CN105456365A - Preparation method of traditional Chinese medicine dropping pill for treating constipation - Google Patents
Preparation method of traditional Chinese medicine dropping pill for treating constipation Download PDFInfo
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- CN105456365A CN105456365A CN201610065223.5A CN201610065223A CN105456365A CN 105456365 A CN105456365 A CN 105456365A CN 201610065223 A CN201610065223 A CN 201610065223A CN 105456365 A CN105456365 A CN 105456365A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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Abstract
The invention relates to a preparation method of a traditional Chinese medicine dropping pill for treating constipation and can effectively solve the problem of therapeutic treatment for constipation. The preparation method includes the steps that polyethylene glycol is dissolved in a water bath mode to serve as a substrate, a mixture of fructus cannabis oil and semen cassia oil is added to the substrate in a stirring state, the mixture is stirred to be uniform, dropping pill liquid medicine is obtained, and the substrate is 4-8 times the total weight of the fructus cannabis oil and the semen cassia oil; the dropping pill liquid medicine is dropwise put into a cooling oil column tube containing a temperature gradient at the temperature of 70-80 DEG C at the speed of 30-60 drops per minute, dropping pills are obtained, centrifugation is conducted, cooling oil is removed, and the traditional Chinese medicine dropping pill is obtained. The traditional Chinese medicine dropping pill is definite and reliable in curative effect, effective in treatment of constipation, simple in preparation process, rich in raw material and low in cost, the obtained dropping pill has the advantages of being small in content difference, good in homogeneity, fast in releasing of medicine ingredients after being taken into the body, high in utilization rate and the like compared with tablets, capsules and the like, meanwhile the dropping pill is convenient to swallow due to the small size and convenient to take, and the curative effect is improved.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of preparation method for the treatment of the Chinese medicine dripping pills of constipation.
Background technology
Constipation is common frdquently encountered disease, and clinical manifestation is: awareness of defecation is few, just secondary also few; Defecation is difficult, effort; Defecation is not smooth; Constipation with dry stool, hard just, defecation is not felt only; Constipation is with stomachache or abdominal discomfort.Some patients is also with Behavioral disturbances such as insomnia, agitation, dreaminess, depression, anxieties.
Because constipation is a kind of comparatively general symptom, symptoms of varying severity, most people usually do not go specially to comprehend, and think that constipation is not disease, need not treat, but the harm of in fact constipation are very large." warning " of constipation has blood in stool sign comprising, anemia, become thin, generate heat, melena, stomachache etc. and Family history of cancer.Hospital admission should be removed if there is warning sign at once, check further.Though the existing multi-medicament having treatment constipation, but for various reasons, it uses and curative effect unsatisfactory, along with the research to Chinese medicine, find that study of semen cassia has liver heat removing and eyesight improving and functions of loosening bowel relieving constipation, Fructus Cannabis also has the effect of nourishing tonify deficiency except having functions of loosening bowel relieving constipation, is particularly useful for old people and the empty patient of body with constipation.Modern study finds that Semen Cassiae seed oil and Fructus Cannabis oil are the main component positions of two medicine relaxing the bowels with lubricant drugs relieving constipations, and they also have the effects such as antioxidation, blood fat reducing, blood pressure lowering, vessel softening except functions of loosening bowel relieving constipation, especially suitable to Senile disease.Semen Cassiae seed oil and Fructus Cannabis oil being share relative to being used alone the wriggling function that significantly can strengthen intestinal from different link, strengthening defecating feces excretion, and the fraud that purgatives medicine easily causes body void can be made up.
Drop pill, after solid or liquid medicine and substrate mix heat fused, instills in not miscible liquid coolant, shrinks a kind of quick-effective preparation being condensed into ball.Drop pill has that dose is few, disintegrate and the feature such as stripping is rapid, and less for extracted amount, fat-soluble stronger Chinese medicine is good dosage form.In addition, produce in drop pill production process without dust, the purification being conducive to Factory Building controls.Its production process is few, with short production cycle, and production automation degree is high, and labor intensity is low, and labor productivity is high.Drop pill dosage is accurate, and principal agent is uniformly dispersed in substrate, and dripping condition is easy to control, and weight differential is little, and equipment is simple, easy to operate.
Semen Cassiae seed oil and Fructus Cannabis oil are directly taken to be had mouthfeel difference, is not easy to deposit and the shortcoming such as transport, even directly affect medical value and curative effect, but how Semen Cassiae seed oil and Fructus Cannabis oil mixture are made drop pill, so far there are no is publicly reported.
Summary of the invention
For above-mentioned situation, for overcoming the defect of prior art, object of the present invention is just to provide a kind of preparation method for the treatment of the Chinese medicine dripping pills of constipation, effectively can solve the medicine for treatment problem to constipation.
The technical scheme that the present invention solves is, a kind of preparation method for the treatment of the Chinese medicine dripping pills of constipation is, get the Polyethylene Glycol that molecular mass is 5500-6500g/moL, 75-85 DEG C of water-bath is dissolved, and makes substrate, adds the mixture of Fructus Cannabis oil and Semen Cassiae seed oil under stirring in substrate, the mass ratio of Fructus Cannabis oil and Semen Cassiae seed oil is 2-3 ︰ 2-3, stir, obtained drop pill medicinal liquid, described substrate is 4-8 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 70-80 DEG C of condition, what drip with 30-60 per minute drips speed, and instillation is equipped with in the cold oil tubulation of thermograde, makes drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 100-150 centistoke;
The described cooling oil surface temperature 40-60 DEG C had in the cold oil tubulation of thermograde, bottom temp 5-10 DEG C.
Determined curative effect of the present invention is reliable, be effective to treat constipation, and preparation technology is simple, abundant raw material, cost is low, the drop pill made, have that content difference is little, homogeneity good relative to tablet, capsule etc., to take in after in body ingredient release rapidly, body absorption rate, utilization rate advantages of higher, be convenient to swallow, taking convenience because drop pill volume is little simultaneously, improving curative effect, is the innovation on treatment constipation medicine.
Detailed description of the invention
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.
The extraction of Fructus Cannabis oil of the present invention: Fructus Cannabis oil is squeezed by the raw product of Fructus Cannabis that (oil yield is 21.65%, proportion is 0.907g/ml), the patent No. can be adopted to be the method preparing Fructus Cannabis oil of ZL201210014652.1, or conventional Fructus Cannabis oil extracting process.
The extraction of Semen Cassiae seed oil of the present invention: take 500g Semen Cassiae, beat powder, be soaked in 2500ml dehydrated alcohol, soak after 30 minutes, the mode of reflux, extract, is adopted to extract 1 hour, filtrate is preserved after filtration, filtering residue adds 2500ml dehydrated alcohol reflux, extract, 40 minutes again, filter, merge 2 filtrates, reclaim under reduced pressure is revolved with Rotary Evaporators, obtain brown yellow oil liquid, be Semen Cassiae slightly oily, by centrifugal for thick for Semen Cassiae oil, 3000rad, 5min, after being separated the supernatant, by supernatant recentrifuge, 3000rad, 10min, draw edible vegetable oil, be Semen Cassiae seed oil.
The present invention can be provided by following examples in concrete enforcement.
Embodiment 1
The present invention, in concrete enforcement, is obtained by following steps:
Get the Polyethylene Glycol that molecular mass is 6000g/moL, 80 DEG C of water-baths are dissolved, obtained substrate, in substrate, the mixture that Fructus Cannabis oil mixes according to mass ratio 1:1 with Semen Cassiae seed oil is added under stirring, stir, obtained drop pill medicinal liquid, described substrate is 8 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 75 DEG C of conditions, fast with 40 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 120 centistokes;
The described cooling oil surface temperature 50 DEG C had in the cold oil tubulation of thermograde, bottom temp 8 DEG C.
