CN106334003A - Chinese herbal compound for livestock labor induction and preparation method thereof and application - Google Patents
Chinese herbal compound for livestock labor induction and preparation method thereof and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses a Chinese herbal compound for livestock labor induction and a preparation method thereof and application. The Chinese herbal compound comprises angelica sinensis, ligusticum wallichii, semen plantaginis, achyranthes bidentata, vitamin C and vitamin D. It is verified through pharmaceutical research that the preparation method is stable in process and suitable for mass production; and the Chinese herbal compound is applied to preparation of medicines for shortening female livestock birth process, treating female livestock postpartum blood stasis and preventing retained placenta of female livestock.
Description
Technical field
The present invention relates to pharmaceutical technology field is and in particular to a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal and its system
Preparation Method and application.
Background technology
With the raising of the gentle technology of raiser's cultivation water, class of hastening parturition medicinal application is more and more extensive, using oxytocic drug
Accelerate stages of labor, not only substantially reduce the degree of fatigue of female animal, and shorten stop prevention in birth canal for the newborn animal because suffocating
Make newborn animal dead, reduce dead generation.In process of production, situations below needs to hasten parturition animal: 1) female animal is long-time
Exert duty and be unable to output newborn animal；2) artificial aiding-birth；3) placenta retention.
Placenta retention is a kind of common disease, how weakening in uterus muscle contractile function extreme in puerperal, Placenta Hominiss because of female animal
Infected and inflammation, the reason such as science does not lead to for feeding and management.Placenta retention after childbirth, is trapped in intrauterine afterbirth
Corrupt decomposition can occur, endometritis, the involution of uterus can be caused to postpone and the prolapsus uteri, impact is pregnant again and gives milk, if uterus
Infection seriously can also lead to toxin produced by mastitiss, spoilage product and bacterium infection can cause deteriorated blood after the absorption of uterus
Disease, or even jeopardize female animal life, reduce production performance.Current viewpoint thinks, placenta retention is to lead to many breedings in puerperal barrier
Impenetrability disease is pathogenetic main or immediate cause, causes larger economic loss to milk cow production.
Theory of Chinese medical science thinks, placenta retention principal pathogenetic mechanism is relevant with QI and blood deficiency in puerperal or blood stasis due to qi deficiency, raises pipe
The improper or fetus of reason is excessive, and it is powerless caused that intrapartum hemorrhage is excessive, wasting QI-blood, punching appoint deficient and uterus to shrink, also can be because of mistake
Degree is exerted duty or is just before giving birth caught cold, and leads to qi depression to blood stasis or blood to be that cold coagulation, stagnation of blood stasis and uterus thrombosis cause.Due to farrowing it
When wasting QI-blood, therefore puerperal all empty with QI and blood be common, the deficiency of vital energy can cause blood stasis, deficiency of vital energy yang-energy to lose in Wen Yun, can cause deficiency and coldness, cold then
Blood clotting, blood operation is smooth and cause blood stasis, blood enters afterbirth, causes afterbirth to swell, and makes blood stasis lochia stay in uterus, insufficiency of vital energy and blood and
Uterus is made to shrink powerless, so afterbirth is detained.Therefore, should be with blood circulation promoting and blood stasis dispelling, promotion uterine contraction as principle in treatment.
For such infected animal exploitation Chinese medicine compound according to instruction of Chinese Medicine theory, according to QI and blood deficiency in puerperal or the deficiency of vital energy
The clinic syndrome such as blood stasis, starts with from aspects such as " blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to induce diuresis ", carries out by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Plantaginiss, Radix Achyranthis Bidentatae, dimension
Raw element c, the Chinese medicine compound of vitamin d composition.Develop the stagnation of QI-blood in puerperal for treating pig and cattle and sheep, childbirth postpone or
The herbal medicine additive of placenta retention etc..
Content of the invention
It is an object of the invention to provide a kind of have blood circulation promoting and blood stasis dispelling, in the hastening parturition for domestic animal of the effect hastened parturition in contracting palace
Medicine compound, in order to treat sow and cattle and sheep stagnation of QI-blood in puerperal, childbirth delay or placenta retention etc..
For achieving the above object, the invention provides a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal, active ingredient
Including Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Plantaginiss, Radix Achyranthis Bidentatae, vitamin c and vitamin d.
Wherein, Radix Angelicae Sinensis: sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Can replenishing and activating blood, menstruction regulating and pain relieving, loosening bowel to relieve constipation, be suitable for
In heart-liver blood deficiency card.Radix Angelicae Sinensis polysaccharide can be by the macrophage directly and (or) in degradation pathways activation hematopoieticmicroenviron-ment, lymph
Cell etc., also can stimulate muscular tissue, promote it to produce the hematopoietic regulation factor, and then promotion functions hematopoietic stem cell granulocyte is huge bites
Cell colony becomes the proliferation and differentiation of unit (cfu-gm), stimulates proliferation of Bone Marrow CFU-GM hemopoietic.Additionally, when giving back with antithrombotic, resisting
Scorching analgesia, blood sugar lowering, the effect such as liver protection profit liver.
Rhizoma Chuanxiong: acrid in the mouth, temperature.Enter liver, spleen, tri-jiao channel.Activating QI to alleviate the depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache rotation
Dizzy, hypochondriac pain abdomen aches, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation block pain, ulcer sores.For menoxenia, closed dysmenorrhea, abdominal mass
Stomachache, chest side of body shouting pain, tumbling and swelling, headache, rheumatic arthralgia.There are obvious sedation and analgesic activity.Rhizoma Chuanxiong is to large intestine, change
Shape, green pus, Bacillus typhi etc. have inhibitory action.In addition Rhizoma Chuanxiong also has the effect of vitamin antagonist e deficiency disease.
Semen Plantaginiss: sweet in the mouth, cold in nature, nontoxic.Enter liver, bladder, small intestinal three warp.Main pouring drips the difficulty in urination, yin channel swells and ache, eczema is let out
Rush down, red stagnant in vain turbid, blood closes dystocia.
Radix Achyranthis Bidentatae: bitter, sweet, sour, flat.Return liver and kidney channel.Eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards.
Main soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, abdominal pain due to blood stasis in puerperal, retention of placenta, pyretic stranguria, stranguria with blood.
Vitamin c (vc): also known as l- ascorbic acid, for acid hexose derivant, it is dilute alcohol formula hexose acid lactone, is high
The primate essential nutrients biological with other minorities.vcIt is antibody and collagen is formed, tissue repairing (includes some oxidations
Reduction), Phenylalanine, tyrosine, the metabolism of Folic Acid, ferrum, the utilization of carbohydrate, fat, the synthesis of protein, dimension
Hold immunologic function, hydroxylation and hydroxytryptamine, keep the complete of blood vessel, promote required, the v simultaneously such as nonheme iron absorptioncAlso have
Have antioxidation, free radical resisting, the effect such as formation of suppression tryrosinase.
Vitamin d (vd): for sterin analog derivative, there is anti-rachitic effect, also known as antirachitic vitamin.vdMaster
Physiological function is wanted to be to improve the absorption to calcium, phosphorus for the human body；Promote growth and bone calcification, promote tooth to perfect；Increased by intestinal wall
The absorption phosphorating, and increase the re-absorption of phosphorus by renal tubules；Prevent aminoacid from losing by kidney.Active vdAlso have extensively
Biological action, such as: suppression Various Tissues cell proliferation, differentiation and change cell biological function, play immunomodulating, improvement
The various biological function such as carbohydrate metabolism.
For this reason, the invention provides a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal, its composition includes following weight
The raw material of Chinese medicine of proportioning: Radix Angelicae Sinensis 250-350 part, Rhizoma Chuanxiong 250-350 part, Semen Plantaginiss 150-250 part, Radix Achyranthis Bidentatae 150-250 part, dimension life
Plain c 0.05-0.15 part, vitamin d 0.05-0.15 part.
Preferably, above-mentioned a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention, its composition include with
The raw material of Chinese medicine of lower weight proportion: Radix Angelicae Sinensis 280-320 part, Rhizoma Chuanxiong 280-320 part, Semen Plantaginiss 180-220 part, Radix Achyranthis Bidentatae 180-220
Part, vitamin c 0.08-0.12 part, vitamin d 0.08-0.12 part.
Most preferably, above-mentioned a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention, its composition includes
The raw material of Chinese medicine of following weight proportion: 300 parts of Radix Angelicae Sinensis, 300 parts of Rhizoma Chuanxiong, 200 parts of Semen Plantaginiss, 200 parts of Radix Achyranthis Bidentatae, vitamin c 0.1
Part, 0.1 part of vitamin d.
In composition described above, drug weight is to be calculated with crude drug, can increase according to corresponding proportion when producing or reduce, such as
Large-scale production can by kilogram in units of, or in units of ton, small-scale production can also be in units of milligram, and weight is permissible
Increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above proportioning obtains through science screening, for special circumstances, such as serious symptom or mild, and fat or thin
Little, can accordingly adjust the proportioning of the amount of composition, increase or decrease less than 100%, drug effect is constant.
A kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention is when being prepared into pharmaceutical preparation, necessary
When can add pharmaceutically acceptable carrier, according to galenic pharmacy routine techniquess preparation.Chinese medicine therein partly can adopt Chinese medicine
Crude drug prepares it is also possible to obtain it is also possible to obtain by other means by the common raw material of Chinese medicine that extracts, such as: pass through
Pulverize, squeeze, calcining, grinding, sieving, percolation, extraction, water extraction, alcohol extraction, ester carries, ketone carries, chromatograph etc., and method obtains active Chinese drug component
Material, these active Chinese drug component materials can be the materials of extractum form, can be dry extract can also be fluid extract, according to preparation
Different need to determine to make different concentration.
A kind of pharmaceutical dosage forms of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention, with unit dose
Form exists, and described unit dosage form refers to the unit of preparation, such as every of tablet, every capsule of capsule, and granule is every
Bag etc..
A kind of Chinese medicine preparation of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention can be any can medicine
Dosage form, these dosage forms include: tablet, capsule, granule, pill, unguentum, powder, solution, injection, suppository, spray
Mist agent, drop, patch.The preparation of the present invention, preferably peroral dosage form, such as: capsule, tablet, oral liquid, granule, ball
Agent, powder, unguentum etc..
A kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention, the preparation of its oral administration often can contain
Excipient, such as binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring agent, flavoring agent and moistening
Agent.Applicable filler includes starch, sucrose, cellulose, mannitol, Lactose and other similar filleies.Suitable collapses
Solution agent includes starch, Polyvinylpyrrolidone and starch derivatives, such as sodium starch glycollate.Suitable lubricant includes,
Such as magnesium stearate.
The invention also discloses a kind of obtain preparation method for the Traditional Chinese medicine compound composition that domestic animal is hastened parturition, walk including following
Rapid: to take Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Plantaginiss and Radix Achyranthis Bidentatae to add 10 times amount decoctings by composition weight proportioning and boil three times, 2 hours every time, merge and decoct
Boil liquid, medicinal residues are filtered, and stand overnight and leaching supernatant, are dried to dry cream after concentrating under reduced pressure；Dry cream is ground into fine powder and crosses 100
Mesh sieve, adds vitamin c, vitamin d and appropriate dextrin by composition weight proportioning, mixes and makes compound.
By the method for mixing, filling and tabletting repeatedly, so that described Traditional Chinese medicine compound composition is distributed in adjuvant and prepare admittedly
Body Orally administered composition；Conventional adjuvant composition is selected from Mannitol, Sorbitol, sodium pyrosulfite, sodium sulfite, thiosulfuric acid
Sodium, Cysteine Hydrochloride, TGA, Methionine, vitamin c, edta disodium, edta calcium sodium, the alkali-metal carbonate of monovalence,
Acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid, aminoacid, sodium chloride, potassium chloride, sodium lactate, xylose
Alcohol, maltose, glucose, Fructose, dextran, glycine, starch, sucrose, Lactose, mannitol, silicon derivative, cellulose
And its derivant, alginate, gelatin, Polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, Calcium Carbonate, calcium bicarbonate, surface work
In property agent, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.
One or more.
The invention also discloses a kind of application of the Traditional Chinese medicine compound composition hastened parturition for domestic animal, above-mentioned Chinese medicine compound combination
Thing shortens the application in domestic animal stages of labor and the medicine of prevention domestic animal placenta retention in preparation.
A kind of preparation of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention is when using according to actual feelings
Condition determines usage and dosage, can take daily 1 to 2 time, presses per kilogram of body weight 0.1 every time to 3g dosage.
The present invention has the advantage that
A kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention, has blood circulation promoting and blood stasis dispelling, hasten parturition in contracting palace
Effect.For treating sow and cattle and sheep stagnation of QI-blood in puerperal, childbirth delay or placenta retention etc., its preparation method grinds through pharmacy
Study carefully confirmation, process stabilizing, be suitable for big production.
Specific embodiment
Following examples are used for the present invention is described, but are not limited to the scope of the present invention.
