CN105497742A - Traditional Chinese medicine composition for treating ulcerative colitis and preparation method of traditional Chinese medicine composition for treating ulcerative colitis - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating ulcerative colitis. The traditional Chinese medicine composition is composed of rhizoma bletillae, herba portulacae, radix codonopsis pilosulae, rhizoma atractylodis macrocephalae, hyacinth bean, semen coicis, fructus amomi, dried radix rehmanniae, fructus corni, rhizoma dioscoreae, poria cocos, fructus lycii, radix paeoniae alba, radix sanguisorbae, herba agrimoniae, flos sophorae, cornu bubali, cortex moutan, radix rehmanniae, fructus gardeniae preparata and/or pharmaceutically acceptable carriers. The traditional Chinese medicine composition has efficacies of gut purging, dampness dissipating, kidney and liver nourishing, Qi regulating, blood circulation promoting, stasis removing, diarrhea relieving and the like and used for treatment of symptoms including stomachache, diarrhea, tenesmus, bloody mucopurulent stool and the like caused by ulcerative colitis.

Description

A kind of Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof.

Background technology

Ulcerative colitis has another name called chronic non-specific ulcerative colitis, based on the shallow property of table that is straight, colon, nonspecific inflammation disease, with the disease of the outer multiple organ injury of intestinal, think that primary disease is relevant with inherited genetic factors at present, be basic with autoimmune mechanism, infection, neural factors are inducement, and pathological changes is mainly at rectum, sigmoid colon.First be the diffuse inflammation change of mucosa shallow-layer.Then hyperemia, edema, plumpness and fragility increase, and produce aphtha, and then develop into large ulcer, and late period, intestinal wall was thickening, narrow, intestinal tube shortens due to colon's hypertrophy.Light-duty patient often has left lower quadrant or full abdominal pressure pain to accompany borborygmus hyperfunction.Heavy and fulminant type patient can have tension of abdominal muscle, rebound tenderness, maybe can touch sigmoid colon and descending colon that spasm or intestinal wall thicken.Digital rectal examination often has tenderness.

The primary disease state of an illness is comparatively obstinate, the normal sustainable existence of symptom or the chronic course of disease replaced in interval stage of attack and catabasis.Concrete clinical manifestation has:

Onset is slow, many in chronic, unresolved, repeated relapsing, minority burst onset, in continuing advances or fulminant mistake

Journey.

Digestive system manifestation: suffer from abdominal pain and suffer from diarrhoea the most common, stomachache is positioned at left lower quadrant, and dull pain, angor, alleviate after an action of the bowels.Suffer from diarrhoea the most common with mucopurulent bloody stool, every day for several times to 10 times not etc., often accompany tenesmus.Still there are Nausea and vomiting, inappetence.

General Symptoms: anemia, becomes thin, hypoproteinemia, Electrolyte imbalance, anxiety.

Intestinal shows outward: often have arthritis, erythema nodosum, chronic active hepatitis, oral ulcer etc.

Left lower quadrant tenderness, some patients can touch streak thickening or the intestinal tube of spasm.

The prevention of primary disease should keep happy, and be careful in one's diet joint, and daily life often has, avoids fatigue.Give up tobacco and wine, diet Fructus Capsici, freezing, raw and cold food, prevention intestinal infection.

The traditional Chinese medical science thinks that ulcerative colitis belongs to " dysentery ", " having loose bowels ", " hemorrhoidal hamorrhage ", the category such as " lower profit ", think that the sick position of primary disease is at intestinal, relevant with the internal organs such as liver, spleen, stomach, intestinal.From the beginning of how because feelings will is smooth, depression of liver-QI, violates and taste; Or because of eating and drinking without temperance, surfeit delicious food, or because of the multiple diet raw food of damp and hot body so that spleen injury, cause dysfunction of the spleen in transportation, clear QI being mixed up with turbid QI; Or because experiencing the heresy of heat-damp in summer pyretic toxicity, thus accumulate in Shi Re Bing Pian, tenesmus intestinal, coagulation of QI-blood, stop up and suppurate; With the passing of time hemorrhage, also must hematozemia impairment of YIN.Prolonged illness people network, can cause blood-stasis internal-depression; Sick deficiency of spleen-YANG and kidneyYANG for a long time, and clear YANG failing to ascend sinking of QI of middle-JIAO, temperature fortune is unable and stomach closes not solid.

This disease is divided into six types by the traditional Chinese medical science:

Insufficiency of the spleen damp-heat type: diarrhoea, not etc., tenesmus, or burning sensation of the anus, do not hold mucus sanguinopurulent under the arm just to number of times in feces, and taste is smelt as of rotten fish, stomachache, oliguria with reddish urine, weakly becomes thin, and heating, bitter taste is indigestion and loss of appetite.Yellowish fur, thready,rolling and rapid pulse.Insufficiency of the spleen resulting in production of dampness, strongly fragrant and generate heat, injure intestinal, the development of evil in febrile disease is not normal, then have diarrhoea, and number of times is not etc.; Damp and hot stifling intestinal, venation is injured, stagnation of QI-blood, turns to pus and blood, therefore holds mucus sanguinopurulent in feces under the arm just, and taste is smelt as of rotten fish; Damp and hot heresy is stopped up in stagnant intestinal, and functional activity of QI being not smooth, then have stomachache, tenesmus; Damp invasion of lower energizer, burning sensation of the anus, oliguria with reddish urine; Deficiency-weakness of spleen-QI, visible spiritlessness and weakness, indigestion and loss of appetitely to become thin; Heating bitter taste, yellowish fur are resembling of retention of damp-heat in the interior; Insufficiency of the spleen then thready pulse; Slippery and rapid pulse is damp and hot pulse condition.

Liver-yang hyperactivity spleen weak type: namely stomachache rush down, and rushes down rear alleviation of pain, often show effect because depression is angry, nervous or exciting, stool folder pus and blood, fullness and distention in the chest and hypochondrium, irritable, dim gas is indigestion and loss of appetite, intestinal toot abdominal distention, does during headache.Light red tongue, stringy and thready pulse.Damaged by excess of seven emotions, liver is lost bar and reaches, functional activity of QI being not smooth, and perverse and unreasonable manner violates spleen, and strong fortune mistake department, causes stomachache namely to be rushed down, rush down rear alleviation of pain, often does the stagnant blood resistance of vapour because feelings will is uncomfortable, stops up and suppurate, can have stool folder pus and blood; Liver-yang hyperactivity then fullness and distention in the chest and hypochondrium, irritable, headache time do; The stagnation of QI is belch, borborygmus abdominal distention then; Insufficiency of the spleen then indigestion and loss of appetite light red tongue, stringy and thready pulse is insufficiency of the spleen the levying of liver-yang hyperactivity.

Stasis blocking intestinal type: abdominal part twinge, very, normal folder pus and blood or atropurpureus clot in stool, complexion is dark dim for the pain of pressing.Tongue is dim red, has purpura, thready and stringy pulse.Stasis blocking intestinal, functional activity of QI being not smooth, therefore have few abdomen to twinge, the pain of pressing is very; Qi depression to blood stasis, stops up and suppurates, therefore often presss from both sides pus and blood or atropurpureus clot in stool; Dark dim, the tongue of complexion dim red, have purpura, thready and stringy pulse is resembling for qi depression to blood stasis.

Due to weakness of spleen and stomach: stool is warded off thin, can hold mucus under the arm, or be mixed with a large amount of intestinal dirt, pus and blood, very then have loose bowels more than, namely improper diet has outbreak, weak asthenia, inappetence, pale complexion.Pale tongue with white fur, soft and thready pulse.Weakness of the spleen and stomach, failure of the spleen to transport and transform, indigestion, clear QI being mixed up with turbid QI, therefore large loose stool is thin, or held mucus under the arm, or be mixed with a large amount of intestinal dirt.Pus and blood, very then have loose bowels more than, namely improper diet has outbreak; Weakness of the spleen and stomach, biochemical weary source, deficiency of both QI and blood, visible weak asthenia, inappetence, pale complexion; Pale tongue with white fur, arteries and veins scholar levying carefully for weakness of the spleen and stomach.

Type of YIN-deficiency and interior-heat: do during diarrhoea, dull pain in abdomen, bright bloody stool is sticky, often with hectic fever in the afternoon, night sweat, dysphoria and insomnia.Red tongue is few bitter, thready and rapid pulse.Chronic diarrhea is not healed, and injures cloudy blood, and can have during diarrhoea and do, dull pain in abdomen, bright bloody stool is sticky; The raw interior-heat of the deficiency of YIN, therefore have hectic fever in the afternoon, night sweat; The deficiency-heat disturbance mind, then dysphoria and insomnia; Red tongue is few bitter, and thready and rapid pulse is resembling for yin asthenia generating intrinsic heat.

Yang deficiency of spleen and stomache: before dawn, borborygmus abdominal pain diarrhea, then pacifies after rushing down, and defecates for mucus blood sample, and namely meeting trembles with fear sends out, and coldness of the body with chills, tastelessness anorexia, desire for hot drinks, the soreness of waist is weak, pale complexion.Pale tongue with white fur, deep,thready and forceless pulse.Have loose bowels with the passing of time, kidney yang deficiency, can not be needle warming moxibustion, dysfunction of the spleen in transportation and transformation, hypofunction of YANG QI before dawn, more severe YIN-cold, therefore abdominal pain diarrhea before having dawn, be also called " diarrhea before dawn "; Rush down rear internal organs gas tonneau, therefore then pacify after rushing down; Phlegm stagnancy, QI and blood is condensed, and injures intestinal network, then stool is mucus blood sample; The raw endogenous cold of yang deficiency, namely visible chance is cold sends out, coldness of the body with chills; Insufficiency of kidney-YANG, then the soreness of waist is weak; Deficiency of spleen-YANG loses surveys tastelessness anorexia, desire for hot drinks; Pale complexion; Pale tongue with white fur, deep,thready and forceless pulse is resembling of deficiency of spleen-YANG and kidneyYANG.

This disease of the decoction for the treatment of traditional Chinese medical science Bian bowel relieving removing dampness, nourishing the kidney and liver, vital energy regualting and blood circulation-promoting, removing blood stasis antidiarrheal.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of ulcerative colitis.The present invention also aims to the preparation method that this Chinese medicine composition a kind of is provided.

In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of ulcerative colitis, be made up of effective ingredient and pharmaceutically acceptable carrier, described effective ingredient is made up by weight of following raw materials according:

Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part Rhizoma Atractylodis Macrocephalae 20-30 part Fructus Amomi 10-15 part Rhizoma Dioscoreae 20-30 part Radix Paeoniae Alba 10-20 part Flos Sophorae water 10-20 part Radix Rehmanniae 20-30 part

Herba Portulacae 5-10 part flat See 5-10 part Radix Rehmanniae 10-25 part Poria 15-25 part Radix Sanguisorbae 15-25 part horn film 5-10 part Fructus Gardeniae 10-20 part

Radix Codonopsis 15-20 part Semen Coicis 15-25 part Fructus Corni 10-20 part Fructus Lycii 10-25 part Herba Agrimoniae 10-15 part Cortex Moutan 15-20 part

Effective ingredient is preferably made up by weight of following raw materials according:

26 parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) 16 parts of Rhizoma Atractylodis Macrocephalaes 26 parts of Fructus Amomis 13 portions of Rhizoma Dioscoreaes 26 portions of Radix Paeoniae Albas 25 parts of Flos Sophorae water 16 parts of Radix Rehmanniae

Fructus Gardeniae 16 parts

Present invention also offers a kind of preparation method of this Chinese medicine composition, comprise the steps:

Radix Codonopsis, that Rhizoma Dioscoreae powder is broken into impalpable powder is for subsequent use;

Fructus Amomi, the Radix Paeoniae Alba, the Radix Rehmanniae 60% alcohol reflux secondary, each one hour, gradation filtered, merging filtrate, and concentrating under reduced pressure becomes relative density to be the clear paste of 1.15 (60 ° of C);

The Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Portulacae, the Rhizoma Atractylodis Macrocephalae, Seem Lablab Album, Semen Coicis, Radix Rehmanniae, Fructus Corni, Poria, Fructus Lycii, Radix Sanguisorbae, Herba Agrimoniae, Flos Sophorae water, horn film, Cortex Moutan, Fructus Gardeniae decoct with water secondary, each 2 hours, filter, merging filtrate, leave standstill 48 hours, get supernatant, concentrating under reduced pressure becomes relative density to be the thick paste of 1.20 (60 ° of C), adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with the carrier of pharmaceutical acceptable, such as: filler is as starch, microcrystalline Cellulose etc.;

Binding agent is as vitamin derivative, starch etc.; Used by the mode of granule, capsule, tablet oral administration.

Chinese medicine composition of the present invention has the effects such as bowel relieving removing dampness, nourishing the kidney and liver, vital energy regualting and blood circulation-promoting, removing blood stasis antidiarrheal, for the disease such as stomachache, diarrhoea, tenesmus, mucopurulent bloody stool that ulcerative colitis causes.

Detailed description of the invention

Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.

Embodiment 1

Chinese medicinal composition granules of the present invention

Radix Codonopsis 180g, that Rhizoma Dioscoreae 260g is ground into impalpable powder is for subsequent use;

Fructus Amomi 130g, Radix Paeoniae Alba 250g, Radix Rehmanniae 260g 60% alcohol reflux secondary, each one hour, gradation filtered, merging filtrate, and concentrating under reduced pressure becomes relative density to be the clear paste of 1.15 (60 ° of C);

Pseudobulbus Bletillae (Rhizoma Bletillae) 160g, Herba Portulacae 80g, Rhizoma Atractylodis Macrocephalae 260g, Seem Lablab Album 80g, Semen Coicis 210g, Radix Rehmanniae 180g, Fructus Corni 160g, Poria 200g, Fructus Lycii 180g, Radix Sanguisorbae 210g, Herba Agrimoniae 130g, Flos Sophorae water 160g, horn film 80g, Cortex Moutan 180g, Fructus Gardeniae 160g decocts with water secondary, each 2 hours, filter, merging filtrate, leave standstill 48 hours, get supernatant, concentrating under reduced pressure becomes relative density to be the thick paste of 1.20 (60 ° of C), add above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 1000g, lactose 200g, mixing, with 75% ethanol wet granulation, pack and get final product.

Embodiment 2

Chinese medicinal composition capsules agent of the present invention

Radix Codonopsis 180g, that Rhizoma Dioscoreae 260g is ground into impalpable powder is for subsequent use;

Fructus Amomi 130g, Radix Paeoniae Alba 250g, Radix Rehmanniae 260g 60% alcohol reflux secondary, each one hour, gradation filtered, merging filtrate, and concentrating under reduced pressure becomes relative density to be the clear paste of 1.15 (60 ° of C);

Pseudobulbus Bletillae (Rhizoma Bletillae) 160g, Herba Portulacae 80g, Rhizoma Atractylodis Macrocephalae 260g, Seem Lablab Album 80g, Semen Coicis 210g, Radix Rehmanniae 180g, Fructus Corni 160g, Poria 200g, Fructus Lycii 180g, Radix Sanguisorbae 210g, Herba Agrimoniae 130g, Flos Sophorae water 160g, horn film 80g, Cortex Moutan 180g, Fructus Gardeniae 160g decoct with water secondary, each 2 hours, filter, merging filtrate, leave standstill 48 hours, get supernatant, concentrating under reduced pressure becomes relative density to be the thick paste of 1.20 (60 ° of C), add above-mentioned fine powder and clear paste, dry, pulverize into fine powder, add dextrin 650g, mixing, loads in capsulae vacuus and get final product.

Embodiment 3

Chinese medicine composition tablet of the present invention

Radix Codonopsis 180g, that Rhizoma Dioscoreae 260g is ground into impalpable powder is for subsequent use;

Fructus Amomi 130g, Radix Paeoniae Alba 250g, Radix Rehmanniae 260g 60% alcohol reflux secondary, each one hour, gradation filtered, merging filtrate, and concentrating under reduced pressure becomes relative density to be the clear paste of 1.15 (60 ° of C);

Pseudobulbus Bletillae (Rhizoma Bletillae) 160g, Herba Portulacae 80g, Rhizoma Atractylodis Macrocephalae 260g, Seem Lablab Album 80g, Semen Coicis 210g, Radix Rehmanniae 180g, Fructus Corni 160g, Poria 200g, Fructus Lycii 180g, Radix Sanguisorbae 210g, Herba Agrimoniae 130g, Flos Sophorae water 160g, horn film 80g, Cortex Moutan 180g, Fructus Gardeniae 160g decoct with water secondary, each 2 hours, filter, merging filtrate

Leave standstill 48 hours, get supernatant, concentrating under reduced pressure becomes relative density to be the thick paste of 1.20 (60 ° of C), adds above-mentioned fine powder and clear paste, dry, pulverize into fine powder, add starch 300g, microcrystalline Cellulose 200g, with 70% ethanol wet granulation, tabletting, coating and get final product.

Claims (4)

1. treat a Chinese medicine composition for ulcerative colitis, be made up of effective ingredient and pharmaceutically acceptable carrier, it is characterized in that, described effective ingredient is made up by weight of following raw materials according.

2. Pseudobulbus Bletillae (Rhizoma Bletillae) 10-20 part Rhizoma Atractylodis Macrocephalae 20-30 part Fructus Amomi 10-15 part Rhizoma Dioscoreae 20-30 part Radix Paeoniae Alba 10-20 part Flos Sophorae water 10-20 part Radix Rehmanniae 20-30 part

The flat aobvious 5-10 part Radix Rehmanniae 10-25 part Poria 15-25 part Radix Sanguisorbae 15-25 part horn film 5-10 part Fructus Gardeniae 10-20 part of Herba Portulacae 5-10 part

Radix Codonopsis 15-20 part Semen Coicis 15-25 part Fructus Corni 10-20 part Fructus Lycii 10-25 part Herba Agrimoniae 10-15 part Cortex Moutan 15-20 part

Chinese medicine composition as claimed in claim 1, is characterized in that described effective ingredient is made up by weight of following raw materials according.

3. the Chinese medicine composition as described in as arbitrary in claim 1-2, is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet.

4. a preparation method for the Chinese medicine composition as described in as arbitrary in claim 1-3, comprises the steps

Radix Codonopsis, that Rhizoma Dioscoreae powder is broken into impalpable powder is for subsequent use;

Fructus Amomi, the Radix Paeoniae Alba, the Radix Rehmanniae 60% alcohol reflux secondary, each one hour, gradation filtered, merging filtrate, and concentrating under reduced pressure becomes relative density to be the clear paste of 1.15 (60 ° of C);

The Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Portulacae, the Rhizoma Atractylodis Macrocephalae, Seem Lablab Album, Semen Coicis, Radix Rehmanniae, Fructus Corni, Poria, Fructus Lycii, Radix Sanguisorbae, Herba Agrimoniae, Flos Sophorae water, horn film, Cortex Moutan, Fructus Gardeniae decoct with water secondary, each 2 hours, filter, merging filtrate, leave standstill 48 hours, get supernatant, concentrating under reduced pressure becomes relative density to be the thick paste of 1.20 (60 ° of C), adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.