Embodiment 2
Treat a Chinese medicine dripping pills for constipation, obtained by following steps:
Get the Polyethylene Glycol that molecular mass is 5500g/moL, 75 DEG C of water-baths are dissolved, obtained substrate, in substrate, the mixture that Fructus Cannabis oil mixes according to mass ratio 2:3 with Semen Cassiae seed oil is added under stirring, stir, obtained drop pill medicinal liquid, described substrate is 4 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 70 DEG C of conditions, fast with 30 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 100 centistokes;
The described cooling oil surface temperature 40 DEG C had in the cold oil tubulation of thermograde, bottom temp 5 DEG C.
Embodiment 3
Treat a Chinese medicine dripping pills for constipation, obtained by following steps:
Get the Polyethylene Glycol that molecular mass is 6500g/moL, 85 DEG C of water-baths are dissolved, obtained substrate, in substrate, the mixture that Fructus Cannabis oil mixes according to mass ratio 3:2 with Semen Cassiae seed oil is added under stirring, stir, obtained drop pill medicinal liquid, described substrate is 6 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 80 DEG C of conditions, fast with 60 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 150 centistokes;
The described cooling oil surface temperature 60 DEG C had in the cold oil tubulation of thermograde, bottom temp 10 DEG C.
Embodiment 4
Treat a Chinese medicine dripping pills for constipation, obtained by following steps:
Get the Polyethylene Glycol that molecular mass is 5800g/moL, 78 DEG C of water-baths are dissolved, obtained substrate, in substrate, the mixture that Fructus Cannabis oil mixes according to mass ratio 2:3 with Semen Cassiae seed oil is added under stirring, stir, obtained drop pill medicinal liquid, described substrate is 7 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 78 DEG C of conditions, fast with 50 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 130 centistokes;
The described cooling oil surface temperature 60 DEG C had in the cold oil tubulation of thermograde, bottom temp 5 DEG C.
Chinese medicine dripping pills of the present invention, through repeated tests, all achieves desirable experimental result, and related experiment data is as follows:
One, the weight test of drop pill
Get drop pill 20 ball, gross weight is 0.795g, the heavy 0.038g of average ball, then distinguishes the weight of accurately weighed every ball.As follows:
The quality inspection of table 1 drop pill
| Numbering | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Ball heavy (g) | 0.037 | 0.038 | 0.038 | 0.036 | 0.039 | 0.037 | 0.041 | 0.038 | 0.040 | 0.036 |
| Numbering | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 |
| Ball heavy (g) | 0.040 | 0.036 | 0.041 | 0.036 | 0.034 | 0.036 | 0.035 | 0.040 | 0.039 | 0.041 |
Every ball weight compares with average ball heavy phase: heavy 0.038g ± 12% of average ball is 0.033g-0.043g, therefore 20 drop pill all meet " Chinese Pharmacopoeia " regulation, " Chinese Pharmacopoeia " version catalog classification in 2015: general rule, unless otherwise specified, drop pill is according to following method inspection in [weight differential] (1):
Inspection Check method gets test sample 20 ball, accurately weighed gross weight, after trying to achieve average ball weight, then distinguishes the weight of accurately weighed every ball.Every ball weight with indicate ball heavy phase and compare (heavy without indicating ball, with average ball anharmonic ratio compared with), the regulation according to the form below, what exceed limit test of weight variation more than 2 balls, and must not must not have 1 ball overrun 1 times.
| Indicate ball to weigh or average ball weight | Limit test of weight variation |
| 0.03g and below 0.03g | ±15％ |
| More than 0.03g is to 0.1g | ±12％ |
| More than 0.1g is to 0.3g | ±10％ |
| More than 0.3g | ±7.5％ |
Two, drop pill dissolve scattered time limit
Inspection Check method checked according to inspection technique disintegration (general rule 0921), and the sieve aperture internal diameter of stainless steel cloth is 0.42mm, and water temperature is 15 ~ 25 DEG C.Get drop pill 6, in 38 DEG C of water-baths, leach completely in 14 minutes, be far superior to the regulation that " Chinese Pharmacopoeia " drop pill leached in 30 minutes.
