CN105497331A - Traditional Chinese medicine formula for treating premature ovarian failure - Google Patents
Traditional Chinese medicine formula for treating premature ovarian failure Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines and Chinese herbal medicines and particularly relates to a traditional Chinese medicine formula for treating premature ovarian failure. The traditional Chinese medicine formula is prepared from traditional Chinese medicine raw materials in parts by weight as follows: 2-3 parts of epimedium roots, 2-3 parts of Japanese pyrola herbs, 1-3 parts of parochetus communis, 2-3 parts of herba of Saussurea medusa Maxim., 2-4 parts of roots of Woods Greenstar, 3-5 parts of Chinese red dates, 2-3 parts of muraenesox cinereus eggs, 1-3 parts of roots of Szechwan-Yunnan Sanicle, 2-3 parts of caulis spatholobi, 1-3 parts of membranous milkvetch roots, 1-3 parts of crocus sativus and 1-3 parts of twotooth achyranthes roots. The traditional Chinese medicine has the remarkable effects of strengthening the middle warmer, tonifying qi and yin, promoting secretion of body fluids, nourishing the liver and the kidney, facilitating secretion of sufficient body fluids, improving the body immunity and treating premature ovarian failure through conditioning of the traditional Chinese medicines.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly a kind of Chinese medicine formula for the treatment of premature ovarian failure.
Background technology
Premature ovarian failure, refer to the women of built Regulations of Error Equation menstruation, before 40 years old, persistence amenorrhea and sexual organ's atrophy is there is due to ovarian failure, often there are the rising of Gonadotropin Level and estrogenic decline, before 40 years old, the sickness rate of premature ovarian failure is about 1% ~ 3%, and the sickness rate in 30 years old is about 0.1%.Clinical manifestation companion sees symptom before and after the menopause such as hectic fever hyperhidrosis in various degree, insomnia and dreamful sleep, irritable, cardiopalmus, tired, nervous, vaginal dryness, sexual disorder, sterility and infertility, amenorrhea in advance, make patient's geromorphism, if can not get adjusting timely and treating, the appearance of osteoporosis, cardiovascular and cerebrovascular disease chronic diseases can be caused, directly affect female life quality, have a strong impact on the normal work of women, bring considerable distress to its physical and mental health and love life simultaneously.
Premature ovarian failure, its cause of disease it be unclear that so far, so become focus and the difficult point of domestic and international reproductive development circle to the research of this disease.At present both at home and abroad research think more premature ovarian failure and hereditary, immune, metabolism and the factor such as iatrogenic relevant.Show chromosome mutation by research data; FSH (FSH) interstitialcellstimulating hormone (ICSH) (LH) and receptor variant thereof; Developmental and Metabolic Disorder or drug effect; chemicotherapy damages; viral infection; immunity and other high risk factors such as factor such as smoking, depression may be its reasons; these factors or make the congenital ovum decreased number of ovary; or its follicular atresia is accelerated; or directly destroyed; make follicle premature depletion, the treatment modern medicine for premature ovarian failure generally adopts hormone replacement therapy.
But premature ovarian failure treatment is more difficult, and doctor trained in Western medicine adopts Hormone Replacement Therapy clinically, needs to use estrogen and progestogen under the guidance of doctor.Time research shows this estrogen and progestogen therapy, have certain effect, can symptom be improved, but unsatisfactory to the recovery of ovarian function, and after drug withdrawal simultaneously, symptom reappears, and makes ovary be in dependent status, has and causes the worse possibility of ovarian function.That is Hormone Replacement Therapy only serves the effect taken stopgap measures, and this method side effect is large, and life-time service exogenous hormones has the danger causing endometrium canceration, and increases the sickness rate of coronary heart disease and cholecystopathy.Therefore the effect of this hormone therapy is undesirable, there is potential safety hazard simultaneously.In western medical treatment, except hormone replacement therapy, also there is induced ovulation, assist and give ovum technology, autologous or allosome ovary transplantation technology, immunosuppressant therapy, supplement calcium preparation or calcitonin treatment.But these western medical treatment methods are nothing more than recovery, maintenance, substitutes these several respects of ovarian function.Up to the present also do not have definite effective method can recover the function of ovary, so the premature ovarian failure cause of disease is complicated, treatment difficulty is comparatively large, and modern medicine not yet makes a breakthrough so far and carries out.
In recent years, along with Chinese medicine development, be more and more concerned with the chemotherapy that natural plant kind medicine substitutes in doctor trained in Western medicine.Chinese medicine has the integrally-regulated effect of multisystem too many levels, can improve ovarian function, improves ovarian reserve ability, and promote follicular development and ovulation, regulating menstruation and assisting pregnancy is antiabortive, is confirmed in long-term clinical practice.Current traditional Chinese medical herbal treatment primary disease, obtains certain curative effect, but this curative effect is not ideal, and effective percentage is low, is in particular in: 1. be all used as medicine with the former medicine complete feed of Chinese medicine at present, drug effect receives impact, and effect is undesirable; 2. prescription compatibility is unreasonable.Just because of these causes, cause existing treatment premature ovarian failure Chinese medicine clinical effectiveness desirable not to the utmost.
Summary of the invention
The invention provides a kind of Chinese medicine formula for the treatment of premature ovarian failure, according to tcm theory, nursed one's health by Chinese medicine, invigorating the spleen and replenishing QI, Yin-nourishing and body fluid promoting, nourishing the liver and kidney, body fluid is sufficient, improves immunity of organisms, and treatment premature ovarian failure has significant effect.
Medicine of the present invention is that crude drug prepares by the Chinese medicine of following parts by weight:
Rhizoma Epimedii 2-3 part, Herba pyrolae japonicae 2-3 part, Flos Caraganae Sinicae 1-3 part, sweet blue or green Herba Saussureae Involueratae 2-3 part, Polyalthia nemoralis A. D C. 2-4 part, Fructus Jujubae 3-5 part, Muraenesocis cinereus ovum 2-3 part, Radix Saniculae Astrantifoliae 1-3 part, Radix seu Caulis Verntilaginis Leiocarpae 2-3 part, Radix Astragali 1-3 part, Stigma Croci 1-3 part, Radix Cucubali 1-3 part.
As preferably, prepare by following parts by weight:
Rhizoma Epimedii 3 parts, Herba pyrolae japonicae 2 parts, Flos Caraganae Sinicae 2 parts, sweet blue or green Herba Saussureae Involueratae 2 parts, Polyalthia nemoralis A. D C. 3 parts, 4 parts, Fructus Jujubae, 2 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 2 parts, Radix seu Caulis Verntilaginis Leiocarpae 3 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 2 parts.
Optimum ratio is separately had to be: Rhizoma Epimedii 2 parts, Herba pyrolae japonicae 3 parts, Flos Caraganae Sinicae 3 parts, sweet blue or green Herba Saussureae Involueratae 3 parts, Polyalthia nemoralis A. D C. 3 parts, 3 parts, Fructus Jujubae, 3 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 3 parts, Radix seu Caulis Verntilaginis Leiocarpae 2 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 3 parts.
Chinese medicine of the present invention, prepare in the steps below:
Take raw material of Chinese medicine according to formula, Muraenesocis cinereus ovum grind into powder, all the other medical materials join in container, add water to cover powder and soak 10 ~ 20 minutes, then add water and no powder 3 ~ 5 centimetres, decoct with high heat and use slow fire boiling again instead 20 ~ 30 minutes to seething with excitement, get filtrate; And then add water and do not have powder 3 ~ 5 centimetres, decoct with high heat and uses slow fire boiling again instead 15 ~ 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges and adds the Muraenesocis cinereus ovum powder of grinding.
When taking, each 200 ~ 300ml, sooner or later respectively once, decoction being taken warmly after meal 14 days is a course for the treatment of.
Pharmacology analysis:
Rhizoma Epimedii: control empty pouring, nebulousurine, leucorrhea, menoxenia, children's's night blindness, carbuncle becomes pus not burst.
Herba pyrolae japonicae: bitter is flat, nontoxic." Shaanxi Chinese medicinal herbal ": often make emmenagogue.For tea-drinking, for gynecological's deficiency of YIN, leucorrhea." Shaanxi medical herbs ": kidney invigorating and YANG supporting, astringing to arrest bleeding.Control cough due to consumptive disease, anemofrigid-damp arthralgia, hemiplegia. the foot and knee being feeble and various hemorrhage.
Sweet blue or green Herba Saussureae Involueratae: micro-hardship, heat.Poisonous.Strong muscle is active, and kidney invigorating and YANG supporting restores menstrual flow and invigorates blood circulation.For rheumatic arthritis, lumbago due to renal deficiency, sexual impotence, women's cold and pain in the lower abdomen, amenorrhea, placenta retention, lung cold cough, measles without adequate eruption.
Flos Caraganae Sinicae: sour, puckery, temperature.Kidney invigorating and YANG supporting, synthetism is stopped blooding.For impotence due to deficiency of the kidney; Wound hemorrhage is controlled in external, injury and bone fracture.
Polyalthia nemoralis A. D C.: sweet is flat.Spleen reinforcing stomach invigorating, tonifying the kidney to consolidate the essence.Cure mainly chronic gastritis, inappetence, myasthenia of limbs, seminal emission.
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to promote the production of body fluid, treatment physical weakness, neurasthenia, incoordination between the spleen and stomach, anorexia and loose stool, epersalgia cough, anemia are become thin, nourishing the liver gives protection against cancer.
Muraenesocis cinereus ovum: strengthening by means of tonics.Main body void is frail; Liver cirrhosis; Fatty liver; Neurasthenia; Anemia.
Radix Saniculae Astrantifoliae: sweet, micro-hardship, temperature.Invigorating the lung and the kidney.For pulmonary tuberculosis, lumbago due to renal deficiency, dizzy.
Radix seu Caulis Verntilaginis Leiocarpae: sweet, temperature.Benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.
The Radix Astragali: tonifying Qi and lifting yang, benefit defend consolidating superficial resistance.
Radix Cucubali: warm in nature, bitter in the mouth acid.Removing heat from blood, invigorates blood circulation, dampness removing, detumescence.Control women's amenorrhea, vicarious menstruation, traumatic injury, rheumatic arthritis, gonorrhea, edema, scrofula, swollen ulcer drug.
Stigma Croci: sweet in the mouth is flat, nontoxic.Enter the heart, Liver Channel.Blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.
Flos Caraganae Sinicae in formula of the present invention, Rhizoma Epimedii, sweet blue or green Herba Saussureae Involueratae, Herba pyrolae japonicae are kidney-reinforcing drug, nourishing kidney; Fructus Jujubae, Polyalthia nemoralis A. D C., Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae Yin-nourishing and body fluid promoting; The Radix Astragali, Radix seu Caulis Verntilaginis Leiocarpae invigorating the spleen and replenishing QI; Stigma Croci, Radix Cucubali removing blood stasis stimulate the menstrual flow, all medicine compatibilities, and treatment premature ovarian failure, treating both the principal and secondary aspects of a disease, has instant effect, eutherapeutic feature.
Clinical test results is as follows:
(1) inclusive criteria:
A year August in January, 2015 to 2015 accepts 60 routine chain reaction in patients with premature ovarians for medical treatment, amenorrhea before clinical manifestation is 45 years old, the symptom of the menopausal syndromes such as each case appearance is infertile, sterile, mood change, paraesthesia, insomnia, hypomnesis, senile vaginitis, genital atrophy, dyspareunia, osteoporosis.Wherein 60 examples include this research range in.
(2), Outcome measure
Effective: above-mentioned symptom disappears, physical function recovers normal.
Take a turn for the better: above-mentioned symptom improves.
Invalid: above-mentioned symptom is without improvement.
(3), experiment conclusion
After treating 3-6 the course for the treatment of, in 60 routine clinical experiment patients, effective 39 people, take a turn for the better 9 people, invalid 12 people, total effective rate 80%.
Detailed description of the invention
Embodiment 1
Rhizoma Epimedii 3 parts, Herba pyrolae japonicae 2 parts, Flos Caraganae Sinicae 2 parts, sweet blue or green Herba Saussureae Involueratae 2 parts, Polyalthia nemoralis A. D C. 3 parts, 4 parts, Fructus Jujubae, 2 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 2 parts, Radix seu Caulis Verntilaginis Leiocarpae 3 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 2 parts.
Embodiment 2
Rhizoma Epimedii 2 parts, Herba pyrolae japonicae 3 parts, Flos Caraganae Sinicae 3 parts, sweet blue or green Herba Saussureae Involueratae 3 parts, Polyalthia nemoralis A. D C. 3 parts, 3 parts, Fructus Jujubae, 3 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 3 parts, Radix seu Caulis Verntilaginis Leiocarpae 2 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 3 parts.
Chinese medicine formula of the present invention, prepare as follows and use:
Take raw material of Chinese medicine according to formula, Muraenesocis cinereus ovum grind into powder, all the other medical materials join in container, add water to cover powder and soak 15 minutes, then add water and do not have powder 5 centimetres, decoct with high heat and use slow fire boiling again instead 25 minutes to boiling, get filtrate; And then add water and do not have powder 5 centimetres, decoct with high heat and uses slow fire boiling again instead 20 minutes to boiling, then remove slag and get filtrate, twice filtrate merges and adds the Muraenesocis cinereus ovum powder of grinding.
When taking, each 250ml, sooner or later respectively once, decoction being taken warmly after meal.
Claims (3)
1. treat a Chinese medicine formula for premature ovarian failure, it is characterized in that being formed by the Chinese medicine proportioning of following parts by weight: Rhizoma Epimedii 2-3 part, Herba pyrolae japonicae 2-3 part, Flos Caraganae Sinicae 1-3 part, sweet blue or green Herba Saussureae Involueratae 2-3 part, Polyalthia nemoralis A. D C. 2-4 part, Fructus Jujubae 3-5 part, Muraenesocis cinereus ovum 2-3 part, Radix Saniculae Astrantifoliae 1-3 part, Radix seu Caulis Verntilaginis Leiocarpae 2-3 part, Radix Astragali 1-3 part, Stigma Croci 1-3 part, Radix Cucubali 1-3 part.
2. the Chinese medicine formula for the treatment of premature ovarian failure according to claim 1, is characterized in that being formed by the Chinese medicine proportioning of following parts by weight: Rhizoma Epimedii 3 parts, Herba pyrolae japonicae 2 parts, Flos Caraganae Sinicae 2 parts, sweet blue or green Herba Saussureae Involueratae 2 parts, Polyalthia nemoralis A. D C. 3 parts, 4 parts, Fructus Jujubae, 2 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 2 parts, Radix seu Caulis Verntilaginis Leiocarpae 3 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 2 parts.
3. the Chinese medicine formula for the treatment of premature ovarian failure according to claim 1, is characterized in that being formed by the Chinese medicine proportioning of following parts by weight: Rhizoma Epimedii 2 parts, Herba pyrolae japonicae 3 parts, Flos Caraganae Sinicae 3 parts, sweet blue or green Herba Saussureae Involueratae 3 parts, Polyalthia nemoralis A. D C. 3 parts, 3 parts, Fructus Jujubae, 3 parts, Muraenesocis cinereus ovum, Radix Saniculae Astrantifoliae 3 parts, Radix seu Caulis Verntilaginis Leiocarpae 2 parts, the Radix Astragali 2 parts, Stigma Croci 2 parts, Radix Cucubali 3 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106334072A (en) * | 2016-10-31 | 2017-01-18 | 吴洁 | Traditional Chinese medicine for treating premature ovary failure and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623385A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Application of traditional Chinese medicine composition in preparing preparation for treating premature ovarian failure of adult females |
| CN102847051A (en) * | 2011-06-27 | 2013-01-02 | 张红旗 | A Chinese medicinal formulation for treating premature ovarian failure |
| CN102885951A (en) * | 2011-07-18 | 2013-01-23 | 天津太平洋制药有限公司 | Medicament for treating premature ovarian failure |
| CN104587189A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine formula for treating premature ovarian failure |
| CN104587188A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Formula of traditional Chinese medicine for treating premature ovarian failure |
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- 2015-12-25 CN CN201510989338.9A patent/CN105497331A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623385A (en) * | 2009-01-22 | 2010-01-13 | 九芝堂股份有限公司 | Application of traditional Chinese medicine composition in preparing preparation for treating premature ovarian failure of adult females |
| CN102847051A (en) * | 2011-06-27 | 2013-01-02 | 张红旗 | A Chinese medicinal formulation for treating premature ovarian failure |
| CN102885951A (en) * | 2011-07-18 | 2013-01-23 | 天津太平洋制药有限公司 | Medicament for treating premature ovarian failure |
| CN104587189A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Traditional Chinese medicine formula for treating premature ovarian failure |
| CN104587188A (en) * | 2015-01-23 | 2015-05-06 | 青岛市中心医院 | Formula of traditional Chinese medicine for treating premature ovarian failure |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106334072A (en) * | 2016-10-31 | 2017-01-18 | 吴洁 | Traditional Chinese medicine for treating premature ovary failure and preparation method thereof |
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Application publication date: 20160420 |