CN105456921A

CN105456921A - External traditional Chinese medicinal composition for treating cold womb and preparation method of external traditional Chinese medicinal composition

Info

Publication number: CN105456921A
Application number: CN201510929271.XA
Authority: CN
Inventors: 程正祥
Original assignee: Shanghai Zhongquan Medical Technology Co Ltd
Current assignee: Shanghai Zhongquan Medical Technology Co Ltd
Priority date: 2015-12-14
Filing date: 2015-12-14
Publication date: 2016-04-06

Abstract

The invention relates to a traditional Chinese medicinal composition for treating cold womb. The traditional Chinese medicinal composition consists of the following five traditional Chinese medicinal raw materials: blumea balsamifera, emblic leafflower fruit, callicarpa nudiflora, radix curcumae longae and folium artemisiae argyi. The medicinal materials can be mutually coordinated, so as to warm kidney and womb, stimulate menstrual flow and promote blood circulation; and the traditional Chinese medicinal composition is applicable to dysmenorrhea, delayed menstrual cycle, hypomenorrhea, amenorrhea, leukorrheal diseases, chronic pelvic pain, infertility, postpartum abdominal pain and the like caused by cold womb. A traditional Chinese medicinal composition compression preparation for treating cold womb in women, which is prepared from the traditional Chinese medicinal composition disclosed by the invention, is concrete in curative effect, low in reoccurrence rate, free from obvious adverse reactions and good in safety.

Description

A kind of external medicine composition for the treatment of cold womb and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, especially relate to a kind of external application Chinese medicine for the treatment of cold womb.

Background technology

" cold womb " is a concept of Chinese medicine.Catching cold in " cold womb " the i.e. uterus of narrow sense, experiences cold-evil; " cold womb " of broad sense can be regarded as that female reproductive system etc. is yin-cold excess, YANG QI deficiency, kidney yang deficiency cold.Ancient medicine is early recognized the cause of disease of cold womb and feature." Medical Treasures of the Golden Chamber " the miscellaneous internal diseases in woman section carries: " disease of married woman, because of void, accumulation of pathogenic cold, stagnation of QI, for Zhu Jingshui breaks off, over the years to having, pathogenic cold coagulating with blood, uterus injured by cold, meridian and collateral being blocked." " Fu Qingzhu works on obstetrics and gynecology kind cervical orifice of uterus " have and carry: the record of " married woman has the lower part of the body ice-cold, and non-fire does not warm up, and when sympathetic, gas absolutely not warm in the moon, it is also thin that people thinks that sky divides, and who knows it is the pole of born of the same parents' fetal cold ".

The traditional Chinese medical science is thought, the general and women's insufficiency of kidney-YANG of cold womb, and uterus loses in warm, or experiences cold-evil, vessels of the uterus retardance is relevant, and its Major Clinical feature is as follows: lower abdomen cold type of pain, pain alleviated while getting warmth, and extremity are not warm, soreness of the waist and knees, or lumbago is as folding, tastelessness, and eating is pungent dry, shortness of breath and fatigue, insomnia and dreamful sleep, nocturia increases, urine frequency or incontinence, loose stool, libido is indifferent, puffiness of the face and limbs, or build is fat, menalgia, through secretly having block; Dimly pale tongue or dark, tongue is white, deep-thready pulse CHI-pulse being weak or heavy.

Cold womb and the gynaecopathia caused is more, as the hypomenorrhea of menopathy, delayed menstrual cycle, dysmenorrhea, amenorrhea, edema during menstruation, diarrhea during menstruation; The profuse leukorrhea of leukorrheal diseases is rare clearly, and notably leukorrhagia is chilly; The vaginal bleeding during pregnancy of pregnancy disease, frequent fetal movement, habitual abortion, abortion, diapause, retention of dead fetus, abdominal pain during pregnancy, ectopic pregnancy; The puerperal abdonimal pain of puerperal disease, puerperal general pain, postpartum lochiorrhea, retention of urine after delivery; Infertile, pelvic inflammatory disease, addiction abdominal mass etc. of miscellaneous diseases.

Current treatment cold womb is mainly acupuncture and treatment by Chinese herbs, Chinese medicine cold womb good effect.As CN201010213222.3 discloses the Chinese medicine composition be made up of 22 taste Chinese medicines such as Colla Corii Asini, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Flos Carthamis, be used for the treatment of cold womb; As CN201510492403.7 discloses the Chinese medicine composition be made up of 11 taste Chinese medicines such as Fructus Evodiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Paeoniaes, be used for the treatment of women's cold womb; As CN201510453834.2 discloses the Chinese medicine composition be made up of 22 taste Chinese medicines such as Herba Galii Teneri, Fructus Cnidii, Radix Morindae Officinalis, Folium Artemisiae Argyis, be used for the treatment of infertility.The Chinese medicine composition flavour of a drug of above-mentioned treatment cold womb are all more, form more complicated, and this adds the cost of medicine on the one hand, adds the risk of safety aspect on the other hand.In order to deal with problems, the present inventor have developed a kind of compositions be made up of 5 taste Chinese medicines, and said composition good effect, cure rate is high, without obvious adverse reaction.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine composition and application thereof for the treatment of cold womb.This Chinese medicine composition, through clinical verification, there is the kidney warming and warm up palace, the effect restored menstrual flow and invigorated blood circulation, obvious curative effects is had to symptoms such as the dysmenorrhea caused by cold womb, delayed menstrual cycle, hypomenorrhea, amenorrhea, leukorrheal diseases, chronic pelvic pain, infertility, puerperal abdonimal pains, and without obvious adverse reaction, clinic recommendation.

For achieving the above object, the technical scheme of employing is:

Treat a Chinese medicine composition for cold womb, it is made up of following traditional Chinese medicinal material raw materials: Herba Blumeae Balsamiferae 8-12 part, Fructus Phyllanthi 8-12 part, Callicarpa nudiflora 4-6 part, Rhizoma Curcumae Longae 12-18 part, Folium Artemisiae Argyi 8-12 part.

Further, the Chinese medicine composition of above-mentioned treatment cold womb, the traditional Chinese medicinal material raw materials group by following weight: Herba Blumeae Balsamiferae 10 parts, Fructus Phyllanthi 10 parts, Callicarpa nudiflora 5 parts, 15 parts, Rhizoma Curcumae Longae, Folium Artemisiae Argyi 10 parts.

That treats the Chinese medicine composition of cold womb presses an agent preparation method, comprises the steps:

(1) raw material is taken according to following weight: Herba Blumeae Balsamiferae 8-12 part, Fructus Phyllanthi 8-12 part, Callicarpa nudiflora 4-6 part, Rhizoma Curcumae Longae 12-18 part, Folium Artemisiae Argyi 8-12 part.

(2) by the Herba Blumeae Balsamiferae that step (1) takes, Fructus Phyllanthi, Callicarpa nudiflora, Rhizoma Curcumae Longae and Folium Artemisiae Argyi pulverize obtained medicated powder coarse powder.

(3) take according to following weight the adjuvant that system presses agent, comprising: iron powder 2800 parts, active carbon 300 parts, saline 1650 parts, absorbent material 100 parts, fully the obtained mixed powder of mixing.The effect of adjuvant is the exothermic mixture pressing agent, and iron powder and active carbon are powder, and saline is 10% salt solution, and absorbent material is water-absorbing resin

(4) step (2) gained medicated powder is fully mixed obtained mixed powder with step (3) gained adjuvant, mixed powder is encapsulated into bag, obtain Chinese medicine composition of the present invention and press agent.

Treat an emplastrum preparation method for the Chinese medicine composition of cold womb, comprise the steps:

(2) by the Herba Blumeae Balsamiferae that step (1) takes, Fructus Phyllanthi, Callicarpa nudiflora, Rhizoma Curcumae Longae and Folium Artemisiae Argyi, add the alcohol reflux of 70% concentration, collection, merge extractive liquid, filters, be evaporated to the concentrated solution of relative density about 1.30.Reflux, extract, twice, each 1 hour, then through collection, merge extractive liquid, after filtering flow process, concentrating under reduced pressure 50 DEG C time.

(3) take the adjuvant making emplastrum according to following weight, comprising: polyvinyl alcohol 45 parts, sodium polyacrylate 36 parts, gelatin30 parts, arabic gum 45 parts, glycerol 300 parts, laurocapram 5 parts, ethyl hydroxybenzoate 2 parts.Polyvinyl alcohol, sodium polyacrylate, gelatin, arabic gum is as binding agent, and glycerol is as solvent, and laurocapram is as penetrating agent, and ethyl hydroxybenzoate is as antiseptic.

(4) fully mixed with step (3) gained adjuvant by step (2) gained concentrated solution, stir, coating, condensation, lid lining form, cuts, and packaging, obtains required emplastrum.

Preferably, Chinese medicine composition of the present invention can be prepared into external preparation.

Further preferably, described external preparation is emplastrum, membranous patch, powder, oil preparation, tincture, press agent etc.

Again further preferably, described external preparation is emplastrum and presses agent.

As most preferably, described external preparation is for pressing agent.

In Chinese medicine composition of the present invention, above-mentioned medical material can be worked in coordination with mutually, can warm up palace by the kidney warming, restore menstrual flow and invigorate blood circulation, for the dysmenorrhea caused by cold womb, delayed menstrual cycle, hypomenorrhea, amenorrhea, leukorrheal diseases, chronic pelvic pain, infertility, puerperal abdonimal pain etc.

Found by a large amount of clinical researches, treatment, observation, the therapeutic effect highly significant of the various diseases that Chinese medicine composition of the present invention causes for women's cold womb, therefore, the second object of the present invention is to provide a kind of pharmaceutical applications, i.e. the application of above-mentioned Chinese medicine composition in the medicine of preparation treatment cold womb.

The present invention presses agent using method: external, opens along packaging bag, will press agent inner bag and take out, and produce heat gradually, be placed in fixing bag, then medicated bag be fixed on affected part, 1 time on the one after jog.

The Chinese medicine composition that the present invention treats women's cold womb presses agent, determined curative effect, and relapse rate is low, and without obvious adverse reaction, safety is good.

Detailed description of the invention

Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling that do according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

The present invention adopts the meridian distribution of property and flavor of traditional Chinese medicinal material raw materials, function cures mainly as follows:

Herba Blumeae Balsamiferae: pungent, micro-hardship, tepor.There is detumescence of dispeling the wind, effect of promoting blood circulation to remove blood stasis.For cold-damp dysentery, stomachache borborygmus, swelling, bones and muscles pain, traumatic injury, tinea skin ulcer.

Fructus Phyllanthi: sweet, sour, puckery, cool.Attach to the lung and stomach meridians.There is clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the effect of cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia.

Callicarpa nudiflora: bitter, micro-pungent is flat.Return spleen, stomach, Liver Channel.There is hemostasis, blood stasis dispelling, effect of pain relieving.Swell and ache for hemoptysis, gastrointestinal hemorrhage, epistaxis, gingiva bleeding gingival hemorrhage, traumatic hemorrhage, traumatic injury, rheumatism.

Rhizoma Curcumae Longae: pungent, bitter, temperature.Return spleen, Liver Channel.There is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea ， mass in the abdomen, rheumatism shoulder arm pain, tumbling and swelling.

Folium Artemisiae Argyi: pungent, bitter, temperature.Return liver,spleen,kidney warp.There is warming the meridian for stopping bleeding, effect of dispersing cold for relieving pain; External removing dampness to relieve itching.For spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile; External treatment skin pruritus.

Embodiment 1

Crude drug prescription: Herba Blumeae Balsamiferae 80g, Fructus Phyllanthi 80g, Callicarpa nudiflora 60g, Rhizoma Curcumae Longae 180g, Folium Artemisiae Argyi 80.

Press the preparation method of agent:

(1) get above 6 taste medical materials, pulverize.

(2) in (1) medicated powder, add the adjuvants such as iron powder 2800g, active carbon 300g, saline 1650g, absorbent material 100g, fully mix.

(3) (2) mixed powder is carried out being encapsulated into bag, to obtain final product.

Embodiment 2

Crude drug prescription: Herba Blumeae Balsamiferae 120g, Fructus Phyllanthi 120g, Callicarpa nudiflora 40g, Rhizoma Curcumae Longae 120g, Folium Artemisiae Argyi 120g.

Press the preparation method of agent:

(1) get above 6 taste medical materials, pulverize.

Embodiment 3

Crude drug prescription: Herba Blumeae Balsamiferae 100g, Fructus Phyllanthi 100g, Callicarpa nudiflora 50g, Rhizoma Curcumae Longae 150g, Folium Artemisiae Argyi 100g.

