CN114984124A - Traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration as well as preparation method and application thereof Download PDFInfo
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- CN114984124A CN114984124A CN202210639570.XA CN202210639570A CN114984124A CN 114984124 A CN114984124 A CN 114984124A CN 202210639570 A CN202210639570 A CN 202210639570A CN 114984124 A CN114984124 A CN 114984124A
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- frankincense
- chinese medicine
- traditional chinese
- necrotic tissue
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a traditional Chinese medicine composition for removing necrotic tissue and promoting granulation and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicine compositions and preparation thereof, the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is prepared from the following traditional Chinese medicine raw materials in parts by weight, wherein the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation comprises 40-160 parts of frankincense, 20-80 parts of myrrh, 20-80 parts of dragon's blood, 15-40 parts of catechu, 10-20 parts of toad venom, 10-80 parts of cinnabar, 50-100 parts of cantharis and 60-150 parts of huechys sanguinea. The traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration adopts a natural traditional Chinese medicine preparation, has mild drug effect, has the effects of resisting bacteria, diminishing inflammation, relieving swelling, relieving pain, stopping bleeding, converging and removing the necrotic tissue and promoting tissue regeneration depending on the adopted important components, and has obvious effect; and the composition is prepared into a granular medicament or a plaster, is convenient to store and is beneficial to maintaining the medicament effect.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions and preparation thereof, and particularly relates to a traditional Chinese medicine composition for removing necrotic tissue and promoting granulation, a preparation method and application thereof, which are suitable for treating sore wounds.
Background
Traumatic injury and external wound are common injuries treated by Chinese and Western medicine. Bleeding from trauma needs to be stopped in time, and excessive bleeding can cause shock and life risk, and the bleeding is accompanied by pain, inflammation and the like. If bleeding cannot be stopped in time, the bleeding can accumulate in the body, macrophages phagocytose bacteria, and take effect or cause other diseases. Therefore, the hemostatic medicament is a necessary product which can not be replaced clinically, and has the characteristic of strong clinical use compliance.
In addition, various traumatic hemorrhages of the skin of the whole body, particularly the method for treating knife wound, sore wound, golden wound and the like, generally adopts suture or is matched with medicines and injection for treatment, thereby achieving the aim of diminishing inflammation; the medicine applied to the incised wound for trauma easily stimulates the skin to feel pain, patients are very difficult to feel, the side effect of the medicine treatment is large, and toxic and side effects such as anaphylactic reaction and the like are easily generated.
In addition, although various antibiotics, represented by penicillin, are effective in controlling bacterial infectious diseases, antibiotics have become powerful weapons for humans against pathogenic bacterial infections. However, in recent years, the wide use of antibiotics for a long time has led to the increasing of the drug resistance of bacteria, and the frequency of drug resistance has been gradually increased, so that the conventional antibiotics can not meet the clinical needs. With the important change of global disease spectrum and medical treatment mode, antibiotics bring many adverse reactions and the influence of corresponding drug resistance, and people expect for the maintenance of traditional Chinese medicine health and the prevention and treatment of diseases. The medical community also expects to cope with the continuously generated drug-resistant bacteria by reasonably using the drugs and developing new traditional Chinese medicines.
The Chinese medicine is known as "Mingzhu on medicine Imperial crown" and has been popularized and applied in various aspects such as medical treatment, beauty treatment, diet, etc. However, the existing traditional Chinese medicine medicament or composition for treating the sore remains a large amount of toxic substances due to the original processing method, and generally has stronger irritation to the wound surface; in addition, because the use or treatment method of the traditional Chinese medicine is very extensive, the new granulation tissue is easily injured when the medicine is changed, and the healing of the wound surface is not facilitated, so that the tissue regeneration and the healing of the wound can not be rapidly realized, and the clinical curative effect is not ideal.
Disclosure of Invention
Based on the technical problems in the prior art, the invention provides a traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration, a preparation method and application thereof, which are suitable for treating sore wound surfaces, in particular to hard wounds such as traumatic injuries.
According to the first aspect of the technical scheme of the invention, the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared from the following traditional Chinese medicine raw materials in parts by weight: 40-160 parts of frankincense, 20-80 parts of myrrh, 20-80 parts of dragon's blood, 15-40 parts of catechu, 10-20 parts of venenum bufonis, 10-80 parts of cinnabar, 50-100 parts of cantharis and 60-150 parts of huechys sanguinea.
Further, the traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60-120 parts of frankincense, 30-60 parts of myrrh, 30-60 parts of dragon's blood, 18-36 parts of catechu, 6-24 parts of toad venom, 12-48 parts of cinnabar, 30-60 parts of cantharis and 30-60 parts of huechys sanguinea.
Furthermore, the traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of frankincense, 5 parts of myrrh, 5 parts of dragon's blood, 3 parts of catechu, 1 part of venenum bufonis, 2 parts of cinnabar, 5 parts of cantharis and 5 parts of huechys sanguinea
Preferably, the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration further comprises vegetable oil, and the vegetable oil and the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration are ground into powder and mixed into paste.
