CN105497869A - Medicine composition for treating acute cervicitis and preparation method thereof - Google Patents
Medicine composition for treating acute cervicitis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating acute cervicitis and a preparation method thereof. The medicine composition is prepared from traditional Chinese medicine ingredients and western medicine ingredients. The traditional Chinese medicine ingredients include rhizome of Blue plantainlily, pistacia weinmannifolia, rhizome of antiotrema dunnianum, all-grass of hippuris vulgaris, pig skin, camellia oleifera oil, alysicarpus vaginalis, mollugo lotoides, roots or leaves of tecomaria capensis, Chinese pholidota herbs, herba dendrobii, rhizome of largeleaf Japanese ginseng, lily bulb extract and fewflower lysionotus herb extract. The western medicine ingredients include josamycin propionate, acetylsalicylic acid, polystictus glycopeptides and vitamin C. Traditional Chinese medicine theories and western medicine theories are combined, medicine is applied according to symptoms, matching is scientific, and the medicine composition has the effects of clearing heat to nourish yin, eliminating stasis to subdue swelling, promoting blood circulation to remove meridian obstruction, resolving dampness to relieve pain and resisting bacteria to diminish inflammations, has a remarkable curative effect on gynecological diseases such as a fever due to yin deficiency, urinary tract infection and acute and chronic cervicitis, is small in irritation, high in safety and low in production cost, and has high medical value and good application prospect.
Description
Technical field
The present invention relates to department of obstetrics and gynecology medical art, particularly relate to a kind of pharmaceutical composition for the treatment of acute cervicitis and preparation method thereof.
Background technology
Acute cervicitis is primarily of caused by the pathogen Diplococcus gonorrhoeae of sexually transmitted disease (STD) and chlamydia trachomatis.The more rare medical worker in addition of the acute cervicitis caused by staphylococci streptococci enterococcus is careless, leaves over the acidity of gauze and unsuitable use high concentration or alkaline medicine liquid washing vagina etc. and all can cause acute cervicitis in birth canal; When during some operation on cervix, the damage of cervix dilating or perforation and diagnostic scrape uterus, the damage of cervix uteri or palace body is also one of cause of disease of acute cervicitis.
Clinical common acute cervicitis is mucopurulent cervicitis, is characterized in that naked eyes see purulence or mucus purulent secretion on cervical canal or cervical canal cotton swab specimen; Chlamydia trachomatis and Diplococcus gonorrhoeae is mainly but the part MPC cause of disease is unclear with easily bringing out cervical canal internal hemorrhage MPC pathogen during cotton swab wiping cervical canal.
Leucorrhoea grow in quantity is that acute cervicitis is modal, sometimes or even only symptom, often in purulence.Deposit with urethritis, cystitis or acute vaginitis, acute endometritis etc. because cervicitis is normal, often make other symptoms of cervicitis be covered, as hypogastric region in various degree, lumbosacral region pendant bitterly and irritation sign of bladder etc.During acute gonococcal cervicitis, fever in various degree and leukocytosis can be had.
At present, treatment acute cervicitis, mainly based on Western medicine, generally adopts the local corrosion such as silver nitrate, chromic acid more, this Therapeutic Method side effect is large, and only little for rotten to the corn face, that inflammatory infiltration is more shallow patient's effect is better, for the patient that morbidity is heavier, effect is bad; Also to have and adopt Chinese material bathe, but therapeutic effect is all undesirable.So development is a kind of safe and effective, the medicine being used for the treatment of acute cervicitis had no side effect is exactly the problem to be solved in the present invention.
Summary of the invention
The technical problem that the present invention solves is to provide a kind of pharmaceutical composition for the treatment of acute cervicitis and preparation method thereof.
For solving the problems of the technologies described above, the technical solution adopted in the present invention is:
A kind of pharmaceutical composition for the treatment of acute cervicitis, be made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Rhizoma Hostae ventricosae 52 ~ 71 parts, purple 48 ~ 66 parts, oil wood, trillium grass 44 ~ 59 parts, Herba Hippuridis Vulgaris 40 ~ 54 parts, Corii Sus domestica 39 ~ 50 parts, oil tea oil 36 ~ 47 parts, Canis familiaris L. ant grass 35 ~ 45 parts, Glinus lotoides 32 ~ 41 parts, Radix seu Folium Tecomariae Capensis 29 ~ 38 parts, Pseudobulbus Pholidotae Chinensis 18 ~ 27 parts, Herba Dendrobii 16 ~ 22 parts, Rhizoma panacis majoris 10 ~ 17 parts, Bulbus Lilii extract 5 ~ 8 parts, Herba Lysionoti Pauciflori extract 3 ~ 5 parts; Described western medicine composition is: Jomybel 0.2 ~ 0.4 part, aspirin 0.2 ~ 0.3 part, Polystictus Glycopeptide 0.1 ~ 0.2 part, vitamin C 0.1 ~ 0.2 part.
