CN105481789B - 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法 - Google Patents

一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法 Download PDF

Info

Publication number
CN105481789B
CN105481789B CN201410468433.XA CN201410468433A CN105481789B CN 105481789 B CN105481789 B CN 105481789B CN 201410468433 A CN201410468433 A CN 201410468433A CN 105481789 B CN105481789 B CN 105481789B
Authority
CN
China
Prior art keywords
amino
hydroxy
aza
oxadiazole
carboxamidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201410468433.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN105481789A (zh
Inventor
王召印
郭巍
朱继东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Organic Chemistry of CAS
Original Assignee
Shanghai Institute of Organic Chemistry of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201410468433.XA priority Critical patent/CN105481789B/zh
Application filed by Shanghai Institute of Organic Chemistry of CAS filed Critical Shanghai Institute of Organic Chemistry of CAS
Priority to CA2961393A priority patent/CA2961393A1/en
Priority to US15/510,984 priority patent/US11053207B2/en
Priority to JP2017514444A priority patent/JP6317034B2/ja
Priority to CN201580049490.7A priority patent/CN106687450B/zh
Priority to PCT/CN2015/089666 priority patent/WO2016041489A1/zh
Priority to EP15841325.2A priority patent/EP3196197A4/en
Publication of CN105481789A publication Critical patent/CN105481789A/zh
Application granted granted Critical
Publication of CN105481789B publication Critical patent/CN105481789B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201410468433.XA 2014-09-15 2014-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法 Active CN105481789B (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN201410468433.XA CN105481789B (zh) 2014-09-15 2014-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
US15/510,984 US11053207B2 (en) 2014-09-15 2015-09-15 Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
JP2017514444A JP6317034B2 (ja) 2014-09-15 2015-09-15 インドールアミン−２，３−ジオキシゲナーゼ阻害剤およびその製造方法
CN201580049490.7A CN106687450B (zh) 2014-09-15 2015-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
CA2961393A CA2961393A1 (en) 2014-09-15 2015-09-15 Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor
PCT/CN2015/089666 WO2016041489A1 (zh) 2014-09-15 2015-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
EP15841325.2A EP3196197A4 (en) 2014-09-15 2015-09-15 Indoleamine-2,3-dioxygenase inhibitor and preparation method therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410468433.XA CN105481789B (zh) 2014-09-15 2014-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法

Publications (2)

Publication Number Publication Date
CN105481789A CN105481789A (zh) 2016-04-13
CN105481789B true CN105481789B (zh) 2020-05-19

Family

ID=55532557

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201410468433.XA Active CN105481789B (zh) 2014-09-15 2014-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
CN201580049490.7A Active CN106687450B (zh) 2014-09-15 2015-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201580049490.7A Active CN106687450B (zh) 2014-09-15 2015-09-15 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法

Country Status (6)

Country Link
US (1) US11053207B2 (enExample)
EP (1) EP3196197A4 (enExample)
JP (1) JP6317034B2 (enExample)
CN (2) CN105481789B (enExample)
CA (1) CA2961393A1 (enExample)
WO (1) WO2016041489A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105481789B (zh) * 2014-09-15 2020-05-19 中国科学院上海有机化学研究所 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
CN106883193B (zh) * 2015-12-15 2021-10-15 上海翰森生物医药科技有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
CN107176933B (zh) * 2016-03-09 2020-10-09 中国科学院上海有机化学研究所 一种含氮烷基化和芳基化亚砜亚胺的吲哚胺-2,3-双加氧酶抑制剂
CN107304191B (zh) * 2016-04-20 2023-09-29 上海翰森生物医药科技有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
WO2017181849A1 (zh) * 2016-04-20 2017-10-26 江苏豪森药业集团有限公司 吲哚胺2,3-双加氧酶抑制剂及其制备方法与应用
CN106109472A (zh) * 2016-06-13 2016-11-16 中山大学 氯氮卓作为吲哚胺2,3-双加氧酶-1抑制剂的用途
SG11201900868XA (en) * 2016-08-02 2019-02-27 Shandong luye pharmaceutical co ltd Ido1 inhibitor and preparation method and application thereof
WO2018072697A1 (zh) * 2016-10-17 2018-04-26 上海医药集团股份有限公司 含噁二唑环化合物、制备方法、中间体、组合物及应用
UY37466A (es) 2016-11-03 2018-01-31 Phenex Discovery Verwaltungs Gmbh N-hidroxiamidinheterociclos sustituidos como moduladores de la indolamina 2,3-dioxigenasa
CN110139857B (zh) * 2016-11-28 2023-07-21 重庆复尚源创医药技术有限公司 作为吲哚胺2,3-双加氧酶抑制剂的亚砜亚胺、磺酰亚胺酰胺、磺酰二亚胺和二酰亚胺磺酰胺化合物
CN108218807A (zh) * 2016-12-22 2018-06-29 上海长森药业有限公司 一种作为吲哚胺-2,3-双加氧酶抑制剂的砜脒及其制备方法和用途
CN106866648B (zh) * 2017-01-03 2019-10-22 中国药科大学 邻苯二甲酰亚胺类吲哚胺-2,3-双加氧酶1抑制剂及其用途
CN106883224B (zh) * 2017-01-03 2019-10-22 中国药科大学 苯并含氮杂环类吲哚胺-2,3-双加氧酶1抑制剂及其用途
CN110191709A (zh) 2017-01-17 2019-08-30 德州大学系统董事会 可用作吲哚胺2,3-双加氧酶和/或色氨酸双加氧酶抑制剂的化合物
WO2018156443A1 (en) * 2017-02-24 2018-08-30 Merck Sharp & Dohme Corp. Novel substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (ido) inhibitors
CN108689958B (zh) * 2017-04-05 2021-09-17 南京华威医药科技集团有限公司 一种含有肼基的吲哚胺2,3-双加氧化酶抑制剂
US11046679B2 (en) 2017-04-24 2021-06-29 Nanjing Transthera Biosciences Co. Ltd. Indoleamine 2,3-dioxygenase inhibitor and application
CN109081818B (zh) * 2017-06-14 2022-04-22 南京华威医药科技集团有限公司 新型吲哚胺2,3-双加氧化酶抑制剂
CN110248931B (zh) * 2017-09-20 2022-12-23 上海翰森生物医药科技有限公司 一种双加氧酶抑制剂的盐及其制备方法和用途
CN109678813A (zh) * 2017-10-18 2019-04-26 中国科学院上海有机化学研究所 吲哚胺-2,3-双加氧酶抑制剂盐及其制备方法
JP7306634B2 (ja) 2017-10-19 2023-07-11 一般社団法人ファルマバレープロジェクト支援機構 Ｉｄｏ／ｔｄｏ阻害剤
CN110092750B (zh) 2018-01-29 2023-07-21 北京诺诚健华医药科技有限公司 五氟硫烷基取代的酰胺类化合物、其制备方法及其在医药学上的应用
WO2019149255A1 (zh) * 2018-02-02 2019-08-08 成都海创药业有限公司 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法和用途
WO2019149159A1 (zh) * 2018-02-02 2019-08-08 山东绿叶制药有限公司 一种包含噁二唑类衍生物的组合物及其制备方法和应用
CN110156674A (zh) * 2018-02-13 2019-08-23 中国科学院上海有机化学研究所 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
WO2020018670A1 (en) 2018-07-17 2020-01-23 Board Of Regents, The University Of Texas System Compounds useful as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan dioxygenase
US11839659B2 (en) 2020-07-02 2023-12-12 Northwestern University Proteolysis-targeting chimeric molecules (PROTACs) that induce degradation of indoleamine 2,3-dioxygenase (IDO) protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102164902A (zh) * 2008-07-08 2011-08-24 因塞特公司 作为吲哚胺2,3-双加氧酶的抑制剂的1,2,5-二唑

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122020016659B8 (pt) * 2005-05-10 2021-07-27 Incyte Holdings Corp moduladores de 2,3-dioxigenase de indolamina e métodos de modulação de atividade de inibição e de imunossupressão
ES2540561T3 (es) * 2005-12-20 2015-07-10 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa
WO2008036643A2 (en) * 2006-09-19 2008-03-27 Incyte Corporation Amidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
US20080182882A1 (en) * 2006-11-08 2008-07-31 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CA2889182A1 (en) * 2012-10-26 2014-05-01 The University Of Chicago Synergistic combination of immunologic inhibitors for the treatment of cancer
CN105481789B (zh) * 2014-09-15 2020-05-19 中国科学院上海有机化学研究所 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102164902A (zh) * 2008-07-08 2011-08-24 因塞特公司 作为吲哚胺2,3-双加氧酶的抑制剂的1,2,5-二唑

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Synthesis and conformational and configurational studies of diastereoisomeric O-protected 4-(arylsulfonimidoyl)butane-1,2,3-triols;J. S. W. Kwong et al.;《Tetrahedron》;20071006;第63卷;第12601–12607页 *

Also Published As

Publication number Publication date
EP3196197A4 (en) 2018-09-05
US20190152932A1 (en) 2019-05-23
CN106687450A (zh) 2017-05-17
EP3196197A1 (en) 2017-07-26
JP2017526727A (ja) 2017-09-14
WO2016041489A1 (zh) 2016-03-24
JP6317034B2 (ja) 2018-04-25
CA2961393A1 (en) 2016-03-24
US11053207B2 (en) 2021-07-06
CN106687450B (zh) 2019-08-16
CN105481789A (zh) 2016-04-13

Similar Documents

Publication Publication Date Title
CN105481789B (zh) 一种吲哚胺-2,3-双加氧酶抑制剂及其制备方法
CN105646389B (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的氨基磺酸脂及其制备方法和用途
CN107176933B (zh) 一种含氮烷基化和芳基化亚砜亚胺的吲哚胺-2,3-双加氧酶抑制剂
JP7026787B2 (ja) ヒストン脱アセチル化酵素１および／または２（ｈｄａｃ１－２）の選択的阻害剤としての新規なヘテロアリールアミド誘導体
JP2022532718A (ja) Ａｃｓｓ２阻害剤およびその使用方法
AU2020271268B2 (en) Inhibitors of Notch signalling pathway and use thereof in treatment of cancers
CN110156674A (zh) 一种作为吲哚胺-2,3-双加氧酶抑制剂的螺环化合物
AU2020340427A1 (en) PERK inhibiting compounds
CN114269720A (zh) 乙酰辅酶a合成酶短链2(acss2)的小分子抑制剂
US11370766B2 (en) Sulfonyl amidine as indoleamine-2,3-dioxygenase inhibitor, and preparation method therefor and use thereof
CN110724076B (zh) 对芳基二甲酰胺类化合物、包含其的药物组合物、其制备方法及其用途
BR122025013774A2 (pt) Compostos inibidores da via de sinalização notch, composição farmacêutica compreendendo os mesmos e uso dos referidos compostos
EP2802563B1 (en) Novel heteroarylamide derivatives having antiandrogenic properties
BR112020000564B1 (pt) Composto de heteroarilamida como inibidor seletivo das histonas desacetilases 1 e/ou 2 (hdac1-2), composição farmacêutica, uso e combinação do mesmo
HK1201838B (en) Novel heteroarylamide derivatives having antiandrogenic properties

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant