CN101288744A - Chinese medicinal composition for treating ulcerative colitis and its preparation method - Google Patents
Chinese medicinal composition for treating ulcerative colitis and its preparation method Download PDFInfo
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- CN101288744A CN101288744A CNA2008101116936A CN200810111693A CN101288744A CN 101288744 A CN101288744 A CN 101288744A CN A2008101116936 A CNA2008101116936 A CN A2008101116936A CN 200810111693 A CN200810111693 A CN 200810111693A CN 101288744 A CN101288744 A CN 101288744A
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Abstract
The invention relates to a Chinese medicine combination for treating ulcerative colitis, which is made from bupleurum, hyacinth bean, scutellaria, radix aucklandiae, alum, bletilla striata, herba patriniae, humifuse euphorbia, pulsatilla chinensis, yam, lotus seed, cinnamon, atractylodes, schisandra chinensis and/or acceptable vectors in medicine. The invention also relates to the preparation method of the Chinese medicine combination. The Chinese medicine combination of the invention has the functions of clearing away heat and toxic materials, dissipating dampness and eliminating lag, supporting the spleen and restricting the liver, checking diarrhea and stopping pains, etc. and is used for chronic repeatedly onset symptoms caused by the ulcerative colitis, such as diarrhea, mucous bloody stool or mucopurulent stool, fever, anemia, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of Chinese medicine composition for the treatment of ulcerative colitis and preparation method thereof.
Background technology
Ulcerative colitis claims chronic non-specific ulcerative colitis again, is a kind of mucous membrane of colon and submucosal inflammatory process of being confined to.The sick multidigit that gets also may extend to descending colon in sigmoid colon and rectum, even whole colon.Pathological changes mainly is positioned at the mucous layer of colon, and based on ulcer, involves rectum and far-end colon more, but can be to proximal spread, so that spread all over whole colon.The course of disease is very long, and state of an illness weight differs, and stage of attack and catabasis alternately occur, or is persistence and increases the weight of gradually.Primary disease is found in any age, but with 20~30 years old for seeing more, the man is slightly more than the woman.China's sickness rate more abroad is low, and primary disease seemingly has increase trend in recent years.
The clinical manifestation of primary disease mainly contains:
1. onset is slow, is chronic, delay property more, repeated relapsing, and minority burst onset is progress or the fulminant process of continuing.
2. digestive system performance: stomachache and diarrhoea are the most common, and stomachache is positioned at left lower quadrant, and dull pain, angor are alleviated after an action of the bowels.Diarrhoea is the most common with mucopurulent bloody stool, and do not wait to 10 times every day for several times, often accompanies tenesmus.Nauseating, vomiting, inappetence are still arranged.
3. General Symptoms: anemia, become thin hypoproteinemia, Water-Electrolyte disorder, anxiety.
4. intestinal shows outward: arthritis is often arranged, erythema nodosum, chronic active hepatitis, oral ulcer etc.
5. left lower quadrant tenderness, part patient can touch streak thickening or the intestinal tube of spasm.
6. if any complication corresponding performance is arranged then.
The cause of disease of ulcerative colitis is unclear fully as yet, thinks that at present the primary disease morbidity is unusual mainly due to immunologic mechanism, and cell, humoral immune reaction all participate in, and relevant with inherited genetic factors.Direct stimulation, fatigue, drinking and eating irregularly mostly are the outbreak inducement of primary disease.The traditional Chinese medical science thinks that ulcerative colitis belongs to categories such as " dysentery ", " having loose bowels ", " having blood in stool ".The sick position of primary disease is at intestinal, and is relevant with internal organs such as liver, spleen, stomach, intestinal.From the beginning of how not smooth because of feelings will, depression of liver-QI is violated and taste; Or because of eating and drinking without temperance, the surfeit delicious food, or, cause dysfunction of the spleen in transportation, clear QI being mixed up with turbid QI because of multiple diet raw food of damp and hot body so that spleen injury; Or because of experiencing the heresy of heat-damp in summer pyretic toxicity, thereby accumulate in the damp and hot malicious heresy, the tenesmus intestinal, coagulation of QI-blood is stopped up and is suppurated; With the passing of time hemorrhage, also must the hematozemia impairment of YIN.Prolonged illness people network can cause blood-stasis internal-depression; Sick deficiency of spleen-YANG and kidneyYANG for a long time, and clear YANG failing to ascend sinking of QI of middle-JIAO, temperature fortune is unable and stomach closes solid.
The traditional Chinese medical science is divided into six types with this disease:
1. insufficiency of the spleen damp-heat type: diarrhoea, number of times does not wait, and tenesmus, or burning sensation of the anus are held the mucus sanguinopurulent under the arm just in the feces, and flavor is stench, stomachache, oliguria with reddish urine, weak becoming thin, heating, bitter taste is indigestion and loss of appetite.Yellowish fur, thready,rolling and rapid pulse.
