CN1462614A - Hydrophilic trauma dressing made from polyurethane and its preparation method - Google Patents
Hydrophilic trauma dressing made from polyurethane and its preparation method Download PDFInfo
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Abstract
A hydrophilic polyurethane dressing for wound is composed of the soft foam chips of hydrophilic polyurethane and the water-proof bacteria-isolating air and moisture permeable polyurethane film. Its preparing process includes such steps as mixing polygolyol, toluene diisocyanate (TDI-80) and propanetriol, stirring, reaction at 80-90 deg.C for 90-120 min to obtain prepolymer of polyurethane, mixing it with polyether, organotin catalyst, alamine catalyst pore-forming agent, stabilizer and water, foaming and ageing to obtain said soft foam chips, preparing the solution of said prepolymer in acetone and/or N,N-dimethyl formamide, adding water, filming, removing solvent, and solidifying reaction to obtain polyurethane film.
Description
One, technical field
The present invention relates to a kind of hydrophilic wound dressing and preparation method thereof.
Two, background technology
Bring the secondary wound when easy adhesion wound such as traditional dressing such as gauze, Cotton Gossypii, breed bacteria, replacing.Some wound dressings of Xiao Shouing on the market, not imbibition, airtight.
International publication number is that the patent application of WO 01/60422 A1 discloses a kind of surgical wound dressings, be composited by suction froth bed and bond matrix, the suction froth bed absorbs after water or saline or the wound exudate volume and does not increase or very little increase is only arranged, and matrix has good breathability.What this patent application was introduced in a large number is performance indications, the detection method of suction froth bed and matrix, only provided the various materials of be suitable for absorbing water froth bed and matrix and produced and sold merchant and trade mark, the trade mark, the material preparation to absorb water froth bed and matrix is not described.
Three, summary of the invention
The present invention is directed to the deficiency that prior art exists, hydrophilic polyurethane wound dressing that a kind of novel treatment surgical wound uses and preparation method thereof is provided, so that make wound dressing not only have good biocompatibility, absorbency, breathability, poisture-penetrability, and stable performance, cost is low.
Technical scheme of the present invention is: adopt homemade softness and internal layer that hydrophilic polyurethane foams section contacts with wound surface as dressing, with the transudate of absorption wound surface and the half hydrogel state adhesion wound surface that is presented; Adopt homemadely have wet, ventilative, waterproof, every the polyurethane film of bacterium performance skin as dressing, be that good environment is created in the healing of wound surface; The compound employing medical pressure-sensing glue bond of internal layer---polyurethane foams section and outer---between the polyurethane film.The internal layer of dressing can also be looked the wound situation and carry out medicine carrying before compound, so that it has treatment functions such as hemostasis, sterilization, antiinflammatory, detumescence.According to test, the thickness of polyurethane foams section is that the thickness of 3～7mm, polyurethane film is that 0.3-1.0mm is the most suitable.
In order further to improve breathability, the compound position of the bonding between internal layer and the skin is the periphery of polyurethane foams section and the corresponding position of polyurethane film.
Before use in order to protect internal layer and self-adhesive; can cover the peeling paper that removes that one deck is not less than monoblock thin film size in the one side that polyurethane film is compounded with polyurethane foams section; peeling paper and polyurethane film bonding, the bonded part is the periphery of polyurethane film and the corresponding position of peeling paper.
The skin of the wound dressing among the present invention can also be selected medical proof fabric or the medical adhesive-bonded fabric that is distributed with air-vent for use.In addition, polyurethane film also can be used as dressing and uses separately, and its structure is: evenly coat medical pressure-sensitive adhesive in the thin film edge, cover the peeling paper that removes that one deck is not less than monoblock thin film size in the gummed one side of thin film again.
According to the structure of polyurethane wound dressing, its preparation method has four kinds: the preparation of polyurethane foams section, the preparation of polyurethane film, polyurethane foams section are compound with polyurethane film; Compound, the polyurethane film of the preparation of polyurethane foams section, the preparation of polyurethane film, polyurethane foams section and polyurethane film and peeling paper compound; Compound, the medical proof fabric of preparation, polyurethane foams section and the medical proof fabric or the medical adhesive-bonded fabric of polyurethane foams section or medical adhesive-bonded fabric and peeling paper compound; The preparation of polyurethane film, polyurethane film and peeling paper compound.In above-mentioned each method, the preparation of polyurethane foams section, the preparation of polyurethane film are crucial, also are main innovation parts of the present invention.Compound, the polyurethane film or the compound of medical adhesive-bonded fabric and peeling paper of polyurethane foams section and polyurethane film or medical adhesive-bonded fabric all adopt the medical pressure-sensing glue bond compound, and the polyurethane foams section is compound with the compound direct bonding of medical proof fabric.Below the preparation of polyurethane foams section and the preparation of polyurethane film are introduced.
1, the preparation of polyurethane foams section
Composition of raw materials:
Polyethylene Glycol (molecular weight 800～2000) 41.0～55.0%
Toluene di-isocyanate(TDI) (TDI-80) 25.0～35.0%
Glycerol 1.5～3.0%
Polyethers 10.0～20.0%
Organotin catalysts 0.5～1.5%
Tertiary amine catalyst 0.5～1.4%
Pore-creating agent 0.1～1.6%
Stabilizing agent 0.5～1.8%
Water 0.8～2.6%
Above-mentioned percent is percetage by weight.
Technological process: be followed successively by synthetic performed polymer, foaming and section, the particular content of each operation is as follows.
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 80～90 ℃ of reactions then and can make base polyurethane prepolymer for use as in 90～120 minutes;
At room temperature with above-mentioned polyethers, organotin catalysts, tertiary amine catalyst, pore-creating agent, stabilizing agent and foaming agent water mix homogeneously, add the base polyurethane prepolymer for use as for preparing then, foaming at room temperature after stirring, ripening was cut into slices and can be made the polyurethane foams section in 24 hours at least.
Polyethers can be selected N3010 or N210 for use; Organotin catalysts can be selected stannous octoate or dibutyltin dilaurate for use; Tertiary amine catalyst can be selected triethylenediamine or two-(dimethylaminoethyl) ether for use; Pore-creating agent can be selected polybutadiene diol or styrene/acrylonitrile graft polyether alcohol for use; Stabilizing agent is silicone based auxiliary agent, generally selects L-580 for use.
2, the preparation of polyurethane film
The performed polymer composition of raw materials:
Polyethylene Glycol (molecular weight 800～4000) 50.0～66.0%
Toluene di-isocyanate(TDI) (TDI-80) 30.0～46.0%
Glycerol 2.0～4.0%
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 80～90 ℃ of reactions then and can make base polyurethane prepolymer for use as in 90～120 minutes;
With above-mentioned synthetic base polyurethane prepolymer for use as and solvent, be mixed with weight percent concentration and be 40.0～55.0% solution, add entry again, casting film-forming, the addition of water be in the solution base polyurethane prepolymer for use as content 0.5～4.0%, remove down at 40～80 ℃ then and desolvate, and can make polyurethane film in 16～24 hours in the cold curing reaction.
Preparation base polyurethane prepolymer for use as solution used solvent can select acetone for use or/and N, dinethylformamide.
The present invention has following beneficial effect:
1, prepared polyurethane foams section has good hydrophilic, performance indications: liquid absorption 7～20g/g, protect liquid measure 0.6～1.5g/g; Ventilative, saturating wet, the waterproof of prepared polyurethane film, every bacterium, vapor transfer rate is 20～60g/m
2.h; Polyurethane foam and thin-film material be through the biological safety evaluation, show non-stimulated, no sensitization, no haemolysis is the biomaterial for medical purpose safe, nontoxic, that biocompatibility is good; Wound dressing is strong through good, the no foreign body reaction of animal experiment proof adhibit quality, adsorptivity, and otch can keep dry, and healing soon and do not have an infection.
2, the compound position of the bonding between dressing internal layer and the skin is the periphery of polyurethane foams section and the corresponding position of polyurethane film or medical adhesive-bonded fabric, the bonded part of peeling paper and polyurethane film or medical adhesive-bonded fabric is the periphery of polyurethane film or medical adhesive-bonded fabric and the corresponding position of peeling paper, has further improved the breathability of wound dressing.
3, preparation method employing provided by the invention is full water foamed, and preparation process can not pollute environment, helps environmental protection.
When 4, the preparation polyurethane foams was cut into slices, foamed process had added organotin catalysts, tertiary amine catalyst, pore-creating agent, stabilizing agent, helped improving the performance of polyurethane foams section.
When 5, preparing polyurethane foams section and polyurethane film, having selected cheap Polyethylene Glycol for use is raw material, can reduce cost.
6, preparation is during polyurethane film, and in the cold curing reaction, but both energy savings can reduce cost again.
Four, description of drawings
Fig. 1 is first kind of structure chart of hydrophilic polyurethane wound dressing provided by the present invention;
Fig. 2 is second kind of structure chart of hydrophilic polyurethane wound dressing provided by the present invention;
Fig. 3 is the third structure chart of hydrophilic polyurethane wound dressing provided by the present invention;
Fig. 4 is the 4th a kind of structure chart of hydrophilic polyurethane wound dressing provided by the present invention.
Among the figure, 1-skin, 2-internal layer, 3-peeling paper.
Five, the specific embodiment
Embodiment 1:
The structure of the polyurethane wound dressing in the present embodiment is composited by pressure sensitive adhesive by outer 1, internal layer 2 as shown in Figure 1, and internal layer is the polyurethane foams section, and skin is a polyurethane film.Preparation method is as follows:
1, the preparation of polyurethane foams section
Composition of raw materials:
Polyethylene Glycol (molecular weight 1000) 47.25%
Toluene di-isocyanate(TDI) (TDI-80) 29.04%
Glycerol 1.97%
Polyethers N210 17.39%
Stannous octoate 0.87%
Triethylenediamine 1.16%
Styrene/acrylonitrile graft polyether alcohol 0.29%
L-580 organosilicon 0.87%
Deionized water 1.16%
Above-mentioned percent is percetage by weight.
Technological process: at room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 80 ℃ of reactions then and can make base polyurethane prepolymer for use as in 120 minutes; At room temperature with above-mentioned polyethers N210, organotin catalysts stannous octoate, tertiary amine catalyst triethylenediamine, pore-creating agent styrene/acrylonitrile graft polyether alcohol, stabilizing agent L-580 organosilicon and foaming agent deionized water mix homogeneously, add the base polyurethane prepolymer for use as for preparing then, foaming at room temperature after stirring, ripening were cut into slices and can be made the polyurethane foams section in 24 hours.
2, the preparation of polyurethane film
The performed polymer composition of raw materials:
Polyethylene Glycol (molecular weight 1000) 60.4%
Toluene di-isocyanate(TDI) (TDI-80) 37.1%
Glycerol 2.5%
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 80 ℃ of reactions then and can make base polyurethane prepolymer for use as in 120 minutes.
Above-mentioned synthetic base polyurethane prepolymer for use as is added acetone, and to be mixed with weight percent concentration be 50% solution, add deionized water again, casting film-forming, the addition of water be in the solution base polyurethane prepolymer for use as content 1.8%, remove down at 50 ℃ then and desolvate, and can make the polyurethane film that thickness is 0.4mm in 16 hours in the cold curing reaction.
3, polyurethane foams section and polyurethane film is compound
The polyurethane foams section is compound with the compound employing medical pressure-sensing glue bond of polyurethane film, and compound position is the periphery of polyurethane foams section and the corresponding position of polyurethane film.
Embodiment 2:
The structure of the polyurethane wound dressing in the present embodiment is composited by pressure sensitive adhesive by outer 1, internal layer 2, peeling paper 3 as shown in Figure 2, and internal layer is the polyurethane foams section, and skin is a polyurethane film.Preparation method is as follows:
1, the preparation of polyurethane foams section
Composition of raw materials:
Polyethylene Glycol (molecular weight 2000) 49.85%
Toluene di-isocyanate(TDI) (TDI-80) 27.81%
Glycerol 2.71%
Polyethers N3010 14.57%
Stannous octoate 1.19%
Triethylenediamine 1.19%
Polybutadiene diol 0.30%
L-580 organosilicon 0.89%
Deionized water 1.49%
Above-mentioned percent is percetage by weight.
Technological process: at room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 85 ℃ of reactions then and can make base polyurethane prepolymer for use as in 100 minutes; At room temperature with above-mentioned polyethers N3010, organotin catalysts stannous octoate, tertiary amine catalyst triethylenediamine, pore-creating agent polybutadiene diol, stabilizing agent L-580 organosilicon and foaming agent deionized water mix homogeneously, add the base polyurethane prepolymer for use as for preparing then, foaming at room temperature after stirring, ripening were cut into slices and can be made the polyurethane foams section in 24 hours.
2, the preparation of polyurethane film
The performed polymer composition of raw materials:
Polyethylene Glycol (molecular weight 2000) 62.0%
Toluene di-isocyanate(TDI) (TDI-80) 34.6%
Glycerol 3.4%
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 85 ℃ of reactions then and can make base polyurethane prepolymer for use as in 100 minutes.
Above-mentioned synthetic base polyurethane prepolymer for use as is added acetone and N, dinethylformamide mixed solution (acetone: N, dinethylformamide=1: 1) being mixed with weight percent concentration is 50% solution, add deionized water again, casting film-forming, the addition of water be in the solution base polyurethane prepolymer for use as content 2.0%, remove down at 55 ℃ then and desolvate, and can make the polyurethane film that thickness is 0.5mm in 20 hours in the cold curing reaction.
3, polyurethane foams section and polyurethane film is compound
The polyurethane foams section is compound with the compound employing medical pressure-sensing glue bond of polyurethane film, and compound position is the periphery of polyurethane foams section and the corresponding position of polyurethane film.
4, the polyurethane foams section covers peeling paper with the complex of polyurethane film
The medical pressure-sensing glue bond of peeling paper and polyurethane film, bonded part are the periphery of polyurethane film and the corresponding position of peeling paper.
Embodiment 3:
The structure of the polyurethane wound dressing in the present embodiment is composited by skin 1, internal layer 2, peeling paper 3 bondings as shown in Figure 3.Internal layer is the polyurethane foams section, and is outer for being distributed with the medical proof fabric or the medical adhesive-bonded fabric of air-vent.Preparation method is as follows:
1, the preparation of polyurethane foams section
Composition of raw materials:
Polyethylene Glycol (molecular weight 1500) 45.44%
Toluene di-isocyanate(TDI) (TDI-80) 34.53%
Glycerol 2.10%
Polyethers N210 12.16%
Stannous octoate 0.61%
Triethylenediamine 0.91%
Polybutadiene diol 0.91%
L-580 organosilicon 1.52%
Deionized water 1.82%
Above-mentioned percent is percetage by weight.
Technological process: at room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 90 ℃ of reactions then and can make base polyurethane prepolymer for use as in 90 minutes; At room temperature with above-mentioned polyethers N210, organotin catalysts stannous octoate, tertiary amine catalyst triethylenediamine, pore-creating agent polybutadiene diol, stabilizing agent L-580 organosilicon and foaming agent deionized water mix homogeneously, add the base polyurethane prepolymer for use as for preparing then, foaming at room temperature after stirring, ripening were cut into slices and can be made the polyurethane foams section in 24 hours.
2, polyurethane foams section and the medical proof fabric that is distributed with air-vent directly compound the or polyurethane foams section of bonding adopt the medical pressure-sensing glue bond compound with the medical adhesive-bonded fabric that is distributed with air-vent.
3, the polyurethane foams section covers peeling paper with the complex of medical proof fabric that is distributed with air-vent or medical adhesive-bonded fabric
Direct bonding of peeling paper and medical proof fabric or peeling paper and medical adhesive-bonded fabric medical pressure-sensing glue bond, bonded part are the periphery of medical adhesive-bonded fabric and the corresponding position of peeling paper.
Embodiment 4:
The structure of the polyurethane wound dressing in the present embodiment is composited by skin 1, internal layer 2, as shown in Figure 4.Internal layer is a polyurethane film, and skin is a peeling paper.Preparation method is as follows:
1, thin polyurethane film preparation
The performed polymer composition of raw materials:
Polyethylene Glycol (molecular weight 3000) 65.0%
Toluene di-isocyanate(TDI) (TDI-80) 32.0%
Glycerol 3.0%
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, be warming up to 85 ℃ of reactions then and can make base polyurethane prepolymer for use as in 105 minutes.
Above-mentioned synthetic base polyurethane prepolymer for use as is added acetone and N, dinethylformamide mixed solution (acetone: N, dinethylformamide=1: 1) being mixed with weight percent concentration is 50% solution, add deionized water again, casting film-forming, the addition of water be in the solution base polyurethane prepolymer for use as content 2.0%, remove down at 55 ℃ then and desolvate, and can make the polyurethane film that thickness is 0.8mm in 24 hours in the cold curing reaction.
2, polyurethane film and peeling paper is compound
Peeling paper and polyurethane film are compound with the medical pressure-sensing glue bond, and the bonded part is the periphery of polyurethane film and the corresponding position of peeling paper.
Claims (9)
1, a kind of hydrophilic polyurethane wound dressing, comprise the internal layer (2) that contacts with wound surface and cover skin (1) on the internal layer, compound between internal layer and the skin by bonding, it is characterized in that internal layer (2) is the section of the soft foam of hydrophilic polyurethane, outer (1) is for ventilative, saturating wet, waterproof, every the polyurethane film of bacterium.
2, hydrophilic polyurethane wound dressing according to claim 1 is characterized in that the thickness of polyurethane foams section is 3～7mm, and the thickness of polyurethane film is 0.3-1.0mm.
3, hydrophilic polyurethane wound dressing according to claim 1 and 2 is characterized in that the compound position of bonding between internal layer (2) and outer (1) is the periphery of polyurethane foams section and the corresponding position of polyurethane film.
4, hydrophilic polyurethane wound dressing according to claim 3, it is characterized in that the one side that is compounded with the polyurethane foams section at polyurethane film is coated with the peeling paper that removes (3) that one deck is not less than monoblock thin film size, peeling paper and polyurethane film bonding, the bonded part is the periphery of polyurethane film and the corresponding position of peeling paper.
5, a kind of hydrophilic polyurethane wound dressing, comprise the internal layer (2) that contacts with wound surface and cover skin (1) on the internal layer, compound between internal layer and the skin by bonding, it is characterized in that internal layer (2) is the soft foam section of hydrophilic polyurethane, outer for being distributed with the medical proof fabric or the medical adhesive-bonded fabric of air-vent, the one side that is compounded with the polyurethane foams section at medical proof fabric or medical adhesive-bonded fabric is coated with the peeling paper that removes (3) that one deck is not less than monoblock medical proof fabric or medical adhesive-bonded fabric size.
6, a kind of hydrophilic polyurethane wound dressing, comprise the internal layer (2) that contacts with wound surface and cover skin (1) on the internal layer, compound between internal layer and the skin by bonding, it is characterized in that internal layer (2) is for ventilative, saturating wet, waterproof, every the polyurethane film of bacterium, outer (1) is peeling paper, and the bonded part is the periphery of polyurethane film and the corresponding position of peeling paper.