Further, described treatment acute cervicitis pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Rhizoma Hostae ventricosae 61.5 parts, purple 57 parts, oil wood, trillium grass 51.5 parts, Herba Hippuridis Vulgaris 47 parts, Corii Sus domestica 44.5 parts, oil tea oil 41.4 parts, Canis familiaris L. ant grass 40 parts, Glinus lotoides 36.5 parts, Radix seu Folium Tecomariae Capensis 33.5 parts, Pseudobulbus Pholidotae Chinensis 22.5 parts, Herba Dendrobii 19 parts, Rhizoma panacis majoris 13.5 parts, Bulbus Lilii extract 6.5 parts, Herba Lysionoti Pauciflori extract 4 parts; Described western medicine composition is: Jomybel 0.3 part, aspirin 0.25 part, Polystictus Glycopeptide 0.15 part, vitamin C 0.15 part.
Further, described Bulbus Lilii extract is Lilium brownie, its preparation method is: get Bulbus Lilii dry product, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie, Lilium brownie is insoluble to acetone soln and diethyl ether solution, has nourishing YIN and moistening the lung, the effect of clearing away heart-fire for tranquillization, and for deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
Further, described Herba Lysionoti Pauciflori extract is fatty acid compound, its preparation method is: get fresh Herba Lysionoti Pauciflori, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, Herba Lysionoti Pauciflori extract fatty acid compound can not only clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, promoting blood flow to regulate menstruation, for leptospirosis, and rheumatalgia, menoxenia, leucorrhea etc., and energy can be provided for body.
Further, described aspirin is synthesized by salicylic acid and acetic anhydride, synthetic method is: salicylic acid powder and acetic anhydride liquid by solid-to-liquid ratio 1g:2ml under the condition of 80 DEG C of heating in water bath, add oxalic acid powder relative to salicylic acid 0.5 times of quality as catalyst, continuous stirring, reaction 60min ~ 70min, then the cold water of 10 DEG C relative to reactant liquor 15 ~ 20 times of weight is added after at room temperature leaving standstill 10min, and water-bath cools 20 ~ 25min in the cold water of 10 DEG C, until no longer include crystal sucking-off, sucking filtration supernatant liquid, and wash the crystal of separating out with the cold water of 10 DEG C, the crystal of gained is acetyl salicylic acid crude, then in crude product, add the ethyl acetate relative to crude product 10 ~ 12 times of weight and 2 perpleexites, be placed in reflux heating and refluxing extraction 2 ~ 3h, then extracting solution is filtered, filtrate is cooled to 20 ~ 24 DEG C of crystallizes, collected by suction crystal, then with the ethyl acetate washing crystal relative to crystal 1 ~ 1.5 times of weight separated out, the clear crystal of dry gained is aspirin.
Further, the preparation method of the pharmaceutical composition of described treatment acute cervicitis is:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 45 ~ 65 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 5 ~ 7h relative to mixing medical material 4 ~ 5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4 ~ 5 times of weight, then slow fire heating extraction is used instead 3 ~ 4 hours, repeat said extracted step 2 ~ 3 time, merge extractive liquid, then extracting solution is spray dried at 75 ~ 85 DEG C the extractum that relative density is 0.95 ~ 1.05, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition.
Further, the pharmaceutical composition of described treatment acute cervicitis is made capsule, capsule can cover bitterness and the stink of medicine discomfort, makes that it is clean and tidy, attractive in appearance, easily swallows.