According to a second aspect of the present invention, there is provided a method for preparing a Chinese medicinal composition for removing necrotic tissue and promoting granulation, comprising the steps of:
step S1, selecting Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea;
step S2, washing and processing Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea;
step S3, mixing and uniformly stirring the frankincense and the myrrh obtained in the step S2, finely grinding the frankincense and the myrrh into fine powder at a slow speed by using a mechanical steel grinder, and sieving the fine powder by using a 300-mesh sieve to obtain mixed fine powder of the frankincense and the myrrh for later use;
step S4, mixing the dragon 'S blood and the catechu obtained in the step S2, stirring uniformly, finely grinding into fine powder at a slow speed by using a mechanical steel grinder, or smashing and mixing by using a stone mortar, and sieving by using a 300-mesh sieve to obtain mixed fine powder of the dragon' S blood and the catechu for later use;
step S5, the cantharis obtained in the step S2 and the huechys sanguinea are mixed and stirred uniformly, finely ground into fine powder by using a mechanical steel grinder, and sieved by a 600-mesh sieve to obtain mixed fine powder of the cantharis and the huechys sanguinea for later use;
step S6, mixing the Olibanum and Myrrha fine powder obtained in step S3, the sanguis Draxonis and Catechu fine powder obtained in step S4, and the Mylabris and huechys sanguinea fine powder obtained in step S5 in proportion;
step S7, weighing venenum Bufonis and Cinnabaris in proportion, and finely grinding into fine powder at slow speed by mechanical steel grinder;
and step S8, mixing the mixed fine powder obtained in the step S6 with the mixed fine powder of the toad venom and the cinnabar obtained in the step S7 to obtain the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation.
Further, the washing and processing of frankincense in step S2 includes the following steps:
step S211, taking raw frankincense medicinal materials, removing impurities, and crushing frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212, putting the vinegar-processed frankincense into a pot, heating the pot with slow fire, frying until smoke is produced, spraying rice vinegar on the surface of the pot, frying until the surface of the pot is glossy, and taking out the pot to cool.
Additionally, the washing and processing of the frankincense in the step S2 specifically includes the following steps:
step S211, taking raw frankincense medicinal materials, removing impurities, and crushing frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212B, frankincense preparation with rush: parching Olibanum with slow fire until the surface is slightly melted, adding medulla Junci, parching to loose texture, taking out, winnowing medulla Junci, and mashing.
Additionally, the washing and processing of the frankincense in the step S2 specifically includes the following steps:
step S211, taking raw frankincense medicinal materials, removing impurities, and crushing frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212C, boiling frankincense: melting Olibanum in water, filtering to remove sawdust and sandstone, decocting with slow fire until dripping water becomes bead and sinks, taking out, spreading on a flat plate, cutting into blocks, and cooling.
According to a third aspect of the technical scheme of the invention, the application of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is provided, the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is made into a strip shape, and the strip shape is suitable for the shape of a deep abscess hole or a fistula and is deeply placed into the deep abscess hole or the fistula.
On the other hand, the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared into a plaster or a patch shape to cover the sore surface.
Compared with the prior art, the traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration, the preparation method and the application thereof have the following beneficial effects:
firstly, the invention adopts natural Chinese medicinal preparation, has mild medicinal effect, has the functions of resisting bacteria, diminishing inflammation, reducing swelling, relieving pain, stopping bleeding, converging, removing necrotic tissue and promoting granulation depending on the adopted important components, and has obvious effect; and the composition is prepared into a granular medicament or a plaster, is convenient to store and is beneficial to maintaining the medicament effect.
Secondly, through the selection of the specific raw materials and the coordination effect of the raw materials, the invention improves the drug effect, achieves the effects of detumescence, acesodyne, removing necrotic tissue, promoting granulation, clearing heat, detoxicating, diminishing inflammation, relieving pain, sterilizing and inhibiting bacteria, further promotes the regeneration of epidermal cells, and achieves the purpose of treating chronic sores; and the treatment course is shortened, and no obvious toxic or side effect exists.
Thirdly, the invention adopts the traditional Chinese medicine components with similar medicine properties to treat stubborn sores from multiple angles, and has the advantages of good detumescence and acesodyne, quick necrotic tissue and granulation promotion, strong anti-infection capability, quick healing and no scar after treatment.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. Additionally, the scope of the present invention should not be limited to only the specific experimental procedures or specific parameters described below.
The invention provides a traditional Chinese medicine composition for removing necrotic tissue and promoting granulation, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 40-160 parts of frankincense, 20-80 parts of myrrh, 20-80 parts of dragon's blood, 15-40 parts of catechu, 10-20 parts of toad venom, 10-80 parts of cinnabar, 50-100 parts of cantharis and 60-150 parts of huechys sanguinea. Through the selection of the specific raw materials and the coordination effect of the raw materials, the invention improves the drug effect, achieves the effects of detumescence and acesodyne, and realizes the functions of removing necrotic tissue and promoting granulation, clearing heat and detoxicating, diminishing inflammation and relieving pain, sterilizing and inhibiting bacteria, thereby promoting the regeneration of epidermal cells and achieving the purpose of treating chronic sores; and the treatment course is shortened, and no obvious toxic or side effect exists. Particularly, the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration simultaneously adopts frankincense, myrrh, dragon's blood, catechu, cantharis and huechys sanguinea, treats stubborn sores from multiple angles by using the common point of the frankincense and the myrrh and the carthamus tinctorius, and the difference between the frankincense and the myrrh, and has the advantages of good swelling and pain relieving effect, quick effect of removing the necrotic tissue and promoting tissue regeneration, strong anti-infection capability, quick healing and no scar after treatment.
