CN105497963A - Polyurethane dressing for trauma hemostasis and preparation method thereof - Google Patents
Polyurethane dressing for trauma hemostasis and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/237—Notopterygium
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention discloses a polyurethane dressing for trauma hemostasis. The polyurethane dressing is mainly prepared from, by mass, 30-40 parts of polyethylene glycol, 1-3 parts of glycerinum, 20-40 parts of methylene diphenyl diisocyanate, 12-18 parts of polyether, 5-11 parts of trichloromethane, 1-4 parts of catalyst, 6-10 parts of scutellaria baicalensis, 8-10 parts of notopterygium roots, 12-20 parts of circium japonicum, 10-13 parts of Callicarpa macrophylla Vahl, 6-11 parts of acacia catechu, 4-9 parts of fresh radix rehmanniae, 3-6 parts of alumen, 5-8 parts of red vinespinach leaf or herb, 8-11 parts of Raphanus sativus L and 6-10 parts of fructus arctii. The polyurethane dressing has good hydrophily, can absorb bleeding blood and seepage of wounds, and is good in hemostasis effect. Effective ingredients in traditional Chinese medicinal materials are effectively extracted, wound healing can be promoted, infection can be avoided, the polyurethane dressing does not adhere to the wound surfaces, and is easy to replace, and secondary trauma is avoided.
Description
Technical field
The present invention relates to field of medical materials, particularly relate to the dressing of a kind of trauma hemostasis polyurethane and preparation method.
Background technology
In recent decades along with the proposition of wound surface " moistening healing " theory and the development of cattle thing material, new pattern compress particularly new polyurethane dressing constantly occurs.Tradition Wound dressing (as gauze, Cotton Gossypii) etc. has many shortcomings: easily breed bacteria, wound fluid easily forms crust together with dry dermal tissue, hinder epithelization: simultaneously wound surface easily and dressing adhesion, changes dressings when uncovering and cause pain, bring secondary insult.New polyurethane dressing can keep the moistening of wound surface, controls steam permeating rate.And resist the intrusion of antibacterial: its spongy porous laminated structure is conducive to the discharge of wound secretion. promote the healing of wound tissue: use and feel comfortable; There is excellent biocompatibility, without aberration inducing effect, without anaphylaxis; Toxicity test meets medical requirement: have excellent toughness and elasticity. good processability. and the plurality of advantages such as processing mode is various.Therefore be used widely in the field such as Wound dressing and organizational project.
Publication No. CN1462614A(application number 03135277.4) Chinese patent literature disclose a kind of hydrophilic trauma dressing made from polyurethane and preparation method thereof, cut into slices with moisture-inhibiting, ventilative, waterproof by the soft foam of hydrophilic polyurethane, be composited every the polyurethane film of bacterium.Preparation method: at room temperature Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, is then warming up to 80 ~ 90 DEG C of reactions, 90 ~ 120 minutes obtained base polyurethane prepolymer for use as; At room temperature by polyethers, organotin catalysts, tertiary amine catalyst, pore-creating agent, stabilizing agent and water mix homogeneously, then add base polyurethane prepolymer for use as, foam after stirring in room temperature, at least ripening is cut into slices and to be obtained polyurethane foams section for 24 hours; Base polyurethane prepolymer for use as is mixed with concentration be the acetone of 40.0 ~ 55.0% or/and DMF solution, then add water, casting film-forming, then at 40 ~ 80 DEG C except desolventizing, within 16 ~ 24 hours, to obtain polyurethane film in cold curing reaction.Publication No. CN104225665A(application number 201410514636.8) Chinese patent literature disclose a kind of organic polyurethane foam dressing and preparation method thereof, be included in polyurethane foam synthesizing formula and add antipathogenic composition, prepare the polyurethane foam with bacteria resistance function, and by gained polyurethane foam through surface modification of low temperature plasma process, on antibacterial polyurethane foamed material surface, add one plasma rete as rate limiting barrier.Publication No. CN105056279A(application number 201510490782.6) Chinese patent literature disclose a kind of double-deck dressing of polyurethane-base of composite collagen, comprise internal layer and skin, described internal layer is the dressing of collagen composite hydrophilic polyurethane foam, described skin is transparent polyurethane film, and internal layer is bonding by medical pressure-sensitive adhesive with outer.