Further, the pharmaceutical composition for the treatment of acute cervicitis is made the preparation method of capsule, comprises the following steps:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 45 ~ 65 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 5 ~ 7h relative to mixing medical material 4 ~ 5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4 ~ 5 times of weight, then slow fire heating extraction is used instead 3 ~ 4 hours, repeat said extracted step 2 ~ 3 time, merge extractive liquid, then extracting solution is spray dried at 75 ~ 85 DEG C the extractum that relative density is 0.95 ~ 1.05, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition;
(5) adjuvant is added in pharmaceutical composition obtained in step (4), the microcrystalline Cellulose of 11 ~ 13 parts is as diluent, 7 ~ 9 parts of carboxymethyl starch sodium as disintegrating agent, 6 ~ 9 parts of Pulvis Talci as lubricant, mix homogeneously is placed in granulator and granulates, powder moisture is dried to lower than 3% at 55 ~ 65 DEG C, sterilizing, and then incapsulate shell, make capsule; Microcrystalline Cellulose white, odorless, tasteless, not there is fibroid and mobility is extremely strong, be widely used in pharmaceutical preparation, mainly in oral capsule, be used as diluent; Carboxymethyl starch sodium has stronger water absorption and dilatancy, comparatively fast can steep in cold water and rise, and grain expansion and not dissolving after water suction, do not form colloid solution, do not hinder the continuation of moisture to infiltrate and affect the further disintegrate of tablet, therefore can be used as the superdisintegrantes of insoluble drugs and soluble agents; Pulvis Talci have nontoxic, tasteless, taste is soft, the strong feature of smoothness, as lubricant.
The pharmacologically active of the present invention's each medicine raw material is as follows:
Purple oil wood: [nature and flavor] micro-hardship, puckery, cool.[function cures mainly] heat-clearing and toxic substances removing, astringing to arrest bleeding; Cure mainly dysentery, enteritis, diarrhoea, traumatic hemorrhage, skin infection eczema.
Rhizoma Hostae ventricosae: [nature and flavor] are bitter; Pungent; Cool [function cures mainly] heat-clearing and toxic substances removing; Eliminating stasis to stop pain; Hemostasis; Lower a fishbone or other bone caught in the throat.Main laryngopharynx swelling and pain; Carbuncle skin infection; Traumatic injury; Stomachache; Toothache; Spit blood; Metrorrhagia; A fishbone or other bone caught in the throat.
Trillium grass: [nature and flavor] are bitter, micro-sweet, cool.[function cures mainly] clearing away heat and nourishing YIN, removing toxic substances; For fever due to yin deficiency, urinary tract infection, hepatitis; Stomatitis is controlled in external, sore swollen toxin.
Herba Hippuridis Vulgaris: [nature and flavor] micro-sweet, bitter, cold.[function cures mainly] antitussive, soothing liver-QI, cooling blood for hemostasis, YIN nourishing and the production of body fluid promoting, deep steaming; Cure mainly high hot excessive thirst, tuberculosis is coughed, the hot hectic fever due to YIN-deficiency of consumptive disease, pain in the hypochondrium, gastroenteritis etc.
Corii Sus domestica: [nature and flavor] are sweet, cool.[function cures mainly] controls few cloudy dysentery, clearing away heat and nourishing YIN; Sore-throat relieving; Hemostasis; Main cloudy exopathogenic heat dysentery; Pharyngalgia; Spit blood; Blood is defeated in battle; Menoxenia; Metrorrhagia
Oil tea oil: [nature and flavor] are cool in nature, sweet in the mouth.[function cures mainly] clearing away heat and eliminating dampness, parasite killing detoxifies.For eruptive disease stomachache, acute ascarid obstructive intestinal obstruction, scabies, burn and scald.
Canis familiaris L. ant grass: [nature and flavor] are sweet is bitter, flat.[function cures mainly] promoting blood circulation to remove obstruction in the collateral, clearing away heat and eliminating dampness, refutes atrophic debility of bones and swells, removing the necrotic tissue and promoting granulation.
Glinus lotoides: [nature and flavor] are light; Cool in nature.[function cures mainly] clearing away heat and eliminating dampness; Removing toxic substances and promoting subsidence of swelling; Main diarrhea due to damp-heat; Cold cough; Rubella; Furuncle; Conjunctival congestion and swelling pain.
Radix seu Folium Tecomariae Capensis: [nature and flavor] are cool in nature, and mildly bitter flavor is pungent.[function cures mainly] heat clearing and inflammation relieving, dissipating blood stasis for subsidence of swelling.Control pulmonary tuberculosis, pneumonia, bronchitis, asthma, laryngopharynx swelling and pain, traumatic injury, swelling and pain due to blood stasis.
