CN105477374A - Healthy food composition with auxiliary protection function of gastric mucosal injury - Google Patents
Healthy food composition with auxiliary protection function of gastric mucosal injury Download PDFInfo
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- CN105477374A CN105477374A CN201511016373.9A CN201511016373A CN105477374A CN 105477374 A CN105477374 A CN 105477374A CN 201511016373 A CN201511016373 A CN 201511016373A CN 105477374 A CN105477374 A CN 105477374A
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Abstract
The invention relates to application of a traditional Chinese medicine composition in preparation of a healthy food with an auxiliary protection function of gastric mucosal injury. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal raw materials in parts by weight: 30-80 parts of lily, 30-80 parts of poria cocos, 40-90 parts of radix scrophulariae, 30-80 parts of ligusticum wallichii, 5-30 parts of endothelium corneum gigeriae galli, 20-60 parts of rhizoma alismatis, 5-30 parts of pseudo-ginseng, 10-50 parts of rhizoma atractylodis macrocephalae, 20-60 parts of angelica sinensis, 50-90 parts of sanguisorba officinalis, 20-60 parts of typhae pollen, 120-180 parts of radix paeoniae alba and 40-90 parts of dendrobe.
Description
Invention field
The present invention relates to a kind of preparation method of Chinese medicine and health food compositions, particularly there is the pharmaceutical preparation that gastric mucosa injury has the preparation method of the health-care food composition of assistant protection function and prepares by the method.
Background technology
Whole inner surfacies of stomach are covered with one deck mucosal tissue, can secreting mucus, form the mucus one mucosal barrier protection gastric tissue of stomach.Gastric mucosa injury is more common in gastritis, gastric ulcer.Often due to chemical factor (smoking, drink, strong tea, coffee and stimulate the medicine of gastric mucosa as aspirin, indometacin etc.), caused by physical factor (supercool, excessively boiling hot, too coarse food or eating and drinking too much at one meal etc.), the factor such as antibacterial or its toxin stimulation.
Gastric mucosa injury is divided into the coat of the stomach damage stomach function regulating disruptiveness damage of breaking without holostrome, and the coat of the stomach damage of breaking without holostrome without obvious clinical symptoms, or can only have the mild pain of epigastrium, takes a turn for the better gradually after clinical observation.
Gastric rupture damage major systemic performance be shock and hemorrhage; Abdominal part presents peritoneal irritation sign more.
After gastric rupture, often there is stomachache immediately, abdominal distention and diffusivity peritoneal irritation sign, it is rare to vomit, can dyspnea be there is in abdominal distention severe patient, damaged mouth close to cardia, during esophagus district, mediastinal emphysema is caused because air can enter mediastinum, hydropneumothorax, chest subcutaneous emphysema, when gastric injury is larger, can to gush out indigested food from abdominal wound, bile and gas; Can also see the stomach split once in a while, some case can in abdominal subcutaneous edema due to disorder of QI in various degree, and liver dullness circle reduces or disappears, and shifting dullness can be positive, hypoactive bowel sounds or disappearance, if be associated with other organs damage, and can with corresponding sings and symptoms.
Protection gastric mucosa comprises following methods:
1. protect the food stomach of gastric mucosa expensive in " supporting " but not " controlling ", suitable diet content and good dietary habit are the important measures preventing and treating gastric mucosa injury.Diet gastric mucosa being had to intense stimulus should be limited, and utilize diet to reduce or increase the secretion of gastric acid, regulate stomach function.Very few to gastric acid secretion or lack patient, can give the food stimulus gastric acid secretion such as concentrated fish soup, chicken soup, mushroom soup of rich nitrogen extractum.The patient of gastroxia then should avoid above-mentioned natural juice thick soup, adopt remove former soup after boiling lean meat, fish, Carnis Gallus domesticus, and Amylum Nelumbinis Rhizomatis, weak tea, various sweet fruit to boil water, dense rice water, congee etc., gastric secretion is reduced, and the steamed bread of edible fresh milk, bean milk, band alkali dry with in and gastric acid.The medicated porridge that rice or Semen setariae are boiled into has the intestines and stomach coordinating function.
