CN115779129A - High-adsorbability porous structure polyurethane dressing - Google Patents
High-adsorbability porous structure polyurethane dressing Download PDFInfo
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- CN115779129A CN115779129A CN202211446153.XA CN202211446153A CN115779129A CN 115779129 A CN115779129 A CN 115779129A CN 202211446153 A CN202211446153 A CN 202211446153A CN 115779129 A CN115779129 A CN 115779129A
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- 229920002635 polyurethane Polymers 0.000 title claims abstract description 40
- 239000004814 polyurethane Substances 0.000 title claims abstract description 40
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 68
- 239000004721 Polyphenylene oxide Substances 0.000 claims abstract description 38
- 239000003054 catalyst Substances 0.000 claims abstract description 38
- 229920000570 polyether Polymers 0.000 claims abstract description 38
- 229920005862 polyol Polymers 0.000 claims abstract description 29
- 150000003077 polyols Chemical class 0.000 claims abstract description 29
- 239000003381 stabilizer Substances 0.000 claims abstract description 23
- 239000004970 Chain extender Substances 0.000 claims abstract description 22
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 14
- 239000000376 reactant Substances 0.000 claims description 49
- 238000003756 stirring Methods 0.000 claims description 24
- 239000008213 purified water Substances 0.000 claims description 16
- 239000012970 tertiary amine catalyst Substances 0.000 claims description 16
- 239000012974 tin catalyst Substances 0.000 claims description 11
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 10
- -1 polyoxypropylene Polymers 0.000 claims description 10
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 238000013329 compounding Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000005187 foaming Methods 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000004745 nonwoven fabric Substances 0.000 claims description 6
- 239000011505 plaster Substances 0.000 claims description 6
- PTBDIHRZYDMNKB-UHFFFAOYSA-N 2,2-Bis(hydroxymethyl)propionic acid Chemical compound OCC(C)(CO)C(O)=O PTBDIHRZYDMNKB-UHFFFAOYSA-N 0.000 claims description 5
- JVYDLYGCSIHCMR-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)butanoic acid Chemical compound CCC(CO)(CO)C(O)=O JVYDLYGCSIHCMR-UHFFFAOYSA-N 0.000 claims description 5
- GTEXIOINCJRBIO-UHFFFAOYSA-N 2-[2-(dimethylamino)ethoxy]-n,n-dimethylethanamine Chemical compound CN(C)CCOCCN(C)C GTEXIOINCJRBIO-UHFFFAOYSA-N 0.000 claims description 5
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000005062 Polybutadiene Substances 0.000 claims description 5
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 claims description 5
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 claims description 5
- 239000012975 dibutyltin dilaurate Substances 0.000 claims description 5
- 150000002009 diols Chemical class 0.000 claims description 5
- 229920002857 polybutadiene Polymers 0.000 claims description 5
- 229920001451 polypropylene glycol Polymers 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 5
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 claims description 5
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 5
- 239000008158 vegetable oil Substances 0.000 claims description 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- 210000001124 body fluid Anatomy 0.000 abstract description 17
- 239000010839 body fluid Substances 0.000 abstract description 17
- 235000011187 glycerol Nutrition 0.000 description 17
- 206010052428 Wound Diseases 0.000 description 12
- 208000027418 Wounds and injury Diseases 0.000 description 12
- 239000000463 material Substances 0.000 description 9
- 208000004210 Pressure Ulcer Diseases 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
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- Polyurethanes Or Polyureas (AREA)
Abstract
The invention belongs to the field of medical dressings, and particularly relates to a high-adsorbability polyurethane dressing with a porous structure, which comprises polyether polyol, toluene diisocyanate, glycerol, a catalyst, a pore-opening agent, a stabilizer, pure water and a chain extender, wherein the polyether polyol accounts for 55-65% of the whole by weight, the toluene diisocyanate accounts for 25-35% of the whole by weight, the glycerol accounts for 2-3.5% of the whole by weight, the catalyst accounts for 1-3% of the whole by weight, the pore-opening agent accounts for 0.5-1.5% of the whole by weight, and the stabilizer accounts for 0.5-2% of the whole by weight; by the improved polyurethane dressing formula, the body fluid exuded from the wound can be effectively adsorbed, and the function of polluting the bedding by the exudation of the body fluid is avoided.
Description
Technical Field
The invention relates to the field of medical dressings, in particular to a polyurethane dressing with a high-adsorbability porous structure.
Background
The dressing refers to auxiliary materials except for main materials of articles for treatment in the medical field, generally refers to gauze and the like for winding wounds, plays a role in protecting and covering the wounds, and is gradually improved from traditional absorbent gauze to the existing interactive wound dressing, calcium alginate dressing, silver dressing, foam dressing, hydrocolloid dressing, polyurethane dressing and hydrogel dressing along with the development of the technology.
In the prior art, polyurethane is used as a main material of the polyurethane dressing, so that the dressing has excellent anticoagulation capability, has excellent toughness and elasticity, can effectively protect a wound, and avoids the situation that the dressing at the wound is cracked due to the movement of a patient.
The existing polyurethane dressing has certain hydrophobicity due to the characteristics of the material, cannot adsorb body fluid or blood at a wound, is easy to cause body fluid exudation, and has poor biocompatibility; therefore, a polyurethane dressing with a high adsorbability and a porous structure is provided for solving the problems.
Disclosure of Invention
In order to make up for the defects of the prior art, the invention provides a high-adsorbability porous structure polyurethane dressing which has the problems that the existing polyurethane dressing cannot adsorb body fluid or blood at a wound due to certain hydrophobicity of the characteristics of the material of the existing polyurethane dressing, the body fluid is easy to seep out, and the biocompatibility is poor.
The technical scheme adopted by the invention for solving the technical problems is as follows: the polyurethane dressing with the high-adsorbability porous structure comprises polyether polyol, toluene diisocyanate, glycerol, a catalyst, a pore-opening agent, a stabilizer, purified water and a chain extender.
Preferably, the polyether polyol is 55 to 65% by weight in the bulk, the toluene diisocyanate is 25 to 35% by weight in the bulk, the glycerol is 2 to 3.5% by weight in the bulk, the catalyst is 1 to 3% by weight in the bulk, the cell opener is 0.5 to 1.5% by weight in the bulk, the stabilizer is 0.5 to 2% by weight in the bulk, the purified water is 1 to 3% by weight in the bulk, and the chain extender is 0.5 to 1% by weight in the bulk.
Preferably, the catalyst comprises an organotin catalyst and a tertiary amine catalyst, the polyether polyol being a combination of one or more of a vegetable oil polyether polyol, a polyoxypropylene triol and a glycerol polyether polyol.
Preferably, the chain extender is an aqueous solution of one or more of 1, 2-propylene glycol-3-sodium sulfonate, dimethylolbutyric acid and dimethylolpropionic acid.
Preferably, the organotin catalyst accounts for 40 to 60 percent by weight of the total catalyst, and the tertiary amine catalyst accounts for 45 to 55 percent by weight of the total catalyst.
Preferably, the organic tin catalyst is one or the combination of two of stannous octoate and dibutyltin dilaurate, and the tertiary amine catalyst is one or the combination of two of triethylene diamine and bis- (dimethylaminoethyl) ether.
Preferably, the stabilizer is a silicone assistant, and the cell opener is one or a combination of two of polybutadiene diol or styrene or acrylonitrile grafted polyether alcohol.
Preferably, the preparation method of the dressing comprises the following steps:
s1: adding polyether glycol, toluene diisocyanate and glycerol into a mixer at the temperature of 20-28 ℃, stirring uniformly for 30-40min at the stirring speed of 70-100r/min, heating the mixture to 85-95 ℃, and reacting for 100-125min to obtain a reactant A;
s2: adding a catalyst, a pore-forming agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 45-60min at the stirring speed of 100-120r/min to obtain a reactant B;
s3: naturally cooling the reactant B to 20-28 ℃, foaming the reactant at room temperature, and curing for 24-36h to obtain a reactant C;
s4: and slicing the reactant C and compounding the sliced reactant C with medical adhesive plaster and non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing.
