CN105497967A - Dry bacterial cellulose membrane dressing - Google Patents
Dry bacterial cellulose membrane dressing Download PDFInfo
- Publication number
- CN105497967A CN105497967A CN201610036064.6A CN201610036064A CN105497967A CN 105497967 A CN105497967 A CN 105497967A CN 201610036064 A CN201610036064 A CN 201610036064A CN 105497967 A CN105497967 A CN 105497967A
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- China
- Prior art keywords
- cellulose film
- bacterial cellulose
- dressing
- dry state
- cellulose membrane
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/225—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention provides a dry bacterial cellulose membrane dressing, which comprises a bacterial cellulose membrane and a protective agent, wherein the bacterial cellulose membrane is in a dry state; the protective agent is distributed on the bacterial cellulose membrane; and the protective agent comprises one or more of polyethylene glycol, polyvinyl alcohol or polyvinyl pyrrolidone. The bacterial cellulose membrane prepared by bacterial fermentation is dried in manners of spin-drying or freezing and the like; a freeze-dried protection fluid is absorbed; and the dry bacterial cellulose membrane dressing provided by the invention is formed through a drying step. The dry bacterial cellulose membrane dressing can be used for adsorbing and infiltrating various medicines, and can also be directly applied to a human affected part as the medical dressing. The dry bacterial cellulose membrane dressing has extremely excellent hygroscopic property and gas permeability, so that a wet bacterial cellulose membrane can be replaced.
Description
Technical field
The present invention relates to field of medical article technology, especially a kind of dry state Bacterial cellulose film dressing.
Background technology
Bacteria cellulose film has extraordinary biocompatibility and breathability, be translucent shape, its can prevent wound infection, keep wound moist, can absorbing wound exudate and not with wound adhesion, and for antibacterial, there is blocking effect, therefore wound is recovered and alleviates cicatrix to have good therapeutic effect.Current Bacterial cellulose dressing is hygrometric state diaphragm, water content is wayward, after loading sealing bags, easily folding or slip in transportation, therefore very hard when taking out from packaging, applying easily to ooze out at wound upper diaphragm institute water content own causes fixing gauze moist, and hygrometric state diaphragm, owing to having certain deformability, is cut to fixed dimension extremely difficult.After bacteria cellulose film diminishing is made as dry film, then to carry out cutting or transporting be feasible way, but after bacteria cellulose film is prepared into dry film, its water absorption rate and fibre structure are subject to heavy damage, and excellent water absorption and breathability etc. greatly weaken originally.
Summary of the invention
The object of the invention is to propose a kind of dry state Bacterial cellulose film dressing, its microscopic three-dimensional structural is not destroyed, substantially all excellent properties of hygrometric state bacteria cellulose film have been possessed, especially have and hygrometric state bacteria cellulose film mutually water absorption rate seemingly and breathability, the bacteria cellulose film that can substitute hygrometric state uses as dressing, and this dressing of dry state have be convenient for carrying be not easy distortion, the advantage that easy cutting etc. are stronger.
For reaching this object, the present invention by the following technical solutions:
A kind of dry state Bacterial cellulose film dressing, comprises bacteria cellulose film and protective agent; Described bacteria cellulose film is dry state; Described protective agent is distributed in described bacteria cellulose film, and described protectant composition is one or more in Polyethylene Glycol, polyvinyl alcohol or polyvinylpyrrolidone.
Bacterial cellulose film dressing applies after on wound, because it has good water absorption and breathability, therefore, it is possible to play the effect of similar adhesive bandage, promotes wound healing, reduces cicatrix.Protectant effect is the hydrating structure such as micropore filling up bacteria cellulose film, avoids in the process of preparation dry state bacteria cellulose film, the water absorption rate caused by hygrometric state diminishing to micropore avalanche during dry state and the problem of microstructural damage.Polyethylene Glycol contains long-chain shape or globular molecule structure, and in cryodesiccated process, long-chain shape or globular molecule can support the space structure of Bacterial cellulose, makes it be unlikely to subside, thus keeps the space structure of Bacterial cellulose.Material not containing any stimulation human body skin in dry state dressing of the present invention, Polyethylene Glycol, polyvinyl alcohol or polyvinylpyrrolidone etc. are all the materials without any toxic and side effects, can not have any toxic and side effects when being attached at human body skin wound.