Three, antioxidation in vitro experiment:
This sample is got 100ul and puts into 96 orifice plates, dilute 10 gradients respectively, respectively add ethanol solution 100ul group as a setting; Sample thief also dilutes and respectively adds DPPH test solution 100ul as sample sets as stated above; Make VE test solution positive controls (VE is the generally acknowledged medicine with antioxidation activity in vitro) and background prescription method the same; Getting 100ulDPPH test solution, to add 100ul dehydrated alcohol be blank group.After point sample completes, lucifuge leaves standstill 25min.OD value is measured in the long ULTISKANGO microplate reader U.S. ThermoFisherScientific of all-wave, calculate suppression ratio according to inhibition of enzyme activity rate=[blank group-(the OD sample sets-OD background group) of OD] blank group × 100% of/OD, concrete data are in table 2.
Table 2 antioxidant activity of the present invention
Amount effect relation curve and the positive control VE of drop pill antioxidation activity in vitro are similar.
The IC of the antioxidation in vitro of drop pill of the present invention and VE
50
The IC of drop pill of the present invention and VE group is calculated by ReedMuench method
50, show that numerical value is as shown in table 3.
The IC of table 3 drop pill of the present invention and VE
50
Table 3 shows the antioxidation activity in vitro of drop pill of the present invention (IC more weak than VE
50numerical value shows that more greatly antioxidation activity in vitro is more weak).
Antioxidation in vitro result of study shows: drop pill of the present invention equally has antioxidation activity in vitro with positive control drug VE.And antioxidation is conducive to the generation of Exercise Mechanics minimizing free radical or accelerates its removing, to resist the side effect of peroxylradicals, current antioxidation is classified as one of main R&D direction by health product, cosmetic industry, is also one of most important functional demand of health-product market.To have antioxidant activity be drop pill of the present invention as health food or functional food according to one of.
Although antioxidation aspect drop pill of the present invention is strong not as good as the activity of VE in vitro, this product also has the multi-efficiencies such as relaxing the bowels with lubricant drugs relieving constipation.
Four, the impact experiment of excised tea fresh leaves motion
On the impact experiment of animal excised tea fresh leaves motion.
(1) get rat preduodenal and each 1cm of ileum, rinse well with tyrode, for subsequent use.Get above-mentioned in vitro intestinal homonymy two ends threading respectively, be fixed between breather and tonotransducer, to insert in 37 DEG C of desk-top bath of liquid grooves of constant temperature and to pass to 95%O
2and 5%CO
2, the normal in vitro intestinal contraction movement of record after stable.Then take out in vitro intestinal to put into drop pill solution of the present invention and soak 30s, again insert in tyrode bath, after its motion stabilization, trace administration activity curve.
Concrete data are as follows:
The impact that table 4 shrinks rat preduodenal
The impact that table 5 shrinks rat ileum
On the impact of animal excised tea fresh leaves motion.
Duodenum accepts gastric juice, pancreatic juice and bile, is the significant points of little intestinal digestion mixing.
Ileum is absorption and digestion food, and the significant points that chyme is moved forward.
Can finding out that Fructus Cannabis oil all has obvious effect to duodenum and ileum from data and image, obviously can increase the tension force of intestinal tube, illustrating that Fructus Cannabis oil has effect of relieving constipation by strengthening the wriggling dynamics of intestinal and amplitude.Fructus Cannabis oil obviously increases intestinal peristalsis promoting dynamics but even slightly slows down to bowel movement frequency influence is less, fully mixing of food and Digestive system can either be promoted like this, can ensure that again the time of staying of chyme at intestinal especially ileum is so that the abundant absorption of nutritional labeling, this is that it has the embodiment of the effect of " tonify deficiency ".
Can find out that Semen Cassiae seed oil also has duodenum and ileum from data and image obviously to increase tension force and improve the effect of intestinal contraction frequency, Semen Cassiae makes chyme accelerate excretion by acceleration intestinal peristalsis promoting and contraction frequency, and has the shortcoming that food nutrition material fully can not be absorbed.
Can find out that drop pill of the present invention increases intestinal tension force from data and image, slowed down relative to Semen Cassiae seed oil the contraction frequency of experiment intestinal segment, nutritional labeling is made to be able to abundant absorption at intestinal especially ileum place, too do not run off, finally reach the object of " not hindering intestinal under rushing down; relieving constipation does not take grain ", be greatly better than effect of single use Fructus Cannabis oil or Semen Cassiae seed oil.
Five, Semen Cassiae seed oil and Fructus Cannabis oil make the dissolution comparison check of different dosage form after combining.
Following dosage form is also can be made into: soft capsule, hard capsule, tablet by for the preparation of the Semen Cassiae seed oil of drop pill and Fructus Cannabis oil mixture.
The soft capsule made drop pill of the present invention and Semen Cassiae seed oil and Fructus Cannabis oil mixture, hard capsule, tablet carry out dissolution test.Inspection Check method should all disintegrates pass through screen cloth at the appointed time according to checking inspection technique disintegration (" Chinese Pharmacopoeia " 2015 editions the 4th, general rule 0921).
Check result is as follows:
The dissolution of table 6 different dosage form compares (unit: minute)
The above results can find out that in dissolution test, drop pill dissolution time of the present invention is the shortest, and dissolution time the most homogeneous (RSD value is minimum).It is drop pill, soft capsule, hard capsule, the absorbed prerequisite of tablets and other formulations medicine that disintegrate leaches, same medicine, and the dosage form of dissolution high (required time is short) absorbs also the fastest.This result shows Semen Cassiae seed oil and Fructus Cannabis oil to make in above-mentioned different dosage form, and drop pill absorbs the fastest dosage form, and the homogeneity of stripping is good.
By above-mentioned data sufficient proof, drop pill of the present invention has relaxing the bowels with lubricant drugs defecating feces excretion, the loss of nutritional labeling effectively can be avoided while " relieving constipation ", there is antioxidant activity, consumption is little, be convenient to take, be easy to after taking absorb, absorb fast, substantially increase drug effect and curative effect, improve curative effect more than 20%, and try out through 68 routine constipation patients, except 1 people is without except positive effect, other constipation symptom all have improvement in various degree, wherein the complete eliminator of constipation is 51 people, symptom improver 16 people, effective percentage is up to more than 98%, and during medication, do not find any untoward reaction, show drug safety, stable curative effect is reliable, be particularly useful for old people and the empty patient of body with constipation, that one on treatment constipation medicine is innovated greatly, economic and social benefit is huge.
Claims (5)
1. treat the preparation method of the Chinese medicine dripping pills of constipation for one kind, it is characterized in that, get the Polyethylene Glycol that molecular mass is 5500-6500g/moL, 75-85 DEG C of water-bath is dissolved, and makes substrate, adds the mixture of Fructus Cannabis oil and Semen Cassiae seed oil under stirring in substrate, the mass ratio of Fructus Cannabis oil and Semen Cassiae seed oil is 2-3 ︰ 2-3, stir, obtained drop pill medicinal liquid, described substrate is 4-8 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 70-80 DEG C of condition, what drip with 30-60 per minute drips speed, and instillation is equipped with in the cold oil tubulation of thermograde, makes drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 100-150 centistoke;
The described cooling oil surface temperature 40-60 DEG C had in the cold oil tubulation of thermograde, bottom temp 5-10 DEG C.