2. liver-yang hyperactivity spleen weak type: stomachache is promptly rushed down, and rushes down the back alleviation of pain, normal angry, nervous or exciting the outbreak because of depression, and stool folder pus and blood, fullness and distention in the chest and hypochondrium, irritated irritability, heating installation is indigestion and loss of appetite, and intestinal toot abdominal distention is done during headache.Light red tongue, stringy and thready pulse.
3. the stasis of blood hinders the intestinal type: abdominal part twinge, the pain of pressing are very often pressed from both sides pus and blood or atropurpureus clot in the stool, complexion is dark dim.Tongue is dim red, and purpura is arranged, thready and stringy pulse.
4. due to weakness of spleen and stomach: stool is warded off thin, can hold mucus under the arm, or be mixed with a large amount of intestinal dirts, pus and blood, and it is more than very then to have loose bowels, and improper diet promptly has outbreak, weak asthenia, inappetence, pale complexion.Pale tongue with white fur, soft and thready pulse.
5. type of YIN-deficiency and interior-heat: do during diarrhoea, dull pain in the abdomen, bright bloody stool is sticky, often with hectic fever in the afternoon, night sweat, dysphoria and insomnia.Red tongue is few bitter, thready and rapid pulse.
6. yang deficiency of spleen and stomache: before dawn, the borborygmus abdominal pain diarrhea, peace then after rushing down, defecating is the mucus blood sample, meet coldly promptly to send out, coldness of the body with chills, the tastelessness anorexia, desire for hot drinks, the soreness of waist is weak, pale complexion.Pale tongue with white fur, deep,thready and forceless pulse.
The traditional Chinese medical science adopts disappear stagnant, subduing the hyperfunction of the liver of heat-clearing and toxic substances removing, removing dampness to hold up spleen, this disease of antidiarrheal analgesic decoction for the treatment.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of ulcerative colitis.
The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.
In order to realize purpose of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of ulcerative colitis, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:
Radix Bupleuri 15-25 part Seem Lablab Album 10-20 part Radix Scutellariae 10-15 part
Radix Aucklandiae 5-10 part Alumen 5-10 part Pseudobulbus Bletillae (Rhizoma Bletillae) 20-25 part
Herba Patriniae 10-20 part Herba Euphorbiae Humifusae 10-25 part Radix Pulsatillae 15-25 part
Rhizoma Dioscoreae 15-20 part Semen Nelumbinis 10-20 part Cortex Cinnamomi 20-30 part
Rhizoma Atractylodis Macrocephalae 10-15 part Fructus Schisandrae Chinensis 25-30 part
Effective ingredient is preferably made by weight by following raw materials according:
13 parts of 16 parts of Radix Scutellariaes of 21 portions of Seem Lablab Albums of Radix Bupleuri
23 parts of 8 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 8 parts of Alumen of the Radix Aucklandiae
20 parts of 18 portions of Radix Pulsatillaes of 16 parts of Herba Euphorbiae Humifusaes of Herba Patriniae
26 parts of 16 portions of Cortex Cinnamomis of 18 parts of Semen Nelumbinis of Rhizoma Dioscoreae
28 parts of 13 parts of Fructus Schisandrae Chinensis of the Rhizoma Atractylodis Macrocephalae
The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:
(1) Alumen, Rhizoma Dioscoreae powder are broken into impalpable powder, and be standby;
(2) Radix Aucklandiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri, Seem Lablab Album, Radix Scutellariae, Herba Patriniae, Herba Euphorbiae Humifusae, the Radix Pulsatillae, Semen Nelumbinis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
Chinese medicine composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.
Chinese medicine composition of the present invention has disappear stagnant, subduing the hyperfunction of the liver of heat-clearing and toxic substances removing, removing dampness and holds up effects such as spleen, antidiarrheal pain relieving, is used for the diseases such as diarrhoea, mucus hemafecia or bloody purulent stool, heating, anemia of the chronic outbreak repeatedly that ulcerative colitis causes.
The specific embodiment:
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1: Chinese medicinal composition granules of the present invention
(1) Alumen 80g, Rhizoma Dioscoreae 180g are ground into impalpable powder, and be standby;
(2) Radix Aucklandiae 80g, Pseudobulbus Bletillae (Rhizoma Bletillae) 230g, Fructus Schisandrae Chinensis 280g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 210g, Seem Lablab Album 160g, Radix Scutellariae 130g, Herba Patriniae 160g, Herba Euphorbiae Humifusae 180g, Radix Pulsatillae 200g, Semen Nelumbinis 160g, Cortex Cinnamomi 260g, Rhizoma Atractylodis Macrocephalae 130g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add lactose 400g, dextrin 800g, mixing sieves, with 75% ethanol wet granulation, drying, pack promptly.
Embodiment 2: Chinese medicinal composition capsules agent of the present invention
(1) Alumen 80g, Rhizoma Dioscoreae 180g are ground into impalpable powder, and be standby;
(2) Radix Aucklandiae 80g, Pseudobulbus Bletillae (Rhizoma Bletillae) 230g, Fructus Schisandrae Chinensis 280g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 210g, Seem Lablab Album 160g, Radix Scutellariae 130g, Herba Patriniae 160g, Herba Euphorbiae Humifusae 180g, Radix Pulsatillae 200g, Semen Nelumbinis 160g, Cortex Cinnamomi 260g, Rhizoma Atractylodis Macrocephalae 130g decoct with water secondary, each 2 hours, filter merging filtrate, left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, dry, be ground into fine powder, add dextrin 700g mixing, in the capsulae vacuus of packing into promptly.
Embodiment 3: Chinese medicine composition tablet of the present invention
(1) Alumen 80g, Rhizoma Dioscoreae 200g are ground into impalpable powder, and be standby;
(2) Radix Aucklandiae 80g, Pseudobulbus Bletillae (Rhizoma Bletillae) 230g, Fructus Schisandrae Chinensis 280g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri 210g, Seem Lablab Album 160g, Radix Scutellariae 130g, Herba Patriniae 160g, Herba Euphorbiae Humifusae 180g, Radix Pulsatillae 200g, Semen Nelumbinis 160g, Cortex Cinnamomi 260g, Rhizoma Atractylodis Macrocephalae 130g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, tabletting, coating are promptly.
Claims (4)
1, a kind of Chinese medicine composition for the treatment of ulcerative colitis is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:
Radix Bupleuri 15-25 part Seem Lablab Album 10-20 part Radix Scutellariae 10-15 part
Radix Aucklandiae 5-10 part Alumen 5-10 part Pseudobulbus Bletillae (Rhizoma Bletillae) 20-25 part
Herba Patriniae 10-20 part Herba Euphorbiae Humifusae 10-25 part Radix Pulsatillae 15-25 part
Rhizoma Dioscoreae 15-20 part Semen Nelumbinis 10-20 part Cortex Cinnamomi 20-30 part
Rhizoma Atractylodis Macrocephalae 10-15 part Fructus Schisandrae Chinensis 25-30 part.
2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:
13 parts of 16 parts of Radix Scutellariaes of 21 portions of Seem Lablab Albums of Radix Bupleuri
23 parts of 8 portions of Pseudobulbus Bletillae (Rhizoma Bletillae)s of 8 parts of Alumen of the Radix Aucklandiae
20 parts of 18 portions of Radix Pulsatillaes of 16 parts of Herba Euphorbiae Humifusaes of Herba Patriniae
26 parts of 16 portions of Cortex Cinnamomis of 18 parts of Semen Nelumbinis of Rhizoma Dioscoreae
28 parts of 13 parts of Fructus Schisandrae Chinensis of the Rhizoma Atractylodis Macrocephalae.
3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.
4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:
(1) Alumen, Rhizoma Dioscoreae are broken into impalpable powder, and be standby;
(2) Radix Aucklandiae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Fructus Schisandrae Chinensis are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;
(3) Radix Bupleuri, Seem Lablab Album, Radix Scutellariae, Herba Patriniae, Herba Euphorbiae Humifusae, the Radix Pulsatillae, Semen Nelumbinis, Cortex Cinnamomi, the Rhizoma Atractylodis Macrocephalae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2402021A1 (en) * | 2010-06-30 | 2012-01-04 | Industrial Technology Research Institute | Pharmaceutical composition for treating or releiving inflammatory bowel disease |
CN104758724A (en) * | 2015-03-26 | 2015-07-08 | 柳晖 | Traditional Chinese medicine composition for treating colitis |
CN104918627A (en) * | 2012-07-03 | 2015-09-16 | 庆熙大学校产学协力团 | Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases |
-
2008
- 2008-05-15 CN CNA2008101116936A patent/CN101288744A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2402021A1 (en) * | 2010-06-30 | 2012-01-04 | Industrial Technology Research Institute | Pharmaceutical composition for treating or releiving inflammatory bowel disease |
US9060989B2 (en) | 2010-06-30 | 2015-06-23 | Industrial Technology Research Institute | Method for treating or relieving inflammatory bowel disease |
CN104918627A (en) * | 2012-07-03 | 2015-09-16 | 庆熙大学校产学协力团 | Pharmaceutical composition having preventative or treatment effect on inflammatory bowel diseases |
CN104918627B (en) * | 2012-07-03 | 2020-01-07 | 庆熙大学校产学协力团 | Pharmaceutical composition having preventive or therapeutic effect on inflammatory bowel disease |
CN104758724A (en) * | 2015-03-26 | 2015-07-08 | 柳晖 | Traditional Chinese medicine composition for treating colitis |
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Open date: 20081022 |