CN105477555A - 一种治疗肺癌的中药配方及其制备方法 - Google Patents

一种治疗肺癌的中药配方及其制备方法 Download PDF

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CN105477555A
CN105477555A CN201511020193.8A CN201511020193A CN105477555A CN 105477555 A CN105477555 A CN 105477555A CN 201511020193 A CN201511020193 A CN 201511020193A CN 105477555 A CN105477555 A CN 105477555A
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王秀珍
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Qingdao Lantu Culture Communication Co Ltd Shinan Branch
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Abstract

本发明属于中医中药技术领域，特别涉及一种治疗肺癌的中药配方及其制备方法。由以下重量份数的中药原料配制而成：柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、鸡肫草3-5份、竹叶兰3-5份、厚叶牛耳草3-5份、山枝根3-5份、黄精3-8份、茯苓3-8份、黄芪3-8份。制备方法是颗粒。本发明通过中药的扶正固本、清热解毒、化痰散结之效，辅助以补虚益气之药，抑制肿瘤繁殖，控制肿瘤扩散转移，增强免疫力，减轻病人痛苦，挽救病人生命。

Description

一种治疗肺癌的中药配方及其制备方法
技术领域
本发明属于中医中药技术领域，特别涉及一种治疗肺癌的中药配方及其制备方法。
背景技术
肺癌是发病率和死亡率增长最快，对人群健康和生命威胁最大的恶性肿瘤之一。近50年来许多国家都报道肺癌的发病率和死亡率均明显增高，男性肺癌发病率和死亡率均占所有恶性肿瘤的第一位，女性发病率占第二位，死亡率占第二位。肺癌的病因至今尚不完全明确，大量资料表明，长期大量吸烟与肺癌的发生有非常密切的关系。已有的研究证明：长期大量吸烟者患肺癌的概率是不吸烟者的10-20倍，开始吸烟的年龄越小，患肺癌的几率越高。
化疗是肺癌的主要治疗方法，90％以上的肺癌需要接受化疗治疗。但化疗可以有效伤癌细胞，同时又会杀伤正常细胞而导致患者的免疫功能被抑制，出现更多的并发症，给患者身体带来极大损伤。中国专利(CN103041291A)公开了一种治疗肺癌的中药，对肺癌患者具有稳定病情，改善症状的作用，但缺乏临床数据支持，效果有待考证，实际推广有一定的限制。
发明内容
本发明的目的是提供一种治疗肺癌的中药配方及其制备方法，通过中药的扶正固本、清热解毒、化痰散结之效，辅助以补虚益气之药，抑制肿瘤繁殖，控制肿瘤扩散转移，增强免疫力，减轻病人痛苦，挽救病人生命。
本发明提供一种治疗肺癌的中药配方，由以下重量份数的中药原料配制而成：柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、鸡肫草3-5份、竹叶兰3-5份、厚叶牛耳草3-5份、山枝根3-5份、黄精3-8份、茯苓3-8份、黄芪3-8份。
进一步优选为由以下重量份数的中药原料配制而成：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、鸡肫草4份、竹叶兰4份、厚叶牛耳草4份、山枝根4份、黄精5份、茯苓6份、黄芪5份。
制备方法步骤如下：按比例选取药物各组分，研磨成细末，混合均匀，将混合物加入8倍的65％乙醇加热回流提取45分钟，将剩余部分再加入6倍的65％的乙醇加热回流提取30分钟，两次提取液合并后过滤，浓缩至密度为1.50的清膏，备用；在清膏内加入糊精、蔗糖制成颗粒后包装。
药理分析：
柴胡：苦，凉；微寒，无毒；入肝、胆经；疏肝解郁。
蒲公英：苦、甘、寒；肝、胃经；清热解毒、消肿散结。
蚤休：苦、寒；心、肝经；清热解毒，平喘止咳，熄风定惊；治痈肿，疔疮，瘰疬，喉痹，慢性气管炎，小儿惊风抽搐，蛇虫咬伤。
紫花地丁：苦、辛、寒；心、肝经；清热解毒、凉血消肿，用于痈肿疮毒、乳痈肠痈。
佛手：味辛、微苦，性温。肝、脾、胃、肺经。能舒肝解郁，理气和中，化痰。
玫瑰花：味甘微苦、性微温，归肝、脾、胃经。疏肝解郁、活血止痛。
香橼：辛、苦、酸、温；入肝、脾、胃经；具有疏肝理气，宽胸化痰，除湿和中；主治胸胁胀痛，咳嗽痰多，脘腹痞痛，食滞呕逆。
大蓟：甘、苦、寒；心、肝、胃经；活血止血、散瘀解毒、消痈。
郁金：辛、苦、寒；入心、肺、肝经；行气解郁，凉血破瘀。治胸腹胁肋诸痛，失心癫狂，热病神昏，吐血，衄血，尿血，血淋，妇女倒经，黄疸。
莪术：辛、苦，温。归肝、脾经；破血行气，消积止痛。用于血瘀腹痛、肝脾肿大、心腹胀痛，积聚，妇女血瘀经闭，跌打损伤作痛饮食积滞。
三棱：辛、苦，平。归肝、脾经。破血行气，消积止痛。用于症瘕痞块，瘀血经闭，食积胀痛。
黄药子：苦，辛，咸，性凉，有小毒。化痰散结，凉血止血。
琥珀：甘、平；入心、肝、膀胱经；镇静安神、活血散瘀、利尿通淋。
牡蛎：味咸；性微寒。重镇安神，潜阳补阴，软坚散结，收敛固涩。用于惊悸失眠，眩晕耳鸣，瘰疬痰核，徵瘕痞块，自汗盗汗，遗精崩带，胃痛泛酸。煅牡蛎收敛固涩。用于自汗盗汗，遗精崩带，胃痛吞酸。
鸡肫草：淡、平。功能清肺止咳，利水祛湿；主治久咳咯血，疟疾，肾结石，胆石症，白带，跌打损伤；外用治湿热疮毒。
竹叶兰：苦，平。功效清热解毒，祛风除湿，止痛，利尿；用于肝炎，关节痛，腰酸腿痛，胃痛，淋证，小便涩痛，脚气水肿，瘰疬，肺痨，牙痛，咽喉痛，感冒，小儿惊风，小儿疳积，咳嗽，食物中毒，跌伤，蛇咬伤，外伤出血。
厚叶牛耳草：味甘；性平。功效补肺止咳，凉血止血；主肺虚咳喘，咯血，血崩。
山枝根：活血通络，解痉止痛。治风湿性关节炎，坐骨神经痛，跌打骨折，小儿麻痹后遗症，产后风瘫，心胃气痛，牙痛。
黄精：补脾益气，滋肾填精，养心安神等功效。常用于治疗老年痴呆心脾两虚，肝肾不足，筋骨软弱，食少口干等症。还有提高超氧化物歧化酶。
茯苓：具有抗氧化，防衰老，增加免疫力，提高大脑细胞活性的作用。茯苓有较强的利尿作用，可治疗肾炎、心衰水肿。另外还有镇静作用，对神经衰弱有效。味淡性平，善益气养血，宁心安神，败毒抗癌；药性平和，利湿而不伤正气，所含茯苓酸具有增强免疫力、抗肿瘤以及镇静、降血糖等的作用；可松弛消化道平滑肌，抑制胃酸分泌，防止肝细胞坏死，抗菌等功效。
黄芪：润燥滑肠。用于肺热咳嗽，痰浊黄稠，胸痹心痛，结胸痞满，乳痈，肺痈，肠痈肿痛，大便秘结。
本发明的中药，通过中药的扶正固本、清热解毒、化痰散结之效，辅助以补虚益气之药，抑制肿瘤繁殖，控制肿瘤扩散转移，增强免疫力，减轻病人痛苦，挽救病人生命。
疗效判断：
1.1一般资料
本发明对175例肺癌患者进行临床观察治疗，其中年龄最小者25岁，最大者78岁，平均年龄54岁；男94例，女81例。
1.2治疗方法
治疗方法：患者服用本发明颗粒，一日3次，连服1个月。
1.3疗效评定标准
临床症候疗效标准将咳嗽、咯痰、痰血、胸闷、胸痛、气急、发热等常见症状按轻、中、重分为3级，分别记为2、4、6分，在治疗前后进行累积对比，按积分比法评价疗效。
显效：治疗后症状体征积分值下降≥2/3；
有效：治疗后症状体征积分值下降≥1/3，但＜2/3；
无效：达不到有效标准者。
1.4治疗效果：
显效102例，占58.3％，有效72例，占41.1％，无效1例，占0.6％，总有效率99.4％。
1.5典型病例：
病例1：刘某某,男,58岁,患者自感身体不舒,咳嗽,吐痰,胸疼,发烧39.5度,到当地医院做胸片,CT,支气管镜，诊断为：左肺中心型肺鳞癌，肿瘤3×4cm，经过放疗化疗后，病情没有好转，持续发烧两个月，用一些退烧药，只能短时缓解，遂来我处就诊，给予本发明中药进行治疗，1月后显效，临床症状消失，随访半年无复发。
病例2：鞠谋，女，36岁，因咳嗽，咳血，吐黄痰，右胸疼，在当地医院做纤维支气管镜检，肉眼检查为：右侧中间段支气管.与上叶开口下方外侧壁有一结节状肿物，组织较脆，易出血。后病理诊断：小细胞性肺癌，见个别磷状上皮细胞癌，胸片诊断：右上中心型肺癌，伴右上叶不张，右肺门纵膈淋巴结转移。因无法手术病人又不愿化疗，遂给予本发明中药进行治疗，1月后有效，临床症状消失，随访半年无复发。
具体实施方式
实施例1：
一种治疗肺癌的中药配方，由以下重量份数的中药原料配制而成：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、鸡肫草4份、竹叶兰4份、厚叶牛耳草4份、山枝根4份、黄精5份、茯苓6份、黄芪5份。
制备方法步骤如下：按比例选取药物各组分，研磨成细末，混合均匀，将混合物加入8倍的65％乙醇加热回流提取45分钟，将剩余部分再加入6倍的65％的乙醇加热回流提取30分钟，两次提取液合并后过滤，浓缩至密度为1.50的清膏，备用；在清膏内加入糊精、蔗糖制成颗粒后包装。
以上已将本发明做一详细说明，以上所述，仅为本发明之较佳实施例而已，当不能限定本发明实施范围，即凡依本申请范围所作均等变化与修饰，皆应仍属本发明涵盖范围内。

Claims (3)

1.一种治疗肺癌的中药配方，其特征在于由以下重量份数的中药原料配制而成：柴胡3-5份、蒲公英1-3份、蚤休2-4份、紫花地丁3-5份、佛手5-8份、玫瑰花5-8份、香橼3-5份、大蓟5-8份、郁金8-12份、莪术5-8份、三棱5-8份、黄药子5-8份、琥珀5-8份、鸡肫草3-5份、竹叶兰3-5份、厚叶牛耳草3-5份、山枝根3-5份、黄精3-8份、茯苓3-8份、黄芪3-8份。
2.如权利要求1所述的一种治疗肺癌的中药配方，其特征在于由以下重量份数的中药原料配制而成：柴胡4份、蒲公英2份、蚤休2份、紫花地丁4份、佛手6份、玫瑰花8份、香橼4份、大蓟8份、郁金10份、莪术6份、三棱6份、黄药子6份、琥珀6份、鸡肫草4份、竹叶兰4份、厚叶牛耳草4份、山枝根4份、黄精5份、茯苓6份、黄芪5份。
3.一种权利要求1所述的治疗肺癌的中药配方的制备方法，其特征在于步骤如下：按比例选取药物各组分，研磨成细末，混合均匀，将混合物加入8倍的65％乙醇加热回流提取45分钟，将剩余部分再加入6倍的65％的乙醇加热回流提取30分钟，两次提取液合并后过滤，浓缩至密度为1.50的清膏，备用；在清膏内加入糊精、蔗糖制成颗粒后包装。
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Publication number Priority date Publication date Assignee Title
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