CN105497398A - Medicine composition for treating ureaplasma urealyticum infection accompanying hypomenorrhea - Google Patents

Medicine composition for treating ureaplasma urealyticum infection accompanying hypomenorrhea Download PDF

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CN105497398A
CN105497398A CN201610021922.XA CN201610021922A CN105497398A CN 105497398 A CN105497398 A CN 105497398A CN 201610021922 A CN201610021922 A CN 201610021922A CN 105497398 A CN105497398 A CN 105497398A
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herba
hypomenorrhea
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pharmaceutical composition
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陈令浩
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Qingdao Chenda Biotechnology Co Ltd
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Qingdao Chenda Biotechnology Co Ltd
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Abstract

The invention belongs to the field of traditional Chinese medicine and discloses a medicine composition for treating ureaplasma urealyticum infection accompanying hypomenorrhea and a preparation method thereof. The medicine composition is prepared from silvery aleuritopteris, caulis sargentodoxae, fructus lycii, radix rehmanniae preparata, semen cuscutae, herbs of adnate elder, winged laggera herbs, herba aristolochiae, rhizoma polygoni cuspidate, herbs of whiteflower lagopsis, roots of lagerflower triplostegia, roots of woolly lespedeza and rhizoma cyperi. The medicine composition has the effects of invigorating blood circulation to eliminate blood stasis, removing dampness for detoxication, nourishing the liver and kidney and nourishing blood to regulate menstruation. Clinical observation results show that according to comparison between an observation group and a reference group, the clinical cure rate and the effect showing rate of patients with ureaplasma urealyticum infection accompanying hypomenorrhea can be obviously increased; the medicine composition has a better long-term curative effect, clinical symptoms of the patients are not prone to reoccurrence, the number of adverse reactions is small, and the medicine composition is a safe and effective Chinese herbal preparation, provides a new method for traditional Chinese medicine therapy of hypomenorrhea and is worthy of further research, application and popularization.

Description

A kind of pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection
Technical field
The invention belongs to the field of Chinese medicines, disclose a kind of hypomenorrhea for the treatment of and accompany pharmaceutical composition of ureaplasma urealyticum infection and preparation method thereof.
Background technology
Hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood volume obviously reduces, or the deficiency of time 2d that passes through, even drop and clean person.Hypomenorrhea, as treated not in time, affects cytula film plantation in uterus, and causing habitual abortion, infertile etc., is the prodrome of amenorrhea.Due to modern society's dog-eat-dog, life, operating pressure increase day by day, add some women repeatedly medicine or factors such as artificial abortion, abuse contraceptive, make the sickness rate of this disease more and more higher, primary disease can cause infertile, miscarriage, even amenorrhea, and causing the series of problems such as mental maladjustment because of physiological change, clinical treatment is rather thorny, and effect is poor.
Reproductive tract Ureaplasma urealyticum (UU) infects can cause vaginitis, cervicitis, endometritis, salpingitis, infertile, embryo diapause etc., and passability is propagated, in rising trend in recent years.UU is opportunist, does not enter tissue and blood, is the prokaryotic micro-organisms of the acellular wall of a class; in height pleomorphism, main parasitic in the cell surface of urogenital tract, when normally carrying; body is protectiveness inhibitory state, now can not fall ill, and non-evident sympton, sign change.But when mycoplasma intrusion reaches a certain amount of or merges other pathogenic infections, urogenital mucous membrane is inflamed damage, UU avails oneself of the opportunity to get in, by the nutrition of absorptive cell, obtain lipid and cholesterol, cause cell injury, its toxic metabolite (as mycoplasma neurolyticum can produce neurotoxin) produces toxic action to host cell membrane, local lymphocytes and macrophage are infiltrated in a large number, TNF showed increased, vascular endothelial cell and blood coagulation cell damage, cause endometrium, endosalpinx surface edema is oozed out, ulcer, hemorrhage, Deng inflammatory reaction, inner membrance is finally caused not repair very well, menstrual blood volume reduces.Severe patient show as heating, stomachache, leucorrhea many, etc. General Symptoms, when urinary tract mucosa is by for a long time, the discomfort such as frequent micturition, urgent micturition can be there is.
At present, treatment hypomenorrhea medicine have the large class of Western medicine and Chinese medicine two, but this two classes medicine all can not prevent or treat ureaplasma urealyticum infection, and western medicine hypomenorrhea administration time is long, and side effect is large, curative effect is not thorough, not only easily cause gastrointestinal reaction, easily increase the weight of endocrine disturbance again, although and existing Chinese patent medicine preparation can treat female irregular menstruation, but offer limited effectiveness, and the ureaplasma urealyticum infection occurred together to hypomenorrhea is often invalid.And differentiation of tcm, treatment hypomenorrhea companion ureaplasma urealyticum infection is often evident in efficacy.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of hypomenorrhea for the treatment of and accompanies pharmaceutical composition of mycoplasma infection and preparation method thereof.
An object of the present invention is to provide a kind of pharmaceutical composition for the treatment of hypomenorrhea companion mycoplasma infection.
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, by modern physiological pathology and pathogen and pathology of tcm, dialectically to combine with differential diagnosis of diseases, a kind of pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection provided is that medicinal raw material is made by Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi.
In order to the synergism of effective active composition in medicine, the present inventor, through the test of long-term, a large amount of screening prescriptions, is preferably as follows technical scheme further:
Treat a pharmaceutical composition for hypomenorrhea companion ureaplasma urealyticum infection, it is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 15-30 part, Caulis Sargentodoxae 10-20 part, Fructus Lycii 15-30 part, Radix Rehmanniae Preparata 10-20 part, Semen Cuscutae 10-20 part, Herba Sambuci Adnatae 8-18 part, Herba Laggerae Alatae 5-15 part, Herba Aristolochiae 7-12 part, Rhizoma Polygoni Cuspidati 3-10 part, Herba lagopsis supinae 16-28 part, Radix Triplostegiae Grandiflorae 15-30 part, Radix Lespedezae Tomentosae 10-20 part, Rhizoma Cyperi 5-15 part.
Further preferably, treat a pharmaceutical composition for hypomenorrhea companion ureaplasma urealyticum infection, it is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 16-24 part, Caulis Sargentodoxae 13-18 part, Fructus Lycii 18-24 part, Radix Rehmanniae Preparata 15-20 part, Semen Cuscutae 12-17 part, Herba Sambuci Adnatae 13-18 part, Herba Laggerae Alatae 7-12 part, Herba Aristolochiae 7-12 part, Rhizoma Polygoni Cuspidati 4-7 part, Herba lagopsis supinae 20-25 part, Radix Triplostegiae Grandiflorae 25-30 part, Radix Lespedezae Tomentosae 10-15 part, Rhizoma Cyperi 8-13 part.
Further preferably, treat a pharmaceutical composition for hypomenorrhea companion ureaplasma urealyticum infection, it is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 18 parts, Caulis Sargentodoxae 14 parts, Fructus Lycii 20 parts, Radix Rehmanniae Preparata 17 parts, Semen Cuscutae 13 parts, Herba Sambuci Adnatae 15 parts, Herba Laggerae Alatae 10 parts, Herba Aristolochiae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba lagopsis supinae 20 parts, Radix Triplostegiae Grandiflorae 27 parts, Radix Lespedezae Tomentosae 12 parts, Rhizoma Cyperi 10 parts.
Side of the present invention separates: monarch drug: Aleuritopteris argentea (Gmel.) Fee is pungent, sweet, flat, kind promoting blood circulation to restore menstrual flow, and eliminating damp, detoxifying is subsided a swelling, and Caulis Sargentodoxae is bitter, and flat, removing toxicity for eliminating carbuncles, expelling wind and removing dampness, parasite killing, it stimulates the menstrual flow in addition and enriches blood, the effect of bone and muscle strengthening, and two medicine compatibility nature and flavor are gentle, promoting blood circulation to restore menstrual flow, eliminating damp, detoxifying.
Ministerial drug: Fructus Lycii is sweet, flat, nourishing the liver and kidney, replenishing vital essence to improve eyesight; Radix Rehmanniae Preparata is sweet, tepor, nourishing YIN and supplementing blood, and beneficial essence fills out marrow; Semen Cuscutae is sweet, temperature, nourishing the liver and kidney, supporing yang controlling nocturnal emission with astringent drugs, and three want compatibility to use nourishing the liver and kidney, to nourish menses.
Adjuvant drug: Herba Sambuci Adnatae is pungent, sweet, warm in nature, dispelling wind and removing obstruction in the collateral, activating blood and promoting diuresis; Herba Laggerae Alatae is pungent, bitter, tepor, expelling wind and removing dampness, subduing swelling and detoxicating, and dissipating blood stasisization is stagnant; Herba Aristolochiae is bitter, temperature, promoting flow of QI and blood, inducing diuresis to remove edema, removing toxic substances; Rhizoma Polygoni Cuspidati is bitter, and acid, is slightly cold, promoting blood circulation to remove blood stasis, dispelling wind and removing obstruction in the collateral, and clearing away heat-damp and promoting diuresis detoxifies, altogether principal drug assistance expelling wind and removing dampness, promoting blood circulation to restore menstrual flow.Herba lagopsis supinae nourshing blood and promoting blood circulation, clearing away heat-damp and promoting diuresis; Radix Triplostegiae Grandiflorae tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation; Radix Lespedezae Tomentosae spleen invigorating tonify deficiency, clearing away heat-damp and promoting diuresis, promoting blood flow to regulate menstruation; Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving, QI and blood regulating.