In a preferred embodiment, the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60-120 parts of frankincense, 30-60 parts of myrrh, 30-60 parts of dragon's blood, 18-36 parts of catechu, 6-24 parts of toad venom, 12-48 parts of cinnabar, 30-60 parts of cantharis and 30-60 parts of huechys sanguinea.
In another embodiment, the traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration is prepared from the following traditional Chinese medicine raw materials in parts by weight: 90 parts of frankincense, 45 parts of myrrh, 45 parts of dragon's blood, 30 parts of catechu, 10 parts of venenum bufonis, 20 parts of cinnabar, 45 parts of cantharis and 45 parts of huechys sanguinea.
In another embodiment, the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of frankincense, 5 parts of myrrh, 5 parts of dragon's blood, 3 parts of catechu, 1 part of venenum bufonis, 2 parts of cinnabar, 5 parts of cantharis and 5 parts of huechys sanguinea. If the weight is calculated, the traditional Chinese medicine composition for removing the necrotic tissue and promoting granulation comprises 100 g of frankincense, 50 g of myrrh, 50 g of dragon's blood, 30 g of catechu, 10 g of venenum bufonis, 20g of cinnabar, 50 g of cantharis and 50 g of huechys sanguinea.
The Olibanum and Myrrha can be used for promoting qi and blood circulation, and the sanguis Draxonis and Catechu can be used for treating tumble injury, superficial infection, swelling and pain, and promoting blood circulation for removing blood stasis; the venenum bufonis is used for astringing sore openings and accelerating wound healing; cinnabaris, Mylabris, and huechys sanguinea can be used for removing necrotic tissue and promoting granulation. In the present invention, the frankincense and the myrrh are used simultaneously, which is one of the innovative points of the present invention.
Frankincense: it is pungent, bitter and warm in flavor, enters heart, liver and spleen meridians, has the functions of promoting blood circulation, relieving pain, eliminating swelling and promoting granulation, and can be used for treating spasm of muscles and tendons, traumatic injury, carbuncle, swelling and pyocutaneous disease.
Myrrh: the medicine is pungent, bitter and even, and enters heart, liver and spleen channels, and the myrrh has the functions of eliminating stasis and relieving pain, and eliminating swelling and promoting granulation, and is used for treating abdominal pain, rheumatic arthralgia, traumatic injury, carbuncle, swelling and sore. The actions of Ru Xiang and Mo Yao are similar but different. Meanwhile, due to the fact that the frankincense and the myrrh are fragrant, the effect of treating traumatic injury, carbuncle, swelling and sore and ulcer is further improved by selecting the proper proportion. Secondly, the two are used in proportion, so that the treatment effect on pains caused by qi stagnation, blood depression and obstruction of veins, such as limb pain, numbness and the like, can be improved. The invention adopts frankincense and myrrh at the same time, treats stubborn sores from multiple angles, has the advantages of good detumescence and acesodyne effects, quick effect of removing necrotic tissue and promoting granulation, strong anti-infection capability, quick healing and no scar after treatment.
Dragon's blood: sweet, salty and neutral in nature; heart and liver meridian entered; has effects in promoting blood circulation, relieving pain, dispelling blood stasis, stopping bleeding, healing sore, and promoting granulation; can be used for treating traumatic injury, heart and abdominal pain, traumatic hemorrhage, and unhealed skin and external diseases.
Catechu: the medicine is bitter in property, astringent and cool, enters heart and lung meridians, has the effects and effects of promoting blood circulation, treating injuries, stopping bleeding, promoting granulation, astringing dampness and healing sores, and is used for treating traumatic injuries and bleeding. Catechu has the effects of promoting blood circulation, removing blood stasis, and astringing to stop bleeding. The invention adopts the dragon's blood and the catechu at the same time, and also has the functions of promoting blood circulation, healing wounds, stopping bleeding, promoting granulation, astringing dampness and healing sores from multiple angles.
And (3) toad venom: the traditional Chinese medicine with certain toxicity plays a role of combating poison with poison in the invention, and is mainly used for detoxifying, relieving pain, inducing resuscitation and refreshing mind. It can be used for treating various pains caused by falling injury, infectious pain and tumor pain, and has analgesic effect. And can refresh the mind and induce resuscitation for patients.
Cinnabar: the toad venom supplement composition has a supplementing effect on toad venom, can stabilize the unstable emotion of a patient caused by pain, and can play a role in clearing away heat and toxic materials. It can be used for relieving mania, palpitation, vexation, insomnia, vertigo, blurred vision, and swelling and pain.
Cantharis: pungent and hot with strong toxicity entering liver, stomach and kidney meridians, and has the actions of breaking blood and resolving stasis, dissipating nodulation and eliminating mass, counteracting toxic pathogen and removing sores. The invention adopts cinnabar and cantharis at the same time, and also has the functions of detoxifying, clearing heat, attacking toxin and corroding sores from multiple angles.
And (3) red wife: detoxicating, clearing away heat, improving eyesight, refreshing brain, etc. and is mainly used in resisting bacteria, tumor, virus, blood fat, blood pressure, etc. The invention adopts the toad venom and the huechys sanguinea simultaneously, and also has the functions of detoxifying, clearing heat, inducing resuscitation and refreshing mind from multiple angles.