The invention has the advantages that:
1. according to the improved polyurethane dressing formula, the body fluid exuded from the wound can be effectively adsorbed, the function that the bed mattress is polluted by the exudation of the body fluid is avoided, the dressing has strong vertical capillary absorption capacity, the adsorption rate of the body fluid is high, the dressing has a good treatment effect on bedsores, the dressing can be effectively applied to skin ulceration, the bedsore treatment effect is obvious, the dressing has good biocompatibility, and the problems that the body fluid exudation is easily caused and the biocompatibility is poor due to the fact that the existing polyurethane dressing has certain hydrophobicity due to the characteristics of the material of the dressing and cannot adsorb the body fluid or blood at the wound are solved;
2. according to the preparation method, the high-adsorbability porous structure polyurethane dressing is prepared, the quality of the prepared high-adsorbability porous structure polyurethane dressing is effectively improved, and the problem that the existing processing method is unstable in quality and low in yield when the high-adsorbability porous structure polyurethane dressing is processed is solved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic flow chart of the method of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example one
Referring to fig. 1, a high-adsorptivity porous polyurethane dressing includes polyether polyol, toluene diisocyanate, glycerol, a catalyst, a pore-opening agent, a stabilizer, purified water and a chain extender;
further, the proportion of the polyether polyol in the whole is 59.5% by weight, the proportion of the toluene diisocyanate in the whole is 35% by weight, the proportion of the glycerol in the whole is 2% by weight, the proportion of the catalyst in the whole is 1% by weight, the proportion of the cell opener in the whole is 0.5% by weight, the proportion of the stabilizer in the whole is 0.5% by weight, the proportion of the purified water in the whole is 1% by weight, and the proportion of the chain extender in the whole is 0.5% by weight;
when the dressing works, the high-adsorbability porous structure polyurethane dressing can form a porous structure in the processing process by adding the pore-forming agent, so that body fluid flowing out of a wound can be adsorbed; through the polyurethane dressing formula after the improvement, realized can effectually adsorbing the body fluid that the wound oozes, the function of pollution bed clothes has been avoided the body fluid to ooze, stronger perpendicular capillary absorptive capacity has, it is fast to the adsorption rate of body fluid, there is good treatment to the bedsore, can effectively be applied to skin ulceration, it is obvious to treat bedsore effect, good biocompatibility has, solved current polyurethane dressing and had certain hydrophobicity because of the characteristic of its self material, can't adsorb body fluid or blood of wound, lead to body fluid to ooze easily, the relatively poor problem of biocompatibility.
Further, the catalyst comprises an organic tin catalyst and a tertiary amine catalyst, and the polyether polyol is one or more of vegetable oil polyether polyol, polyoxypropylene triol and glycerol polyether polyol.
Further, the chain extender is one or more of 1, 2-propylene glycol-3-sodium sulfonate, dimethylol butyric acid and dimethylol propionic acid.
Further, the organotin catalyst accounts for 45% by weight of the whole catalyst, and the tertiary amine catalyst accounts for 55% by weight of the whole catalyst;
further, the organic tin catalyst is one or the combination of two of stannous octoate and dibutyltin dilaurate, and the tertiary amine catalyst is one or the combination of two of triethylene diamine and bis- (dimethylaminoethyl) ether;
when the composite material works, the organic tin catalyst and the tertiary amine catalyst are compounded to react quickly, molecular chains grow quickly, a high-molecular-weight polymer material is formed to promote the reaction speed of-NCO and H2O, the high-molecular-weight polymer material reacts quickly to generate a large amount of carbon dioxide gas, the gelation speed of the material is accelerated, and the material can quickly form a porous structure.
Further, the stabilizer is a silicone assistant, and the cell opener is one or a combination of polybutadiene diol or styrene or acrylonitrile grafted polyether alcohol.
Further, the preparation method of the dressing comprises the following steps:
s1: adding polyether glycol, toluene diisocyanate and glycerol into a mixer at the temperature of 20 ℃, stirring uniformly for 30min at the stirring speed of 70r/min, heating the mixture to 85 ℃, and reacting for 100min to obtain a reactant A;
s2: adding a catalyst, a pore-opening agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 45min at the stirring speed of 100r/min to obtain a reactant B;
s3: naturally cooling the reactant B to 20 ℃, foaming the reactant at room temperature, and curing for 24 hours to obtain a reactant C;
s4: slicing the reactant C and compounding the reactant C with the medical adhesive plaster and the non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing;
during operation, the preparation method is used for preparing the polyurethane dressing with the high-adsorbability porous structure, so that the quality of the prepared polyurethane dressing with the high-adsorbability porous structure is effectively improved, and the problem of low yield due to instable quality when the existing processing method is used for processing the polyurethane dressing with the high-adsorbability porous structure is solved.
Example two
Comparative example one, as another embodiment of the present invention, further, includes polyether polyol, toluene diisocyanate, glycerol, catalyst, pore-forming agent, stabilizer, purified water, and chain extender;
further, the proportion of the polyether polyol in the whole is 60% by weight, the proportion of the toluene diisocyanate in the whole is 32% by weight, the proportion of the glycerol in the whole is 3% by weight, the proportion of the catalyst in the whole is 2% by weight, the proportion of the cell opener in the whole is 1% by weight, the proportion of the stabilizer in the whole is 0.5% by weight, the proportion of the purified water in the whole is 1% by weight, and the proportion of the chain extender in the whole is 0.5% by weight.
Further, the catalyst comprises an organic tin catalyst and a tertiary amine catalyst, and the polyether polyol is one or more of vegetable oil polyether polyol, polyoxypropylene triol and glycerol polyether polyol.
Further, the chain extender is one or more of 1, 2-propylene glycol-3-sodium sulfonate, dimethylol butyric acid and dimethylol propionic acid.
Further, the organotin catalyst accounts for 40-60% of the total catalyst by weight, and the tertiary amine catalyst accounts for 45-55% of the total catalyst by weight;
further, the organic tin catalyst is one or the combination of stannous octoate and dibutyltin dilaurate, and the tertiary amine catalyst is one or the combination of triethylene diamine and bis- (dimethylaminoethyl) ether.
Further, the stabilizer is a silicone assistant, and the cell opener is one or a combination of polybutadiene diol or styrene or acrylonitrile grafted polyether alcohol.
Further, the preparation method of the dressing comprises the following steps:
s1: adding polyether polyol, toluene diisocyanate and glycerol into a mixer at the temperature of 23 ℃, uniformly stirring and mixing for 35min at the stirring speed of 84r/min, heating the mixture to 90 ℃, and reacting for 110min to obtain a reactant A;
s2: adding a catalyst, a pore-forming agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 50min at the stirring speed of 115r/min to obtain a reactant B;
s3: naturally cooling the reactant B to 25 ℃, foaming the reactant at room temperature, and curing the reactant for 28 hours to obtain a reactant C;
s4: and slicing the reactant C and compounding the reactant C with the medical adhesive plaster and the non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing.
EXAMPLE III
Comparative example one and example two, as another embodiment of the present invention, further, include polyether polyol, toluene diisocyanate, glycerol, catalyst, cell opener, stabilizer, purified water and chain extender;
further, the proportion of the polyether polyol in the whole was 59% by weight, the proportion of the toluene diisocyanate in the whole was 27% by weight, the proportion of the glycerin in the whole was 3.5% by weight, the proportion of the catalyst in the whole was 3% by weight, the proportion of the cell opener in the whole was 1.5% by weight, the proportion of the stabilizer in the whole was 2% by weight, the proportion of the purified water in the whole was 3% by weight, and the proportion of the chain extender in the whole was 1% by weight.
Further, the catalyst comprises an organic tin catalyst and a tertiary amine catalyst, and the polyether polyol is one or more of vegetable oil polyether polyol, polyoxypropylene triol and glycerol polyether polyol.
Further, the chain extender is an aqueous solution of one or more of 1, 2-propylene glycol-3-sodium sulfonate, dimethylolbutyric acid and dimethylolpropionic acid.
Further, the organotin catalyst accounts for 40-60% of the total catalyst by weight, and the tertiary amine catalyst accounts for 45-55% of the total catalyst by weight;
further, the organic tin catalyst is one or the combination of two of stannous octoate and dibutyltin dilaurate, and the tertiary amine catalyst is one or the combination of two of triethylene diamine and bis- (dimethylaminoethyl) ether.
Further, the stabilizer is an organic silicon assistant, and the cell opening agent is one or a combination of two of polybutadiene diol or styrene or acrylonitrile grafted polyether alcohol.
Further, the preparation method of the dressing comprises the following steps:
s1: adding polyether polyol, toluene diisocyanate and glycerol into a mixer at the temperature of 28 ℃, uniformly stirring and mixing for 40min at the stirring speed of 100r/min, heating the mixture to 95 ℃, and reacting for 125min to obtain a reactant A;
s2: adding a catalyst, a pore-forming agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 60min at the stirring speed of 120r/min to obtain a reactant B;
s3: naturally cooling the reactant B to 28 ℃, foaming the reactant at room temperature, and curing the reactant for 36 hours to obtain a reactant C;
s4: and slicing the reactant C and compounding the reactant C with the medical adhesive plaster and the non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing.
The working principle is as follows: the first step is as follows: adding polyether glycol, toluene diisocyanate and glycerol into a mixer at the temperature of 20-28 ℃, stirring uniformly for 30-40min at the stirring speed of 70-100r/min, heating the mixture to 85-95 ℃, and reacting for 100-125min to obtain a reactant A; the second step: adding a catalyst, a pore-opening agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 45-60min at the stirring speed of 100-120r/min to obtain a reactant B; the third step: naturally cooling the reactant B to 20-28 ℃, foaming the reactant at room temperature, and curing for 24-36h to obtain a reactant C; the fourth step: and slicing the reactant C and compounding the sliced reactant C with medical adhesive plaster and non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (8)
1. A high-adsorbability porous polyurethane dressing is characterized in that: comprises polyether polyol, toluene diisocyanate, glycerol, a catalyst, a cell opener, a stabilizer, purified water and a chain extender.
2. The high sorption porous structure polyurethane dressing of claim 1, wherein: the proportion of the polyether polyol in the whole is 55-65% by weight, the proportion of the toluene diisocyanate in the whole is 25-35% by weight, the proportion of the glycerol in the whole is 2-3.5% by weight, the proportion of the catalyst in the whole is 1-3% by weight, the proportion of the cell opener in the whole is 0.5-1.5% by weight, the proportion of the stabilizer in the whole is 0.5-2% by weight, the proportion of the purified water in the whole is 1-3% by weight, and the proportion of the chain extender in the whole is 0.5-1% by weight.
3. The high sorption porous structure polyurethane dressing of claim 2, wherein: the catalyst comprises an organic tin catalyst and a tertiary amine catalyst, and the polyether polyol is one or a combination of more of vegetable oil polyether polyol, polyoxypropylene triol and glycerol polyether polyol.
4. The high sorption porous structure polyurethane dressing of claim 3, wherein: the chain extender is one or more of 1, 2-propylene glycol-3-sodium sulfonate, dimethylolbutyric acid and dimethylolpropionic acid.
5. The high sorption porous structure polyurethane dressing of claim 4, wherein: the percentage of the organic tin catalyst in the whole catalyst is 40-60% by weight, and the percentage of the tertiary amine catalyst in the whole catalyst is 45-55% by weight.
6. The high sorption porous structure polyurethane dressing of claim 5, wherein: the organic tin catalyst is one or the combination of stannous octoate and dibutyltin dilaurate, and the tertiary amine catalyst is one or the combination of triethylene diamine and bis- (dimethylaminoethyl) ether.
7. The high-adsorptivity porous structure polyurethane dressing as claimed in claim 6, wherein: the stabilizer is an organic silicon assistant, and the cell opening agent is one or a combination of two of polybutadiene diol or styrene or acrylonitrile grafted polyether alcohol.
8. The high-adsorptivity porous structure polyurethane dressing as claimed in claim 7, wherein: the preparation method of the dressing comprises the following steps:
s1: adding polyether glycol, toluene diisocyanate and glycerol into a mixer at the temperature of 20-28 ℃, uniformly stirring and mixing for 30-40min at the stirring speed of 70-100r/min, heating the mixture to 85-95 ℃, and reacting for 100-125min to obtain a reactant A;
s2: adding a catalyst, a pore-opening agent, a stabilizer, purified water and a chain extender into the reactant A, and continuously stirring for 45-60min at the stirring speed of 100-120r/min to obtain a reactant B;
s3: naturally cooling the reactant B to 20-28 ℃, foaming at room temperature, and curing for 24-36h to obtain a reactant C;
s4: and slicing the reactant C and compounding the sliced reactant C with medical adhesive plaster and non-woven fabric to obtain the high-adsorbability porous structure polyurethane dressing.
Priority Applications (1)
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CN116178670A (en) * | 2023-04-28 | 2023-05-30 | 山东一诺威聚氨酯股份有限公司 | Polyurethane composite material for medical dressing foam and preparation method thereof |
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CN1462614A (en) * | 2003-06-24 | 2003-12-24 | 四川大学 | Hydrophilic trauma dressing made from polyurethane and its preparation method |
CN1470544A (en) * | 2003-06-24 | 2004-01-28 | 中国科学院广州化学研究所 | Method for preparing amino silicone oil modified polyurethane |
CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
CN113480715A (en) * | 2021-07-27 | 2021-10-08 | 沈翔 | Polyurethane film dressing and preparation method thereof |
CN114560988A (en) * | 2022-04-13 | 2022-05-31 | 中国科学院长春应用化学研究所 | High-comfort polyurethane sponge, preparation method and application product thereof |
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CN1462614A (en) * | 2003-06-24 | 2003-12-24 | 四川大学 | Hydrophilic trauma dressing made from polyurethane and its preparation method |
CN1470544A (en) * | 2003-06-24 | 2004-01-28 | 中国科学院广州化学研究所 | Method for preparing amino silicone oil modified polyurethane |
CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
CN113480715A (en) * | 2021-07-27 | 2021-10-08 | 沈翔 | Polyurethane film dressing and preparation method thereof |
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CN116178670A (en) * | 2023-04-28 | 2023-05-30 | 山东一诺威聚氨酯股份有限公司 | Polyurethane composite material for medical dressing foam and preparation method thereof |
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