All medicines close 5, are use mutually, have promoting blood circulation to remove blood stasis, eliminating damp, detoxifying, nourishing liver and kidney, the effect of nourishing blood for regulating menstruation, and the hypomenorrhea effect for companion's mycoplasma infection is unique.
Further, in pharmaceutical composition of the present invention, the function of each crude drug and function cure mainly as described below.
Aleuritopteris argentea (Gmel.) Fee: [nature and flavor] are pungent; Sweet; Flat.[return through] lung; Liver Channel.[function cures mainly] expelling phlegm for arresting cough; Promoting blood circulation to restore menstrual flow; Dampness removing; Removing toxic substances and promoting subsidence of swelling.Main cough; Menoxenia; Amenorrhea is suffered from abdominal pain; Leucorrhea with red and white discharge; Pulmonary tuberculosis hemoptysis; Loose stool and diarrhea; Difficulty and pain in micturition; Lung abscess; Acute mastitis; Rheumatic arthritis; Traumatic injury; Intercostal neuralgia; Epidemic hemorrhagic conjunctivitis; Skin ulcer swells.
Caulis Sargentodoxae: [nature and flavor] are bitter; Flat; Nontoxic.[return through] liver; Large intestine channel.[function cures mainly] removing toxicity for eliminating carbuncles; Promoting blood circulation and stopping pain; Expelling wind and removing dampness; Parasite killing.Main intestinal carbuncle; Dysentery; Mastalgia; Dysmenorrhea; Amenorrhea; Traumatic injury; Rheumatic arthralgia; Abdominal pain due to worm stagnation.[usage and dosage] takes orally: decoct soup, 9-15g; Or wine boils, infusing drugs in wine.External: appropriate; Mash deposited affected part.
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Semen Cuscutae: [nature and flavor] are sweet, temperature.[return through] returns liver,kidney,spleen warp.[function cures mainly] nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen is suffered from a deficiency of the kidney and is rushed down; Externally treating leucoderma.[usage and dosage] 6 ~ 12g; Suitable amount used externally." book on Chinese herbal medicine converges and says ": " warming the spleen helps the medicine of stomach also for Semen Cuscutae, the kidney invigorating nourishing the liver.But to mend and not high, temperature and not dry, therefore enter kidney channel, void can be mended, in fact can be in order to, cold can temperature, heat can be cool, wet can be dry, dryly can to moisten.If non-Cortex Phellodendri, the Rhizoma Anemarrhenae, bitter cold and not warm, has the gas rushing down kidney channel; If non-Cortex Cinnamomi, Fructus Alpiniae Oxyphyllae, hot and not cool, there is the dry of kidney channel; If non-Herba Cistanches, trivial sun, sweet salty and stagnant gas, has wet person's ratio of raw kidney channel also.”
Herba Sambuci Adnatae: [nature and flavor] acrid in the mouth; Sweet; Warm in nature.[return through] returns spleen; Kidney channel.[function cures mainly] dispels the wind; Diuretic; Invigorate blood circulation; Dredging collateral.Main acute and chronic nephritis; Rheumatalgia; Rubella pruritus; Children's's single board computer numbness sequela; Chronic lambago and skelalgia; Sprain stasis of blood pain; Fracture.
Herba Laggerae Alatae: [nature and flavor] acrid in the mouth; Bitter; Slightly warm in nature.[function cures mainly] dispels the wind, and dehumidifying, changes stagnant, dissipating blood stasis, detumescence, removing toxic substances.Main cold, fever; Cough due to lung-heat; Rheumatic arthritis; Diarrhoea; Oedema due to nephritis; Amenorrhea; Traumatic injury; Furuncle carbuncle; Scrofula; Venom; Eczema pruritus.[usage and dosage] takes orally: decoct soup, 9-15g, fresh person 30-60g; Or smash juice clothes.External: appropriate, smashes deposited; Or decoct washing.
Herba Aristolochiae: [nature and flavor] are bitter; Temperature.[return through] liver; Spleen; Kidney channel.[function cures mainly] promoting flow of QI and blood; Inducing diuresis to remove edema; Removing toxic substances.Main stomachache; Colicky; Edema during pregnancy; Puerperal, vim and vigour were suffered from abdominal pain; Snake bite and insect sting.1. " book on Chinese herbal medicine converges and says ": Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable then peaceful, the inverse then vexed work of pain.
Rhizoma Polygoni Cuspidati: [nature and flavor] are bitter; Acid; Cold nature.[return through] liver; Gallbladder meridian.[function cures mainly] promoting blood circulation to remove blood stasis; Dispelling wind and removing obstruction in the collateral; Clearing away heat-damp and promoting diuresis; Removing toxic substances.Housewife female's amenorrhea; Dysmenorrhea; Lochiostasis; Lump in the abdomen; Injury from falling down; Rheumatic arthralgia; Jaundice due to damp-heat; Stranguria with turbid discharge leukorrhagia; Sore swollen toxin; Venom; Burn due to hot liquid or fire.[usage and dosage] takes orally: decoct soup, 10-15g; Or infusing drugs in wine; Or enter ball, loose.External: appropriate, grinds into powder and dresses; Or decoct extract soak; Or endure cream and embrocate.
Herba lagopsis supinae: [nature and flavor] acrid in the mouth; Micro-hardship; Cold in nature.[return through] returns Liver Channel.[function cures mainly] nourshing blood and promoting blood circulation; Clearing away heat-damp and promoting diuresis.Main menoxenia; The stagnant stomachache of the stasis of blood in puerperal; Blood deficiency is dizzy; It is unsuccessful partly to penetrate; Traumatic injury; Edema; Dysuria; Conjunctival congestion and swelling pain; Carbuncle sore; Chilblain; Toothache; Erythra pruritus.[usage and dosage] takes orally: decoct soup, 9-12g; Or endure cream.
Radix Triplostegiae Grandiflorae: [nature and flavor] sweet, micro-hardship is flat.[function cures mainly] tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances.For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility.External is stopped blooding." Yunnan Chinese herbal medicine ": regulating menstruation and activating blood, kidney tonifying.Control amenorrhea, menoxenia, lumbago due to renal deficiency, seminal emission, sexual impotence, infertility.
Radix Lespedezae Tomentosae: [nature and flavor] are sweet; Micro-light; Property is put down.[return through] spleen channel.[function cures mainly] spleen invigorating tonify deficiency; Clearing away heat-damp and promoting diuresis; Promoting blood flow to regulate menstruation.Main asthenia; Blood deficiency is dizzy; Edema; Ascites; Dysentery; Amenorrhea; Dysmenorrhea.[usage and dosage] takes orally: decoct soup, 15-30g.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.[usage and dosage] 6 ~ 9g.
Present invention also offers the preparation method of this pharmaceutical composition, it comprises the steps: described Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi to mix in prescription ratio, add the water relative to mixture quality 4 ~ 10 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, adding ethanol makes alcohol content be 30%v/v, leave standstill after 24 hours, obtain supernatant, be the ultrafiltration post ultrafiltration of 7500-9000 again through the molecular weight that dams, ultrafiltrate subtracts and is concentrated into relative density 1.05-1.10 (60 DEG C record), inlet temperature 140 ~ 150 DEG C, carry out spraying dry under leaving air temp 75 ~ 80 DEG C of conditions, obtain active constituents of medicine; This composition is independent or mix with medicine acceptable carrier, makes pharmaceutical composition of the present invention according to galenic pharmacy routine techniques.
Described pharmaceutically acceptable carrier, as starch, Icing Sugar, dextrin, microcrystalline cellulose, amylum pregelatinisatum, micropowder silica gel, fructose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate, polyvinylpyrrolidone, glycerol, POLYSORBATE 80, agar, calcium carbonate, calcium bicarbonate, etc.
Pharmaceutical composition described above preferably makes peroral dosage form, such as, and tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution etc.Preferably, pharmaceutical composition described above preferably makes tablet, capsule or granule, most preferably is capsule.
The present invention is the Therapeutic Principle of inventor according to Chinese medicine " determination of cause of disease according to differentiation of symptoms and signs; examine because opinion is controlled " and the thought of " preventive treatment of disease ", sum up the relation between hypomenorrhea and paathogenic factor, on the basis of understanding hypomenorrhea paathogenic factor, the paathogenic factor that understanding hypomenorrhea is common further, make because of, sick, demonstrate,prove and combine, repeatedly study, progressively improve, the good Chinese medicine preparation of last successful a kind of curative effect, and demonstrated the curative effect of Chinese medicine preparation of the present invention by clinical case further.Clinical observation result shows: observation group can significantly improve clinical cure rate and the obvious effective rate of being accompanied dismemberent urea pathogen infection patient by hypomenorrhea compared with matched group; Have better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few, is one Chinese medicine preparation safely and effectively, for Chinese medicine hypomenorrhea provides new method, is worth studying and applying further.Refer to as follows.