Medical dressing development rapidly, and presents functionalization and diversified trend development, and polyurethane dressing has the advantage that traditional dressing does not have, and therefore can develop the polyurethane dressing that a kind of fusion has active ingredient of Chinese herbs.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of good biocompatibility, the trauma hemostasis polyurethane dressing of good water absorption and preparation method.
Technical scheme of the present invention is:
Trauma hemostasis polyurethane dressing, is prepared from primarily of following raw materials according, is mass parts: Polyethylene Glycol 30-40, glycerol 1-3, methyl diphenylene diisocyanate 20-40, polyethers 12-18, chloroform 5-11, catalyst 1-4, Radix Scutellariae 6-10, Rhizoma Et Radix Notopterygii 8-10, Radix Cirsii Japonici 12-20, Folium Callicarpae Formosanae 10-13, catechu 6-11, Radix Rehmanniae 4-9, Alumen 3-6, Herba basellae rubrae 5-8, Radix Raphani 8-11, Fructus Arctii 6-10.
In preferred scheme, Polyethylene Glycol 32-38, glycerol 1.5-2.5, methyl diphenylene diisocyanate 25-35, polyethers 13-17, chloroform 6-10, catalyst 2-3, Radix Scutellariae 7-9, Rhizoma Et Radix Notopterygii 8.5-9.5, Radix Cirsii Japonici 14-18, Folium Callicarpae Formosanae 11-12, catechu 7-10, Radix Rehmanniae 5-8, Alumen 4-5, Herba basellae rubrae 6-7, Radix Raphani 9-10, Fructus Arctii 7-9.
Be more preferably, Polyethylene Glycol 35, glycerol 2, methyl diphenylene diisocyanate 30, polyethers 15, chloroform 8, catalyst 2.5, Radix Scutellariae 8, Rhizoma Et Radix Notopterygii 9, Radix Cirsii Japonici 16, Folium Callicarpae Formosanae 11.5, catechu 8.5, Radix Rehmanniae 6.5, Alumen 4.5, Herba basellae rubrae 6.5, Radix Raphani 9.5, Fructus Arctii 8.
The preparation method of described trauma hemostasis polyurethane dressing, step is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol dipping 2-5 hour, then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality), big fire boils 22-30 minute, and (preferred, 24-28 minute is boiled in big fire; Be more preferably, big fire boils 26 minutes), filter, filtering residue adds water and boils, filters, merges twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 1-2 hour (preferred, to be incubated 1.5 hours), obtained performed polymer;
(5) by polyethers, chloroform and catalyst stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds, add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C vacuum drying 20-24 hour (preferred, dry 22 hours), obtains polyurethane dressing.
The preparation method of described trauma hemostasis polyurethane dressing, doubly (preferred, the 5-6 that the amount of dehydrated alcohol is institute's impregnated raw material quality is doubly for the 4-7 that the amount of step (2) dehydrated alcohol is institute's impregnated raw material quality; Be more preferably, 5.5 times that the amount of dehydrated alcohol is institute's impregnated raw material quality).
The preparation method of described trauma hemostasis polyurethane dressing, step (2) dipping 3-4 hour (preferred, to flood 3.5 hours).
The preparation method of described trauma hemostasis polyurethane dressing, the amount of step (3) Mel is the 0.08-0.14 of raw materials quality doubly (preferred, the amount of Mel is 0.11 times of raw materials quality).
The preparation method of described trauma hemostasis polyurethane dressing, step (3) was pulverized 120-200 mesh sieve and (preferably, was pulverized 140-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
The preparation method of described trauma hemostasis polyurethane dressing, step (5) described catalyst can be the one in 4-methyl-diaminopropane, stannous 2-ethylhexoate and ethoxy trimethylene diamine.