Through the bacteria cellulose film that bacterial fermentation is prepared into; by to dry or the mode such as freezing carries out drying; then frozen-dried protective liquid is sucked; dry state Bacterial cellulose film dressing of the present invention is formed again through drying steps; can be used for absorption and infiltrate various medicine, also directly can be used for human body injury place using dry state as Medical dressing.Described frozen-dried protective liquid is containing above-mentioned one or more aqueous solution protectant.
Because dry state dressing of the present invention has extremely strong water absorption, therefore, it is possible to the absorption body fluid that oozes out of human body skin injury place and in hygrometric state, both the pollutions such as antibacterial can be completely cut off, can breathe freely fully again, and reduce cicatrix with its good biocompatibility, be especially usually used in the recovery of the cesarean edge of a knife.
Simultaneously, also there is better tack, the moistening place of whole dry state dressing can attach human body skin, therefore the lighter in weight being still in the dressing of dry state is around not easy be affected by gravity and come off, but also it is fixing to carry out attaching with adhesive plaster etc., and the bacteria cellulose film of hygrometric state is because weight is large and can not attach fixing with adhesive plaster so use more inconvenient.
In the bacteria cellulose film preparation process of hygrometric state; usually the very large monoblock of area (considerably beyond injury place area) can be prepared; generally can be cut into specific dimensions (such as 50 × 100mm; 100 × 100mm; 100 × 400mm etc.) load sealing bag afterwards; hygrometric state diaphragm has larger elasticity and is therefore cut into and determines that size is more difficult, and adds the operation of one cutting, also has higher cost.And dry state dressing of the present invention, can directly sell with a monoblock dry state dressing of larger area, easily dry state dressing health shears can be cut into any required size when needing use, even in emergency circumstances (be such as carried into field to use as adhesive bandage) direct hands and break disconnected also can use, so have the advantage of easy cutting easy to use.
In a word, dry state dressing of the present invention for hygrometric state diaphragm all advantages and also there is easy transport, easily cutting and the stronger advantage such as easily to attach.
Purposes due to described bacteria cellulose film is the dressing as being attached at human body skin, and therefore those skilled in the art should predict, in the protectant process of interpolation, should containing the material stimulating wound, and such as acid or alkaline components.
After described dry state Bacterial cellulose film dressing is dipped in pure water, the residuals got after bubbling out liquid removal moisture measures;
(1) get residuals 0.05g, add dilute hydrochloric acid 5ml and barium chloride test solution 1ml, jolting, filter; In filtrate, add 10% phosphorus molybdenum acid solution 1ml, produce yellow-green precipitate;
(2) get residuals 0.1g, put in test tube, add potassium thiocyanate and each 0.1g of cobalt nitrate, after mixing, add dichloromethane 5ml, solution is in blue.
Polyethylene Glycol is nontoxic, nonirritant, and mildly bitter flavor has good water solublity, can detect confirm that whether described dry state Bacterial cellulose film dressing is containing Polyethylene Glycol according to above-mentioned decision method.
Described bacteria cellulose film is formed by the bacterial fermentation of at least one in achromobacter, rhizobium, Rhodopseudomonas, Aerobacter, azotobacter, Sarcina, Acetobacter sp., Alcaligenes, Agrobacterium.
The molecular weight ranges of described Polyethylene Glycol is 400 ~ 40000.
Polyethylene Glycol is water-soluble, ethanol and other organic solvents many, inoperative with many chemicals, is not hydrolyzed, never degenerates, nontoxic, to eyes and skin without obvious stimulation.
Preferably, be also distributed with antibacterial silver salt, described antibacterial silver salt is one or more in silver nitrate, Argentous fluoride, silver perchlorate.
Silver nitrate, Argentous fluoride, silver perchlorate are all strong oxidizers, there is convergence, corrosion and the effect of kill bacteria, especially to bacillus pyocyaneus, escherichia coli, tubercule bacillus, streptococcus, staphylococcus aureus, spore, fungus, anthrax bacillus, clostridium tetani have killing action, can be antibacterial skin.
Preferably, be also distributed with wound healing accelerator, described wound healing accelerator is the collagen protein of pig or cattle animal origin.
Pig, cattle are all mammals, and more similar compared with other class animals and human beings classes of its collagen protein with it, can promote quick growth and the reparation of damaged skin like this.
Detailed description of the invention
Technical scheme of the present invention is further illustrated below by detailed description of the invention.
embodiment one
Prepare the method for described dry state Bacterial cellulose film dressing, step comprises:
Step a, the cellulose membrane obtained by bacterial fermentation, use pure water cleaning bacteria cellulose film, until the pH of described bacteria cellulose film is 6.Here, because antibacterial is produce acid during the fermentation, bacteria cellulose film, below 3, is washed pH and 6 is shown to have washed very thorough (pure water pH is about 6) by the pH of raw material;
The bacteria cellulose film cleaned with pure water is put into the inorganic alkali solution that concentration is 1.0mol/L, is warming up to 63 DEG C, after stirring 4h, take out described bacteria cellulose film;
With water cleaning to the pH of described bacteria cellulose film be 6 and described bacteria cellulose film in the content of bacterial endotoxin be less than or equal to 0.25EU/ml, obtain the bacteria cellulose film of purification; Use pure water to clean, remove unnecessary inorganic base, make bacteria cellulose film be in neutral state.
Step b, by the bacteria cellulose film of the purification obtained by extruding mode dewater, fluid loss deadweight more than 50%; After first time dehydration, bacteria cellulose film can absorb frozen-dried protective liquid more fully, protects liquid component to be more evenly distributed in dry film after lyophilizing.
Step c, be immersed in frozen-dried protective liquid by the bacteria cellulose film of dehydration, to be restoredly pull out wherein after more than 80% of original weight before dehydration, frozen-dried protective liquid is the pure water solution of Polyethylene Glycol containing 2%;
Polyethylene Glycol and glassware for drinking water have extraordinary intermiscibility, therefore 1%, 2%, 3%, 4%, 5%, 10% to such an extent as to the mutual dissolving of any ratio such as 50% is all feasible, originally can accept as long as regard as, therefore without the need to limiting the dissolving ratio of Aqueous Solutions of Polyethylene Glycol, those skilled in the art all can implement and solve technical problem of the present invention.
Steps d ,-30 DEG C of pre-freezes 3 hours, reinstall in the cold well of freezer dryer, and-30 DEG C of insulation 2-3 hour, observe resistance and reach maximum, about 97%, constant 2 hours; Arrange vacuum 0.37mbar, baffle temperature, from-30 DEG C, keeps 5 hours, then every 5 hours, heats up 5 DEG C, does 5 times; 36 hours main drying times, then end vacuum 10 hours.
After step e, sealing, radiation sterilization is used as wound dressing.
The dry state Bacterial cellulose dressing that the present embodiment is made, water suction exceedes 180 times of dry mass.Method of testing is measure the weight of dry state dressing, then immerses drenched rear taking-up in pure water, wipes surface moisture and weighs, the ratio of two weight.
Measure breathability, its ventilation rate is more than 2200 grams of every square meter every days, and this attribute is evaluated with moisture-vapor transmission.A certain amount of distilled water is injected in cup, (dry state dressing must become hygrometric state when being attached at wound owing to adsorbing body fluid to block rim of a cup after fully being soaked by dry state dressing, the diaphragm therefore with permeation functions is hygrometric state in fact), cup is put into sealed container to guarantee temperature and the relative humidity (being generally 35 ± 1 DEG C, 50 ± 5%) in space residing for cup.Steam can be determined by the gross mass variable quantity measuring cup through the amount of tested film, and gross mass variable quantity is moisture-vapor transmission divided by the time again divided by rim of a cup area.