Clinical observation
1 data and method
1.1 physical data: observe in January, 2014 to a 2014 year December and go to a doctor in my institute's Out-patient Clinic of Department of Gynecology, are diagnosed as hypomenorrhea card, and patient 108 example of the Ureaplasma urealyticum positive, is divided into observation group and matched group to observe at random, often organize 54 routine.Observation group age 22-37 year, 27.2 ± 4.8 years old mean age, matched group age 22-38 year, average 26.9 ± 4.6 years old; Observation group's course of disease is the longest 4.5 years, the shortest 6 months, and average 1.84 ± 1.07 years, the matched group course of disease was the longest 4.5 years, the shortest 5 months, average 1.76 ± 1.01 years; Two groups of physical data compare no difference of science of statistics (P > 0.05), have comparability.
1.2 diagnostic criterias: the diagnostic criteria of writing the hypomenorrhea of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " of " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China promulgation in 2002 according to Zhang Yuzhen etc.
Hypomenorrhea: hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, through the menopathy that amount is also few.
Ureaplasma urealyticum detects culture method: adopt the test kit produced by Zhuhai Dier Bioengineering Co., Ltd. to carry out UU cultivation, detection specimen inserted in Culture Mycoplasma liquid, in 37 DEG C of calorstats, cultivate 36 ~ 48h.As become pink for positive culture medium by orange colour, time negative, color is unchanged.
1.3 exclusion standards: have cryptorrhea, luteal phase defect; There are the Chronic consumptions persons such as hyperthyroidism, tuberculosis, severe anemia; There is oral hormone in 3 months, use contraceptive person; Chlamydia infection person; Untoward reaction person is there is in drug administration process; Not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or statistical disposition person.
1.4 Therapeutic Method:
Observation group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, every day twice, each 2-4 grain, withdraws during menstrual onset, is a course for the treatment of, takes 3 months continuously with 3 months.
Matched group: use Western medicine capable artificial cycle estrogen and progestogen sequential therapy, from menstruation the 5th day, the oral progynova 1mg of patient, 1 time/d, serve on 21d; Started from the 15th day, add with Progesterone soft gelatin capsule 100mg, 2 times/d, take to the 21st day and progynova drug withdrawal simultaneously.Continuous treatment 3 menstrual cycle.
1.5 observation index:
1.5.1 observe change--menstrual blood volume color, the matter of menstruation before and after two groups of treatments, pass through the time, menstrual cycle, endometrium thickness (during menstrual cycle 24d B ultrasonic monitoring).
1.5.2 the therapeutic effect of two groups of patients is observed.
1.5.3 the observation of adverse effect during medication: with or without occurring untoward reaction and record during observing medication, as gastrointestinal upset, anaphylaxis, vaginal bleeding time prolongation etc.As the person that occurs serious adverse reaction, discontinue medication immediately, exit this research.
1.5.4 following up a case by regular visits to property observation: treatment is followed up a case by regular visits to after terminating rear third time menstrual onset, record related symptoms is observed.
1.6 criterions of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment menoxenia ", draft following criterion of therapeutical effect: recovery from illness: treat rear menstrual cycle, recover normal through amount, other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle; Effective: menstrual blood volume increases by 1/3, and other transference cures alleviate, and drug withdrawal 3 menstrual cycle are without recidivist; Effective: treat rear menstrual cycle, through amount, comparatively treat front improvement menstrual period, other symptoms alleviate before comparatively treating; Invalid: treatment after menstrual cycle, through amount and menstrual period without improvement.
1.7 statistical methods: adopt SPSS15.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ 2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 liang of group patient comparitive study: observation group's recovery from illness 24 example, effective 18 examples, effective 11 examples, invalid 1 example, obvious effective rate 77.78%, total effective rate 98.15%; Matched group recovery from illness 12 example, effective 14 examples, effective 19 examples, no effect 9, obvious effective rate 48.15%, total effective rate 83.33%, observation group compares with matched group obvious effective rate, total effective rate, difference has statistical significance (P < 0.05), illustrates that clinical cure rate and the obvious effective rate of hypomenorrhea significantly can improve compared with matched group in observation group.In table 1.
Table 1 liang group patient comparitive study (n%, example)
Note: compare with matched group, * P < 0.05.
Before and after 2.2 treatments, endometrium thickness compares: two groups for the treatment of endometrium thickness rear luteal phase more also thicken with before treatment, difference has statistical significance (P < 0.01), compare between two groups after treatment, difference has statistical significance (P < 0.05), and treatment group effect is more excellent.In table 2.
Front and back endometrium thickness treated by table 2 and the time in menstrual period compares
Note: compare with before treatment, * P < 0.05, * * P < 0.01; Compare with matched group after treatment, #p < 0.05.
After 2.3 liang of group treatments, Follow-up results compares: time after treatment is finished to effective follow-up of patients, in the routine effective patient of observation group 42,40 routine patient menstrual are normal, and have 1 routine patient when following up a case by regular visits to, hypomenorrhea, 1 example follows up a case by regular visits to disappearance.And in the routine effective Patients Patients of matched group 28, have 17 routine patient menstrual normal, have 8 routine patient menstrual very few, 2 routine patient's amenorrheas, 1 example follows up a case by regular visits to disappearance.Illustrate that the patient of matched group clinical symptoms after drug withdrawal has bounce-back, also illustrate that Ureaplasma urealyticum is the high risk factor of hypomenorrhea simultaneously.Can illustrate that observation group compares with matched group and has better late result accordingly, and the clinical symptoms of patient not easily recurs, also demonstrate the hypomenorrhea patient that Chinese medicine preparation of the present invention can treat companion's ureaplasma urealyticum infection, make body obtain good recovery, improve physical function.
The observation of adverse effect during 2.4 medications: have 1 routine patient to occur slight gastrointestinal reaction during observation group's patient medication.12 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as Nausea and vomiting, upper abdomen dull pain; Have 3 routine patients to occur irregular colporrhagia, observation group compares with matched group, and difference has statistical significance, and observation group's less adverse effect, patient compliance is better.
To sum up: observation group can significantly improve clinical cure rate and the obvious effective rate of being accompanied ureaplasma urealyticum infection patient by hypomenorrhea compared with matched group; Have better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few, is one Chinese medicine preparation safely and effectively, for Chinese medicine hypomenorrhea provides new method, is worth studying and applying further.
Compared with prior art, tool of the present invention has the following advantages and progress significantly: (1) good effect.Found by a large amount of clinical practices, the pharmaceutical composition that the present invention relates to can not only promote cervicitis site absorption, blocks or reverse scorching card development, and persistent, and treating both the principal and secondary aspects of a disease, has no side effect, efficacy consolidation.Further, lot of experiments research display, Most patients takes medicine of the present invention and namely occurs obvious curative effects 1 course for the treatment of.(2) safety is high.Because medicine of the present invention is prepared from by adopting Chinese medicine material, toxicity is low, and patient medication is safer.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 18 parts, Caulis Sargentodoxae 14 parts, Fructus Lycii 20 parts, Radix Rehmanniae Preparata 17 parts, Semen Cuscutae 13 parts, Herba Sambuci Adnatae 15 parts, Herba Laggerae Alatae 10 parts, Herba Aristolochiae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba lagopsis supinae 20 parts, Radix Triplostegiae Grandiflorae 27 parts, Radix Lespedezae Tomentosae 12 parts, Rhizoma Cyperi 10 parts.
Preparation method: described Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi are mixed in prescription ratio, add the water relative to mixture quality 4 ~ 10 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, adding ethanol makes alcohol content be 30%v/v, leave standstill after 24 hours, obtain supernatant, then be the ultrafiltration post ultrafiltration of 7500-9000 through the molecular weight that dams, ultrafiltrate subtracts and is concentrated into relative density 1.05-1.10 (60 DEG C record), inlet temperature 140 ~ 150 DEG C, carry out spraying dry under leaving air temp 75 ~ 80 DEG C of conditions, obtain active constituents of medicine, make this capsule according to galenic pharmacy routine techniques.
The present embodiment capsule, every containing crude drug 1.9g/0.4g.
Embodiment 2 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 16 parts, Caulis Sargentodoxae 15 parts, Fructus Lycii 24 parts, Radix Rehmanniae Preparata 15 parts, Semen Cuscutae 15 parts, Herba Sambuci Adnatae 13 parts, Herba Laggerae Alatae 8 parts, Herba Aristolochiae 9 parts, Rhizoma Polygoni Cuspidati 4 parts, Herba lagopsis supinae 20 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Lespedezae Tomentosae 12 parts, Rhizoma Cyperi 8 parts.
Preparation method: with reference to embodiment 1.
Embodiment 3 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 20 parts, Caulis Sargentodoxae 15 parts, Fructus Lycii 22 parts, Radix Rehmanniae Preparata 18 parts, Semen Cuscutae 15 parts, Herba Sambuci Adnatae 10 parts, Herba Laggerae Alatae 12 parts, Herba Aristolochiae 12 parts, Rhizoma Polygoni Cuspidati 6 parts, Herba lagopsis supinae 22 parts, Radix Triplostegiae Grandiflorae 30 parts, Radix Lespedezae Tomentosae 10 parts, Rhizoma Cyperi 8 parts.