Pseudobulbus Pholidotae Chinensis: [nature and flavor] are sweet, light, cool.[function cures mainly] clearing away heat and nourishing YIN, preventing phlegm from forming and stopping coughing.For cough due to lung-heat, pulmonary tuberculosis hemoptysis, tuberculous lymphadenitis, infantile malnutrition, taste-blindness rate; Chronic osteomyelitis is controlled in external.
Herba Dendrobii: [nature and flavor] are sweet, are slightly cold.[function cures mainly] reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.
Rhizoma panacis majoris: [nature and flavor] are bitter sweet, cold.[function cures mainly] yin nourishing, lung heat clearing, dissipating blood stasis, hemostasis, analgesic therapy.Control calentura excessive thirst, cough due to yin deficiency, consumptive disease wound is spitted blood, epistaxis, pharyngalgia, rheumatic arthritis, infantile convulsion, traumatic injury.
Bulbus Lilii extract: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded; Clearing away heat and eliminating dampness, depressed liver-energy dispersing and function of gallbladder promoting; Main jaundice; Painful abdominal mass is amassed; Women leucorrhea.
Herba Lysionoti Pauciflori extract: clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, promoting blood flow to regulate menstruation.For cough, bronchitis, dysentery, leptospirosis, rheumatalgia, traumatic injury, menoxenia, leucorrhea.
Jomybel: be applicable to pharyngitis that micrococcus scarlatinae causes and tonsillitis, sinusitis caused by sensitive organism, otitis media, acute bronchitis and abscess of mouth, pneumonia caused by mycoplasma pneumoniae, the skin soft-tissue infection that sensitive bacterial causes, also can be used for the staphy lococcus infection to penicillin, erythromycin-resistant.
Aspirin: heat clearing away is antipyretic, for heating, headache, neuralgia, toothache, menstrual pain, myalgia, arthralgia etc.
Polystictus Glycopeptide: strengthen immune function of human body, Selective depression tumor, obvious leukocyte increasing and platelet, have antiviral, infection, defying age, radioprotective, resisting fatigue, the effects such as blood fat reducing.Be applicable to chronic hepatitis B, liver cirrhosis, hepatic injury, malignant tumor, Radiotherapy chemotherapy and Post operation leukopenia, urinary tract infection, immunologic hypofunction, have a delicate constitution, dizzy, weak, indigestion and loss of appetite, listless etc.
Vitamin C: vitamin C participates in the synthesis of amino acid metabolism, the synthesis of neurotransmitter, collagen protein and histiocyte interstitial, the permeability of blood capillary can be reduced, accelerate solidifying of blood, stimulate coagulation function, promote that ferrum is at intestinal absorption, impelling rate and blood-lipid decreased, increasing the resistance to infecting, promote that the quick growth of cell is to accelerating wound.
Compared with prior art, beneficial effect of the present invention is embodied in: the present invention can play effect of clearing away heat and nourishing YIN, dissipating blood stasis for subsidence of swelling, promoting blood circulation to remove obstruction in the collateral, removing dampness pain relieving, anti-inflammation effectively by selected plurality of Chinese, Chinese medicine extract, combined with westem metronidazole, aspirin, Polystictus Glycopeptide, acetylspiramycin again, the slight illness of sufferer can be alleviated fast, the development of effective blocking-up or reverse acute cervicitis, improves immunity of organisms; By the combination of Chinese and Western medicine, treating both the principal and secondary aspects of a disease, to fever due to yin deficiency, the gynaecopathias such as urinary tract infection, acute and chronic cervicitis are evident in efficacy, and this pharmaceutical composition zest is little, and safety is high, and production cost is low, has good market using value.
Detailed description of the invention
Embodiment 1:
A kind of pharmaceutical composition for the treatment of acute cervicitis, be made up of Chinese medicine ingredients and western medicine composition, component meter by weight, Chinese medicine ingredients is: Rhizoma Hostae ventricosae 52 parts, purple 48 parts, oil wood, trillium grass 44 parts, Herba Hippuridis Vulgaris 40 parts, Corii Sus domestica 39 parts, oil tea oil 36 parts, Canis familiaris L. ant grass 35 parts, Glinus lotoides 32 parts, Radix seu Folium Tecomariae Capensis 29 parts, Pseudobulbus Pholidotae Chinensis 18 parts, Herba Dendrobii 16 parts, Rhizoma panacis majoris 10 parts, Bulbus Lilii extract 5 parts, Herba Lysionoti Pauciflori extract 3 parts; Western medicine composition is: Jomybel 0.2 part, aspirin 0.2 part, Polystictus Glycopeptide 0.1 part, vitamin C 0.1 part.
Described a kind of pharmaceutical composition for the treatment of acute cervicitis is made the preparation method of capsule, comprises the following steps:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 45 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 5h relative to mixing medical material 4 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4 times of weight, then slow fire heating extraction is used instead 3 hours, repeat said extracted step 2 time, merge extractive liquid, then extracting solution is spray dried at 75 DEG C the extractum that relative density is 0.95, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 times of weight, then the volumetric concentration adding 4 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14h, then centrifugal, centrifugation rate is 600r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition;
(5) adjuvant is added in pharmaceutical composition obtained in step (4); the microcrystalline Cellulose of 11 parts is as diluent; 7 parts of carboxymethyl starch sodium as disintegrating agent, 6 parts of Pulvis Talci as lubricant; mix homogeneously is placed in granulator and granulates; be dried to powder moisture lower than 3% at 55 DEG C, sterilizing, and then incapsulate shell; make capsule, every 1.0g.
Embodiment 2: a kind of pharmaceutical composition for the treatment of acute cervicitis, be made up of Chinese medicine ingredients and western medicine composition, component meter by weight, Chinese medicine ingredients is: Rhizoma Hostae ventricosae 61.5 parts, purple 57 parts, oil wood, trillium grass 51.5 parts, Herba Hippuridis Vulgaris 47 parts, Corii Sus domestica 44.5 parts, oil tea oil 41.5 parts, Canis familiaris L. ant grass 40 parts, Glinus lotoides 36.5 parts, Radix seu Folium Tecomariae Capensis 33.5 parts, Pseudobulbus Pholidotae Chinensis 22.5 parts, Herba Dendrobii 19 parts, Rhizoma panacis majoris 13.5 parts, Bulbus Lilii extract 6.5 parts, Herba Lysionoti Pauciflori extract 4 parts; Western medicine composition is: Jomybel 0.3 part, aspirin 0.25 part, Polystictus Glycopeptide 0.15 part, vitamin C 0.15 part
Described a kind of pharmaceutical composition for the treatment of acute cervicitis is made the preparation method of capsule, comprises the following steps:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 55 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 6h relative to mixing medical material 4.5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4.5 times of weight, then slow fire heating extraction is used instead 3.5 hours, repeat said extracted step 2 time, merge extractive liquid, then extracting solution is spray dried at 80 DEG C the extractum that relative density is 1.00, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 6 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2.5 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 27 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4.5 times of weight, then the volumetric concentration adding 5 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 15h, then centrifugal, centrifugation rate is 700r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 12.5min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3.5 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 7h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition;
(5) adjuvant is added in pharmaceutical composition obtained in step (4); the microcrystalline Cellulose of 12 parts is as diluent; 8 parts of carboxymethyl starch sodium as disintegrating agent, 7.5 parts of Pulvis Talci as lubricant; mix homogeneously is placed in granulator and granulates; be dried to powder moisture lower than 3% at 60 DEG C, sterilizing, and then incapsulate shell; make capsule, every 1.0g.
Embodiment 3: a kind of pharmaceutical composition for the treatment of acute cervicitis, be made up of Chinese medicine ingredients and western medicine composition, component meter by weight, Chinese medicine ingredients is: Rhizoma Hostae ventricosae 71 parts, purple 66 parts, oil wood, trillium grass 59 parts, Herba Hippuridis Vulgaris 54 parts, Corii Sus domestica 50 parts, oil tea oil 47 parts, Canis familiaris L. ant grass 45 parts, Glinus lotoides 41 parts, Radix seu Folium Tecomariae Capensis 38 parts, Pseudobulbus Pholidotae Chinensis 27 parts, Herba Dendrobii 22 parts, Rhizoma panacis majoris 17 parts, Bulbus Lilii extract 8 parts, Herba Lysionoti Pauciflori extract 5 parts; Western medicine composition is: Jomybel 0.4 part, aspirin 0.3 part, Polystictus Glycopeptide 0.2 part, vitamin C 0.2 part.
Described a kind of pharmaceutical composition for the treatment of acute cervicitis is made the preparation method of capsule, comprises the following steps:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 65 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 7h relative to mixing medical material 5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 5 times of weight, then slow fire heating extraction is used instead 4 hours, repeat said extracted step 3 time, merge extractive liquid, then extracting solution is spray dried at 85 DEG C the extractum that relative density is 1.05, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 5 times of weight, then the volumetric concentration adding 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 16h, then centrifugal, centrifugation rate is 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 15min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori younger sister extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition;
(5) adjuvant is added in pharmaceutical composition obtained in step (4); the microcrystalline Cellulose of 13 parts is as diluent; 9 parts of carboxymethyl starch sodium as disintegrating agent, 9 parts of Pulvis Talci as lubricant; mix homogeneously is placed in granulator and granulates; be dried to powder moisture lower than 3% at 65 DEG C, sterilizing, and then incapsulate shell; make capsule, every 1.0g.
Clinical treatment case:
1. clinical case is selected
1.1 choice criteria: choose the acute cervicitis patient that certain hospital clinical is accepted for medical treatment.
1.2 select and divide into groups: inventor collects 180 routine acute cervicitis patients altogether, is divided into three groups at random, often organizes 60 people.
2. test method:
Give three groups of patients capsule using the embodiment of the present invention 1, embodiment 2 and embodiment 3 to prepare respectively, every day three times, each two panels.5 days courses for the treatment of, be used in conjunction 3 courses for the treatment of.
3. criterion of therapeutical effect and therapeutic outcome
3.1 criterion of therapeutical effect
(1) fully recover: the various symptoms of cervicitis all disappear;
(2) effective: leucorrhea reduces, soreness of waist colic symptoms disappears, urine urgency-frequency transference cure;
(3) invalid: symptom is not improved, or have the trend increased the weight of.
3.2 therapeutic outcomes:
| Group | Recovery from illness | Effectively | Invalid | Untoward reaction | Total effective rate % |
| Embodiment 1 | 54 | 3 | 3 | 0 | 95 |
| Embodiment 2 | 57 | 2 | 1 | 0 | 98.3 |
| Embodiment 3 | 56 | 2 | 2 | 0 | 96.7 |
4. conclusion: in clinical trial process, the patient accepting Drug therapy of the present invention finds no any untoward reaction, as seen from the data in Table 1, the total effective rate of medicine of the present invention to acute cervicitis reaches more than 95%, it is the safe and effective medicine of acute cervicitis, and instant effect, without any side effects, there is good clinical meaning.
Typical case:
Mrs Dai in case 1:25 year always feels lower abdominal pain two months ago, is all uncomfortable in any case, also often with the leucorrhea that pus is thick.Symptom is initial, thinks it is that work is tired out, has some tonic more and should be able to recover after a while.But As time goes on, pain is not only felt any better but also has been occurred frequent micturition, urgent micturition, all be unable to do without lavatory, and leucorrhoea grow in quantity is thick or purulence, sometimes can carry the blood streak secretly; After taking a course for the treatment of of medicine of capsule prepared by the embodiment of the present invention 1, patients symptomatic obviously alleviates, and after taking 3 courses for the treatment of continuously, patient recovers, and follows up a case by regular visits to, do not recur after one month.
Mrs Tang in case 2:26 year was once abortion before 2 years, after surgery due to do not note maintenance and have a rest, infectd acute cervicitis, the Mrs Later Tang Dynasty to examination in hospital, and treat under the guidance of doctor, by using antibiotic and external used medicine to treat, but effect is not very desirable, and year term Mrs Tang thinks pregnancy after marriage, but do not cherish in half a year always, and dense thick leucorrhea is gradually many, lower abdominal pain, urine urgency-frequency; Start to take the medicine of capsule prepared by the embodiment of the present invention 2 afterwards, one the course for the treatment of Mrs Later Tang Dynasty various symptoms alleviate, full recovery after three courses for the treatment of, pays a return visit after three months, not only do not recur, and Mrs Tang is conceived smoothly.