The components of the traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration mainly comprise the medicines for treating traumatic injury in the traditional Chinese medicine, and because the natural medicines of the compositions have certain toxicity, the toxicity is easily aggravated when the compositions are used in a matching way, and further, the toxic and side effects are very strong. If the compatibility of the components is not properly selected, the components cannot play a role in treating diseases, but cause the phenomenon that patients are poisoned and die, which is why the prior art tries to avoid or does not use the components together or at the same time. The inventor properly utilizes the effective components of the medicines by selecting the compatibility or the proportion for a long time, reduces the toxicity of the medicines in the components by a proper processing method, and improves the treatment effect of the traditional Chinese medicine composition for removing the necrotic tissue and promoting granulation.
In another aspect of the present invention, a method for preparing a traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is provided, which comprises the following steps:
step S1, selecting Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea;
the Olibanum is selected from light green, granular, natural, pollution-free, transparent, sandstone bark impurity-free, powder-sticky, and gas-fragrant Olibanum, and is produced from natural Olibanum in natural environment, preferably from middle east region including but not limited to Aman, Somali, and also Arabian peninsula. The frankincense plays the inherent roles of activating blood circulation, relieving pain, eliminating swelling and promoting tissue regeneration well.
The Olibanum is processed by vinegar-baking method, which comprises cleaning or cutting the materials, adding a certain amount of rice vinegar, parching, and baking until the surface is bright. Preferably, every 100kg of Olibanum is parched with 5kg of vinegar.
Myrrha is oleoresin from Dinghua tree, Hadi tree, or trunk of Viola tree of Oleaceae. The myrrh is mainly selected from myrrh produced in Somali, Russia and India, etc. And (4) collecting myrrh from 11 months per year to 2 months or 6-7 months next year, wherein the content of the myrrh is higher. The myrrh is prepared by naturally oozing myrrh from cracks of bark; or cutting bark of the tree, and collecting the resin which is yellow white liquid, and solidifying to obtain red brown hard block of Myrrha. After the picking, the bark and impurities are removed, and the tree is stored in a dry and ventilated place. The raw materials of the myrrh are extracted in a later stage, the myrrh used in the traditional Chinese medicine composition for removing the necrotic tissue and promoting granulation is a myrrh extract, the myrrh extract contains 25-35% of resin, 2.5-9% of volatile oil and 57-70% of gum or a melt. Extracting most of myrrh by ether, and air-drying and storing the myrrh extract; the myrrh extract was dried in air and then in the form of a block.
Sanguis Draxonis is prepared from resin exuded from fruit of daemonorops draco of Palmaceae. The material is preferably derived from java, sumatra, borneo, Indonesia. In the present invention, the dragon's blood must be compatible with the catechu.
The catechu is preferably in the form of segments obtained by collecting branches and trunks of albizia julibrissin in winter, removing outer skin, chopping into large pieces, decocting in water, concentrating, and drying. Distributed in the southern region of Yunnan province, and cultivated in Hainan province. Further, generally in 12 months to 3 months next year, collecting the dry branches of the albizia julibrissin durazzini, peeling off the outer skin, chopping into small pieces, putting the small pieces in a soil pot or a copper pot, adding water for decocting, collecting decoction, filtering, concentrating the filtrate into syrup, cooling, and pouring into a special model to obtain the catechin paste. In the present invention, the catechu paste is preferably used as a medicine.
Dried secretion of retroauricular gland and skin gland of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider of Bufo siccus family; catching Bufo siccus in summer and autumn, cleaning, squeezing white serous fluid of retroauricular gland and skin gland, and sun drying on round model or glass plate to obtain Bufonis venenum.
Cinnabar, preferably mercury sulfide (HgS) containing realgar as impurity, theoretically contains 86.2% of mercury and 13.8% of sulfur.
Mylabris, preferably dry body of Mylabris phalerata or Mylabris phalerata belonging to family Genkwaceae. Preferably caught in summer and autumn, suffocated or killed by scalding, and dried in the sun.
The huechys sanguinea is preferably dried whole insect of huechys sanguinea of Cicadidae. Captured in the open and dry period in 6-8 months per year. The red-bug can secrete venom to stimulate the skin of a person to foam, so that the red-bug is suitable for wearing gloves and masks during catching. After being caught, the mixture is steamed or baked and then dried in the sun.
Step S2, washing and processing Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea; the method specifically comprises the following component processing methods.
Step S21, processing frankincense: the method comprises the following steps:
step S211, taking raw frankincense medicinal materials, removing impurities, and crushing frankincense; preferably selecting an impurity removal mode combining manual impurity removal and mechanical impurity removal; crushing frankincense by using a spiral mill to obtain frankincense particles with the particle size of less than 2 cm, preferably less than 0.5 cm.