The preparation method of described trauma hemostasis polyurethane dressing, step (5) high-speed stirred rotating speed is 3000-4000 rev/min (preferred, rotating speed is 3500 revs/min).
Trauma hemostasis polyurethane dressing technique provided by the invention is simple, and preparation science, Chinese medicine proportioning is rigorous.In addition, excellent results of the present invention also shows:
1, the present invention has good hydrophilic, Absorbable rod wound oozing of blood and sepage, and haemostatic effect is good;
2, the present invention effectively extracts the effective ingredient in Chinese medicine material, can wound healing, prevention infection;
3, the present invention and wound surface adhesion, easily change, prevent secondary insult.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1trauma hemostasis polyurethane dressing, is prepared from (every part of 10g) primarily of following raw materials according: Polyethylene Glycol 30 parts, glycerol 1 part, methyl diphenylene diisocyanate 20 parts, polyethers 12 parts, chloroform 5 parts, 4-methyl-diaminopropane 1 part, Radix Scutellariae 6 parts, Rhizoma Et Radix Notopterygii 8 parts, Radix Cirsii Japonici 12 parts, Folium Callicarpae Formosanae 10 parts, 6 parts, catechu, Radix Rehmanniae 4 parts, Alumen 3 parts, Herba basellae rubrae 5 parts, Radix Raphani 8 parts, Fructus Arctii 6 parts.
The preparation method of above-mentioned trauma hemostasis polyurethane dressing is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol to flood 2 hours (4 times that the amount of dehydrated alcohol is institute's impregnated raw material quality), then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality, the amount of Mel is 0.08 times of raw materials quality), big fire boils 22 minutes, filters, filtering residue adds water and boils, filter, merge twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize 120 mesh sieves and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 1 hour, obtained performed polymer;
(5) by polyethers, chloroform and 4-methyl-diaminopropane stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds (rotating speed is 3000 revs/min), add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C of vacuum dryings 20 hours, obtain polyurethane dressing.
embodiment 2trauma hemostasis polyurethane dressing, is prepared from (every part of 10g) primarily of following raw materials according: Polyethylene Glycol 40 parts, glycerol 3 parts, methyl diphenylene diisocyanate 40 parts, polyethers 18 parts, chloroform 11 parts, stannous 2-ethylhexoate 4 parts, Radix Scutellariae 10 parts, Rhizoma Et Radix Notopterygii 10 parts, Radix Cirsii Japonici 20 parts, Folium Callicarpae Formosanae 13 parts, 11 parts, catechu, Radix Rehmanniae 9 parts, Alumen 6 parts, Herba basellae rubrae 8 parts, Radix Raphani 11 parts, Fructus Arctii 10 parts.
The preparation method of trauma hemostasis polyurethane dressing is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol to flood 5 hours (7 times that the amount of dehydrated alcohol is institute's impregnated raw material quality), then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality, the amount of Mel is 0.14 times of raw materials quality), big fire boils 30 minutes, filters, filtering residue adds water and boils, filter, merge twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize 200 mesh sieves and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 2 hours, obtained performed polymer;
(5) by polyethers, chloroform and stannous 2-ethylhexoate stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds (rotating speed is 4000 revs/min), add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C of vacuum dryings 24 hours, obtain polyurethane dressing.