7, a kind of claim 1,2,3,4,5, the preparation method of 6 described hydrophilic polyurethane wound dressings, comprise the preparation of polyurethane foams section, the preparation of polyurethane film, the polyurethane foams section is compound with polyurethane film, or the preparation of polyurethane foams section, the preparation of polyurethane film, polyurethane foams section and polyurethane film or medical proof fabric or medical adhesive-bonded fabric compound, polyurethane film or medical proof fabric or medical adhesive-bonded fabric and peeling paper compound, or the preparation of polyurethane film, polyurethane film and peeling paper compound
(1) preparation of polyurethane foams section
Composition of raw materials:
Polyethylene Glycol (molecular weight 800～2000) 41.0～55.0%
Toluene di-isocyanate(TDI) (TDI-80) 25.0～35.0%
Glycerol 1.5～3.0%
Polyethers 10.0～20.0%
Organotin catalysts 0.5～1.5%
Tertiary amine catalyst 0.5～1.4%
Pore-creating agent 0.1～1.6%
Stabilizing agent 0.5～1.8%
Water 0.8～2.6%
Above-mentioned percent is percetage by weight,
Technological process: be followed successively by synthetic performed polymer, foaming and section,
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, are warming up to 80～90 ℃ of reactions then and can make base polyurethane prepolymer for use as in 90～120 minutes,
At room temperature with above-mentioned polyethers, organotin catalysts, tertiary amine catalyst, pore-creating agent, stabilizing agent and water mix homogeneously, add the base polyurethane prepolymer for use as for preparing then, foaming at room temperature after stirring, ripening was cut into slices and can be made the polyurethane foams section in 24 hours at least
(2) preparation of polyurethane film
The performed polymer composition of raw materials:
Polyethylene Glycol (molecular weight 800～4000) 50.0～66.0%
Toluene di-isocyanate(TDI) (TDI-80) 30.0～46.0%
Glycerol 2.0～4.0%
At room temperature above-mentioned Polyethylene Glycol, toluene di-isocyanate(TDI) (TDI-80) and glycerol are stirred, are warming up to 80-90 ℃ of reaction then and can make base polyurethane prepolymer for use as in 90～120 minutes,
With above-mentioned synthetic base polyurethane prepolymer for use as and solvent, be mixed with weight percent concentration and be 40.0～55.0% solution, add entry again, casting film-forming, the addition of water be in the solution base polyurethane prepolymer for use as content 0.5～4.0%, remove down at 40～80 ℃ then and desolvate, and can make polyurethane film in 16～24 hours in the cold curing reaction
(3) polyurethane foams section and polyurethane film or medical proof fabric or medical adhesive-bonded fabric is compound
The compound employing medical pressure-sensing glue bond of polyurethane foams section and polyurethane film or medical adhesive-bonded fabric is compound, and polyurethane foams section and medical proof fabric directly bond compound,
(4) polyurethane film or medical proof fabric or medical adhesive-bonded fabric and peeling paper is compound
The compound employing medical pressure-sensing glue bond of polyurethane film or medical adhesive-bonded fabric and peeling paper is compound, and medical proof fabric and peeling paper directly bond compound.
8, the preparation method of hydrophilic polyurethane wound dressing according to claim 7, it is characterized in that organotin catalysts is stannous octoate or dibutyltin dilaurate, tertiary amine catalyst is triethylenediamine or two-(dimethylaminoethyl) ether, pore-creating agent is polybutadiene diol or styrene/acrylonitrile graft polyether alcohol, and stabilizing agent is silicone based auxiliary agent.
9,, it is characterized in that preparing the used solvent of base polyurethane prepolymer for use as solution and be acetone or/and N, dinethylformamide according to the preparation method of claim 7 or 8 described polyurethane wound dressings.
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| CN 03135277 CN1202785C (en) | 2003-06-24 | 2003-06-24 | Hydrophilic trauma dressing made from polyurethane and its preparation method |
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| CN 03135277 CN1202785C (en) | 2003-06-24 | 2003-06-24 | Hydrophilic trauma dressing made from polyurethane and its preparation method |
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