Step S212, vinegar mastic: heating Olibanum in pan with slow fire, parching to smoke, slightly melting surface, spraying rice vinegar, parching until the surface is glossy, and cooling. Preferably, each 100kg of frankincense is processed by vinegar in the proportion of 3 kg to 10 kg of rice vinegar; further, preferably, every 100kg of frankincense is processed by vinegar according to the proportion of 6 kg of rice vinegar; the mild fire temperature in this embodiment is preferably controlled to be any temperature between 80 degrees celsius and 260 degrees celsius, and is more preferably controlled to be any temperature between 100 degrees celsius and 180 degrees celsius. In a preferred embodiment, 50 kg of frankincense is heated for 15 to 20 minutes by adopting a slow fire at 150 ℃, and when the surface of the frankincense is slightly melted, rice vinegar sprayed by rotation is used for vinegar steaming; and (3) placing the fried vinegar frankincense in a cooling room with the temperature of 18-25 ℃, and naturally cooling. In a cool room, the ventilation and cleanness need to be kept. Vinegar processed Olibanum has effects of promoting blood circulation, relieving pain, astringing, promoting granulation, and correcting odor and taste.
Step S212 or step S212B, the incense made by rush: parching Olibanum with slow fire until the surface is slightly melted, adding medulla Junci, parching to loose texture, taking out, removing medulla Junci, and mashing. Preferably, the amount of Olibanum is 6.25kg per 100 kg. Preferably, each 100kg of frankincense is processed by using 3 kg to 10 kg of rush in a ratio; further, preferably, every 100kg of frankincense is processed by using 6.25kg of rush
Step S212 or using step S212C, boiling frankincense: melting Olibanum in water, filtering to remove sawdust and sandstone, decocting with slow fire until dripping water becomes bead and sinks, taking out, spreading on a flat plate, cutting into blocks, and cooling. The impurities in the processed Olibanum are not more than 2%.
Step S22, processing myrrh: removing impurities, and pulverizing into pieces.
Preparing myrrh: parching the cleaned Myrrha with slow fire until the surface is slightly melted, and cooling. Or parching until the surface is slightly melted, spraying rice vinegar, parching until the outer layer is bright and transparent, and cooling.
In the preferred embodiment, 3 kg to 10 kg of rice vinegar is used for vinegar processing of myrrh per 100 kg; further, preferably, every 100kg of myrrh is processed by vinegar with the proportion of 6 kg of rice vinegar; the mild fire temperature in this embodiment is preferably controlled to be any temperature between 80 degrees celsius and 260 degrees celsius, and is more preferably controlled to be any temperature between 100 degrees celsius and 180 degrees celsius. In a preferred embodiment, 50 kg of myrrh is heated for 35 to 45 minutes by adopting a slow fire at 150 ℃, rotary spraying of rice vinegar is used for vinegar steaming when the surface of the myrrh is slightly melted, and preferably, 3 jin of rice vinegar is used for every 50 jin of myrrh; and (3) placing the fried vinegar myrrh in a cooling room with the temperature of 18-25 ℃, and naturally cooling. In a cool room, the room needs to be kept ventilated and clean.
Step S23, processing dragon' S blood: taking a dragon's blood raw medicinal material, removing dust by adopting a ventilation method, removing oil stain by adopting a water washing method, drying for 30 minutes by adopting ultrasonic waves, knocking the dried dragon's blood raw medicinal material into small blocks, preferably small blocks smaller than 1cm, finely grinding the dried dragon's blood raw medicinal material into fine powder by adopting a mechanical steel grinder, and sieving the fine powder by using a 300-mesh sieve to obtain the dragon's blood fine powder for later use.
Step S24, the catechu is processed, which comprises the following steps:
and step S241, finely grinding the catechu into fine powder by a mechanical steel grinder, slowly grinding the catechu for 20 minutes at the speed of 2500 revolutions per minute, and sieving the ground catechu through a 300-mesh sieve to obtain the catechu fine powder for later use.
Step S242, dissolving Catechu in ether at a certain ratio, and extracting. Preferably, 0.5g of catechu fine powder is mixed with 30ml of diethyl ether for proportional extraction. In the extract, ultrasonic treatment is carried out for 10 minutes, and filtration is carried out to obtain the catechu extract.
Step S25, processing cantharis and huechys sanguinea:
processing cantharis: removing impurities, and removing feet and wings; heating edible semen Setariae in a pan to 160 deg.C, spraying a little water to stick rice on the pan, adding Mylabris when slight smoke is emitted, parching, taking out, and removing rice grains. In the preferred embodiment, cantharis is processed at the ratio of 10 jin to 2 jin; further, finely grinding the rice-processed cantharis into fine powder at a slow speed by using a mechanical steel grinder, and sieving the fine powder with a 300-mesh sieve to obtain the fine powder of the cantharis for later use. The grinding speed of the mechanical steel grinder is preferably 200-500 rpm, and the grinding temperature in the grinding process is kept below 50 ℃.
Processing the huechys sanguinea: removing impurities, and removing feet and wings; heating edible millet in a pot to 160 ℃, spraying a little water until the rice is stuck on the pot, adding huechys sanguinea when slight smoke is emitted, slightly stir-frying, taking out, and removing rice grains. In the preferred embodiment, the red bride is processed according to the proportion of 10 jin of red bride and 3 jin of rice; further, finely grinding the rice-processed huechys sanguinea by using a mechanical steel grinder at a slow speed into fine powder, and sieving by using a 300-mesh sieve to obtain fine huechys sanguinea powder for later use. The grinding speed of the mechanical steel grinder is preferably 200-500 rpm, and the grinding temperature in the grinding process is kept below 50 ℃.
And step S3, mixing and uniformly stirring the frankincense and the myrrh obtained in the step S2, finely grinding the frankincense and the myrrh into fine powder at a slow speed by using a mechanical steel grinder, and sieving the fine powder with a 300-mesh sieve to obtain mixed fine powder of the frankincense and the myrrh for later use. The mechanical steel mill preferably has a milling speed of 200 rpm to 500 rpm, preferably 260 rpm in one embodiment, and maintains the milling temperature below 50 degrees celsius during the milling process. The obtained fine powder of the mixture of Olibanum and Myrrha is left standing in a medicine room at a constant temperature of 25 deg.C for 15 days to 45 days, preferably 30 days, to allow them to be fully fused. In the invention, a 300-mesh sieve pore is selected for use, so that the absorption of sore wounds is facilitated, and the medicine is fused with a human body.
Step S4, mixing the dragon 'S blood obtained in the step S2 with the catechu, stirring evenly, and finely grinding into fine powder at a slow speed by using a mechanical steel grinder, or smashing and mixing by using a stone mortar, and sieving by using a 300-mesh sieve to obtain mixed fine powder of the dragon' S blood and the catechu for later use. The grinding speed of the mechanical steel mill is preferably 200 rpm to 500 rpm, in one embodiment preferably 260 rpm, and the grinding temperature during grinding is maintained below 50 degrees celsius. Standing the obtained mixed fine powder of sanguis Draxonis and Catechu in a medicine room at constant temperature of 25 deg.C for 10-25 days, preferably 15 days, to allow them to be fully fused.
And step S5, mixing the cantharis obtained in the step S2 with the huechys sanguinea, uniformly stirring, finely grinding into fine powder by using a mechanical steel grinder, and sieving by using a 600-mesh sieve to obtain mixed fine powder of the cantharis and the huechys sanguinea for later use. The grinding speed of the mechanical steel mill is preferably 2500 rpm to 5000 rpm, and in one embodiment is preferably 4000 rpm.
Step S6, mixing the fine powder of Olibanum and Myrrha obtained in step S3, the fine powder of sanguis Draxonis and Catechu obtained in step S4, and the fine powder of Mylabris and huechys sanguinea obtained in step S5 in proportion (mixing according to the drug combination proportion), and stirring and mixing uniformly by using a stirrer; the stirring speed of the stirrer is controlled as follows: the initial stirring speed is 200r/min, and the working stirring speed is 500r/min (revolutions per minute); stirring was continued for 15 to 20 minutes.
And step S7, weighing the venenum bufonis and the cinnabar in proportion, finely grinding the venenum bufonis and the cinnabar into fine powder at a slow speed by using a mechanical steel grinder, or smashing and mixing the fine powder by using a stone mortar, and sieving the mixture by using a 600-mesh sieve to obtain mixed fine powder of the venenum bufonis and the cinnabar for later use.
Step S8, mixing the mixed fine powder obtained in the step S6 with the mixed fine powder of the toad venom and the cinnabar obtained in the step S7 to obtain the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation.
In the simple step, the method comprises the step (1), the screened frankincense, the myrrh, the dragon's blood, the catechu and the cinnabar are placed into a green lycoris mortar for hammer smashing until the mixture is called as mixed paste, and the toad venom, the cantharis and the huechys sanguinea which are ground into fine powder are mixed or mixed and kneaded together with the hammer smashing into the mixed paste. And (2) blending the mixture of the mashups with the vegetable oil to form a paste after blending, wherein the viscosity of the paste should be more than 5 pascal seconds (Pa.S) and less than 15 pascal seconds (Pa.S). The vegetable oil is preferably sesame oil.
Further, in the step (1), the frankincense, the myrrh, the dragon's blood and the catechu are screened and cleaned, and are placed in a shade place for five days to be dried in the shade, and the water content of the frankincense, the myrrh, the dragon's blood and the catechu is lower than two ten-thousandth; and after the wings, legs and heads of the cantharis and the huechys sanguinea are all removed, the dried frankincense, the myrrh, the dragon's blood and the catechu are ground into fine powder and sieved by a sieve with 300 meshes.
Alternatively, the fine powder sieved through the 300 mesh sieve is mixed with sterile water into a dough-like shape, the viscosity of the dough-like shape is more than 7 pascal seconds (Pa.S) and less than 10 pascal seconds (Pa.S), and the dough-like shape is placed in a storage tank for standby.
In another embodiment of the present invention, an application of the Chinese medicinal composition for removing necrotic tissue and promoting granulation is provided, wherein one of the applications is to mix the Chinese medicinal composition for removing necrotic tissue and promoting granulation with vegetable oil to form a shape suitable for a sore or a sore hole, for example, a strip-shaped spindle medicine is processed to treat deep abscess; such deep abscesses are typically treated surgically, as opposed to prior treatment regimens, where the present invention allows for the elimination of surgery and open drainage.
In other applications, the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration can be directly spread on the surface of a sore to accelerate wound healing. Such as bedsores, ulcers, carbuncles, various burns, etc. For example, the powder of the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is sprayed on the surface of a sore, sterile gauze stained with the powder of the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation is wet-coated on the surface of the ulcer, a medical cotton pad is covered on the surface of the sterile gauze, and the plaster is pasted through an adhesive plaster.