Preparation method: with reference to embodiment 1.
Embodiment 4 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 22 parts, Caulis Sargentodoxae 18 parts, Fructus Lycii 15 parts, Radix Rehmanniae Preparata 15 parts, Semen Cuscutae 15 parts, Herba Sambuci Adnatae 15 parts, Herba Laggerae Alatae 12 parts, Herba Aristolochiae 10 parts, Rhizoma Polygoni Cuspidati 3 parts, Herba lagopsis supinae 25 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Lespedezae Tomentosae 10 parts, Rhizoma Cyperi 5 parts.
Preparation method: with reference to embodiment 1.
Embodiment 5 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 24 parts, Caulis Sargentodoxae 16 parts, Fructus Lycii 18 parts, Radix Rehmanniae Preparata 15 parts, Semen Cuscutae 10 parts, Herba Sambuci Adnatae 8 parts, Herba Laggerae Alatae 12 parts, Herba Aristolochiae 12 parts, Rhizoma Polygoni Cuspidati 8 parts, Herba lagopsis supinae 28 parts, Radix Triplostegiae Grandiflorae 18 parts, Radix Lespedezae Tomentosae 16 parts, Rhizoma Cyperi 9 parts.
Preparation method: with reference to embodiment 1.
Embodiment 6 capsule
Prescription: Aleuritopteris argentea (Gmel.) Fee 20 parts, Caulis Sargentodoxae 15 parts, Fructus Lycii 15 parts, Radix Rehmanniae Preparata 20 parts, Semen Cuscutae 15 parts, Herba Sambuci Adnatae 10 parts, Herba Laggerae Alatae 15 parts, Herba Aristolochiae 7 parts, Rhizoma Polygoni Cuspidati 10 parts, Herba lagopsis supinae 25 parts, Radix Triplostegiae Grandiflorae 20 parts, Radix Lespedezae Tomentosae 10 parts, Rhizoma Cyperi 10 parts.
Preparation method: with reference to embodiment 1.
Embodiment 7 tablet
Prescription: Aleuritopteris argentea (Gmel.) Fee 20 parts, Caulis Sargentodoxae 15 parts, Fructus Lycii 18 parts, Radix Rehmanniae Preparata 15 parts, Semen Cuscutae 12 parts, Herba Sambuci Adnatae 13 parts, Herba Laggerae Alatae 12 parts, Herba Aristolochiae 10 parts, Rhizoma Polygoni Cuspidati 6 parts, Herba lagopsis supinae 25 parts, Radix Triplostegiae Grandiflorae 25 parts, Radix Lespedezae Tomentosae 15 parts, Rhizoma Cyperi 12 parts.
Preparation method: described Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi are mixed in prescription ratio, add the water relative to mixture quality 4 ~ 10 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, adding ethanol makes alcohol content be 30%v/v, leave standstill after 24 hours, obtain supernatant, then be the ultrafiltration post ultrafiltration of 7500-9000 through the molecular weight that dams, ultrafiltrate subtracts and is concentrated into relative density 1.05-1.10 (60 DEG C record), inlet temperature 140 ~ 150 DEG C, carry out spraying dry under leaving air temp 75 ~ 80 DEG C of conditions, obtain active constituents of medicine, make tablet according to galenic pharmacy routine techniques.
Embodiment 8 granule
Prescription: Aleuritopteris argentea (Gmel.) Fee 22 parts, Caulis Sargentodoxae 16 parts, Fructus Lycii 30 parts, Radix Rehmanniae Preparata 20 parts, Semen Cuscutae 15 parts, Herba Sambuci Adnatae 18 parts, Herba Laggerae Alatae 10 parts, Herba Aristolochiae 7 parts, Rhizoma Polygoni Cuspidati 6 parts, Herba lagopsis supinae 25 parts, Radix Triplostegiae Grandiflorae 15 parts, Radix Lespedezae Tomentosae 20 parts, Rhizoma Cyperi 12 parts.
Preparation method: described Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi are mixed in prescription ratio, add the water relative to mixture quality 4 ~ 10 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, adding ethanol makes alcohol content be 30%v/v, leave standstill after 24 hours, obtain supernatant, then be the ultrafiltration post ultrafiltration of 7500-9000 through the molecular weight that dams, ultrafiltrate subtracts and is concentrated into relative density 1.05-1.10 (60 DEG C record), inlet temperature 140 ~ 150 DEG C, carry out spraying dry under leaving air temp 75 ~ 80 DEG C of conditions, obtain active constituents of medicine, make this granule according to galenic pharmacy routine techniques.

Claims (10)

1. treat hypomenorrhea companion ureaplasma urealyticum infection a pharmaceutical composition, it is characterized in that by Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae,
Rhizoma Cyperi is that medicinal raw material is made.
