KR20030033473A - Compositions comprising medicinal herb extract for preventing and improving women's diseases - Google Patents

Abstract

PURPOSE: Provided is a compositions comprising a medicinal herb extract for preventing and improving women's diseases, such as dysmenorrhea, psychroalgia, climacteric diseases and the like. CONSTITUTION: A compositions comprising a medicinal herb extract for preventing and improving women's diseases is characterized by comprising, as an active ingredient, 1.2-3.6 wt.% of Angelica uchiyamana, 0.6-2.4 wt.% of Cnidium officinale, 2.4-4.8 wt.% of Paeonia japonica (Makino) Miyabe et Takada., 0.6-2.4 wt.% of Atractylodes japonica(Koidz) Kitag., 0.6-2.4 wt.% of Poria cocos, 0.3-1.5 wt.% of corn' hair, 01-1.5 wt.% of dried ginger, 0.3-1.5 wt.% of ginseng, 0.3-1.5 wt.% of job's tear, and 0.3-1.5 wt.% of Astraglus memdranaceus.

Description

Compositions comprising medicinal herb extract for preventing and improving women's diseases}

The present invention relates to a composition for improving and preventing gynecological diseases containing herbal medicines. In particular, the present invention relates to a composition for improving and preventing gynecological diseases containing eleven drugs, including Angelica and Peony.

Gynecological disease is a disease that occurs only in women and can be broadly divided into four types: menstrual disease, genital disease, pregnancy disease, and postpartum disease. Gynecological disease usually includes various phenomena that occur from menarche 14 to menopause around 50 years old and the resulting diseases. For example, unmarried women have many menstrual and genital diseases. The most common symptoms are menstrual pain and obesity. In addition, due to excessive diet may cause menstrual irregularities or amenorrhea. Married women are more likely to get pregnant and postpartum. Because of the influence of traditional male preferences, numerous artificial heritages have been pointed out as the cause of damaging the medicament and causing gynecological diseases.

Since ancient times, in oriental medicine, many herbal medicines and their compositions have been used for the treatment of gynecological diseases such as circumference, cheonma, chrysanthemum, and baeknyeoncho. . Geumgyeokyeo says that during pregnancy pregnant women's belly is hungry and sick, you must use Dangwi peony acid, and the wife must use Dangwi peony acid for all diseases that the stomach is sick. The pharmacological action of Dangwijakjaksan first improves anemia by the hematopoietic action, and the second, Danggui, peony expands blood vessels, and cheongung promotes blood circulation by promoting blood circulation. Fourth, Dongguk, Cheongung, Taxa and Peony inhibit uterine smooth muscle spasms and strengthen the tension of uterine smooth muscle to prevent miscarriage. Fifth, Taxa lowers the viscosity of blood. Strengthens tension and relieves spasms of visceral muscles.

According to the pharmacological action of each drug, Angelica has vitamin B12, Folic acid, and iron, which is a hematopoietic effect to improve blood flow, increase blood hematocrit, and vitamin E, which acts on Vitamin E deficiency, promotes uterine development, There is a function control action when the uterus is contracted to relax and irregular contractions to increase the contractile force to prevent miscarriage. Essential oils also dilate blood vessels, lower blood pressure, promote cerebral blood flow, and expand peripheral blood vessels to improve peripheral circulation. Peony contains various types of sugars, mucus, organic acids and trace minerals, which reduces the limit of malnutrition, inhibits vascular smooth muscle spasm of Paeoniflorin, inhibits gastric acid secretion, and improves urinary tract by strengthening bladder's motility. And reinforcement of the uterus, kidney muscles to strengthen the ability to relieve back pain caused by the uterus and kidneys. Bokryeong contains β-Pachymose, Pachymic acid, protein, fat, potassium, Lecithin, etc. It supplies nutrition to all cells, activates brain cells, stabilizes the mind, improves weakness and suppresses reabsorption of tubules. Promotes relieve edema. Bleaching suppresses central nervous system excitability by β-eudesmol and Hinesol. It stimulates digestive fluid secretion, promotes digestion and absorption, and promotes the release of stagnant venom into the gastric lumen. In the uterus, Ferulic acid has analgesic, analgesic, and smooth muscle relaxation effects. It suppresses intestinal spasms, contraction and relaxation of the pregnant uterus, and essential oils act on the central nervous system. Antagonize Finally, taxa reduces vascular swelling by inhibiting tubule resorption, thereby reducing stromal edema. Alisol A and Alisol A-24-Monoacetate alleviate fatty liver, while Choline and Lecithin reduce Cholesterol and Triglyceride levels It acts as a hyperlipidemia and relieve atherosclerosis.

The present invention has been made in view of the need to improve and enhance the medicinal effects of the sugar extracts, the object of the present invention is to provide a composition for preventing and improving gynecological diseases.

In order to achieve the above object, the present invention has been used for the treatment of gynecological diseases in oriental medicine for thousands of years in oriental medicine, Dongguk, Cheongung, Baekjak, Baekchul, Fuling, Corn beard, Deodeok, health, Yulmu, Safflower, Hwanggi The study was conducted to confirm that the water extract of the drug is an effective substance effective in improving and preventing gynecological diseases. Therefore, the present invention is a 1.2-3.6 weight ratio Angelica, 0.6-2.4 weight ratio Cheongung, 2.4-4.8 weight ratio Baekjak, 0.6-2.4 weight ratio Baekyeong, 0.6-2.4 weight ratio Fuling, 0.3-1.5 weight ratio corn beard, 0.3-1.5 The present invention provides a composition for improving gynecological diseases comprising four ginseng in weight ratio, health in 0.1-1.5 weight ratio, rate of 0.3-1.5 weight ratio, safflower seed in 0.9-2.7 weight ratio, and sulfur in 0.3-1.5 weight ratio as active ingredients.

The composition of the composition is less than the weight ratio of each constituent drug, the drug effect is less, and there is no difference between the drug effect more than the above weight ratio was selected in consideration of economics and the like.

The present invention preferably further comprises the step of concentrating after the extraction step, the solvent used in the extraction of the present invention is preferably purified water, ethanol, methanol, propanol or butanol and a mixed solvent thereof, purified water, ethanol or Methanol is more preferred and purified water is most preferred.

In addition, the water extract used in the present invention is prepared by the following method. First, buy high-quality raw materials, select them, and remove invisible parts and wash them cleanly so that foreign substances do not mix. Next, the selected and washed raw materials are weighed according to the blending ratio, a predetermined amount of purified water is added thereto, and the extract is filtered for a predetermined time at 95 ° C to 100 ° C, and the extract is filtered. Oligosaccharides are mixed in the extract according to the blending ratio and immediately sterilized for 1 hour at 95 ℃ to 100 ℃.

The composition of the present invention is an extract composition prepared by the above method by extracting the mixture of Baekjak, Angelica, safflower seed, Cheongung, Baekchul, Astragalus, Bokryeong, Deodeok, Corn, Yulmu, and Health.

The composition of the present invention may further include conventionally used excipients, disintegrants, sweeteners, lubricants, flavoring agents, etc., tablets, capsules, powders, granules, suspensions, emulsifiers, syrups by conventional methods It may be formulated as a pharmaceutical preparation for unit administration or for several administrations, such as a liquid or parenteral preparation, and is preferably formulated as a liquid.

The dosage level for a particular patient of the composition of the present invention may vary depending on the weight, age, sex, health condition, diet, time of administration, method of administration, excretion rate, severity of disease, and the like of the patient.

The present inventors confirmed that the extract thus prepared shows a marked increase in the efficacy of osteoporosis, such as osteoporosis, by removing the tackiness that is too weak to the Donggwijaksan acid composition having the above effects and adding six drugs including safflower seed. To complete.

Therefore, the eleven drugs including Angelica and Peony are extracted together with purified water, and the product obtained through the manufacturing process, such as concentration, provides a pharmaceutical composition of herbal ingredients with no side effects and excellent efficacy in the prevention and improvement of gynecological diseases. It will be useful to replace existing therapeutic agents.

The present invention will be described with reference to the following specific examples, but the present invention is not limited thereto.

Example 1

Angelica 4g, Cheonung 2.33g, Baekjak 6g, Baekchul 2.33g, Bokryeong 2g, Corn Beard (Occa) 1.5g, Deodeok (Sasam) 1.5g, Health 1g, Yulmu (Euiin) 1.5g, Safflower Seed 3.5g, Astragalus 2g was washed well, and put into a 500ml round flask, 166ml of purified water was placed in a reflux condenser, and extracted for 6 hours in a 95-100 ° C water bath. The extract was filtered hot at 60 ° C. or higher and the solvent was evaporated to give 80 ml of a fluid extract, and 5 g of oligosaccharide was added to prepare a pouch (84 ml fluid extract).

Example 2

Angelica 4g, Cheonung 2.33g, Baekjak 6g, Baekchul 2.33g, Bokryeong 2g, Corn Beard (Occa) 1.5g, Deodeok (Sasam) 1.5g, Health 1g, Yulmu (Euiin) 1.5g, Safflower Seed 3.5g, Astragalus 2g was washed well, and put into a 1L round flask, 166ml of purified water was put in a reflux condenser, and extracted for 10 hours in a 120 ° C oil-bath. The extract was filtered hot at 60 ° C. or higher, the solvent was evaporated to concentration and lyophilized to obtain 12.42 g of powder. Then, 5 g of oligosaccharide was added and a small amount of purified water and a small amount of ethanol for alcohol were mixed well. When ethanol hardened by evaporation and removal at room temperature, it was ground using a ball mill to prepare a powder (17.42 g).

Example 3

Prepared in the same manner as in Example 2 to obtain a granule by spray drying to prepare a hard capsule (Hard capsule).

Example 4

Prepared in the same manner as in Example 2 was mixed with a small amount of alcohol ethanol and purified water to prepare a soft capsule.

The composition of the present invention having the configuration as described above has an improvement effect on symptoms such as female menopausal period, female cold, constitution improvement, menstrual irregularities.

Claims (1)

1.2-3.6 weight ratio Angelica, 0.6-2.4 weight ratio Cheongung, 2.4-4.8 weight ratio Baek-jak, 0.6-2.4 weight ratio Baek-eup, 0.6-2.4 weight ratio Bokyeong, 0.3-1.5 weight ratio Corn beard, 0.3-1.5 weight ratio Samsam, A composition for improving gynecological disease, comprising 0.1-1.5 weight percent health, 0.3-1.5 weight ratio yulmu, 0.9-2.7 weight ratio safflower seed, and 0.3-1.5 weight ratio sulfur.