Typical case: xxx, man, 22 years old.Machine incised wound hand thumb during operation, pain, bleeds, limitation of activity, and after simple dressing, emergency is gone to a doctor, and uses the polyurethane dressing of the present embodiment gained trauma hemostasis, applies pressure wound surface 5 minutes, stoppings of bleeding, after carry out prosthesis, operation is smooth, better.
embodiment 3trauma hemostasis polyurethane dressing, is prepared from (every part of 10g) primarily of following raw materials according: Polyethylene Glycol 32 parts, glycerol 1.5 parts, methyl diphenylene diisocyanate 25 parts, polyethers 13 parts, chloroform 6 parts, ethoxy trimethylene diamine 2 parts, Radix Scutellariae 7 parts, Rhizoma Et Radix Notopterygii 8.5 parts, Radix Cirsii Japonici 14 parts, Folium Callicarpae Formosanae 11 parts, 7 parts, catechu, Radix Rehmanniae 5 parts, Alumen 4 parts, Herba basellae rubrae 6 parts, Radix Raphani 9 parts, Fructus Arctii 7 parts.
The preparation method of trauma hemostasis polyurethane dressing is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol to flood 3 hours (5 times that the amount of dehydrated alcohol is institute's impregnated raw material quality), then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality, the amount of Mel is 0.08 times of raw materials quality), big fire boils 24 minutes, filters, filtering residue adds water and boils, filter, merge twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize 140 mesh sieves and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 1 hour, obtained performed polymer;
(5) by polyethers, chloroform and ethoxy trimethylene diamine stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds (rotating speed is 3000 revs/min), add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C of vacuum dryings 20 hours, obtain polyurethane dressing.
Typical case: xxx, female, 26 years old.Accidentally throw from eminence when climbing the mountain, leg, ancon and the scratch of hand many places with it, bleed more, with being about to, it delivers to the treatment of neighbouring clinic, wound carry out clean after, make the dressing of the present embodiment gained trauma hemostasis polyurethane apply pressure wound surface, use after 2 minutes, wound stops hemorrhage, delivers to hospital do further inspection with binder after fixing dressing.
embodiment 4trauma hemostasis polyurethane dressing, is prepared from (every part of 10g) primarily of following raw materials according: Polyethylene Glycol 38 parts, glycerol 2.5 parts, methyl diphenylene diisocyanate 35 parts, polyethers 17 parts, chloroform 10 parts, stannous 2-ethylhexoate 3 parts, Radix Scutellariae 9 parts, Rhizoma Et Radix Notopterygii 9.5 parts, Radix Cirsii Japonici 18 parts, Folium Callicarpae Formosanae 12 parts, 10 parts, catechu, Radix Rehmanniae 8 parts, Alumen 5 parts, Herba basellae rubrae 7 parts, Radix Raphani 10 parts, Fructus Arctii 9 parts.
The preparation method of trauma hemostasis polyurethane dressing is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol to flood 4 hours (6 times that the amount of dehydrated alcohol is institute's impregnated raw material quality), then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality, the amount of Mel is 0.14 times of raw materials quality), big fire boils 28 minutes, filters, filtering residue adds water and boils, filter, merge twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize 180 mesh sieves and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 2 hours, obtained performed polymer;
(5) by polyethers, chloroform and stannous 2-ethylhexoate stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds (rotating speed is 4000 revs/min), add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C of vacuum dryings 24 hours, obtain polyurethane dressing.
embodiment 5trauma hemostasis polyurethane dressing, is prepared from (every part of 10g) primarily of following raw materials according: Polyethylene Glycol 35 parts, glycerol 2 parts, methyl diphenylene diisocyanate 30 parts, polyethers 15 parts, chloroform 8 parts, 4-methyl-diaminopropane 2.5 parts, Radix Scutellariae 8 parts, Rhizoma Et Radix Notopterygii 9 parts, Radix Cirsii Japonici 16 parts, Folium Callicarpae Formosanae 11.5 parts, 8.5 parts, catechu, Radix Rehmanniae 6.5 parts, Alumen 4.5 parts, Herba basellae rubrae 6.5 parts, Radix Raphani 9.5 parts, Fructus Arctii 8 parts.