But it is to be noted, this method is coarse evaluation air penetrability, owing to when the dry state dressing paste in actual use procedure invests wound being not (be different from pure water because of human body fluid composition and seepage discharge is limited) of fully soaking, and the existence of moisture reduces permeability, therefore dry state dressing of the present invention ventilation rate in actual use more will be better than the steam air penetrability adopting this method mensuration.
embodiment two
Step a, use pure water cleaning bacteria cellulose film, until the pH of bacteria cellulose film is 6, bacteria cellulose film cleaned for pure water is put into the inorganic alkali solution that concentration is 1.0mol/L, be warming up to 95 DEG C, after stirring 24h, take out described bacteria cellulose film, with pure water cleaning to the pH of bacteria cellulose film be 5 and bacteria cellulose film in the content of bacterial endotoxin be less than 0.125EU/ml time, obtain the bacteria cellulose film of purification;
Step b, the bacteria cellulose film of purification that step a is obtained, the method using extruding dry removes institute's water content, makes weight reduce 90%;
Step c, the bacteria cellulose film of dehydration is immersed in the aqueous solution containing 2% polyvinyl alcohol, to be restoredly after more than 80% of original weight before dehydration, pulls Bacterial cellulose diaphragm out, be neatly placed on pallet;
Steps d, at-30 DEG C pre-freeze 3h, the bacteria cellulose film that pre-freeze is obtained, load freezer dryer cold well in ,-30 DEG C insulation 2-3h, observe resistance and reach maximum, about 97%, constant 2h; Arrange vacuum 0.37mbar, baffle temperature, from-30 DEG C, keeps 5h, and then every 5h, heats up 5 DEG C, do 5 times; Main drying time 36h, then end vacuum 10h;
Step e, cut into preliminary dimension, after sealing, radiation sterilization is used as wound dressing.
The Bacterial cellulose dry film dressing that the present embodiment is made, water suction exceedes 170 times of dry mass, and ventilation rate is more than 2100 grams of every square meter every days.
embodiment three
Step a, use pure water cleaning bacteria cellulose film, until the pH of bacteria cellulose film is 6.5, bacteria cellulose film cleaned for pure water is put into the potassium hydroxide solution that concentration is 0.1mol/L, be warming up to 80 DEG C, after stirring 12h, take out described bacteria cellulose film, with pure water cleaning to the pH of bacteria cellulose film be 6 and bacteria cellulose film in the content of bacterial endotoxin for being less than 0.125EU/ml time, obtain the bacteria cellulose film of purification;
Step b, the bacteria cellulose film of purification obtained by step a, remove institute's water content by the method for centrifuge dehydration, makes weight reduce 90%;
Step c, the bacteria cellulose film of dehydration is immersed in the mixed aqueous solution containing 2% polyvinylpyrrolidone, to be restoredly after more than 80% of original weight before dehydration, pulls Bacterial cellulose diaphragm out, be neatly placed on pallet;
Steps d ,-30 DEG C of pre-freeze 3h, obtain the bacteria cellulose film of pre-freeze, loads in the cold well of freezer dryer, and-30 DEG C of insulation 2-3h, observe resistance and reach maximum, about 97%, constant 2h; Arrange vacuum 0.37mbar, baffle temperature, from-30 DEG C, keeps 5h, and then every 5h, heats up 5 DEG C, do 5 times; Main drying time 36h, then end vacuum 10h.
Step e, cut into the rectangle film block of 3cm × 6cm, after sealing, radiation sterilization is used as wound dressing.
The Bacterial cellulose dry film dressing that the present embodiment is made, water suction exceedes 160 times of dry mass, and ventilation rate is more than 2000 grams of every square meter every days.
Above content is only preferred embodiment of the present invention, and for those of ordinary skill in the art, according to thought of the present invention, all will change in specific embodiments and applications, this description should not be construed as limitation of the present invention.
Claims (6)
1. a dry state Bacterial cellulose film dressing; it is characterized in that: comprise bacteria cellulose film and protective agent; described bacteria cellulose film is dry state; described protective agent is distributed in described bacteria cellulose film, and described protective agent is one or more in Polyethylene Glycol, polyvinyl alcohol or polyvinylpyrrolidone.
2. dry state Bacterial cellulose film dressing as claimed in claim 1, is characterized in that, after described dry state Bacterial cellulose film dressing is dipped in pure water, the residuals got after bubbling out liquid removal moisture measures;
(1) get residuals 0.05g, add dilute hydrochloric acid 5ml and barium chloride test solution 1ml, jolting, filter; In filtrate, add 10% phosphorus molybdenum acid solution 1ml, produce yellow-green precipitate;
(2) get residuals 0.1g, put in test tube, add potassium thiocyanate and each 0.1g of cobalt nitrate, after mixing, add dichloromethane 5ml, solution is in blue.
3. dry state Bacterial cellulose film dressing as claimed in claim 1, it is characterized in that, described bacteria cellulose film is formed by the bacterial fermentation of at least one in achromobacter, rhizobium, Rhodopseudomonas, Aerobacter, azotobacter, Sarcina, Acetobacter sp., Alcaligenes, Agrobacterium.
4. dry state Bacterial cellulose film dressing as claimed in claim 1, it is characterized in that, the molecular weight ranges of described Polyethylene Glycol is 400 ~ 40000.
5. dry state Bacterial cellulose film dressing as claimed in claim 1, is characterized in that, be also distributed with antibacterial silver salt, and described antibacterial silver salt is one or more in silver nitrate, Argentous fluoride, silver perchlorate.
6. dry state Bacterial cellulose film dressing as claimed in claim 1, it is characterized in that, be also distributed with wound healing accelerator, described wound healing accelerator is the collagen protein of pig or cattle animal origin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610036064.6A CN105497967A (en) | 2016-01-20 | 2016-01-20 | Dry bacterial cellulose membrane dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610036064.6A CN105497967A (en) | 2016-01-20 | 2016-01-20 | Dry bacterial cellulose membrane dressing |
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| Publication Number | Publication Date |
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| CN105497967A true CN105497967A (en) | 2016-04-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610036064.6A Pending CN105497967A (en) | 2016-01-20 | 2016-01-20 | Dry bacterial cellulose membrane dressing |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822980A (en) * | 2017-01-21 | 2017-06-13 | 北京科技大学 | One kind plasticizing nanometer bacteria cellulose functional dressings and preparation method thereof |
| CN107158478A (en) * | 2017-05-19 | 2017-09-15 | 北京鼎瀚恒海生物科技股份有限公司 | A kind of bacteria cellulose Graftskin and preparation method thereof |
| CN112409777A (en) * | 2020-11-09 | 2021-02-26 | 江苏鑫易达新材料科技有限公司 | Medical antibacterial breathable TPU film and preparation method thereof |
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| WO2007027849A2 (en) * | 2005-08-31 | 2007-03-08 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
| CN101745141A (en) * | 2010-01-15 | 2010-06-23 | 东华大学 | Bacterial cellulose (BC) based antibacterial dry film applied to acute injury as well as preparation method and application thereof |
| CN102352051A (en) * | 2011-09-30 | 2012-02-15 | 北京科技大学 | Method for preparing collagen-modified bacteria cellulose compound film |
-
2016
- 2016-01-20 CN CN201610036064.6A patent/CN105497967A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007027849A2 (en) * | 2005-08-31 | 2007-03-08 | Board Of Regents, The University Of Texas System | Multiribbon nanocellulose as a matrix for wound healing |
| CN101745141A (en) * | 2010-01-15 | 2010-06-23 | 东华大学 | Bacterial cellulose (BC) based antibacterial dry film applied to acute injury as well as preparation method and application thereof |
| CN102352051A (en) * | 2011-09-30 | 2012-02-15 | 北京科技大学 | Method for preparing collagen-modified bacteria cellulose compound film |
Non-Patent Citations (2)
| Title |
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| MA XIA等: "Feasibility of bacterial cellulose membrane as a wound dressing", 《中国组织工程研究与临床康复》 * |
| ZHIJIANG CAI等: "Bacterial cellulose/poly(ethylene glycol) composite: characterization and first evaluation of biocompatibility", 《CELLULOSE》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822980A (en) * | 2017-01-21 | 2017-06-13 | 北京科技大学 | One kind plasticizing nanometer bacteria cellulose functional dressings and preparation method thereof |
| CN107158478A (en) * | 2017-05-19 | 2017-09-15 | 北京鼎瀚恒海生物科技股份有限公司 | A kind of bacteria cellulose Graftskin and preparation method thereof |
| CN112409777A (en) * | 2020-11-09 | 2021-02-26 | 江苏鑫易达新材料科技有限公司 | Medical antibacterial breathable TPU film and preparation method thereof |
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Application publication date: 20160420 |