Further, it is preferable to use vegetable oil to mix with the powder of the Chinese medicinal composition for removing necrotic tissue and promoting granulation to form a paste, apply the paste to the sore surface, and then apply the paste to the wound with sterile gauze or air-permeable non-woven fabric adhesive plaster.
On the other hand, the traditional Chinese medicine composition powder for removing the necrotic tissue and promoting tissue regeneration is mixed with vaseline or a sterile adhesive to form a flexible adhesive film layer, a PU film bottom lining layer is used as a plaster base material, and the flexible adhesive film layer is coated on the plaster base material to form a plaster patch, so that the traditional Chinese medicine composition powder is convenient to use in daily emergency. The plaster base material comprises a bottom lining layer for bearing plaster and a plaster covering layer arranged on one side of the bottom lining layer for bearing plaster, wherein the bottom lining layer is a PU film layer, and the other side of the bottom lining layer is also provided with the bottom lining covering layer. The plaster substrate is square, round, oval or polygonal. In a preferred embodiment, tear seams are provided on the plaster cover layer and the backing cover layer, respectively, to facilitate use. Additionally, the plaster covering layer is made of release paper; the material of the bottom lining covering layer is a PET film (polyester film). The traditional Chinese medicine composition plaster for removing the necrotic tissue and promoting tissue regeneration disclosed by the invention is applied to human skin by using the PU film layer as the bottom lining layer of the plaster, and the PU film has good air permeability and no stimulation, so that the skin is dry and comfortable, no skin allergy occurs, and the good water resistance of the plaster is convenient for an applicator to perform activities such as bathing, swimming exercise, object washing and the like; the high elasticity of the plaster enables the joint part of the plaster to be stretched comfortably; the good adhesiveness of the plaster does not generate raised edges, and the plaster can be continuously applied for 7 days without falling off after use, thereby achieving good treatment effect.
Furthermore, the traditional Chinese medicine composition plaster for removing the necrotic tissue and promoting tissue regeneration is prepared into a skin-friendly low-irritation plaster, and the plaster comprises a tough bottom plate layer, a flexible adhesive layer and a release film. The bottom plate layer passes through the static laminating with the adhesive layer, and the adhesive layer is kept away from the bottom plate layer one side and is equipped with the glue layer, covers at the glue layer surface from the type membrane. The bottom plate layer is made of PET (polyethylene terephthalate) and has the thickness of 0.036 cm; the adhesive layer is made of TPU material, and the thickness is 0.025 cm; the release film is made of PE material and has a thickness of 0.1 cm. The glue in the glue layer 4 is dimethyl silicone oil. An opening which is convenient to tear is arranged in the middle of the release film, and the release film is divided into two pieces by the opening. The surface of the adhesive layer is provided with air holes. The glue layer is also provided with a medicine layer.
In the following, the mouse comparison test of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration and the acne paste commonly used in the prior art is as follows:
experimental materials: selecting 20 SD rats with the body weights of 190-220 g; the same portion of the rat back was shaved (3X 3 cm) 2 ) Respectively injecting anesthetic into abdominal cavities of rats, performing contusion on shaved areas of the rats by adopting a sharp knife, and continuously performing modeling for 3 times; applying gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and gram-negative bacteria such as Escherichia coli, influenza, and Streptococcus pyogenes to the contusionHaemophilus, and the like. Dividing the molded rats into 4 groups of 5 rats, wherein the first group is coated with the traditional Chinese medicine composition ointment for removing the necrotic tissue and promoting tissue regeneration prepared by the invention; the second group was coated with a commercially available ciprofloxacin cream; the third group is coated with erythromycin ointment; the fourth group is coated with ointment of Artocarpus heterophyllus; once every 7 days for 21 consecutive days. The results are shown in Table 1. The longitudinal length and the transverse length of the wound surface of each group of rats are measured by a vernier caliper, the scab area of the wound surface is calculated, the scab removing healing time of each group of rats is recorded, and the average value is calculated.
Table 1: contusion healing condition comparison table
As can be seen from the table 1, compared with the control group, the traditional Chinese medicine composition ointment for removing the necrotic tissue and promoting tissue regeneration of the invention has the advantages of faster healing of the contusion and shortening of the healing time.
The traditional Chinese medicine composition ointment for removing the necrotic tissue and promoting tissue regeneration is used for curing patients as follows: the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared into a plaster or a patch shape to cover the sore surface.
After a certain Liu, 35 years old men and the right thigh of the man are contused for a large area, the ointment of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration basically heals within 3 weeks, and the ointment heals after being continuously applied for two weeks, so that surface scars are not seen.
The plum is a certain woman of 37 years old, the toes of the woman are squeezed by a machine to be injured, and the plum is basically healed within 4 weeks after the ointment of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is applied.
The traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration can be used for treating various surgical wounds such as furuncle, innominate toxic swelling, erysipelas and the like; the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared into a plaster-shaped patch, and the plaster-shaped patch is covered on the surface of a sore, has strong penetrability, and can promote blood circulation to remove blood stasis, and relieve swelling and pain. Furthermore, the invention is used for treating various sores, stubborn sores, carbuncle-abscess, back-developing, erysipelas, furuncle, fistula, ulceration and suppuration and various stubborn sores which are not healed by wound ulcer for many years, and particularly the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared into a strip shape to form a spindle medicine for removing the necrotic tissue and promoting the tissue regeneration, wherein the spindle medicine in the strip shape is suitable for deep abscess, hole shapes or fistula shapes and can be deeply placed into the deep abscess holes or fistula to achieve the curative effect.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 40-160 parts of frankincense, 20-80 parts of myrrh, 20-80 parts of dragon's blood, 15-40 parts of catechu, 10-20 parts of venenum bufonis, 10-80 parts of cinnabar, 50-100 parts of cantharis and 60-150 parts of huechys sanguinea.