Case 3:24 year Mrs Yang, before 3 years, artificial abortion is crossed once, marries 2 years, does not take any contraceptives unpregnancy so far, pruritus vulvae and scorching hot, also has the soreness of waist and hypogastric region pendant pain and occasional to occur the symptoms such as postcoital bleeding in addition; Menstruation rule, in amount, the black dull and dysmenorrhea of color, non-menstrual period are always with dense thick leucorrhea, diagnosis is found to be the secondary infertility that acute cervicitis causes, after taking a course for the treatment of of medicine of capsule prepared by the embodiment of the present invention 3, pruritus vulvae and scorching hot, the soreness of waist and hypogastric region pendant pain disappear, and leucorrhea reduces, after taking three courses for the treatment of continuously, the all symptoms of patient all take a turn for the better, and pay a return visit after half a year, conceived one month of patient.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. treat the pharmaceutical composition of acute cervicitis for one kind, it is characterized in that, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, described Chinese medicine ingredients is: Rhizoma Hostae ventricosae 52 ~ 71 parts, purple 48 ~ 66 parts, oil wood, trillium grass 44 ~ 59 parts, Herba Hippuridis Vulgaris 40 ~ 54 parts, Corii Sus domestica 39 ~ 50 parts, oil tea oil 36 ~ 47 parts, Canis familiaris L. ant grass 35 ~ 45 parts, Glinus lotoides 32 ~ 41 parts, Radix seu Folium Tecomariae Capensis 29 ~ 38 parts, Pseudobulbus Pholidotae Chinensis 18 ~ 27 parts, Herba Dendrobii 16 ~ 22 parts, Rhizoma panacis majoris 10 ~ 17 parts, Bulbus Lilii extract 5 ~ 8 parts, Herba Lysionoti Pauciflori extract 3 ~ 5 parts, described western medicine composition is: Jomybel 0.2 ~ 0.4 part, aspirin 0.2 ~ 0.3 part, Polystictus Glycopeptide 0.1 ~ 0.2 part, vitamin C 0.1 ~ 0.2 part.
2. a kind of pharmaceutical composition for the treatment of acute cervicitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is made up of Chinese medicine ingredients and western medicine composition, component meter by weight, Chinese medicine ingredients is: Rhizoma Hostae ventricosae 61.5 parts, purple 57 parts, oil wood, trillium grass 51.5 parts, Herba Hippuridis Vulgaris 47 parts, Corii Sus domestica 44.5 parts, oil tea oil 41.5 parts, Canis familiaris L. ant grass 40 parts, Glinus lotoides 36.5 parts, Radix seu Folium Tecomariae Capensis 33.5 parts, Pseudobulbus Pholidotae Chinensis 22.5 parts, Herba Dendrobii 19 parts, Rhizoma panacis majoris 13.5 parts, Bulbus Lilii extract 6.5 parts, Herba Lysionoti Pauciflori extract 4 parts; Western medicine composition is: Jomybel 0.3 part, aspirin 0.25 part, Polystictus Glycopeptide 0.15 part, vitamin C 0.15 part.
3. a kind of pharmaceutical composition for the treatment of acute cervicitis as described in claim 1 ~ 2 any one, it is characterized in that, described Bulbus Lilii extract is Lilium brownie, its preparation method is: get Bulbus Lilii dry product, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie.
4. a kind of pharmaceutical composition for the treatment of acute cervicitis as described in claim 1 ~ 2 any one, it is characterized in that, described Herba Lysionoti Pauciflori extract is fatty acid compound, its preparation method is: get fresh Herba Lysionoti Pauciflori, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound.
5. a kind of pharmaceutical composition for the treatment of acute cervicitis as described in Claims 1 to 4 any one, is characterized in that, the preparation method of described pharmaceutical composition is:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 45 ~ 65 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 5 ~ 7h relative to mixing medical material 4 ~ 5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4 ~ 5 times of weight, then slow fire heating extraction is used instead 3 ~ 4 hours, repeat said extracted step 2 ~ 3 time, merge extractive liquid, then extracting solution is spray dried at 75 ~ 85 DEG C the extractum that relative density is 0.95 ~ 1.05, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Radix Rosae Platyphyllae extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition.
6. a kind of pharmaceutical composition for the treatment of acute cervicitis as claimed in claim 5, is characterized in that, described pharmaceutical composition is made capsule.
