietic.In addition, when giving back, there is antithrombotic, anti-inflammatory and antalgic, blood sugar lowering, protecting the liver the effects such as sharp liver.
Herba Leonuri: nature and flavor are bitter, pungent, are slightly cold.Return liver, pericardium, urinary bladder channel.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing.For menoxenia, dysmenorrhea amenorrhea, lochiorrhea, edema oliguria, sore swollen toxin.
Vitamin E: one group of fatsoluble vitamin, comprises tocopherols, tocotrienol class.There is anti-oxidation function, by animal normal growth is required with fertility.A kind of effective antioxidant and immunomodulator.VE is in enhancing immunity of livestock, oxidation resistance and prevent infertility, improve livestock and poultry production performance and improve in animal meat quality etc. and have important function.Prevent in cell and the readily oxidizable substance such as cell membrane and fatty acid oxidized and destroyed, thus protect the complete of cell membrane.Vitamin E or a kind of natural feed antioxidant.Also there are some researches show that vitamin E has the effects such as anti-stress, antiviral, infection in addition.
NCG, i.e. N-carbamylglutamic acid.By promoting the endogenous synthesis of arginine, improving multiparous animal nest litter size and birth weight, strengthening the reproductive capacity of buck, promote young animal g and D.NCG can promote glutamine or proline synthesis citrulline, and then promotes arginic synthesis.Nitric oxide and polyamines act on extensively in life entity, and arginine is their required precursor substance of synthesis, and NCG effectively can improve arginic content, to maintain arginine-level and body normal physiological function very important.NCG can participate in body ornithine cycle in animal body, long half time, metabolic stability, has biological function widely.
For this reason, the invention provides a kind of Chinese medicine, Chinese medicine of the present invention, be prepared from by the crude drug of following weight proportion:
Herba Epimedii 150-250g, Fructus Lycii 50-150g, Radix Angelicae Sinensis 50-150g, Herba Leonuri 50-150g, vitamin E 50-150g and NCG50-150g.
Preferably
Herba Epimedii 180-220g, Fructus Lycii 80-120g, Radix Angelicae Sinensis 80-120g, Herba Leonuri 80-120g, vitamin E 80-120g and NCG80-120g.
Most preferred
Herba Epimedii 200g, Fructus Lycii 100g, Radix Angelicae Sinensis 100g, Herba Leonuri 100g, vitamin e1 00g (sterling) and NCG100g.
More than in composition, drug weight calculates with crude drug, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can in units of milligram, and weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
The ratio of above proportioning is through that science screening obtains, for special circumstances, as serious symptom or mild, fat or modest, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is constant.
Single medicinal material more than in composition, especially ministerial drug and adjuvant drug, also can be replaced by the suitable Chinese medicine with the identical property of medicine, its drug effect of the Chinese medicine preparation after replacement is constant.
Traditional Chinese medicine compound composition of the present invention, when being prepared into pharmaceutical preparation, can add medicine acceptable carrier if desired, prepares according to the routine techniques of galenic pharmacy.Chinese medicine part wherein can adopt raw material of Chinese medicine medicine to prepare, also can be obtained by the common raw material of Chinese medicine that extracts, also can obtain by other means, as: by pulverizing, squeezing, calcine, grind, sieve, percolation, extraction, water extraction, alcohol extraction, ester carry, the material that method obtains active Chinese drug component material, these active Chinese drug component materials can be extractum form such as ketone is carried, chromatography, can be dry extract also can be fluid extract, need to determine to make different concentration according to the difference of preparation.
Pharmaceutical dosage forms of the present invention, exists in a unit, and described unit dosage form refers to the unit of preparation, as every sheet of tablet, and every capsules of capsule, granule every bag etc.
Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.Preparation of the present invention, preferably peroral dosage form, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc.
Traditional Chinese medicine compound composition of the present invention, the preparation of its oral administration can containing conventional excipient, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and wetting agent.The filler be suitable for comprises starch, sucrose, cellulose, mannitol, lactose and other similar filler.Suitable disintegrating agent comprises starch, polyvinylpyrrolidone and starch derivatives, such as sodium starch glycollate.Suitable lubricant comprises, such as magnesium stearate.By mixing, fill, the method that tabletting etc. are conventional prepares solid oral composition.Repeatedly mix and active substance can be made to be distributed in those compositionss of a large amount of filler of whole use, conventional adjunct ingredient comprises: mannitol, sorbitol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, vitamin C, EDETATE SODIUM, Ethylenediaminetetraacetic Acid Calcium Salt, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
Preparation of the present invention according to condition determination usage and dosage, can take 1-2 time in use every day, each by per kilogram of body weight 0.5-5g dosage.
The present invention further provides preparation method: get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), be dried to dry cream.Dried cream powder is broken into fine powder, and add VE, NCG and appropriate dextrin, mixing, makes 1000g, subpackage and get final product.
Confirm through study of pharmacy, this preparation process is stablized, and is applicable to large production.
Pharmacodynamics is tested
1. this Chinese medicine is to the experimental result of sow serum hormone index:
Laboratory animal: DLY three way cross sow 9 more than six-month-old, be divided into 3 groups, grouping situation is in table 1.
Table 1 sow serum hormone testing result
Note: * represents significant difference (P<0.05); * represents that difference extremely significantly (P<0.01); .
In Chinese drug-treated group sow serum, E2, P contents level is significantly higher than matched group and positive drug group, and Chinese drug-treated group and positive drug group FSH level are significantly higher than matched group.Illustrate that this Chinese medicine can regulate sow hormonal readiness, with positive drug ratio, Be very effective.
2. this Chinese medicine is to the experimental result of milk cow production performance:
Laboratory animal
Raw Postpartum Cows 60, body weight 400-500 kilogram.Be divided into following three groups.
Table 2 milk cow production performance situation
Note: * represents significant difference (P<0.05); * represents that difference extremely significantly (P<0.01); .
As seen from Table 2, this Chinese medicine can significantly improve milch cow post-partum estrus rate, and can significantly shorten the post-partum estrus time.Be very effective is better than hormone group, can be used for large production.
The technical problem to be solved in the present invention is that this Chinese medicine is prepared into a kind of compound Chinese medicinal preparation compositions by Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri, vitamin E, NCG, the present invention finds unexpectedly, the collocation of each component of the present invention has synergistic function, this Chinese medicine has the kidney invigorating and promotes the sexual maturity, promoting blood flow to regulate menstruation.Move and Postpartum Anoestrus after being used for the treatment of the puberty of pig and cattle and sheep.
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Herba Epimedii 200g, Fructus Lycii 100g, Radix Angelicae Sinensis 100g, Herba Leonuri 100g, vitamin e1 00g (sterling) and NCG100g.
The preparation method of granule is as follows:
Get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), be dried to dry cream.Dried cream powder is broken into fine powder, and add VE, NCG and appropriate dextrin, mixing, makes 1000g, subpackage and get final product.
Embodiment 2
Herba Epimedii 150g, Fructus Lycii 50-g, Radix Angelicae Sinensis 50g, Herba Leonuri 50g, vitamin E 50g and NCG50g.
The preparation method of tablet is as follows:
Get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), be dried to dry cream.Dried cream powder is broken into fine powder, adds VE, NCG and appropriate dextrin, mixing, tabletting and get final product.
Embodiment 3
Herba Epimedii 250g, Fructus Lycii 150g, Radix Angelicae Sinensis 150g, Herba Leonuri 150g, vitamin e1 50g and NCG150g.
The preparation method of capsule is as follows:
Get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), add VE, NCG mixing, encapsulated and get final product.
Embodiment 4
Herba Epimedii 180g, Fructus Lycii 80g, Radix Angelicae Sinensis 80g, Herba Leonuri 80g, vitamin E 80g and NCG80g.
The preparation method of oral liquid is as follows:
Get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), add VE, NCG mixing, add water subpackage and get final product.
Embodiment 5
Herba Epimedii 220g, Fructus Lycii 120g, Radix Angelicae Sinensis 120g, Herba Leonuri 120g, vitamin e1 20g and NCG120g.
The preparation method of granule is as follows:
Get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), be dried to dry cream.Dried cream powder is broken into fine powder, and add VE, NCG and appropriate dextrin, mixing, makes 1000g, subpackage and get final product.
Claims (5)
1. domestic animal is promoted the sexual maturity a Traditional Chinese medicine compound composition of invigorating blood circulation, and is prepared from by the crude drug of following weight proportion:
Herba Epimedii 180-220g, Fructus Lycii 80-120g, Radix Angelicae Sinensis 80-120g, Herba Leonuri 80-120g, vitamin E 80-120g and NCG80-120g.
2. compositions according to claim 1, is prepared from by the crude drug of following weight proportion:
Herba Epimedii 200g, Fructus Lycii 100g, Radix Angelicae Sinensis 100g, Herba Leonuri 100g, vitamin e1 00g and NCG100g.
3. compositions according to claim 1 is any pharmaceutically useful dosage form.
4. compositions according to claim 3, described dosage form is selected from: tablet, capsule, granule, pill, powder, unguentum, sublimed preparation, powder, solution, injection, suppository, spray, drop, patch.
5. the preparation method of compositions according to claim 1, step is as follows: get 4 medical materials such as Herba Epimedii, Fructus Lycii, Radix Angelicae Sinensis, Herba Leonuri and add 10 times amount soak by water three times, each 2 hours, merge decoction liquor, filter, hold over night, leaching supernatant, be evaporated to relative density 1.21 ~ 1.27 (50 DEG C), be dried to dry cream.Dried cream powder is broken into fine powder, adds VE, NCG, makes compositions.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106334003A (en) * | 2016-10-20 | 2017-01-18 | 中悦民安（北京）科技发展有限公司 | Chinese herbal compound for livestock labor induction and preparation method thereof and application |
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Inventor after: Yin Peng Inventor after: Zhao Tianjun Inventor after: Yu Xiaohong Inventor after: Liang Bing Inventor before: Yin Peng Inventor before: Shi Yaran Inventor before: Yu Xiaohong Inventor before: Liang Bing |
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Application publication date: 20160427 |