Summary of the invention
For the weak point that prior art exists, the object of the present invention is to provide a kind of CCN biocontainment laboratory, install quick, cheap, pressure reduction, humiture can be realized, there is the entrance guard management that degree of safety is high, ensure that experiment safety.
Object of the present invention is achieved through the following technical solutions:
A kind of CCN biocontainment laboratory, comprise door, first changing rooms, second changing rooms, laboratory, machine room, air inlet system and outlet system of air, described door is entering of CCN biocontainment laboratory, enter in machine room by door, described machine room, first changing rooms, second changing rooms, laboratory sets gradually, described air inlet system is communicated with successively and comprises roughing efficiency air filter, medium effeciency filter, plenum chamber, centrifugal blower and monoblock type laminar flow hood, the air outlet of described monoblock type laminar flow hood is placed in the indoor in laboratory, described air inlet system is used for air clean for laboratory conveying continuously and keeps laboratory to be in positive pressure environment always, described outlet system of air is communicated with successively and comprises high efficiency particulate air filter and Diffusion of gas stream blowing unit, and the air inlet of described high efficiency particulate air filter is placed in the indoor in laboratory, and the air-out speed of described outlet system of air is less than the intake velocity of air inlet system, be provided with P2 Viral experiment room control system in described machine room, in the control system of P2 Viral experiment room, be provided with door lock control system and internal environment monitoring system.
In order to realize the present invention better, between described laboratory and the external world, be provided with pass-through box.
Further technical scheme is: be provided with FFU filter element in described laboratory.
Further technical scheme is: described door lock control system comprises door open button, the door lock that described door is provided with enabling controls, the door of described first changing rooms is provided with the changing rooms door lock control A of enabling, the door of described second changing rooms is provided with the changing rooms door lock control B of enabling, described door open button controls with door lock respectively, changing rooms door lock control A, changing rooms door lock control B are electrically connected, the control instruction that door open button is used for opposite house lock control, changing rooms door lock control A, changing rooms door lock control B send enabling respectively.
The present invention's preferred door lock control system structure technology scheme is: also include system power supply scram button in described door lock control system, and system power supply scram button is used for cutting system power supply.
In order to realize the various control modes of door open button better, described door open button control gate.Described door open button is provided with door lock and controls corresponding enabling signal indicator lamp.Be specially: described door open button be provided with control with door lock respectively, changing rooms door lock control A, changing rooms door lock control B enabling signal indicator lamp one to one.
The preferred technical scheme of internal environment monitoring system of the present invention is: described internal environment monitoring system comprises temperature sensing module, ozone concentration detecting module, humidity detecting module and pressure differential detection module, and described temperature sensing module, ozone concentration detecting module, humidity detecting module and pressure differential detection module respectively correspondence are arranged at corresponding surveyed area place, laboratory; Described temperature sensing module is for detecting the temperature value of laboratory internal environment and timely the temperature value detected being transferred to internal environment monitoring system; Described ozone concentration detecting module is for detecting the ozone concentration of laboratory internal environment and timely the ozone concentration detected being transferred to internal environment monitoring system; Described humidity detecting module is for detecting the humidity value of laboratory internal environment and timely the humidity value detected being transferred to internal environment monitoring system; Described pressure differential detection module is for detecting the differential pressure conditions of laboratory internal environment and timely the differential pressure conditions detected being transferred to internal environment monitoring system.
As preferably, also lamp light control system is provided with in the control system of described P2 Viral experiment room, described first changing rooms, the second changing rooms, laboratory, machine room inside are provided with light units respectively, described lamp light control system is electrically connected with each light units, and described lamp light control system opens and closes for the light units controlled in the first changing rooms, the second changing rooms, laboratory, machine room.
As preferably, the door in described CCN biocontainment laboratory, the first changing rooms, the second changing rooms, laboratory, the equal stainless steel of machine room or the manufacture of plastic-blasting galvanized steel plain sheet form.