2. the preparation method of the Chinese medicine dripping pills for the treatment of constipation according to claim 1, it is characterized in that, get the Polyethylene Glycol that molecular mass is 6000g/moL, 80 DEG C of water-baths are dissolved, obtained substrate, adds the mixture that Fructus Cannabis oil mixes according to mass ratio 1:1 with Semen Cassiae seed oil, stirs under stirring in substrate, obtained drop pill medicinal liquid, described substrate is 8 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 75 DEG C of conditions, fast with 40 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 120 centistokes;
The described cooling oil surface temperature 50 DEG C had in the cold oil tubulation of thermograde, bottom temp 8 DEG C.
3. the preparation method of the Chinese medicine dripping pills for the treatment of constipation according to claim 1, it is characterized in that, get the Polyethylene Glycol that molecular mass is 5500g/moL, 75 DEG C of water-baths are dissolved, obtained substrate, adds the mixture that Fructus Cannabis oil mixes according to mass ratio 2:3 with Semen Cassiae seed oil, stirs under stirring in substrate, obtained drop pill medicinal liquid, described substrate is 4 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 70 DEG C of conditions, fast with 30 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 100 centistokes;
The described cooling oil surface temperature 40 DEG C had in the cold oil tubulation of thermograde, bottom temp 5 DEG C.
4. the preparation method of the Chinese medicine dripping pills for the treatment of constipation according to claim 1, it is characterized in that, get the Polyethylene Glycol that molecular mass is 6500g/moL, 85 DEG C of water-baths are dissolved, obtained substrate, adds the mixture that Fructus Cannabis oil mixes according to mass ratio 3:2 with Semen Cassiae seed oil, stirs under stirring in substrate, obtained drop pill medicinal liquid, described substrate is 6 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 80 DEG C of conditions, fast with 60 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 150 centistokes;
The described cooling oil surface temperature 60 DEG C had in the cold oil tubulation of thermograde, bottom temp 10 DEG C.
5. the preparation method of the Chinese medicine dripping pills for the treatment of constipation according to claim 1, it is characterized in that, get the Polyethylene Glycol that molecular mass is 5800g/moL, 78 DEG C of water-baths are dissolved, obtained substrate, adds the mixture that Fructus Cannabis oil mixes according to mass ratio 2:3 with Semen Cassiae seed oil, stirs under stirring in substrate, obtained drop pill medicinal liquid, described substrate is 7 times of Fructus Cannabis oil and Semen Cassiae oil mixture gross weight; By drop pill medicinal liquid under 78 DEG C of conditions, fast with 50 per minute drip, instillation has in the cold oil tubulation of thermograde, and collect molding drop pill, centrifugal segregation cold oil, must treat the Chinese medicine dripping pills of constipation;
Described cold oil is dimethicone, and kinematic viscosity is 130 centistokes;
The described cooling oil surface temperature 60 DEG C had in the cold oil tubulation of thermograde, bottom temp 5 DEG C.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991650A (en) * | 2009-08-21 | 2011-03-30 | 陈大刚 | Cassia seed and fructus cannabis capsules |
| CN102600358A (en) * | 2012-03-31 | 2012-07-25 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese laxative medicine and product thereof |
| CN104922216A (en) * | 2014-03-22 | 2015-09-23 | 绿之韵生物工程集团有限公司 | Bowel-relaxing pharmaceutical composition and preparation method thereof |
-
2016
- 2016-01-29 CN CN201610065223.5A patent/CN105456365A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991650A (en) * | 2009-08-21 | 2011-03-30 | 陈大刚 | Cassia seed and fructus cannabis capsules |
| CN102600358A (en) * | 2012-03-31 | 2012-07-25 | 广州白云山和记黄埔中药有限公司 | Traditional Chinese laxative medicine and product thereof |
| CN104922216A (en) * | 2014-03-22 | 2015-09-23 | 绿之韵生物工程集团有限公司 | Bowel-relaxing pharmaceutical composition and preparation method thereof |
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| Title |
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| 宋育航等: "RP-HPLC法测定润肠口服液中大黄酚含量", 《现代中药研究与实践》 * |
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Application publication date: 20160406 |