2. The traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration according to claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 60-120 parts of frankincense, 30-60 parts of myrrh, 30-60 parts of dragon's blood, 18-36 parts of catechu, 6-24 parts of toad venom, 12-48 parts of cinnabar, 30-60 parts of cantharis and 30-60 parts of huechys sanguinea.
3. The traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration as claimed in claim 2, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of frankincense, 5 parts of myrrh, 5 parts of dragon's blood, 3 parts of catechu, 1 part of venenum bufonis, 2 parts of cinnabar, 5 parts of cantharis and 5 parts of huechys sanguinea.
4. The composition of claim 2, which comprises vegetable oil, and is mixed with the ground powder of the composition of claims 1-3 to form a paste.
5. A preparation method of a traditional Chinese medicine composition for removing necrotic tissue and promoting tissue regeneration is characterized by comprising the following steps:
step S1, selecting Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea;
step S2, washing and processing Olibanum, Myrrha, sanguis Draxonis, Catechu, Bufonis venenum, Cinnabaris, Mylabris, and huechys sanguinea;
step S3, mixing and uniformly stirring the frankincense and the myrrh obtained in the step S2, finely grinding the frankincense and the myrrh into fine powder at a slow speed by using a mechanical steel grinder, and sieving the fine powder by using a 300-mesh sieve to obtain mixed fine powder of the frankincense and the myrrh for later use;
step S4, mixing the dragon 'S blood and the catechu obtained in the step S2, stirring uniformly, finely grinding into fine powder at a slow speed by using a mechanical steel grinder, or smashing and mixing by using a stone mortar, and sieving by using a 300-mesh sieve to obtain mixed fine powder of the dragon' S blood and the catechu for later use;
step S5, the cantharis obtained in the step S2 and the huechys sanguinea are mixed and stirred uniformly, finely ground into fine powder by using a mechanical steel grinder, and sieved by a 600-mesh sieve to obtain mixed fine powder of the cantharis and the huechys sanguinea for later use;
step S6, mixing the fine powder of Olibanum and Myrrha obtained in step S3, the fine powder of sanguis Draxonis and Catechu obtained in step S4, and the fine powder of Mylabris and huechys sanguinea obtained in step S5 in proportion;
step S7, weighing venenum Bufonis and Cinnabaris in proportion, and finely grinding into fine powder at slow speed by mechanical steel grinder;
and step S8, mixing the mixed fine powder obtained in the step S6 with the mixed fine powder of the toad venom and the cinnabar obtained in the step S7 to obtain the traditional Chinese medicine composition for removing necrotic tissue and promoting granulation.
6. The method for preparing a Chinese medicinal composition for removing necrotic tissue and promoting granulation as claimed in claim 5, wherein the washing and processing of Olibanum in step S2 comprises the following steps:
step S211, taking the raw medicinal materials of frankincense, removing impurities, and crushing the frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212, putting the vinegar-processed frankincense into a pot, heating the pot with slow fire, frying until smoke is produced, spraying rice vinegar on the surface of the pot, frying until the surface of the pot is glossy, and taking out the pot to cool.
7. The method for preparing a Chinese medicinal composition for removing necrotic tissue and promoting granulation as claimed in claim 5, wherein the washing and processing of Olibanum in step S2 comprises the following steps:
step S211, taking raw frankincense medicinal materials, removing impurities, and crushing frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212B, frankincense preparation with rush: parching Olibanum with slow fire until the surface is slightly melted, adding medulla Junci, parching to loose texture, taking out, removing medulla Junci, and mashing.
8. The method for preparing a Chinese medicinal composition for removing necrotic tissue and promoting granulation as claimed in claim 5, wherein the washing and processing of Olibanum in step S2 comprises the following steps:
step S211, taking the raw medicinal materials of frankincense, removing impurities, and crushing the frankincense; crushing frankincense by using a spiral grinder to obtain frankincense particles with the particle size of less than 2 cm;
step S212C, boiling frankincense: melting Olibanum in water, filtering to remove sawdust and sandstone, decocting with slow fire until dripping water becomes bead and sinks, taking out, spreading on a flat plate, cutting into blocks, and cooling.
9. The application of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is characterized in that the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is made into a strip shape, and the strip shape is suitable for the shape of a deep abscess hole or a fistula so as to be deeply placed into the deep abscess hole or the fistula.
10. The application of the traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is characterized in that the prepared traditional Chinese medicine composition for removing the necrotic tissue and promoting tissue regeneration is prepared into a plaster or a patch shape to cover the sore surface.
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Non-Patent Citations (2)
| Title |
|---|
| 李学声: "秘方抓虎丹", 辽宁中医杂志, no. 12, 31 December 1982 (1982-12-31), pages 145 - 114 * |
| 李春深: "实用临床抗肿瘤中药", 天津科学技术出版社, pages: 145 - 114 * |
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