7. a kind of preparation method for the treatment of the medicament composition capsule agent of acute cervicitis as claimed in claim 6, is characterized in that, comprise the following steps:
(1) Rhizoma Hostae ventricosae is taken according to described proportioning, purple oil wood, trillium grass, Herba Hippuridis Vulgaris, Corii Sus domestica, oil tea oil, Canis familiaris L. ant grass, Glinus lotoides, Radix seu Folium Tecomariae Capensis, Pseudobulbus Pholidotae Chinensis, Herba Dendrobii, Rhizoma panacis majoris, the baking oven being placed in 45 ~ 65 DEG C is dried to all medical material water content lower than 3%, then the water soaking medical material 5 ~ 7h relative to mixing medical material 4 ~ 5 times of weight is added, add again after boiling with high heat and continue to boil relative to the water of mixing medical material 4 ~ 5 times of weight, then slow fire heating extraction is used instead 3 ~ 4 hours, repeat said extracted step 2 ~ 3 time, merge extractive liquid, then extracting solution is spray dried at 75 ~ 85 DEG C the extractum that relative density is 0.95 ~ 1.05, decompression spraying dry makes extract powder, cross 100 mesh sieves, for subsequent use,
(2) Bulbus Lilii dry product is got, be crushed to 100 orders, adding relative to the volumetric concentration of Bulbus Lilii powder 5 ~ 7 times of weight is the ethanol of 85%, heating in water bath reflux, extract, 3 times, each extraction 2 ~ 3 hours, merge extractive liquid, by extracting solution concentration and recovery ethanol to ethanol content lower than 1%, then deionized water dissolving is added, leave standstill 24 ~ 30 hours, filter, filtrate is joined on macroporous adsorptive resins and adsorb, and then add and do not washed off the removing such as saccharide by the material adsorbed relative to the water of filtrate 4 ~ 5 times of weight, then the volumetric concentration adding 4 ~ 6 times of resin volumes is the adsorbent on the ethanol-eluting resin column of 70%, collect eluent, be condensed into extractum, add the anhydrous alcohol solution relative to extractum 3 times of weight, acetone-diethyl ether solution is added while continuous stirring, described acetone-diethyl ether solution be by mass concentration be 24% acetone soln and mass concentration be 24% diethyl ether solution be acetone-diethyl ether solution that 1:1 is mixed with by volume, stop immediately adding when just there is white flock precipitate, leave standstill 14 ~ 16h, then centrifugal, centrifugation rate is 600 ~ 800r/min, get the supernatant, add the above-mentioned acetone-diethyl ether solution relative to supernatant 3 times of weight, leave standstill the completely rear collecting precipitation of 10 ~ 15min question response, drying precipitated Lilium brownie, for subsequent use,
(3) fresh Herba Lysionoti Pauciflori is got, wrap in fat-free filter paper, put into the extraction tube of apparatus,Soxhlet's, the petroleum ether solution relative to Herba Lysionoti Pauciflori 3 ~ 4 times of weight is added in extraction flask, heating extraction bottle, petroleum ether is gasified, the petroleum ether of gasification is risen by connection tube and enters into condenser, congealing into after liquid instills in extraction tube, extract the fatty acid compound dissolving and contain in Herba Lysionoti Pauciflori, in pipe to be extracted petroleum ether liquid level reach with siphon equal altitudes after, the petroleum ether being dissolved with fatty acid compound flows back to extraction flask through siphon, the petroleum ether flowed back in extraction flask continues by heating and gasifying, rise, condensation, in instillation extraction tube, circulation 6 ~ 8h like this, reclaim the petroleum ether in extraction flask, remaining solid is Herba Lysionoti Pauciflori extract fatty acid compound, for subsequent use,
(4) take the obtained Herba Lysionoti Pauciflori extract of the obtained Bulbus Lilii extract of step (2), step (3) and Western medicine Jomybel by described proportioning, extract powder that aspirin, Polystictus Glycopeptide, vitamin C obtain with step (1) mixs homogeneously, sterilizing, obtains described pharmaceutical composition;
(5) adjuvant is added in pharmaceutical composition obtained in step (4); the microcrystalline Cellulose of 11 ~ 13 parts is as diluent; 7 ~ 9 parts of carboxymethyl starch sodium as disintegrating agent, 6 ~ 9 parts of Pulvis Talci as lubricant; mix homogeneously is placed in granulator and granulates; powder moisture is dried to lower than 3% at 55 ~ 65 DEG C; sterilizing, and then incapsulate shell, make capsule.
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| CN1876051A (en) * | 2005-06-07 | 2006-12-13 | 贵阳云岩西创药物科技开发有限公司 | Chinese medicinal preparation for treating gynecological disease, its preparation process and quality control method |
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| CN1876051A (en) * | 2005-06-07 | 2006-12-13 | 贵阳云岩西创药物科技开发有限公司 | Chinese medicinal preparation for treating gynecological disease, its preparation process and quality control method |
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| VAN DEN BOSSCHE: "Characterization of impurities in josamycin using dual liquid chromatography combined with mass spectrometry.", 《REACTIONS WEEKLY》 * |
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