Embodiment 1
A kind of preparation of the Traditional Chinese medicine compound composition hastened parturition for domestic animal: take Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Plantaginiss, Radix Achyranthis Bidentatae etc. four
Medical material adds 10 times amount decoctings and boils three times, 2 hours every time, medicinal residues is filtered, and stands overnight and leaching supernatant, is evaporated to phase
To density 1.21～1.27 (50 DEG C), it is dried to dry cream.Dry cream is ground into fine powder and crosses 100 mesh sieves, adds vc、vdAnd appropriate dextrin,
Mix, wherein vc、vdAdd using after equal increments method mix homogeneously, make 1000g, subpackage obtains final product.
Embodiment 2
A kind of experimental result to Farrowing for the Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention:
Laboratory animal: 90 just before giving birth female Landrace, it is divided into 3 groups, packet situation is shown in Table 1.
Table 1: Traditional Chinese medicine compound composition Farrowing situation result
| All duration of labor | Litter size | Son's number alive | Stillborn fetuses sum | |
| Matched group | 4.7±0.64 | 11.6±2.45 | 8.4±2.07 | 96 |
| Chinese medicine group | 3.19±0.39** | 12.3±2.17 | 11.1**±1.37 | 36 |
| Positive drug group | 4.25±0.47* | 12.1±2.18 | 10.7*±1.52 | 42 |
Note: * represents significant difference (p < 0.05)；* represents that difference is extremely notable (p < 0.01).
Chinese medicine group sow average stages of labor pole is significantly higher than matched group, and Chinese medicine group son alive number pole is significantly higher than matched group, result
Show, Chinese medicine group and positive drug group can make sow stages of labor shorten, reduce still birth rate.Illustrate that this Chinese medicine has raising childbirth ability
Effect, effect is significant compared with positive drug group.
Embodiment 3
A kind of preventive effect to milch cow placenta retention for the Traditional Chinese medicine compound composition hastened parturition for domestic animal disclosed by the invention:
Laboratory animal is just before giving birth age the last week, parity, body condition and the essentially identical milch cow 60 of feeding and management.Be divided into
Lower three groups.
Table 2: the preventive effect to milch cow placenta retention for the Traditional Chinese medicine compound composition
| Head number | Placenta retention number | Placenta retention sickness rate | Row clothing time/h | |
| Matched group | 20 | 5 | 25 | 15.26±5.08 |
| Chinese medicine group | 20 | 2 | 10** | 7.19±2.14** |
| Positive drug group | 20 | 3 | 15* | 8.21±3.45** |
Note: * represents significant difference (p < 0.05)；* represents that difference is extremely notable (p < 0.01).
As seen from Table 2, Chinese medicine has good effect to prevention milch cow placenta retention, not only can reduce placenta retention
Occur, and can greatly shorten the time of afterbirth discharge.Effect pole is significantly better than matched group, can be used for producing greatly.
Although, the present invention is described in detail, at this above to have used general explanation and specific embodiment
On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore,
These modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (10)
1. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal it is characterised in that: the composition bag of described Traditional Chinese medicine compound composition
Include the raw material of Chinese medicine of following weight proportion: Radix Angelicae Sinensis 250-350 part, Rhizoma Chuanxiong 250-350 part, Semen Plantaginiss 150-250 part, Radix Achyranthis Bidentatae 150-
250 parts, vitamin c 0.05-0.15 part, vitamin d 0.05-0.15 part.
2. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to claim 1 it is characterised in that: described Chinese medicine
The composition of compound includes the raw material of Chinese medicine of following weight proportion: Radix Angelicae Sinensis 280-320 part, Rhizoma Chuanxiong 280-320 part, Semen Plantaginiss
180-220 part, Radix Achyranthis Bidentatae 180-220 part, vitamin c 0.08-0.12 part, vitamin d 0.08-0.12 part.
3. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to claim 2 it is characterised in that: described Chinese medicine
The composition of compound includes the raw material of Chinese medicine of following weight proportion: 300 parts of Radix Angelicae Sinensis, 300 parts of Rhizoma Chuanxiong, 200 parts of Semen Plantaginiss, cattle
200 parts of knee joint, 0.1 part of vitamin c, 0.1 part of vitamin d.
4. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to any one of claims 1 to 3, its feature exists
In: the dosage form of described Traditional Chinese medicine compound composition includes: tablet, capsule, granule, pill, unguentum, powder, solution, injection
Agent, suppository, spray, drop and patch.
5. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to any one of claims 1 to 3, its feature exists
In: the dosage form of described Traditional Chinese medicine compound composition is including capsule, tablet, oral liquid, granule, pill, powder and unguentum
Peroral dosage form.
6. a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to claim 5 it is characterised in that: described oral
Dosage form contains excipient, and described excipient includes binding agent, filler, diluent, tablet agent, lubricant, disintegrating agent, coloring
Agent, flavoring agent and wetting agent, described filler includes starch, sucrose, cellulose, mannitol and Lactose, described disintegrating agent bag
Include starch, Polyvinylpyrrolidone and starch derivatives, described lubricant includes magnesium stearate.
7. the preparation method of a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to any one of claims 1 to 3,
It is characterized in that: methods described comprises the steps: to take Radix Angelicae Sinensis, Rhizoma Chuanxiong, Semen Plantaginiss and Radix Achyranthis Bidentatae to add 10 times by composition weight proportioning
Amount decocting boils three times, 2 hours every time, merges decoction liquor, medicinal residues are filtered, stand overnight and leaching supernatant, after concentrating under reduced pressure
It is dried to dry cream；Dry cream is ground into fine powder and crosses 100 mesh sieves, adds vitamin c, vitamin d and appropriate paste by component weight proportion
Essence, mixes and makes compound.
8. preparation method according to claim 7 it is characterised in that: described wherein vitamin c and described vitamin d adopt
Add after equal increments method mix homogeneously.
9. preparation method according to claim 8 it is characterised in that: by repeatedly mixing, filling and tabletting method, make
Described Traditional Chinese medicine compound composition is distributed in adjuvant prepares solid oral composition, and described adjuvant composition is selected from Mannitol, Pyrusussuriensiss
Alcohol, sodium pyrosulfite, sodium sulfite, sodium thiosulfate, Cysteine Hydrochloride, TGA, Methionine, vitamin c, edta
Disodium, edta calcium sodium, the alkali-metal carbonate of monovalence, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulphuric acid, phosphoric acid,
Aminoacid, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, Fructose, dextran, glycine, starch, sugarcane
Sugar, Lactose, mannitol, silicon derivative, cellulose and its derivates, alginate, gelatin, Polyvinylpyrrolidone, glycerol, soil
Temperature 80, agar, Calcium Carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, height
One or more of ridge soil, Pulvis Talci, calcium stearate and magnesium stearate.
10. the application of a kind of Traditional Chinese medicine compound composition hastened parturition for domestic animal according to any one of claim 1-3, it is special
Levy and be: described Traditional Chinese medicine compound composition is applied and shortened female animal stages of labor, treatment female animal stagnation of QI-blood in puerperal and prevention mother in preparation
In the medicine of poultry placenta retention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610917850.7A CN106334003A (en) | 2016-10-20 | 2016-10-20 | Chinese herbal compound for livestock labor induction and preparation method thereof and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610917850.7A CN106334003A (en) | 2016-10-20 | 2016-10-20 | Chinese herbal compound for livestock labor induction and preparation method thereof and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106334003A true CN106334003A (en) | 2017-01-18 |
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Citations (4)
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|---|---|---|---|---|
| CN103844030A (en) * | 2012-12-04 | 2014-06-11 | 广西商大科技有限公司 | Nutritive feed additive capable of increasing survival ratio of embryos in first half period of cow gestation |
| CN105521157A (en) * | 2015-12-31 | 2016-04-27 | 中悦民安（北京）科技发展有限公司 | A traditional Chinese medicine compound prescription for inducing oestrus and activating blood circulation for livestock |
| CN105535094A (en) * | 2016-01-11 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for facilitating beast, bird and fish production performance |
| CN105794718A (en) * | 2016-03-16 | 2016-07-27 | 浙江省农业科学院 | Raising management method for improving sow reproductive performance |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103844030A (en) * | 2012-12-04 | 2014-06-11 | 广西商大科技有限公司 | Nutritive feed additive capable of increasing survival ratio of embryos in first half period of cow gestation |
| CN105521157A (en) * | 2015-12-31 | 2016-04-27 | 中悦民安（北京）科技发展有限公司 | A traditional Chinese medicine compound prescription for inducing oestrus and activating blood circulation for livestock |
| CN105535094A (en) * | 2016-01-11 | 2016-05-04 | 中悦民安（北京）科技发展有限公司 | Traditional Chinese medicine composition for facilitating beast, bird and fish production performance |
| CN105794718A (en) * | 2016-03-16 | 2016-07-27 | 浙江省农业科学院 | Raising management method for improving sow reproductive performance |
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| Title |
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| 李绪权: ""加味脱花煎对孕牛的引产效果"", 《中兽医医药杂志》 * |
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Application publication date: 20170118 |