The preparation method of trauma hemostasis polyurethane dressing is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol to flood 3.5 hours (5.5 times that the amount of dehydrated alcohol is institute's impregnated raw material quality), then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality, the amount of Mel is 0.11 times of raw materials quality), big fire boils 26 minutes, filters, filtering residue adds water and boils, filter, merge twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize 160 mesh sieves and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 1.5 hours, obtained performed polymer;
(5) by polyethers, chloroform and 4-methyl-diaminopropane stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds (rotating speed is 3500 revs/min), add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C of vacuum dryings 22 hours, obtain polyurethane dressing.
The pharmacology of the present invention's raw material of Chinese medicine used is as follows:
Radix Scutellariae: base is former: be the root of labiate Radix Scutellariae.Nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Rhizoma Et Radix Notopterygii: base is former: be the root and rhizome of samphire Rhizoma Et Radix Notopterygii, Radix et Rhizoma Notopterygii or angelica.Nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Function cures mainly: cold expelling, dispels the wind, dehumidifying, pain relieving.For anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Radix Cirsii Japonici: base is former: be the aerial parts of feverfew Ji.Nature and flavor: cool in nature, sweet in the mouth, hardship.Function cures mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, haematemesis, hematuria, have blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Folium Callicarpae Formosanae: base is former: be the herb of Verbenaceae callicarpa pedunculata.Nature and flavor: bitter, puckery are flat.Function cures mainly: hemostasis, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis, traumatic hemorrhage is controlled in external, burn.
Catechu: base is former: be peeling branch, the dry dry soft extracts of pulse family albizzia plant catechu tree.Nature and flavor: bitter, puckery, are slightly cold.Gui Jing: return lung meridian.Function cures mainly: removing dampness promoting tissue regeneration and ulcer healing.For ulcer being unable to heal, eczema, aphtha, falls and flutters the pain of injury, traumatic hemorrhage.
Radix Rehmanniae: base is former: be the fresh rhizome of scrophulariaceae rehmannia glutinosa plant.Nature and flavor: sweetness and bitterness, cold.Gui Jing: enter the heart, liver, kidney channel.Function cures mainly: heat clearing away, and removing heat from blood promotes the production of body fluid.Control epidemic febrile disease impairment of YIN, large hot excessive thirst, crimson tongue, coma, macule, spit blood, epistaxis, asthenia hectic fever due to YIN-deficiency, hemoptysis, quenches one's thirst, constipation, metrorrhagia.
Alumen: base is former: be mineral alunite, through the crystallization that processing is refined.Nature and flavor: sour, puckery, cold.Gui Jing: return lung, spleen, liver, large intestine channel.Function cures mainly: external removing toxic substances parasite killing, dampness removing to stop itchin, and hemostasis antidiarrheal for oral administration, dispels wind-phlegm.External treatment is used for eczema, and scabies, Ting discharging ear, take orally for incessant chronic diarrhea, have blood in stool, metrorrhagia, epilepsy is gone mad.
Herba basellae rubrae: base is former: be leaf or the herb of Basellaceae plant Herba basellae rubrae.Nature and flavor: sweet, light, cool.Gui Jing: enter the heart, liver, spleen, large and small intestinal warp.Function cures mainly: heat-clearing and toxic substances removing, bone-setting pain stopping.For appendicitis, dysentery, constipation, cystitis, fracture is controlled in external, traumatic injury, traumatic hemorrhage, burn and scald.
Radix Raphani: base is former: be fresh of crucifer Radix Raphani.Nature and flavor: Xin Gan are cool.Gui Jing: enter lung, stomach warp, function cures mainly: removing food stagnancy is stagnant, heat of reducing phlegm, the therapeutic method to keep the adverse QI flowing downwards, alleviating distention in middle-JIAO, removing toxic substances.Control food stagnation distension, phlegmatic cough aphonia, spit blood, epistaxis, quenches one's thirst, dysentery, migraine and general headache.