2 have the health product or medicine of protecting gastric mucosa effect.Known prolamin has repairs gastric mucosa effect, material in prolamin can the muscle protein of targeted stimulation human gastrointestinal tract and the synthesis of glycogen, the generation of human stomach mucosa can be improved, promote gastric motility, be known to gastrointestinal disease such as solution intractable gastritis and gastric ulcers to effective native protein, clinical effectiveness is remarkable.As the health food being raw material with the Chinese herbal medicine of invigorating the spleen and benefiting QI nourishing the stomach effect.Conventional has the Rhizoma Dioscoreae of invigorating the spleen and benefiting QI class, the Fructus Amomi of class of regulating the flow of vital energy, the Fructus Gardeniae etc. of heat clearing away class.Other have good protective effect to gastric mucosa as Hericium erinaceus (Bull. Ex Fr.) Pers., and the Total saponin tool contained by the Radix Astragali, Radix Codonopsis, Radix Ginseng is antibacterial, antiviral and improve immunity, effective to the gastric mucosa injury caused by infecting.The health food being raw material with these compositions has protection gastric mucosa effect preferably.
The present inventor finds in clinical and production practices; prior art formula amount is large; medical material waste is serious; oral difficulty; and do not report that above-mentioned preparation had gastric mucosa injury and has assistant protection function; the present invention improves formula on the basis of existing technology, deletes the expensive medical material of part, the research work adopt the Chinese crude drug of medicine-food two-purpose in formula, having carried out in health food.The present invention, through experimentation, finds unexpectedly, and formula of the present invention has gastric mucosa injury and has assistant protection function, thus completes the present invention.
Summary of the invention:
The invention provides a kind of Chinese medicine composition in preparation, to there is gastric mucosa injury and have application in the health food of assistant protection function,
Described Chinese medicine composition is prepared from by the raw material of Chinese medicine medicine of following weight proportion, Bulbus Lilii 30-80 weight portion, Poria 30-80 weight portion, Radix Scrophulariae 40-90 weight portion, Rhizoma Chuanxiong 30-80 weight portion, Endothelium Corneum Gigeriae Galli 5-30 weight portion, Rhizoma Alismatis 20-60 weight portion, Radix Notoginseng 5-30 weight portion, Rhizoma Atractylodis Macrocephalae 10-50 weight portion, Radix Angelicae Sinensis 20-60 weight portion, Radix Sanguisorbae 50-90 weight portion, Pollen Typhae 20-60 weight portion, Radix Paeoniae Alba 120-180 weight portion, Herba Dendrobii 40-90 weight portion.Preferably, described Chinese medicine composition is prepared from by the raw material of Chinese medicine medicine of following weight proportion, Bulbus Lilii 60 weight portion, Poria 60 weight portion, Radix Scrophulariae 75 weight portion, Rhizoma Chuanxiong 45 weight portion, Endothelium Corneum Gigeriae Galli 15 weight portion, Rhizoma Alismatis 45 weight portion, Radix Notoginseng 15 weight portion, the Rhizoma Atractylodis Macrocephalae 30 weight portion, Radix Angelicae Sinensis 45 weight portion, Radix Sanguisorbae 75 weight portion, Pollen Typhae 45 weight portion, the Radix Paeoniae Alba 150 weight portion, Herba Dendrobii 75 weight portion.
In raw material of Chinese medicine: Rhizoma Atractylodis Macrocephalae parched with bran, Endothelium Corneum Gigeriae Galli (parched) selected by Endothelium Corneum Gigeriae Galli.
More than in composition, weight calculates with crude drug, more than composition is by weight as proportioning, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production also can by gram or milligram in units of, weight can increase or reduce, but the constant rate of raw medicinal herbs weight proportion between each composition.
Compositions of the present invention, preferred preparation method, step is as follows:
Medical material decocts with water 1-3 time, each 1.5-3 hour, collecting decoction, and filter, filtrate is concentrated in right amount, add ethanol, make alcohol content reach 60-80%, leave standstill, filter, reclaim ethanol, filtrate concentrates, and add water cold preservation, filters, obtains active substance, be then prepared into Halth-care composition.
Most preferred, described Chinese medicine composition preparation method step is as follows:
Medical material decocts with water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated in right amount, adds ethanol, make alcohol content reach 7%, leave standstill, filter, reclaim ethanol, filtrate concentrates, add water cold preservation, filters, obtain active substance, through formulation method, be then prepared into Halth-care composition.
The preparation of said products can adopt conventional manufacturing techniques, as using active substance of the present invention as active component, adds adjuvant if desired, as sweeting agent, correctives, the galenic pharmacy routine techniques such as excipient is prepared into tablet, capsule etc., or be prepared into food with food routine techniques.Compositions of the present invention can be that any one is applicable to oral dosage form, as tablet, and capsule, granule, oral liquid, powder, pills etc., also can be prepared into applicable edible food form, as caked sugar, cookies, milk product, ice lolly, bread, fruit jam etc.
Fang Zhong, Bulbus Lilii, Radix Scrophulariae, Herba Dendrobii yin nourishing stomach reinforcing are monarch drug, and Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Pollen Typhae, Radix Notoginseng blood nourishing acupuncture-stimulating are accessory drugs, and the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Alismatis, Radix Sanguisorbae invigorating spleen to remove dampness are adjuvant drug, QI and blood is prosperous, taste and, naturally pain only disease remove.Endothelium Corneum Gigeriae Galli regulating QI to relieve pain, blood stasis dispelling removing food stagnancy is for making medicine.Experiment proved kind conventional amount used use safety, in side, composition cooperatively interacts and has synergistic function.
Compared to the prior art, difference is method of the present invention, provides a kind of new purposes, below by way of experimental data, beneficial effect of the present invention is described:
Testing medicine used is the active substance prepared according to the method for the embodiment of the present invention 1, is called invention formulation,
The impact of experiment 1 on mice paper ear swelling
The impact of experiment 2 on mice hot plate reaction
Test the impact of 3 Dichlorodiphenyl Acetate induced mice writhing responses
The impact of experiment 4 on the emptying motion of Mouse Stomach
Experimental result is in Table 1-4.
Table 1 invention formulation is on the impact of mice paper ear swelling
Table 2 invention formulation is on the impact of mice hot plate reaction
The impact of table 3 invention formulation Dichlorodiphenyl Acetate induced mice writhing response
Table 4 invention formulation is on the impact of the emptying motion of Mouse Stomach
Enhancing immunity is tested
Must affect, in table 5 mouse thymus/weight ratio and spleen/weight ratio:
Table 5 is on the impact of mouse immune organ internal organs/weight ratio
On the impact of mouse cell immunologic function, in table 6,7:
Table 6 pair mouse lymphocyte conversion capability experimental result (lymphopoiesis ability)
Table 7 is on mice delayed allergy (the sufficient sole of the foot thickens method) impact (sufficient sole of the foot thickness difference mm)
On the impact of mouse antibodies cellulation, in table 8:
Table 8 is on mouse antibodies cellulation number impact (plaque number/106 splenocyte)
On mouse monokaryon--the impact of macrophage function, in table 9:
Table 9 is on mouse monokaryon--the impact (phagocytic index) of macrophage carbonic clearance
The protective effect of gastric mucosa injury
Experimental technique:
Get body weight and be 180 ~ 220g and the rat of water 48h is can't help in fasting, be divided at random blank group, of the present invention group, by 10ml//kg body weight gavage distilled water or Radix Aucklandiae extract, every rat oral gavage 1.5ml hydrochloric acid-alcohol mixeding liquid after 40min, after 40min, de-cervical vertebra puts to death rat, opens abdomen and gets stomach, use clamp cardia, inject 1% formalin 5ml by pylorus, clamping pylorus, is placed in 1% formalin by full stomach and fixes 10min.Cut off along greater gastric curvature, stomach is turned up, wash away gastric content gently with clear water.Stomach is laid on glass plate, by ruler measurement gastric mucosa injury length, using damaged length (damage width is greater than 1mm person to be doubled to calculate) summation as Gastric mucosal injury index, carry out statistical procedures, and calculating injury tolerance: result shows, of the present invention group of injury tolerance is 35.8%, and blank group is 91.5%.
Carry out the Protection to Mouse Gastric Mucous Membrane damage in addition; method is: dehydrated alcohol method, aspirin method, water logging stress method and reserpine legal system for Mouse Gastric Mucous Membrane damage model; gastric mucosa injury area after medicine is measured, result: medicine of the present invention all has inhibitory action in various degree to four kinds of gastric mucosa injurys after using medicine of the present invention.
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Embodiment 1
Bulbus Lilii 60 weight portion, Poria 60 weight portion, Radix Scrophulariae 75 weight portion, Rhizoma Chuanxiong 45 weight portion, Endothelium Corneum Gigeriae Galli 15 weight portion, Rhizoma Alismatis 45 weight portion, Radix Notoginseng 15 weight portion, the Rhizoma Atractylodis Macrocephalae 30 weight portion, Radix Angelicae Sinensis 45 weight portion, Radix Sanguisorbae 75 weight portion, Pollen Typhae 45 weight portion, the Radix Paeoniae Alba 150 weight portion, Herba Dendrobii 75 weight portion.
Its preparation method is as follows:
Medical material decocts with water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated in right amount, add ethanol, make alcohol content reach 70%, leave standstill, filter, reclaim ethanol, filtrate concentrates, and add water cold preservation, filters, obtains active substance, be prepared into pill further according to galenic pharmacy routine techniques.
Embodiment 2
Bulbus Lilii 30 weight portion, Poria 30 weight portion, Radix Scrophulariae 40 weight portion, Rhizoma Chuanxiong 30 weight portion, Endothelium Corneum Gigeriae Galli 5 weight portion, Rhizoma Alismatis 20 weight portion, Radix Notoginseng 5 weight portion, the Rhizoma Atractylodis Macrocephalae 10 weight portion, Radix Angelicae Sinensis 20 weight portion, Radix Sanguisorbae 50 weight portion, Pollen Typhae 20 weight portion, the Radix Paeoniae Alba 120 weight portion, Herba Dendrobii 40 weight portion.
Its preparation method is as follows:
Medical material decocts with water 1 time, each 1.5 hours, collecting decoction, and filter, filtrate is concentrated in right amount, add ethanol, make alcohol content reach 60%, leave standstill, filter, reclaim ethanol, filtrate concentrates, and add water cold preservation, filters, obtains active substance, be prepared into tablet further according to galenic pharmacy routine techniques.
Embodiment 3
Bulbus Lilii 80 weight portion, Poria 80 weight portion, Radix Scrophulariae 90 weight portion, Rhizoma Chuanxiong 80 weight portion, Endothelium Corneum Gigeriae Galli 30 weight portion, Rhizoma Alismatis 60 weight portion, Radix Notoginseng 30 weight portion, the Rhizoma Atractylodis Macrocephalae 50 weight portion, Radix Angelicae Sinensis 60 weight portion, Radix Sanguisorbae 90 weight portion, Pollen Typhae 60 weight portion, the Radix Paeoniae Alba 180 weight portion, Herba Dendrobii 90 weight portion.
Its preparation method is as follows:
Medical material decocts with water 3 times, each 3 hours, collecting decoction, and filter, filtrate is concentrated in right amount, add ethanol, make alcohol content reach 80%, leave standstill, filter, reclaim ethanol, filtrate concentrates, and add water cold preservation, filters, obtains active substance, be prepared into granule further according to galenic pharmacy routine techniques.
Embodiment 4
The preparation of capsule
The pharmaceutically active substance that Example 1 obtains, through the formulation preparation method of routine, is prepared into capsule
Embodiment 5
The preparation of tablet
The pharmaceutically active substance that Example 1 obtains, through the formulation preparation method of routine, is prepared into tablet
Embodiment 6
The preparation of pill
The pharmaceutically active substance that Example 1 obtains, through the formulation preparation method of routine, is prepared into pill
Embodiment 7
The preparation of granule
The pharmaceutically active substance that Example 1 obtains, through the formulation preparation method of routine, is prepared into granule
Embodiment 8
The preparation of oral liquid
The pharmaceutically active substance that Example 1 obtains, through the formulation preparation method of routine, is prepared into oral solutions.
Claims (6)
1. Chinese medicine composition has gastric mucosa injury in preparation and has an application in the health food of assistant protection function, and described Chinese medicine composition is prepared from by the raw material of Chinese medicine medicine of following weight proportion,
Bulbus Lilii 30-80 weight portion, Poria 30-80 weight portion, Radix Scrophulariae 40-90 weight portion, Rhizoma Chuanxiong 30-80 weight portion, Endothelium Corneum Gigeriae Galli 5-30 weight portion, Rhizoma Alismatis 20-60 weight portion, Radix Notoginseng 5-30 weight portion, Rhizoma Atractylodis Macrocephalae 10-50 weight portion, Radix Angelicae Sinensis 20-60 weight portion, Radix Sanguisorbae 50-90 weight portion, Pollen Typhae 20-60 weight portion, Radix Paeoniae Alba 120-180 weight portion, Herba Dendrobii 40-90 weight portion.
2. application according to claim 1, is characterized in that, described Chinese medicine composition is prepared from by the raw material of Chinese medicine medicine of following weight proportion,
Bulbus Lilii 60 weight portion, Poria 60 weight portion, Radix Scrophulariae 75 weight portion, Rhizoma Chuanxiong 45 weight portion, Endothelium Corneum Gigeriae Galli 15 weight portion, Rhizoma Alismatis 45 weight portion, Radix Notoginseng 15 weight portion, the Rhizoma Atractylodis Macrocephalae 30 weight portion, Radix Angelicae Sinensis 45 weight portion, Radix Sanguisorbae 75 weight portion, Pollen Typhae 45 weight portion, the Radix Paeoniae Alba 150 weight portion, Herba Dendrobii 75 weight portion.
3. application according to claim 1, is characterized in that, wherein said Chinese medicine composition preparation method step is as follows:
Medical material decocts with water 1-3 time, each 1.5-3 hour, collecting decoction, and filter, filtrate is concentrated in right amount, add ethanol, make alcohol content reach 60-80%, leave standstill, filter, reclaim ethanol, filtrate concentrates, and add water cold preservation, filters, obtains active substance, be then prepared into Halth-care composition.
4. application according to claim 3, is characterized in that, wherein said Chinese medicine composition preparation method step is as follows:
Medical material decocts with water 2 times, each 2 hours, collecting decoction, and filter, filtrate is concentrated in right amount, adds ethanol, make alcohol content reach 70%, leave standstill, filter, reclaim ethanol, filtrate concentrates, add water cold preservation, filters, obtain active substance, through formulation method, be then prepared into Halth-care composition.
5. application according to claim 1, is characterized in that, described Chinese medicine composition is the pharmaceutical dosage form that any one can be taken.
6. application according to claim 1, is characterized in that, described Chinese medicine composition is capsule, tablet, pill, granule, oral liquid, drop pill, unguentum.
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