Press the preparation method of agent:

(1) get above 6 taste medical materials, pulverize.

Embodiment 4

The preparation method of emplastrum:

(1) get above-mentioned medical material, add 70% alcohol reflux, collection, merge extractive liquid, filter, be evaporated to the concentrated solution of relative density about 1.30.

(2) by above-mentioned concentrated solution and polyvinyl alcohol 45g, sodium polyacrylate 36g, gelatin30g, arabic gum 45g, glycerol 300g, laurocapram 5g, ethyl hydroxybenzoate 2g, fully mix, stir, coating, condensation, and lid lining form, cuts, and packaging, to obtain final product.

Embodiment 5

The preparation method of emplastrum:

Embodiment 6

The preparation method of emplastrum:

Clinical trial example 1

209 routine cold womb dysmenorrhea patients are treated in clinical practice, minimum 19 years old of age, the oldest 49 years old, average 34.5 years old, the shortest person of medical history 9 months, most elder 20 years, average 6.8 years.

With reference to the diagnosis basis of the dysmenorrhea in " disease of tcm Standardization of diagnosis and curative effect ", the following diagnostic criteria of all patients is made a definite diagnosis: being expert to occur hypogastralgia, falling inflation, companion's lumbago or other are uncomfortable through front and back or menstrual period, the no positive sign of gynaecological examination, gets rid of the secondary dysmenorrhea that endometriosis and adenomyosis etc. cause.Chinese medical discrimination is cold blood stasis type: through row cold and pain in the lower abdomen, get Re Zeshu, hypomenorrhea, and color purple is dim block; Companion's coldness of the body with chills, clear urine in large amounts; Tongue is white, thready pulse or heavy tight.

Prepared by all patient's external embodiment of the present invention 3 methods presses agent, during use, medicated bag cloth bag is fixed on affected part, 1 time on the one.Within premenstrual 5 days, bring into use, use 3 menstrual cycle continuously.Criterion of therapeutical effect with reference to the treatment dysmenorrhea in " disease of tcm Standardization of diagnosis and curative effect " is evaluated, and curative effect determinate standard is as follows:

Cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends.

Effective: pain relief or pain disappear, but can not maintain more than 3 months.

Invalid: pain has no improvement.

Continuous treatment 3 menstrual cycle, after drug withdrawal, all cases all follow up a case by regular visits to 3 months.Found that: recovery from illness 143 example, effective 63 examples, invalid 3 examples, effective percentage is 98.6%, without obvious adverse reaction in medication process.

Clinical trial example 2

The menoxenia patient that 119 routine cold womb cause is treated in clinical practice, wherein delayed menstrual cycle 48 example, amenorrhea 15 example, hypomenorrhea 56 example.17 ~ 42 years old age, average 28 years old, the course of disease 3 months ~ 2 years.

All carry out B ultrasonic, gynecologial examination and vaginal secretions routine examination during patient assessment, result prompting has no organic disease, and gets rid of the physiological menstruation irregularis because gestation, blue and green phase, climacteric etc. cause.With reference to the diagnosis basis in " disease of tcm Standardization of diagnosis and curative effect ", all patients all meet the diagnostic criteria of menoxenia.(1) delayed menstrual cycle, menstrual cycle more than 35 days, more than continuous 2 menstrual cycle; (2) amenorrhea, has passed through and has interrupted the secondary amenorrhea of more than 3 months; (3) hypomenorrhea, menstrual cycle is normal, through measuring seldom, less than 30ml, even drop is namely clean.Chinese medical discrimination is cold blood stasis type: menstrual cycle is delayed, and amount is few, and color is dim clot, severe patient amenorrhea, and cold and pain in the lower abdomen obtains hot alleviating, aversion to cold and cold limbs, and tongue is white, deep and tense pulse; Or kidney yang deficiency: Hypomenorrhea, color is light red or dim red, and matter is rare, and spinal column is aching and limp, dizziness and tinnitus, or lower abdomen is cold, frequent urination at night, pale tongue, weak pulse or late heavy.