Fructus Arctii: base is former: be the fruit of feverfew Fructus Arctii.Nature and flavor: pungent, bitter, cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella, laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
test example 1the imbibition of gained trauma hemostasis polyurethane of the present invention dressing (embodiment 5), protect the mensuration of liquid and anthemorrhagic performance:
1, the mensuration of absorbent: under room temperature, is cut into 2 × 2 × 0.5cm by made for the present invention dressing
315 pieces of size, are divided into three groups, often organize 7 pieces, and every block is weighed (mo), immerse respectively in pure water, normal saline and guinea pig blood (being added with 2.5% sodium citrate solution 1ml in every 10ml blood), 2h all takes out after impregnating, blot the water on surface with filter paper, weigh (m
1), calculate pick up, result gets its meansigma methods.Pick up I=(m
1-mo)/mo × 100%.
2, the mensuration of water retainability: made for the present invention dressing scissors are cut into 2 × 2 × 0.5cm
35 pieces of size, weigh (mo), puts into distilled water and flood 2h, takes out and put into centrifuge, under rotating speed 1000 revolutions per seconds centrifugal 3 minutes, takes out and weigh (m2), by following formulae discovery protect liquid measure (
in), result gets the meansigma methods after calculating.
In=（m
2-mo）/mo。
3, the mensuration of anthemorrhagic performance: get healthy new zealand white rabbit 15, whole rabbit ear is lost hair or feathers.Sterilization, aseptic condition, at ear edge end 1/3rd, rabbit ear left and right place, cuts out the wound surface of 1 × 1cm, comprises and cut off arteria auricularis with scalpel, form wound surface respectively with the made dressing of the present invention and hospital gauze pressure wound surface, record bleeding stopping period, result gets its meansigma methods.
Result of the test: test records, and the liquid absorption of the made dressing of the present invention is 3.2g, inhaling pure water rate is 1513%, and inhaling normal saline rate is 1562%, and the rate of sucking blood is 1443%, and protecting liquid rate is 67%.Be 106 seconds to the hemorrhage average bleeding stopping period of rabbit arterial, and the average bleeding stopping period of conventional hospital gauze it is 312 seconds.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. trauma hemostasis polyurethane dressing, is characterized in that, be prepared from primarily of following raw materials according, be mass parts: Polyethylene Glycol 30-40, glycerol 1-3, methyl diphenylene diisocyanate 20-40, polyethers 12-18, chloroform 5-11, catalyst 1-4, Radix Scutellariae 6-10, Rhizoma Et Radix Notopterygii 8-10, Radix Cirsii Japonici 12-20, Folium Callicarpae Formosanae 10-13, catechu 6-11, Radix Rehmanniae 4-9, Alumen 3-6, Herba basellae rubrae 5-8, Radix Raphani 8-11, Fructus Arctii 6-10.
2. trauma hemostasis polyurethane dressing as claimed in claim 1, is characterized in that, Polyethylene Glycol 32-38, glycerol 1.5-2.5, methyl diphenylene diisocyanate 25-35, polyethers 13-17, chloroform 6-10, catalyst 2-3, Radix Scutellariae 7-9, Rhizoma Et Radix Notopterygii 8.5-9.5, Radix Cirsii Japonici 14-18, Folium Callicarpae Formosanae 11-12, catechu 7-10, Radix Rehmanniae 5-8, Alumen 4-5, Herba basellae rubrae 6-7, Radix Raphani 9-10, Fructus Arctii 7-9.
3. trauma hemostasis polyurethane dressing as claimed in claim 1, is characterized in that, Polyethylene Glycol 35, glycerol 2, methyl diphenylene diisocyanate 30, polyethers 15, chloroform 8, catalyst 2.5, Radix Scutellariae 8, Rhizoma Et Radix Notopterygii 9, Radix Cirsii Japonici 16, Folium Callicarpae Formosanae 11.5, catechu 8.5, Radix Rehmanniae 6.5, Alumen 4.5, Herba basellae rubrae 6.5, Radix Raphani 9.5, Fructus Arctii 8.
4. the preparation method of the trauma hemostasis polyurethane dressing as described in as arbitrary in claim 1-3, it is characterized in that, step is:
(1) get Radix Cirsii Japonici and Radix Scutellariae roguing, in the Chinese liquor that input is boiled, heat 10 minutes, take out, hot sand is placed in intense fire in frying pan and fries to flexible state, put into raw material and stir-fry to cokled surface, take out, dry in the air cool;
(2) Rhizoma Et Radix Notopterygii and Herba basellae rubrae roguing is got, put into warm milk to macerate, take out, dry, load together with Radix Rehmanniae in container with Folium Callicarpae Formosanae, add dehydrated alcohol dipping 2-5 hour, then use the microwave extraction 30 seconds of 200 watts, leave standstill and be cooled to room temperature, sucking filtration, extract twice, merge twice filtrate, recycling design is condensed into thick paste;
(3) Alumen is broken into pieces, load in penetrating bag together with catechu, be placed in non iron container with Fructus Arctii, Radix Raphani and step (1) made raw material, add water and Mel heating decoction (7 times that amount of water is boiled raw materials quality), big fire boils 22-30 minute, and (preferred, 24-28 minute is boiled in big fire; Be more preferably, big fire boils 26 minutes), filter, filtering residue adds water and boils, filters, merges twice filtrate, be condensed into thick paste and step (2) made thick paste mixes, dry, pulverize and make smalls;
(4) by Polyethylene Glycol, glycerol and methyl diphenylene diisocyanate stirring and evenly mixing, be heated to 80 DEG C and be incubated 1-2 hour (preferred, to be incubated 1.5 hours), obtained performed polymer;
(5) by polyethers, chloroform and catalyst stirring and evenly mixing, join in step (4) made performed polymer, high-speed stirred 30 seconds, add the made smalls of step (3) again and continue stirring 1 minute, pour into after mix homogeneously in foaming mould and foam under room temperature, ripening, section, 50 DEG C vacuum drying 20-24 hour (preferred, dry 22 hours), obtains polyurethane dressing.
5. the trauma hemostasis preparation method of polyurethane dressing as claimed in claim 4, is characterized in that, doubly (preferred, the 5-6 that the amount of dehydrated alcohol is institute's impregnated raw material quality doubly for the 4-7 that the amount of step (2) dehydrated alcohol is institute's impregnated raw material quality; Be more preferably, 5.5 times that the amount of dehydrated alcohol is institute's impregnated raw material quality).
6. the trauma hemostasis preparation method of polyurethane dressing as claimed in claim 4, is characterized in that, step (2) dipping 3-4 hour (preferred, to flood 3.5 hours).
7. the trauma hemostasis preparation method of polyurethane dressing as claimed in claim 4, is characterized in that, the amount of step (3) Mel is the 0.08-0.14 of raw materials quality doubly (preferred, the amount of Mel is 0.11 times of raw materials quality).
8. the trauma hemostasis preparation method of polyurethane dressing as claimed in claim 4, is characterized in that, step (3) was pulverized 120-200 mesh sieve and (preferably, pulverized 140-180 mesh sieve; Be more preferably, pulverized 160 mesh sieves).
9. the trauma hemostasis preparation method of polyurethane dressing as claimed in claim 4, it is characterized in that, step (5) described catalyst can be the one in 4-methyl-diaminopropane, stannous 2-ethylhexoate and ethoxy trimethylene diamine.
10. as the preparation method of trauma hemostasis polyurethane as claimed in claim 4 dressing, it is characterized in that, step (5) high-speed stirred rotating speed is 3000-4000 rev/min (preferred, rotating speed is 3500 revs/min).
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Address after: 730000 Gansu province Xigu District of Lanzhou City Xinye Road No. 102-182 Applicant after: Wang Shumei Address before: 250000, room 3, building 5, building 501, seven East District, Ming Lake District, Lixia District, Shandong, Ji'nan, China Applicant before: Wang Shumei |
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Application publication date: 20160420 |