CN1054976C - Freckle removing agent - Google Patents
Freckle removing agent Download PDFInfo
- Publication number
- CN1054976C CN1054976C CN 93100545 CN93100545A CN1054976C CN 1054976 C CN1054976 C CN 1054976C CN 93100545 CN93100545 CN 93100545 CN 93100545 A CN93100545 A CN 93100545A CN 1054976 C CN1054976 C CN 1054976C
- Authority
- CN
- China
- Prior art keywords
- extract
- growth factors
- solution
- tissue
- dimethyl sulfoxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a freckle removing agent prepared from 0.5 to 10% of astragalus extract, 0.5 to 10% of persimmon leaf extract, 5 to 30% of dimethyl sulfoxide and balance of distilled water; in addition, 0.1 muG/ml to 10 muG/ml of solution of epidermal growth factors and fibroblast growth factors is added to the raw materials. The freckle removing agent uses the extract of astragalus from Neimenggu and persimmon leaves; dimethyl sulfoxide is used as a carrier system to transport the extract to subcutaneous parts; meanwhile, the effects of epidermal growth factors and fibroblast growth factors can increase skin nutrients and improve the healthy growth of endothelial tissue, fibrous tissue and epidermal tissue; and accordingly, the generation of melanin pigmentation is prevented, and pigmentation melanin is dissolved and absorbed by cells.
Description
The present invention relates to a kind of anti-freckle agent, be particularly suitable for treating cutaneous pigmentation diseases such as chloasma hepaticum, freckle, nevus, melanotic nevus.
The reason of cutaneous pigmentation diseases such as chloasma hepaticum, freckle, nevus, melanotic nevus is many and complicated, medically also fails to understand fully Ming Liao.But, should be appreciated that it generates reason and just can suit the remedy to the case to the formation of all kinds of speckles.
(1) chloasma hepaticum
Chloasma hepaticum easily betides women's face, and left-right symmetric occurs usually, and size and form have nothing in common with each other, and brown, pitchy, black, Lycoperdon polymorphum Vitt are arranged.
Because melanin generates, reason complexity, very dark with hormonal relation, the hypophysis that particularly correlates adrenal gland and ovary deeply accounts for critical function, and pigmentation takes place in their faults or because of daylight brings out, and the following describes various chloasma hepaticum.
(a) maidenhood chloasma hepaticum
Only betide young woman's special pigmentation, mainly betide unmarried women's of 14-25 year maidenhood chloasma hepaticum, betide chew around, present dark brown from nose lower edge lip.
(b) gestational chloasma hepaticum
This is the normal chloasma hepaticum that takes place of the antenatal generation of middle-aged women, produces the back Lock-out.
(c) eyelid chloasma hepaticum
Surround the eyelid blackout of woman's eyes, or present black speck at lower eyelid, before and after menstruation, when tired or when not having enough sleep enrichment, just begin to form in 22-23 year of thinking the spring after date.
(d) uterus property chloasma hepaticum
Betide the genitals obstacle---for example menoxenia, menstrual pain, uterus, ovary are unusual etc., and middle-aged women chloasma hepaticum occur at positions such as cheekbones at pregnancy termination or climacteric during obstacle.
(e) traumatic chloasma hepaticum
During the pre-process and post-process mistake of scratch, incised wound etc., this is residual pigment partly, becomes chloasma hepaticum.
(f) dislike the fluidity chloasma hepaticum
Cause of diseases such as viscera disease such as gastrointestinal, liver, adenopathy change, tuberculosis, cancer cause.
Daylight chloasma hepaticum, warm property chloasma hepaticum are still arranged in addition, toxicity chloasma hepaticum etc.Directly GULONG water and perfume (with addition of goods of oleum bergamottae etc.) are applied to skin, directly bear the DT, the Photdynaric effect because of spice becomes chloasma hepaticum sometimes, is common in American-European women.
(2) senile plaque
Senile plaque be because of in, the old people veins beneath the skin becomes fragile, the subcutaneous and speckle that causes of the melanin pigmentation in hemorrhage, the blood of breaking.
(3) blackhead
Because of the sebaceous gland mouth of pipe fat that is cured stops up, cause the sebaceous gland necrosis, satisfy because of the epidermis keratinization and bury it in subcutaneous, form speckle.
Present common ammoniated mercury, sulfur, hydrogen peroxide etc. are as the bleach of speckle.P.M.H. also commonly used makes an addition to and treats speckle in the ointment.Very advanced P.M.H. ointment commonly used at present can be the formation that influences speckle from melanic ferment.But it is the same with ammoniated mercury, sulfur, hydrogen peroxide, the as easy as rolling off a log generation that causes skin allergy and can not fundamentally treat speckle.
The anti-freckle agent that the objective of the invention is to avoid above-mentioned the deficiencies in the prior art part and a kind of generation that can fundamentally stop melanin pigmentation is provided and the melanin of calmness is dissolved and absorbed by cell.
Purpose of the present invention can reach by following measure: the present invention is by Radix Astragali extract 0.5～10%, Folium Kaki extract 0.5～10%, dimethyl sulfoxide 5～30%, surplus is that distilled water is formed, the epidermal growth factor that adds 0.1 μ G～10 μ G/ml solution in addition again, the fibroblast growth factor of 0.1 μ G～10 μ G/ml solution.
Purpose of the present invention can also reach by following measure: the percentage by weight of Radix Astragali extract, Folium Kaki extract, dimethyl sulfoxide, distilled water was got 2: 2: 30 in the anti-freckle agent: 66 for best, the epidermal growth factor that adds is got 2 μ G/ml solution, and fibroblast growth factor is got 2 μ G/ml solution for best.
The present invention selects astragalus mongholicus Bge and Folium Kaki extract for use, by dimethyl sulfoxide as carrier system, it is sent to subcutaneous, add the effect of epidermal growth factor and fibroblast growth factor, make skin increase nutrient and endothelial tissue fibrous tissue and epidermal tissue's healthy growth, fundamentally stop the generation of melanin pigmentation and calm melanin is dissolved and absorbed by cell.
The astragalus mongholicus Bge root contains: the folic acid of B-sitosterol, linoleic acid, linolenic acid, choline, betanin, aminoacid, sucrose, glucuronic acid and trace.
Can quicken the stripped epidermis cell merisis of human body by experimental observation to Radix Astragali natural constituent, the speed of growth that shows as Radix Astragali group human skin cell piece of tissue outgrowth begins obviously faster than matched group from the 15th day of cultivating.And observing Radix Astragali effective ingredient has the effect that prolongs the In vitro culture Skin Cell life-span, and the matched group Skin Cell life-span is 35 days, stops division from 35 days cells, and begins to shrink, wither away; And Radix Astragali group cell still continues the certain splitting ability of maintenance after 35 days, begins to occur decay up to 85 talentes, and this moment, the radius of cell lump outgrowth grew to 3.25mm.
Radix Astragali natural constituent can strengthen in the epidermis cell vigor of antioxidase system such as self SOD.By the biochemiluminescence instrument, observe Radix Astragali effective ingredient and can improve that the enzyme activity of SOD reaches about 50% in the human skin cell.
In addition, Radix Astragali active ingredient can also suppress gamma-rays and bring out the damage of the reactive oxygen free radical of generation to epidermis cell, mainly shows the generation that suppresses lipid peroxidation and lipofuscin, and it suppresses percentage rate and is respectively 92.5% and 81%.
The chemical constituent of Folium Kaki is that vitamin C 3500MG/100 restrains Lao Ye, leucodelphindin-3-glycoside, flavonoid glycoside.Its astringent taste composition is: Shibuol, acetylcholine and fructose.
The active ingredient of Folium Kaki is disappeared warm property chloasma hepaticum and is stoped its generation.Be rich in vitamin C in its effective ingredient, the freckle that can disappear, its astringent taste composition has significant discoloration to chloasma.Its effective ingredient is similar to Radix Astragali natural extract to the effect of epidermis cell.
Epidermal growth factor be except strengthening skin histology, corneal epithelial tissue external, the propagation and the differentiation of lung and bronchiolar epithelium tissue, and it can also increase the activity and the dopamine level of ODC Ornithine decarboxylase; Promote the propagation of cell, increase the transhipment and the glycolysis of material.
Epidermal growth factor can dissolve calm pigment promoting cell proliferation simultaneously, and speckle is disappeared.Add that fibroblast growth factor plays a driving role to the growth of subcutaneous tissue cell, can suppress the generation of melanosis.
As carrier the active ingredient of the Radix Astragali and Folium Kaki is sent to subcutaneously with dimethyl sulfoxide, subcutaneous tissue is fully absorbed.
Because epidermal growth factor and fibroblast growth factor have the mode that acts on receptor of its uniqueness, can act on skin histology better by carrier system, reach more significant effect.
During making, the Radix Astragali, Folium Kaki extract and epidermal growth factor, fibroblast growth factor are dissolved in the dimethyl sulfoxide, dimethyl sulphoxide solution being added in the distilled water is the cost anti-freckle agent again.
The present invention will now be further detailed embodiment:
Embodiment one:
Get Radix Astragali extract 1%, the epidermal growth factor of Folium Kaki extract 1% and 0.1 μ G/ml solution, 0.1 the fibroblast growth factor of μ G/ml solution (these two kinds of somatomedin deniers, can ignore its proportion), be dissolved in the dimethyl sulfoxide that accounts for 10% ratio, dimethyl sulphoxide solution is added in the distilled water that accounts for 88% ratio again, promptly can be made into anti-freckle agent of the present invention.The anti-freckle agent of this kind proportioning is suitable for treating freckle.