The present invention comparatively prior art compares, and has the following advantages and beneficial effect:
(1) the present invention installs quick, cheap, can realize pressure reduction, humiture, have the entrance guard management that degree of safety is high, ensure that experiment safety.
(2) band HVAC system of the present invention, can independent operating; Adopt monolithic construction, install easily; And short construction period, small investment, simple installation, operating cost is low.It is easy that the present invention improves cleaniliness classs, and autgmentability is strong, and recycling is worth high; And conveniently moving, installation are quick, cheap.Skeleton of the present invention adopts modularization section aluminum frame, and intensity is high, but also adopts microcomputerized control; Also with ozone/VHP sterilizing function, pressure reduction, humiture, entrance guard management, system monitoring.The present invention has the function such as fault alarm, efficient D0P leak detection, and function is very complete, one-stop cleaning system solution, meets the requirement of CGMP certification.
Embodiment
As shown in Fig. 1 ~ Fig. 6, a kind of CCN biocontainment laboratory, comprise door 1, first changing rooms 2, second changing rooms 3, laboratory 5, machine room 6, air inlet system and outlet system of air, door 1 is entered for CCN biocontainment laboratory, enter in machine room 6 by door 1, machine room 6, first changing rooms 2, second changing rooms 3, laboratory 5 sets gradually, air inlet system is communicated with successively and comprises roughing efficiency air filter 7, medium effeciency filter 8, centrifugal blower 10, plenum chamber 11 and monoblock type laminar flow hood 12, the air outlet of monoblock type laminar flow hood 12 is placed in the indoor in laboratory 5, air inlet system is used for carrying clean air for laboratory 5 continuously and keeping laboratory 5 to be in positive pressure environment always.Outlet system of air is communicated with successively and comprises high efficiency particulate air filter 13 and Diffusion of gas stream blowing unit 14, and the air inlet of high efficiency particulate air filter 13 is placed in the indoor in laboratory 5, and the air-out speed of outlet system of air is less than the intake velocity of air inlet system.Be provided with P2 Viral experiment room control system 61 in machine room 6, in P2 Viral experiment room control system 61, be provided with door lock control system 62 and internal environment monitoring system 64.The profile structure of door 1, first changing rooms 2, second changing rooms 3 of the present invention, laboratory 5, machine room 6 adopts the aluminium alloy extrusions of research and development meticulously, door the 1, first changing rooms 2, second changing rooms 3, laboratory 5, machine room 6 etc., as module frame, ensure that the overall lines linearity requirement after module strength and installation.The integrated conventional keel structure of this section bar has been convenient to buckle.The integrated drift angle of this section bar, ditch circular arc, be convenient to install and lay PVC epoxy ground.Model calling is convenient and swift.Overall plastic-blasting is adopted to meet outward appearance and instructions for use after model calling.The buckle structure of door 1, first changing rooms 2, second changing rooms 3 of the present invention adopts building enclosure, adopts the keel buckle of industry universal to produce, and is developed as 100 type hollow gypsum purification plates through research improvement.The buckle structure of this 100 type hollow gypsum purification plate has the characteristics such as the not dust suction of cleanliness factor height, sound-insulating, fire prevention A level.
As shown in Figure 2, be provided with pass-through box 4 between described laboratory 5 and the external world, the simple operations such as experimental apparatus transmission can be realized by pass-through box 4.
According to one embodiment of present invention, be provided with FFU filter element 9, FFU filter element 9 in laboratory 5 and can carry out purification run to laboratory 5.
As shown in Figure 4, door lock control system 62 comprises door open button 621, the door lock that door 1 is provided with enabling controls 15, the door of the first changing rooms 2 is provided with the changing rooms door lock control A21 of enabling, the door of the second changing rooms 3 is provided with the changing rooms door lock control B31 of enabling, door open button 621 controls 15 with door lock respectively, changing rooms door lock control A21, changing rooms door lock control B31 is electrically connected, door open button 621 is for opposite house lock control 15, changing rooms door lock control A21, changing rooms door lock control B31 sends the control instruction of enabling respectively, door lock controls 15, changing rooms door lock control A21, changing rooms door lock control B31 responds this control instruction respectively and opens corresponding door lock, changing rooms door lock control A21 and changing rooms door lock control B31 interlocks.
According to one embodiment of present invention, also include system power supply scram button 623 in door lock control system 62, system power supply scram button 623 is for cutting system power supply.
The door opening state that each door lock controls is checked, described door open button 621 control gate 1 for the ease of people.Door open button 621 is provided with and controls 15 respectively with door lock, changing rooms door lock control A21, changing rooms door lock control B31 enabling signal indicator lamp 624 one to one.
As shown in Figure 6, internal environment monitoring system 64 comprises temperature sensing module 641, ozone concentration detecting module 642, humidity detecting module 643 and pressure differential detection module 644, and temperature sensing module 641, ozone concentration detecting module 642, humidity detecting module 643 and pressure differential detection module 644 respectively correspondence are arranged at corresponding surveyed area place, laboratory 5.Temperature sensing module 641 is for detecting the temperature value of laboratory 5 internal environment and timely the temperature value detected being transferred to internal environment monitoring system 64.The present invention coordinates constant temperature and humidity machine, provides air quantity required for the present invention, cold, can reach clean requirement.Operating desk of the present invention adopts hundred grades of laminar flow bench, carries out experimental implementation.Ozone concentration detecting module 642 is for detecting the ozone concentration of laboratory 5 internal environment and timely the ozone concentration detected being transferred to internal environment monitoring system 64.Humidity detecting module 643 is for detecting the humidity value of laboratory 5 internal environment and timely the humidity value detected being transferred to internal environment monitoring system 64.Pressure differential detection module 644 is for detecting the differential pressure conditions of laboratory 5 internal environment and timely the differential pressure conditions detected being transferred to internal environment monitoring system 64.Above-mentioned functions module of the present invention can combinationally use, and when combinationally using, by multiple functional module access air-conditioning system, completing unified air-supply pressure regulation poor, ensureing experimental situation cleanliness factor.Host computer can also be connected by unified for multiple functional module control system, carry out entirety supervision, real-time monitoring system ruuning situation.If desired, can close, open single or multiple connected functional module, carry out partial operation.Can be adjusted by technological requirement module room-size and layout.
As shown in Figure 5, lamp light control system 63 is also provided with in P2 Viral experiment room control system 61, first changing rooms 2, second changing rooms 3, laboratory 5, machine room 6 inside are provided with light units 631 respectively, lamp light control system 63 is electrically connected with each light units 631, and lamp light control system 63 opens and closes for the light units 631 controlled in the first changing rooms 2, second changing rooms 3, laboratory 5, machine room 6.
According to one embodiment of present invention, door 1, first changing rooms 2, second changing rooms 3 in CCN biocontainment laboratory, laboratory 5, machine room 6 all stainless steel or the manufacture of plastic-blasting galvanized steel plain sheet form.
Concrete condition is implemented in design of the present invention:
1, condition of work:
2, structural parameters:
1., workspace temperature: 18-26 DEG C, illumination: >=300Lux,
Relative humidity: 35-65%RH, noise :≤65dB.
2., workspace cleanliness factor: local laminar flow, ten thousand grades.
3., workspace on average blows wind speed: >=0.36m/s,
Workspace return air inlet wind speed :≤1.5m/s
4., circulated air and pressure reduction maintains wind air quantity, all can set according to actual conditions.The basic function that the present invention possesses
● this product enters interlocking and the identity validation of a few fan door in laboratory by independently gate control system controllers.
● door-opening mode is determined by technique, swipe the card respectively, fingerprint recognition, light-sensitive system carry out choosing dress.
● showing control system in operation screen by being integrated into gate inhibition, controlling the constant temperature and humidity machine of configuration, ensureing that the environment of whole module reaches requirement of experiment.
● during experiment, in advance according to technological requirement regulation experiment institute's chilling requirement and air quantity.
● the purification route that all personnel passing in and out laboratories must abide by the regulations and program, must not change privately; All goods will by regulation from pass-through box turnover laboratory.
● in use procedure, illuminating lamp is often opened, and ensures illumination requirement in laboratory.
● scram button is installed, provides and in emergency circumstances open the clean gas-tight door of all interlockings fast.
● there are enough memory space putting on articles with easy to use.The memory space for Long-Time Service is also had at laboratory working area place.
● in laboratory, be equipped with Biohazard Safety Equipment.
● establish cleaning facility, hand basin: stainless steel, include induction tap, automatic hand dryer
● there are reliable supply of electric power and emergency lighting.
● purifying door: band observation window, door closer.
● efficient air distributor: stainless steel punch forming.
● air-supply unit: include fresh wind port, new wind return air mixing section, air supply section, flow equalization section (maintenance section), middle effect section, wind outlet section, muffler section.
● air draft unit: outlet has high efficiency particulate air filter to filter.
● operating desk: stainless steel makes.
Method of operating of the present invention is as follows:
The course of work of CCN biocontainment laboratory has been come by automatic control system cooperative mechanical formula differential pressure indicator.All automatic control processes are completed by DDC purification air-conditioning thermostatic constant wet control system (SiemensPLC, PID proportional integral derivative) controller.All control operations are all undertaken by liquid crystal touch screen.Color liquid crystal touch screen, except the running parameters such as the online concentration of displays temperature, humidity, ozone or VHP, warning, is also responsible for the setting operation of all kinds of parameter.Touch-screen screen display and operation point multipage display, menu in Chinese guides, and is respectively:
Runnable interface of the present invention can Display on the same screen Current Temperatures, humidity, testing button, screen is arranged simultaneously " stop/run " button and clock display.
Its parameter is as following table (table 1):
Table 1 automatic control system runnable interface controling parameter
Parameter title |
Conditions dictate/effect |
Remarks |
1.. temperature, humidity |
Temperature humidity |
|
2.. the online concentration of ozone/VHP |
Ozone/VHP real-time concentration |
Select dress as required |
3.. manual test pattern |
Whether test blower fan, disinfection system, interlocking etc. are normal |
Select dress as required |
4.. automatic disinfection pattern |
Automatic disinfection |
Select dress as required |
5.. stop/run |
Start/stop test or automatic disinfection pattern |
|
Can parameters (parameter has respectively " temperature, humidity arrange ", " ozone or VHP sterilization, safe concentration are arranged ", " report to the police and arrange " three interfaces) on runnable interface.
The automatic control system major function of CCN biocontainment laboratory is as follows:
1., epidemic disaster display
Real time humiture in display air lock chamber room body.
2., ozone/VHP concentration on-line monitoring, control
Ozone/VHP concentration on-line monitoring, control, can set sterilizing concentration and safe concentration also attaches delay function.
3., warning function
This system has perfect warning function.
Mainly contain: air-valve is reported to the police, constant temperature and humidity machine is reported to the police, gate inhibition reports to the police, system alarm.
When any one or more warning data over run, corresponding touch-screen warning function glittering (redness) also sends chimes of doom, until failture evacuation.
4., sudden-stop function
System provides in emergency circumstances, opens the function of all interlocking doors fast.
The installation operation of CCN biocontainment laboratory is as follows:
1) doorframe and body of wall assemble, and adopt screw to connect, connecting portion is doorframe outer stiffening plate and wallboard keel.
2) door-plate and doorframe are hinged, easy installation and removal.
3) aluminium alloy extrusions, as module frame; Integrated conventional keel structure has been convenient to buckle.The integrated drift angle of this section bar, ditch circular arc, be convenient to install and lay PVC epoxy ground.
The present invention is after product testing, complete between the functions such as its entrance guard management, system monitoring, fault alarm, efficient D0P leak detection, one-stop cleaning system solution.And meet the requirement of CGMP certification, its performance meets design and Specification requirement.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.