2. the pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 15-30 part, Caulis Sargentodoxae 10-20 part, Fructus Lycii 15-30 part, Radix Rehmanniae Preparata 10-20 part, Semen Cuscutae 10-20 part, Herba Sambuci Adnatae 8-18 part, Herba Laggerae Alatae 5-15 part, Herba Aristolochiae 7-12 part, Rhizoma Polygoni Cuspidati 3-10 part, Herba lagopsis supinae 16-28 part, Radix Triplostegiae Grandiflorae 15-30 part, Radix Lespedezae Tomentosae 10-20 part, Rhizoma Cyperi 5-15 part.
3. the pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 16-24 part, Caulis Sargentodoxae 13-18 part, Fructus Lycii 18-24 part, Radix Rehmanniae Preparata 15-20 part, Semen Cuscutae 12-17 part, Herba Sambuci Adnatae 13-18 part, Herba Laggerae Alatae 7-12 part, Herba Aristolochiae 7-12 part, Rhizoma Polygoni Cuspidati 4-7 part, Herba lagopsis supinae 20-25 part, Radix Triplostegiae Grandiflorae 25-30 part, Radix Lespedezae Tomentosae 10-15 part, Rhizoma Cyperi 8-13 part.
4. the pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection as claimed in claim 3, is characterized in that being made up of the medicinal raw material of following preferred weight part proportioning: Aleuritopteris argentea (Gmel.) Fee 18 parts, Caulis Sargentodoxae 14 parts, Fructus Lycii 20 parts, Radix Rehmanniae Preparata 17 parts, Semen Cuscutae 13 parts, Herba Sambuci Adnatae 15 parts, Herba Laggerae Alatae 10 parts, Herba Aristolochiae 8 parts, Rhizoma Polygoni Cuspidati 5 parts, Herba lagopsis supinae 20 parts, Radix Triplostegiae Grandiflorae 27 parts, Radix Lespedezae Tomentosae 12 parts, Rhizoma Cyperi 10 parts.
5. the pharmaceutical composition of the treatment hypomenorrhea companion ureaplasma urealyticum infection as described in as arbitrary in claim 1-4, it is characterized in that preparation method comprises the steps: described Aleuritopteris argentea (Gmel.) Fee, Caulis Sargentodoxae, Fructus Lycii, Radix Rehmanniae Preparata, Semen Cuscutae, Herba Sambuci Adnatae, Herba Laggerae Alatae, Herba Aristolochiae, Rhizoma Polygoni Cuspidati, Herba lagopsis supinae, Radix Triplostegiae Grandiflorae, Radix Lespedezae Tomentosae, Rhizoma Cyperi to mix in prescription ratio, add the water relative to mixture quality 4 ~ 10 times, decoct 2 ~ 3 hours, filter acquisition first extracting solution; The medicinal residues that filtration obtains add the water relative to described medicinal residues quality 2 ~ 4 times again, decoct 1 ~ 2 hour, filter acquisition second extracting solution; First extracting solution and the second extracting solution are merged, adding ethanol makes alcohol content be 30%v/v, leave standstill after 24 hours, obtain supernatant, be the ultrafiltration post ultrafiltration of 7500-9000 again through the molecular weight that dams, ultrafiltrate subtracts and is concentrated into relative density 1.05-1.10 (60 DEG C record), inlet temperature 140 ~ 150 DEG C, carry out spraying dry under leaving air temp 75 ~ 80 DEG C of conditions, obtain active constituents of medicine; This composition is independent or mix with medicine acceptable carrier, makes pharmaceutical composition of the present invention according to galenic pharmacy routine techniques.
6. the pharmaceutical composition of the treatment hypomenorrhea companion ureaplasma urealyticum infection as described in as arbitrary in claim 1-4, is characterized in that described pharmaceutical composition preferably makes peroral dosage form.
7. the pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection as claimed in claim 6, is characterized in that described peroral dosage form is preferably tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution etc.; Make tablet, capsule or granule further.
8. the pharmaceutical composition for the treatment of hypomenorrhea companion ureaplasma urealyticum infection as claimed in claim 7, is characterized in that described peroral dosage form is preferably capsule.
9. the purposes of the arbitrary described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment hypomenorrhea companion ureaplasma urealyticum infection.
10. the purposes of the arbitrary described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment hypomenorrhea.
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Citations (1)

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Publication number Priority date Publication date Assignee Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103041100A (en) * 2012-12-14 2013-04-17 青岛中科英泰商用系统有限公司 Traditional Chinese medicine preparation for treatment of hypomenorrhea and preparation method thereof

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