Embodiment two:
Get Radix Astragali extract 2%, the fibroblast growth factor of the epidermal growth factor of Folium Kaki extract 2% and 2 μ G/ml solution, 2 μ G/ml solution is dissolved in the dimethyl sulfoxide that accounts for 20% ratio, dimethyl sulphoxide solution is added in the distilled water that accounts for 76% ratio again, promptly can be made into anti-freckle agent of the present invention.The anti-freckle agent of this kind proportioning is suitable for treating chloasma hepaticum.
Embodiment three:
Get Radix Astragali extract 5%, the epidermal growth factor of Folium Kaki extract 5% and 10 μ G/ml solution, the fibroblast growth factor of 10 μ G/ml solution is dissolved in the dimethyl sulfoxide that accounts for 30% ratio, dimethyl sulphoxide solution is added in the distilled water that accounts for 60% ratio again, promptly can be made into anti-freckle agent of the present invention.The anti-freckle agent of this kind proportioning is suitable for treating senile plaque.
The present invention has following advantage compared to existing technology: can fundamentally stop melanin Calm generation, and calm melanin is dissolved and by Cell uptake, skin is increased Add nutrient, make endothelial tissue, fibr tissue and epidermal tissue's healthy growth.
Claims (2)
1, a kind of anti-freckle agent, it is characterized in that: this anti-freckle agent is made up of the epidermal growth factor of Radix Astragali extract 0.5～10%, Folium Kaki extract 0.5～10%, dimethyl sulfoxide 5～30%, 0.1 μ G～10 μ G/ml solution, the fibroblast growth factor of 0.1 μ G～10 μ G/ml solution, and the water of surplus is formed.
2, anti-freckle agent according to claim 1, it is characterized in that: Radix Astragali extract, Folium Kaki extract in the anti-freckle agent, the percentage by weight of dimethyl sulfoxide, water is 2: 2: 30: 66, wherein add 2 μ G/ml solution epidermal growth factors, 2 μ G/ml solution fibroblast growth factors.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100545 CN1054976C (en) | 1993-01-03 | 1993-01-03 | Freckle removing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93100545 CN1054976C (en) | 1993-01-03 | 1993-01-03 | Freckle removing agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1083352A CN1083352A (en) | 1994-03-09 |
| CN1054976C true CN1054976C (en) | 2000-08-02 |
Family
ID=4983089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93100545 Expired - Fee Related CN1054976C (en) | 1993-01-03 | 1993-01-03 | Freckle removing agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1054976C (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101342223B (en) * | 2008-08-01 | 2013-02-20 | 杭州前进药业有限公司 | Jade butterfly beauty treatment speckle removing plaster and preparation method thereof |
-
1993
- 1993-01-03 CN CN 93100545 patent/CN1054976C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1083352A (en) | 1994-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8071106B2 (en) | Topical formulation containing latex of fraction thereof, and cosmetic treatment method | |
| CN104856892A (en) | Cosmetic or skin care product preparation rich in growth factors and preparation method therefor | |
| KR20160064410A (en) | Composition comprising spicules for skin care | |
| CN103385820B (en) | Repair eye cream | |
| CN105193673B (en) | A kind of clear acne repairs liquid and preparation method thereof | |
| CN101791283A (en) | Cosmetic capable of eliminating striae gravidarum and scars | |
| CN108743921A (en) | It is a kind of to prevent the reparation liquid and its preparation method and application that scar is formed | |
| CN111991285A (en) | Smoothing toner for refining pores and preparation method thereof | |
| CN103156843A (en) | Composition for whitening and removing freckles and preparation thereof | |
| KR20180134468A (en) | Cosmetic compositions comprising spicule, marine collagen and deep ocean water and their preparation | |
| Zelickson et al. | Melanocyte changes following PUVA therapy | |
| CN1054976C (en) | Freckle removing agent | |
| CN110227176A (en) | Scar eliminating silicone gel dressing and preparation method thereof | |
| CN105267261A (en) | Plant extract combination having skin repair promoting and healing promoting function | |
| CN110559227A (en) | Skin cream for preventing and repairing striae gravidarum and preparation method thereof | |
| Nganlasom et al. | Effects of Centella asiatica linn. and Garcinia mangostana linn. on the healing of dermal wounds in diabetic rats | |
| KR101917026B1 (en) | Cosmetic composition for skin wrinkle improvement and prevention | |
| CN110151595B (en) | Compound composition for preventing and treating stretch marks | |
| JPH06279294A (en) | Collagen synthesis promoter | |
| KR101679391B1 (en) | Composition for treating wound containing stellera chamaejasme extract or fraction thereof and method for treating wound in a subject | |
| CN108853369B (en) | Preparation method and application of natural plant antibacterial liquid PAMs hydrogel patch | |
| JPH06189780A (en) | Hyaluronic acid production promoting agent | |
| CN112402311A (en) | Moisturizing body lotion and preparation method thereof | |
| CN110420199A (en) | It is a kind of for wound healing and the water gel of cosmetics and its preparation method and application | |
| KR101667308B1 (en) | Anti-wrinkle cosmetic composition containing timosaponin, hyaluronic acid, collagen, calendula flower extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |