CN112266454B - Application of hydroxyl-terminated polymer in preparation of multifunctional polyurethane soft foam dressing - Google Patents
Application of hydroxyl-terminated polymer in preparation of multifunctional polyurethane soft foam dressing Download PDFInfo
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Abstract
The invention discloses an application of a hydroxyl-terminated polymer in preparing multifunctional polyurethane soft foam dressing, wherein hydrophilic substances including hydroxyl-terminated polyethylene glycol alkyl ether, single-ended hydroxyl polyvinylpyrrolidone and hydroxyl-terminated polyether quaternary ammonium salt are mixed with a surfactant and water to prepare a functional foaming component A; then reacting polyether polyol, a chain extender and a catalyst with polyisocyanate to prepare a polyurethane prepolymer component B; and then mixing and foaming the functional foaming component A and the polyurethane prepolymer B to prepare the multifunctional polyurethane soft foam plastic which is used for producing the medical dressing with the functions of hydrophile, water absorption, moisture retention, antibiosis, sterilization, hemostasis and healing promotion.
Description
Technical Field
The invention relates to an application of a hydroxyl-terminated polymer in preparation of a multifunctional polyurethane soft foam dressing, in particular to an application of hydroxyl-terminated polyethylene glycol monoalkyl ether, single-ended hydroxyl polyvinylpyrrolidone and hydroxyl-terminated polyether quaternary ammonium salt in preparation of a polyurethane soft foam dressing with hydrophilic, water-absorbing, moisture-preserving, antibacterial, bactericidal, hemostatic and healing-promoting functions, belonging to the field of medical functional polymer materials.
Background
Polyurethane (PU) is a generic name for a macromolecular polymer having a urethane (-NHCOO-) repeating unit in the main chain, is generally produced by polyaddition of polyol and polyisocyanate, belongs to a typical block copolymer, and has various product forms including Polyurethane elastomer, Polyurethane fiber, Polyurethane foam, Polyurethane coating, Polyurethane adhesive, Polyurethane prepolymer and the like. Compared with other high polymer materials, the polyurethane material also has the characteristics of easy molecular structure design, adjustable performance, good processing performance, various processing modes, excellent mechanical performance and the like. By means of functional modification of polyurethane material, excellent performance of polyurethane is maintained, and unique biological, optoelectromagnetic and thermal and other physical and chemical properties are endowed, so that the method becomes a main method for expanding the application field of polyurethane material. Currently popular polyurethane functionalization methods are: surface modified coatings and grafts, blending modifications, interpenetrating networks, and chemical copolymerizations. Wherein, the functional groups and the polyurethane material are compounded at the molecular level through the bonding action, thereby not only fully playing the performance of each component, but also having synergistic effect.
Polyurethane foam plastics prepared by different raw materials, formulas and manufacturing processes are widely used general materials, wherein the open-cell PU soft foam plastics have high elasticity, flexibility, air permeability, adsorption characteristics and good biocompatibility. In recent years, functional open-cell PU soft foam plastics have been applied to the manufacture of medical dressings, and various reports about the manufacture of polyurethane foam dressings are reported at home and abroad, for example, US4773406 and US4773408 adopt a method of adding sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, pectin, gelatin, guar gum, locust bean gum, collagen and karaya gum to prepare the soft foam plastics with the thickness of 1-10 cm and the density of 0.16-0.8 g/cm3The polyurethane foam dressing of (1). US7022890 uniformly dopes super water absorbents such as starch-grafted sodium acrylate, polyacrylamide, etc. in polyurethane foam to obtain highly water-absorbent polyurethane foam, but since these water-absorbent materials are dispersed in the foam and easily dissolved in water to escape with water, the use is limited. CN1462614 prepares the wound dressing by compounding hydrophilic polyurethane soft foam slice and polyurethane film which is moisture permeable, air permeable, waterproof and bacterium-proof. US4906240 obtains the absorbent layer foam by reacting polyethylene glycol and glycerol with TDI to obtain a prepolymer and then foaming. CN1741824 as TDI andthe ethylene oxide/propylene oxide trihydroxy random polymer containing 75% by mass of ethylene oxide is used as a raw material to prepare a prepolymer, and then foam obtained through foaming has micropores with the diameter of 10-80 mu m, has relatively high absorption rate and high moisture permeability, and retains secretion absorbed from wounds. CN201811511343.9 dimethylolpropionic acid is used as a chain extender in polyurethane prepolymer, chitosan is added in the foaming process, and then the chitosan quaternary ammonium salt-containing antibacterial polyurethane foam dressing is prepared by foaming. CN201810455427.9 also adopts a similar method, and polyhexamethylene guanidine hydrochloride or polyhexamethylene guanidine phosphate is added into a foaming agent for the foaming process of polyurethane prepolymer mixing to prepare the cationic antibacterial polyurethane foam dressing.
It is also known through searching that the antibacterial polyurethane foam dressing on the market at present is to spray a layer of inorganic silver ion antibacterial agent on the surface of the PU foam dressing, but the polyurethane foam dressing with silver-loaded surface has the problems that silver ions are released too fast and are easy to fall off, so that the service life of the dressing is short, and the silver ions directly contact with the skin in the using process and may influence the healing of wounds. Also for human use, ultra-micro TiO is included2The antibacterial polyurethane soft foam dressing is prepared by taking powder, sulfadiazine silver, sulfanilamide and silver nitrate as antibacterial agents and adopting a polyurethane soft foam carrier impregnation method or a polyurethane prepolymer method and the like. The inorganic antibacterial agent is added into the polyurethane foam dressing by a physical doping or adsorption method, and the polyurethane foam dressing is released and separated out under the action of wound exudate when contacting with a wound surface to achieve the purpose of killing bacteria. In conclusion, the polyurethane foam dressing is mainly concentrated on the preparation of water absorption or antibacterial materials, and the polyurethane foam dressing has single function and cannot meet the multifunctional requirement of the wound dressing. Therefore, the research and development of the medical pillow has good flexibility, air permeability, water absorption, moisture retention, hemostasis, anti-inflammation and eliminationThe polyurethane soft foam dressing with the functions of swelling, antibiosis, sterilization, healing promotion and the like is imperative.
It is well known to those skilled in the art to introduce cations, such as ammonium, sulfonium, and phosphonium based cations, preferably ammonium based cations, into the backbone or side chain structure of the polyurethane; or introduction of anions such as sulfonic acid groups or carboxyl groups; or simultaneously introduces zwitterion pairs, so that the research and exploration of the hydrophilicity, the ion exchange function and the antibacterial function of the product are not stopped. In the literature, the functional polyurethane is prepared mainly from small molecules of N-methyldiethanolamine, dimethylolpropionic acid, ethylenediamine ethanesulfonic acid, mercaptoethanol, and hydroxyethylimino oxalic acid; and mainly introduces anions and cations or some coordination groups into the polyurethane material by a method of end capping or chain extension of the polyurethane prepolymer. Therefore, the functional modification of the existing polyurethane has limitations and limitations. So over the last decade attention has been transferred to the field of polymer polyol functionalization development.
The skilled person is well aware of the great freedom of designability of the polymer polyol molecules, so that some cationic polymer polyols have emerged, for example: CN 02815856.3; CN 03122339.7; CN 201210125277.8; absorption by Polyurethane foam New Method of Separation, J. chem. SOC. (A), (1970) 1803-1805; polymeric and immobilized crown compound materials for separation, Tetrahedron, 53(1997) 1343-; click-ligation of cosmetic to polyurethane polyols for polyurethane foams, Polymer. int., 62 (2013) 783-790; detection of ammonium with a free sensing method by using sampling and magnetic nanoparticles as signal-amplifying tags, J.radio. Nucl. chem.298 (2013) 1393-; polyurethane-based change composition membranes Preparation, conversion and its application in detection of ion-selective electrode for detection of copper (II), J.Ind.Eng.chem., 29 (2015), 392-399, and the like. However, the functional polyol has high cost price and is not popular in the market.
In order to overcome the defects of the prior art, the inventor develops the polyurethane flexible foam plastic containing the quaternary ammonium cation polyether chain, the polyvinylpyrrolidone chain and the polyethylene glycol chain in the molecular structure through molecular design and research, the polyurethane flexible foam plastic can be applied to multifunctional polyurethane flexible foam dressing, the needed raw materials are mostly commercial products, the synthesis process is adopted, and the technology is easy to popularize.
It is well known to those skilled in the art that polyethylene glycol (PEG) is an amphiphilic polymer having excellent lubricity, moisture retention, dispersibility, adhesive, antistatic agent, softening agent, etc., and can change the structure of biological membranes of various cells, so that lipid molecules of plasma membranes at the contact points of two cells are dispersed and recombined, and the cells are fused due to the mutual affinity of the plasma membranes of the bilayers at the interface between the two cells and the surface tension of the two plasma membranes. The invention selects hydroxyl-terminated polyethylene glycol monoalkyl ether as a modifier for foaming a polyurethane prepolymer according to the molecular design principle of organic chemistry to form a polyurethane soft foam with macromolecules laterally linked with the polyethylene glycol monoalkyl ether, thereby enhancing the characteristics of the polyurethane soft foam such as flexibility, hydrophilicity, water absorption, moisture retention, lubricity and the like.
Polyvinylpyrrolidone (PVP) is also known to those skilled in the art as an artificially synthesized water-soluble polymer having the general properties of an aqueous polymer such as colloid protection, film-forming property, adhesion, hygroscopicity, solubilization or aggregation, but its most distinctive feature is its excellent solubility and physiological compatibility. Has no irritation to skin, mucosa, and eye, and has effects in removing toxic substances, stopping bleeding, increasing dissolution concentration, preventing peritoneal adhesion, and promoting blood sedimentation. The inventor selects hydroxyl-terminated polyvinylpyrrolidone as a modifier for foaming of polyurethane prepolymer according to the molecular design principle of organic chemistry to form polyurethane soft foam with macromolecular side-linked polyvinylpyrrolidone chains, thereby enhancing the characteristics of hydrophilic lubrication, hemostasis and detoxification, water absorption and moisture retention and the like of the polyurethane soft foam.
The professional is also well aware that the formulation of disinfectants and antibacterial sterilizing materials is widely applied to both small molecular quaternary ammonium salts and macromolecular quaternary ammonium salts. According to the molecular design principle of organic chemistry, the hydroxyl-terminated polyether quaternary ammonium salt is selected as a modifier for foaming of the polyurethane prepolymer to form the polyurethane soft foam with macromolecular side chains bonded with polyether quaternary ammonium cations, so that the characteristics of the polyurethane soft foam, such as antibiosis, sterilization, hydrophilicity, water absorption, moisture retention, and the like, are enhanced.
Disclosure of Invention
The invention aims to solve the problem of single function of the existing polyurethane flexible foam dressing and provides a preparation method of a multifunctional polyurethane flexible foam dressing.
The invention provides an application of a hydroxyl-terminated polymer in preparation of a multifunctional polyurethane flexible foam dressing, which is realized by the following steps:
step one, sequentially weighing a hydroxyl-terminated polymer, a surfactant and water in a stirrer, controlling the temperature to be 20-25 ℃, stirring and mixing for 0.5 hour to obtain a functional foaming component A for later use.
Wherein the hydroxyl-terminated polymer refers to hydroxyl-terminated polyethylene glycol monoalkyl ether, hydroxyl-terminated polyvinylpyrrolidone and hydroxyl-terminated polyether quaternary ammonium salt.
The hydroxyl-terminated polyethylene glycol monoalkyl ether is also called polyethylene glycol monoalkyl ether or alkoxy polyethylene glycol, and refers to one or more of hydroxyl-terminated polyethylene glycol monomethyl ether, hydroxyl-terminated polyethylene glycol monoethyl ether or hydroxyl-terminated polyethylene glycol monoallyl ether with the weight average molecular weight of 600-6000.
The hydroxyl-terminated polyvinylpyrrolidone refers to single-ended hydroxyl-terminated polyvinylpyrrolidone with the weight average molecular weight of 1000-6000.
The hydroxyl-terminated polyether quaternary ammonium salt has a structure shown in a general formula (I) or a general formula (II):
wherein R in the general formula (I) or the general formula (II)1、R2And R3Are respectively selected from substituted or unsubstituted C1~C18One of the hydrocarbon radicals, X-Refers to Cl-Or Br-N is a natural number in the range of 1-200, and the sum of p and q is respectively equal to the natural number in the range of 2-200;
the surfactant is one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, alkylene oxide block copolymer nonionic surfactant or organosilicon surfactant.
Wherein the alkylene oxide block copolymer type nonionic surfactant is preferably one of products of L-62, L-64, L-68 or F68 grades produced by Haian petrochemical plants of Jiangsu province.
The silicone surfactant is preferably one of Dow Corning 198, Dow Corning 1382, Dow Corning 1718 or Dow Corning 3274 manufactured by Dow Corning, USA.
The mass ratio of the hydroxyl-terminated polymer to the surfactant to the water is 3-30: 0.2-12: 0.05 to 5;
step two, sequentially weighing polyether polyol, a chain extender and a catalyst in a reaction kettle, stirring uniformly, adding polyisocyanate, raising the temperature of materials in the reaction kettle to 50-90 ℃, stirring for reacting for 2-8 hours, and then cooling to 20-25 ℃ to obtain a polyurethane prepolymer; weighing a foaming agent, adding the foaming agent into the polyurethane prepolymer, and uniformly mixing to obtain a polyurethane prepolymer component B for later use;
wherein the polyether polyol refers to one or more than two of polyethylene glycol, polypropylene glycol, propylene glycol-ethylene glycol copolymer, polytetrahydrofuran glycol or glycerol polyether with the weight-average molecular weight of 1000-8000;
the chain extender refers to one or more than two of glycerol, trimethylolmethane, trimethylolethane, trimethylolpropane, N-methyldiethanolamine or triethanolamine;
the catalyst refers to one of dibutyltin dilaurate, stannous octoate, stannous oxalate, dibutyltin dimaleate, dibutyltin didodecyl sulfide or dibutyltin diacetate.
The polyisocyanate refers to one of toluene diisocyanate, diphenylmethane diisocyanate, p-phenylene diisocyanate, tetramethylxylylene diisocyanate, 1, 6-hexamethylene diisocyanate, isophorone diisocyanate, dicyclohexylmethane diisocyanate, trimethylhexane diisocyanate, toluene diisocyanate trimer, diphenylmethane diisocyanate trimer, 1, 6-hexamethylene diisocyanate trimer, isophorone diisocyanate trimer or pentamethylene diisocyanate trimer.
The foaming agent is one or more than two of dichloromethane, acetone, tetrahydrofuran, pentane or petroleum ether.
The using amount mass ratio of the polyisocyanate to the polyether polyol to the chain extender to the catalyst to the foaming agent is 20-200: 30-300: 0.8-8: 1-5: 2-8;
and step three, placing 30-60 parts by mass of the functional foaming component A and 30-120 parts by mass of the polyurethane prepolymer component B into a high-speed stirrer, stirring for 0.05-5 minutes at 2000-6000 rpm, quickly pouring materials in the high-speed stirrer into a foaming box, foaming at 20-50 ℃, and curing for 7-70 hours to obtain the multifunctional polyurethane soft foam plastic for manufacturing medical dressings.
Detailed Description
The application of the hydroxyl-terminated polymer in the preparation of multifunctional polyurethane flexible foam dressing is provided by the following specific examples.
EXAMPLE 1 preparation of multifunctional polyurethane Flexible foam dressing-1
Step one, preparation of functional foaming component (A-1)
12 g of hydroxyl-terminated polyethylene glycol monomethyl ether with the weight-average molecular weight of 2000, 12 g of single-terminal hydroxyl polyvinylpyrrolidone with the weight-average molecular weight of 3800, 22 g of brominated N- (hydroxyl-terminated polyethylene glycol-2000) -N-dodecyl-N, N-dimethylammonium with the weight-average molecular weight of 2200 and the structure shown in formula (I-1) and 8g of purified water, which are produced by Jiangsu Heian petrochemical plant, are sequentially weighed and added into a stirrer together, and the functional foaming component (A-1) is prepared after stirring for half an hour at normal temperature.
Step two, preparation of polyurethane prepolymer (B-1)
Adding 76 g of polyethylene glycol-2000 with the weight-average molecular weight of 2000, 3 g of glycerol, 1.3 g of stannous octoate and 26g of toluene diisocyanate into a reaction kettle, heating to 70-80 ℃ under the protection of nitrogen, reacting for 4 hours, reducing the temperature of materials in the reaction kettle to room temperature, adding 4g of foaming agent prepared from dichloromethane and petroleum ether with the boiling range of 30-60 ℃ according to the mass ratio of 4/6, and uniformly mixing to obtain the polyurethane prepolymer (B-1).
Step three, preparation of multifunctional polyurethane flexible foam dressing-1
And (3) putting the functional foaming component (A-1) prepared in the step one and the polyurethane prepolymer (B-1) prepared in the step two into a high-speed stirrer, stirring at 4000 rpm for 0.3 min, quickly pouring the materials in the high-speed stirrer into a foaming box, foaming at 40-45 ℃, and curing for 20 h to obtain the multifunctional polyurethane soft foam dressing-1.
EXAMPLE 2 preparation of multifunctional polyurethane Flexible foam dressing-2
According to the method and the operation steps of the embodiment 1, the N- (hydroxyl-terminated polyethylene glycol-2000) -N-dodecyl-N, N-dimethylammonium bromide with the structure shown in the formula (I-1) in the step one of the embodiment 1 is changed into N- (hydroxyl-terminated polyethylene glycol-2000) -N-benzyl-N, N-dimethylammonium chloride with the structure shown in the formula (I-2), and the multifunctional polyurethane flexible foam dressing-2 is prepared.
EXAMPLE 3 preparation of multifunctional polyurethane Flexible foam dressing-3
The method and procedure of example 1 were followed to change the N- (hydroxy terminated polyethylene glycol-2000) -N-dodecyl-N, N-dimethylammonium bromide having the structure shown in formula (I-1) from step one of example 1 to N- (hydroxy terminated polyethylene glycol-2000) -N-benzyl-N, N-dimethylammonium chloride having the structure shown in formula (I-2); and in the second step, the polyether glycol-2000 with the weight average molecular weight of 2000 is changed into polytetrahydrofuran diol-3000 produced by BASF company, and the multifunctional polyurethane flexible foam dressing-3 is prepared.
EXAMPLE 4 preparation of multifunctional polyurethane Flexible foam dressing-4
According to the method and operation steps of example 1, the hydroxyl-terminated polyethylene glycol monomethyl ether in the first step of example 1 is changed into hydroxyl-terminated polyethylene glycol monoethyl ether, and the N- (hydroxyl-terminated polyethylene glycol-2000) -N-dodecyl-N, N-dimethylammonium bromide with the structure shown in formula (I-1) in the first step is changed into N- (hydroxyl-terminated polyethylene glycol-2000) -N-benzyl-N, N-dimethylammonium chloride with the structure shown in formula (I-2); and in the second step, the polyether glycol-2000 with the weight average molecular weight of 2000 is changed into polytetrahydrofuran diol-3000 produced by BASF company, and the multifunctional polyurethane flexible foam dressing-4 is prepared.
EXAMPLE 5 preparation of multifunctional polyurethane Flexible foam dressing-5
According to the method and the operation steps of the example 1, the hydroxyl-terminated polyethylene glycol monomethyl ether in the first step of the example 1 is changed into hydroxyl-terminated polyethylene glycol monoethyl ether, and the brominated N- (hydroxyl-terminated polyethylene glycol-2000) -N-dodecyl-N, N-dimethylammonium with the structure shown in the formula (I-1) in the first step is changed into hydroxyl-terminated polyether quaternary ammonium salt with the structure shown in the formula (II-1); and in the second step, the polyether glycol-2000 with the weight average molecular weight of 2000 is changed into polytetrahydrofuran diol-3000 produced by BASF company, and the multifunctional polyurethane flexible foam dressing-5 is prepared.
Wherein n + m in said formula (II-1) is equal to 20.
Example 6 Properties of the multifunctional polyurethane Flexible foam dressings of examples 1-5
Respectively takeExamples 1-5 multifunctional polyurethane flexible foam dressing strips with length, width, height 100, 10, 1 mm were weighed (W1) After immersing in 200 ml of water for 5 seconds, the mixture was drained for 30 minutes and weighed (W)2) From (W)2-W1)/W1The water absorption was calculated and the antibacterial properties of the multifunctional polyurethane foam dressings of examples 1-5 were determined according to the method of GB/T20944.3-2008, the results of which are shown in table 1.
The above description is the preferred embodiment of the present invention, and it is within the scope of the appended claims to cover all modifications of the invention which may occur to those skilled in the art without departing from the spirit and scope of the invention.
Claims (7)
1. The application of the hydroxyl-terminated polymer in preparing the multifunctional polyurethane flexible foam dressing is characterized by comprising the following steps:
step one, sequentially weighing a hydroxyl-terminated polymer, a surfactant and water in a stirrer, controlling the temperature to be 20-25 ℃, stirring and mixing for 0.5 hour to prepare a functional foaming component A for later use;
wherein the hydroxyl-terminated polymer refers to hydroxyl-terminated polyethylene glycol monoalkyl ether, hydroxyl-terminated polyvinylpyrrolidone and hydroxyl-terminated polyether quaternary ammonium salt;
wherein the hydroxyl-terminated polyethylene glycol monoalkyl ether refers to one or more of hydroxyl-terminated polyethylene glycol monomethyl ether, hydroxyl-terminated polyethylene glycol monoethyl ether or hydroxyl-terminated polyethylene glycol monoallyl ether with the weight-average molecular weight of 600-6000;
the hydroxyl-terminated polyvinylpyrrolidone refers to single-ended hydroxyl polyvinylpyrrolidone with the weight-average molecular weight of 1000-6000;
the hydroxyl-terminated polyether quaternary ammonium salt refers to a compound with a structure shown in a general formula (I) or a general formula (II):
wherein R in the general formula (I) or the general formula (II)1、R2And R3Are respectively selected from substituted or unsubstituted C1~C18One of the hydrocarbon radicals, X-Refers to Cl-Or Br-N is a natural number in the range of 1-200, and the sum of p and q is respectively equal to the natural number in the range of 2-200;
the mass ratio of the hydroxyl-terminated polymer to the surfactant to the water is 3-30: 0.2-12: 0.05-5;
step two, sequentially weighing polyether polyol, a chain extender and a catalyst in a reaction kettle, uniformly stirring, adding polyisocyanate, raising the temperature of materials in the reaction kettle to 50-90 ℃, stirring for reaction for 2-8 hours, and cooling to 20-25 ℃ to obtain a polyurethane prepolymer; weighing a foaming agent, adding the foaming agent into the polyurethane prepolymer, and uniformly mixing to obtain a polyurethane prepolymer component B for later use;
the mass ratio of the polyisocyanate to the polyether polyol to the chain extender to the catalyst to the foaming agent is 20-50: 30-300: 0.8-8: 1-5: 2-8;
and step three, adding 30-60 parts by mass of the functional foaming component A and 30-120 parts by mass of the polyurethane prepolymer component B into a high-speed stirrer, stirring for 0.05-5 minutes at 2000-6000 rpm, quickly pouring materials in the high-speed stirrer into a foaming box, foaming at 20-50 ℃, curing for 7-70 hours, and thus obtaining the multifunctional polyurethane soft foam plastic for manufacturing medical dressings.
2. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the surfactant is one or more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, alkylene oxide block copolymer nonionic surfactant or organosilicon surfactant.
3. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the polyether polyol refers to one or more than two of polyethylene glycol, polypropylene glycol, propylene glycol-ethylene glycol copolymer, polytetrahydrofuran glycol or glycerol polyether with the weight-average molecular weight of 1000-8000.
4. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the chain extender refers to one or more than two of glycerol, trimethylolmethane, trimethylolethane, trimethylolpropane, N-methyldiethanolamine or triethanolamine.
5. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the catalyst refers to one of dibutyltin dilaurate, stannous octoate, stannous oxalate, dibutyltin dimaleate, dibutyltin didodecyl sulfide or dibutyltin diacetate.
6. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the polyisocyanate refers to one of toluene diisocyanate, diphenylmethane diisocyanate, p-phenylene diisocyanate, tetramethylxylylene diisocyanate, 1, 6-hexamethylene diisocyanate, isophorone diisocyanate, dicyclohexylmethane diisocyanate, trimethylhexane diisocyanate, toluene diisocyanate trimer, diphenylmethane diisocyanate trimer, 1, 6-hexamethylene diisocyanate trimer, isophorone diisocyanate trimer or pentamethylene diisocyanate trimer.
7. The use of a hydroxyl terminated polymer in the preparation of a multifunctional polyurethane flexible foam dressing according to claim 1, wherein: the foaming agent refers to one or more than two of dichloromethane, acetone, tetrahydrofuran, pentane or petroleum ether.
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