Prepared by all patient's external embodiment of the present invention 3 methods presses agent, during use, medicated bag cloth bag is fixed on affected part, 1 time on the one, uses 3 menstrual cycle continuously.Criterion of therapeutical effect with reference to the treatment dysmenorrhea in " disease of tcm Standardization of diagnosis and curative effect " is evaluated, and curative effect determinate standard is as follows:

Cure: menstrual cycle recovers normal, and can maintain more than 3 months.

Effective: menstrual cycle recovers normal, but can not maintain more than 3 months.

Invalid: change is seen at menstrual cycle end.

Continuous treatment 3 menstrual cycle, after drug withdrawal, all cases all follow up a case by regular visits to 3 months.Found that: recovery from illness 68 example, effective 42 examples, no effect 9, effective percentage is 92.4%, without obvious adverse reaction in medication process.

Clinical trial example 3

The leukorrheal diseases patient that 89 routine cold womb cause is treated in clinical practice.25 ~ 45 years old age, average 32 years old, the course of disease 3 months ~ 3 years.

With reference to the diagnosis basis in " disease of tcm Standardization of diagnosis and curative effect ", all patients all meet the diagnostic criteria of leukorrheal diseases, and eliminate leukorrheal diseases caused by gynecological tumor and the diseases induced patient of malignant diseases: profuse leukorrhea, continue for ever; Though or leukorrhagia amount is few, yellow skin is red or dark green, and matter is thick turbid or rare as water clearly, stink smell or stench.Chinese medical discrimination is kidney yang deficiency: secretions amount is many, rarely as water, or transparent clearly continues for ever as Ovum Gallus domesticus album, and soreness of waist abdomen is cold, and frequent micturition is long clearly, and night more so.Pale tongue, white and thin fur, deep-slow pulse.

Cure: the amount of vaginal secretions, color, abnormal smells from the patient, matter all recover normal, all diseases disappear.

Effective: the amount of vaginal secretions, color, abnormal smells from the patient, matter and all diseases alleviate.

Invalid: all diseases of leukorrhagia are unchanged.

Continuous treatment 3 menstrual cycle, after drug withdrawal, all cases all follow up a case by regular visits to 3 months.Found that: recovery from illness 57 example, effective 24 examples, invalid 8 examples, effective percentage is 91.0%, without obvious adverse reaction in medication process.

Pharmacological test example

(1) pharmacological testing sample preparation

Herba Blumeae Balsamiferae extract: get Herba Blumeae Balsamiferae 500g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing Herba Blumeae Balsamiferae 2g.

Fructus Phyllanthi extract: get Fructus Phyllanthi 500g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing Fructus Phyllanthi 2g.

Callicarpa nudiflora extract: get Callicarpa nudiflora 500g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing Callicarpa nudiflora 2g.

Rhizoma Curcumae Longae extract: get Rhizoma Curcumae Longae 500g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing Rhizoma Curcumae Longae 2g.

Folium Artemisiae Argyi extract: get Folium Artemisiae Argyi 500g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing Folium Artemisiae Argyi 2g.

Combined extracts: Herba Blumeae Balsamiferae 100g, Fructus Phyllanthi 100g, Callicarpa nudiflora 50g, Rhizoma Curcumae Longae 150g, Folium Artemisiae Argyi 100g, 70% alcohol reflux 2 times, collection, merge extractive liquid, filter, and is evaporated to every ml solution containing crude drug 2g.

(2) on the impact of cold and stagnate primary dysmenorrhea model mice

Choose cleaning grade female unpregnancy ICR mice 150, weight 18 ~ 22g, be divided at random 15 groups (often organizing 10): blank group, model group, the positive group of ibuprofen, high dose group, the low dose group of 6 kinds of concentrated solutions in (1).For three days on end, to model group and ibuprofen positive group mouse peritoneal injection estradiol benzoate (10mg/Kg), mouse hind leg and hypogastric region are immersed (room temperature 23 ± 2 DEG C) in (20 ± 2) DEG C cold water simultaneously and carry out cold stimulation, every day 1 time, each 10min.Administration and modeling are carried out simultaneously, gastric infusion 1 time every day (high dose group 10mL/kg, low dose group 5mL/kg), blank group and model group give the 0.5%CMC-Na of 10mL/kg, the positive group of ibuprofen gives the ibuprofen of 0.12g/kg, for three days on end, only, mouse writhing number of times in rear 30min injected in record for 30min after last administration, lumbar injection oxytocin inj 4U/.Adopt t inspection to carry out statistical procedures, it the results are shown in table 1.Result shows: writhing number of times in the primary dysmenorrhea model mice 30min that compositions can effectively suppress oxytocin compound cold stimulation to be induced, and each component has synergism, and compositions effect is better than the extract of each component.

table 1each extract is on the impact of cold and stagnate primary dysmenorrhea model mice writhing number of times

Note: compare with blank group, △ P<0.05, △ △ P<0.01; Compare with model group, * P<0.05, * * P<0.01.

(3) on the impact of body blood reducing stasis model mice microcirculation and clotting time

Choose female KM kind mice 140, weight 18 ~ 22g, be divided at random 14 groups (often organizing 10): blank group, model group, high dose group, the low dose group of 6 kinds of concentrated solutions in (1).Gastric infusion 1 time every day (high dose group 10mL/kg, low dose group 5mL/kg), blank group and model group give the 0.5%CMC-Na of 10mL/kg, continuous 5 days.After 4th day gavage, model group and each administration group subcutaneous injection adrenalin hydrochloride respectively, volume is 1mL/kg, water is can't help in fasting, the adrenalin hydrochloride of same dose is again injected after each swimming of group mice ice-water bath 5min, 2h, blank group injection equal-volume normal saline after 2h.0.5h after last gastric infusion, animal subject, with 10% chloral hydrate anesthesia, is fixed in laboratory table, Doppler's microcirculation tester is observed and the situation of change of auricular microcirculation during 40min after measuring medicine, 1h after administration, each group orbital venous plexus gets blood, and capillary tube method measures clotting time.Adopt t inspection to carry out statistical procedures, it the results are shown in table 2.Result shows: compositions can have clear improvement to body blood reducing stasis model mice microcirculation, and can obviously extend cold blood stasis clotting time of mice, and each component has synergism, compositions effect is better than the extract of each component.

table 2each extract is on the impact of body blood reducing stasis model Mice Auricle microcirculation and clotting time

Claims

1. treat a Chinese medicine composition for cold womb, it is made up of following traditional Chinese medicinal material raw materials: Herba Blumeae Balsamiferae 8-12 part, Fructus Phyllanthi 8-12 part, Callicarpa nudiflora 4-6 part, Rhizoma Curcumae Longae 12-18 part, Folium Artemisiae Argyi 8-12 part.

2. a kind of Chinese medicine composition for the treatment of cold womb as claimed in claim 1, it is characterized in that: the Chinese medicine composition of described treatment cold womb, the traditional Chinese medicinal material raw materials group by following weight: Herba Blumeae Balsamiferae 10 parts, Fructus Phyllanthi 10 parts, Callicarpa nudiflora 5 parts, 15 parts, Rhizoma Curcumae Longae, Folium Artemisiae Argyi 10 parts.

3. that treats the Chinese medicine composition of cold womb presses an agent preparation method, comprises the steps:

(2) by the Herba Blumeae Balsamiferae that step (1) takes, Fructus Phyllanthi, Callicarpa nudiflora, Rhizoma Curcumae Longae and Folium Artemisiae Argyi pulverize obtained medicated powder.

(3) add in step (2) gained medicated powder and take according to following weight: the adjuvants such as iron powder 2800 parts, active carbon 300 parts, saline 1650 parts, absorbent material 100 parts, the fully obtained mixed powder of mixing.

(4) step (3) mixed powder is carried out being encapsulated into bag, obtain Chinese medicine composition of the present invention and press agent.

4. treat an emplastrum preparation method for the Chinese medicine composition of cold womb, comprise the steps:

(2) by the Herba Blumeae Balsamiferae that step (1) takes, Fructus Phyllanthi, Callicarpa nudiflora, Rhizoma Curcumae Longae and Folium Artemisiae Argyi, add 70% alcohol reflux, collection, merge extractive liquid, filters, be evaporated to the concentrated solution of relative density about 1.30.

(3) adjuvant is taken according to following weight: polyvinyl alcohol 45 parts, sodium polyacrylate 36 parts, 30 parts, gelatin, arabic gum 45 parts, glycerol 300 parts, laurocapram 5 parts, ethyl hydroxybenzoate 2 parts.