CN105435251A - Contrast media applicable to cold-heat complication type irritable bowel syndrome - Google Patents
Contrast media applicable to cold-heat complication type irritable bowel syndrome Download PDFInfo
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- CN105435251A CN105435251A CN201511021885.4A CN201511021885A CN105435251A CN 105435251 A CN105435251 A CN 105435251A CN 201511021885 A CN201511021885 A CN 201511021885A CN 105435251 A CN105435251 A CN 105435251A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and particularly relates to contrast media applicable to cold-heat complication type irritable bowel syndrome. The contrast media comprise a liposome and microbubbles wrapped in the liposome, wherein the liposome is prepared from components in parts by weight as follows: 10-25 parts of lecithin and 45-70 parts of a traditional Chinese medicine carrier and is characterized in that the traditional Chinese medicine carrier is prepared from traditional Chinese medicine raw materials in parts by weight as follows: 20-30 parts of dried ginger, 20-30 parts of asarum sieboldii, 10-15 parts of white mustard, 10-15 parts of rhizoma coptidis, 20-30 parts of Primula malacoides, 10-15 parts of Aleuritopteris hopeana (C. Chr.) Ching, 10-15 parts of manyprickle acanthopanax root, 10-15 parts of Gynura crepidioides Benth., 10-15 parts of stir-fried white atractylodes rhizome, 10-15 parts of immature orange fruit, 10-15 parts of calcined ark shells and 5-10 parts of smoked plums. The contrast media have the advantages of inhibition of too fast gastrointestinal peristalsis and nourishment of the gastrointestinal tract.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, relate to a kind of gastrointestinal tract contrast medium, be specifically related to a kind of contrast agent being applicable to intermingling cold and heat type irritable bowel syndrome.
Background technology
Gastrointestinal tract is hollow organ, often has gases affect, and ultrasonic detection from body surface is difficult to obtain satisfied ultrasonogram, and the diagnosis of gastroenteropathy often relies on gastroscope and the barium meal examination of x line.In recent years due to development and the application of gastrointestinal acoustic contrast art and ultrasonic endoscope two technology, widen the diagnostic area of gastrointestinal disease.Ultrasonic examination can the hierarchical structure of clear display gastrointestinal wall, find the position of gastrointestinal wall tumor, size and geometric, estimate that pathological changes invades the degree of gastrointestinal wall, particularly understand the transfer case of peripheral organs, make up the deficiency of gastroscope and x ray examination, the selection for clinical treatment provides reliable foundation.
Wherein, gastro intestinal ultrasonic contrast examination method adopts contrast agent to fill stomach, enteric cavity, by improving the ultrasonic internal medium of gastrointestinal, being beneficial to ultrasonic wave acoustic beam and penetrating, and gastrointestinal structure and its pathological changes are conveniently shown more clearly.
But suffering from the patient of irritable bowel syndrome when taking contrast agent, often there will be the situation that contrast agent one or two hour has just arrived ileocecus, normal condition should at three to six hours, thus can not radiography smoothly.There is this situation normally because gastrointestinal peristalsis is too fast, accelerate contrast agent displacement.Therefore, for this class patient in angiographic procedure can gastrointestinal peristalsis inhibition too fast, and can radiography smoothly, become problem demanding prompt solution.
Summary of the invention
The object of this invention is to provide a kind of contrast agent being applicable to intermingling cold and heat type irritable bowel syndrome, have gastrointestinal peristalsis inhibition too fast, nourish gastrointestinal advantage.
The symptom of intermingling cold and heat type irritable bowel syndrome is: have a pain in abdomen or borborygmus diarrhoea, just lower sticky smooth, or folder foam, or diarrhoea and constipation are handed over and done, unhappy loss of appetite, gastral cavity abdomen pain relieved by pressing, xerostomia.Red tongue, greasy fur, stringy and rolling pulse.Concrete reason is analyzed as follows: prolonged illness is lost and controlled or natural endowment difference, and cause coldheat complex, cold-evil stays in the intestines and stomach, then have a pain in abdomen, and borborygmus are suffered from diarrhoea, just lower sticky not smooth, even folder foam; Coldheat complex, disorder of movement of QI, therefore see that diarrhoea and constipation are handed over and done; Pathogenic heat more very time visible xerostomia, unhappy loss of appetite, cold-evil's impairment of YANG, then gastral cavity abdomen likes warm pain relieved by pressing, red tongue greasy fur, and stringy and rolling pulse is that cold and heat cherish assorted levying.Therefore, the present invention proposes following technical scheme.
The invention provides a kind of contrast agent being applicable to intermingling cold and heat type irritable bowel syndrome, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 10 ~ 25 parts, lecithin, middle drug carrier 45 ~ 70 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Zingiberis 20 ~ 30 parts, Herba Asari 20 ~ 30 parts, Caulis et Folium Sinapis albee 10 ~ 15 parts, Rhizoma Coptidis 10 ~ 15 parts, Flos Primulae Vittatae 20 ~ 30 parts, little tackle all problems at once 10 ~ 15 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 15 parts, exist everywhere 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 15 parts, Fructus Aurantii Immaturus 10 ~ 15 parts, Concha Arcae (calcined) 10 ~ 15 parts, Fructus Mume 5 ~ 10 parts.
The gas of filling in described microvesicle is the oxygen of volume ratio 4 ~ 8: 1 and the mist of carbon dioxide composition.
Wherein, preferred version is as follows:
Described contrast agent is made up of liposome and the microvesicle be wrapped in described liposome, and described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Zingiberis 25 parts, Herba Asari 25 parts, Caulis et Folium Sinapis albee 12 parts, Rhizoma Coptidis 12 parts, Flos Primulae Vittatae 25 parts, little tackle all problems at once 12 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, exist everywhere 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, Fructus Aurantii Immaturus 12 parts, Concha Arcae (calcined) 12 parts, Fructus Mume 8 parts.
Contrast agent preparation method of the present invention is as follows:
(1) get above-mentioned raw material of Chinese medicine by weight to pulverize, cross 40 ~ 80 mesh sieves, add the distilled water of mixing Chinese medicine powder quality 4 ~ 8 times, decoct 1 ~ 2h, filter, obtain Aqueous extracts filtrate, Aqueous extracts concentrating under reduced pressure obtains water extracting liquid, 95% ethanol of its quality 3 ~ 4 times is added in residue, reflux 2 ~ 3h, extract 2 ~ 3 times, merge extractive liquid, filter, obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, mix with the water extracting liquid obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, dry cream is placed in super micron mill to be pulverized, sieve, obtain 800 ~ 1000 object micropowders,
(2) join in dehydrated alcohol by lecithin, stirring and dissolving at 37 ~ 42 DEG C, add the Chinese crude drug micropowders that step (1) obtains in the solution obtained, rotary evaporation volatilizes solvent and obtains pro-liposome;
(3) aseptically, the pro-liposome that taking-up (2) obtains is sub-packed in cillin bottle, and the mist then injecting oxygen and carbon dioxide composition, to replace the air of cillin bottle head, seals and get final product.
Pharmacology analysis:
Rhizoma Zingiberis: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.
Herba Asari: pungent, temperature.GUIXIN, lung, kidney channel.Expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Caulis et Folium Sinapis albee: acrid in the mouth, temperature, nontoxic.Enter lung.Warming spleen and stomach for dispelling cold.Control cough out of breath, stomach, abdomen cold type of pain.
Rhizoma Coptidis: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Flos Primulae Vittatae: bitter, cold.Heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire, hemostasis.Control infantile hyperpyrexia convulsion, acute gastroenteritis, dysentery.
Littlely to tackle all problems at once: light, flat.Strengthening the spleen and stomach, invigorating the spleen and replenishing QI.Cure mainly flu, infantile malnutrition, the old deficiency of vital energy.
Radix Et Caulis Acanthopanacis Senticosi: pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Exist everywhere: bitter, micro-pungent, flat.Spleen strengthening and bloatedness reducing.For dyspepsia, insufficiency of the spleen edema.
Rhizoma Atractylodis Macrocephalae (parched): there is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.
Fructus Aurantii Immaturus: bitter; Pungent; Cold.Return spleen; Stomach; Liver; Heart channel.Effect: stop in stagnant; Feeling of fullness distending pain; Constipation; Heavy after dysentery; Blocked-up chest; Gastroptosis; Uterine prolapse; Proctoptosis.
Concha Arcae (calcined): salty is flat.Return lung, stomach, Liver Channel.Expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.
Fructus Mume: sour, puckery is flat.Return liver, spleen, lung, large intestine channel.Astringe the lung, astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.
In the present invention, during Rhizoma Zingiberis, Herba Asari, Caulis et Folium Sinapis albee warming YANG to expel cold warm up; Rhizoma Coptidis, Flos Primulae Vittatae heat clearing and damp drying; Littlely to tackle all problems at once, Radix Et Caulis Acanthopanacis Senticosi, invigorating the spleen and benefiting QI of existing everywhere; Rhizoma Atractylodis Macrocephalae (parched), Fructus Aurantii Immaturus, Concha Arcae (calcined) nourishing the stomach, play nourishing effect to stomach; Fructus Mume sour and sweet drugs can transforme into YIN, all medicines of mediation cold and heat.
Drug carrier sheerly Chinese medicine preparation in the present invention, prove through years of researches and clinical practice: drug safety is reliable, medicine valency is cheap, carry taking convenience, avoid toxic and side effects and the anaphylaxis of chemicals, be applicable to intermingling cold and heat type irritable bowel syndrome patient, and to stomach tool Yellow Gentian Extract.
Outcome measure:
Take effect: without senses of discomfort such as stomachache, vomitings, radiography is clear, start to discharge contrast agent in 3 ~ 6 hours after checking.
Take a turn for the better: the senses of discomfort such as stomachache, vomiting alleviate, and radiography is clear, start to discharge contrast agent in 2 ~ 3 hours after checking.
Invalid: all diseases are not improved, namely contrast agent arrives ileocecus in 1 ~ 2 hour.
Take result: check patient 50 example, be intermingling cold and heat type irritable bowel syndrome patient, the made contrast agent of the present invention that swallows, if feel stimulating gastrointestinal road, have the gastric lavage immediately of allergic symptom emetic.After inspection, take effect 35 examples, accounts for 70%, and take a turn for the better 15 examples, accounts for 30%.
An attached routine case is described further:
Case 1: finish certain, female, 42 years old, civil servant.The regular pain of the intestines and stomach, does ultrasonic contrast at the beginning, and within 2 hours, contrast agent arrives ileocecus, fails smooth radiography.Take contrast agent of the present invention to check, occur without stomachache, vomiting situation, radiography is clear, and stomach is fishhook-type, on an empty stomach without stomach pool stream; Antrum pleat irregular arrangement, increases thick.Gastric antrum community and stomach ditch plumpness, have no clear and definite ridge shadow and filling defect.Gastric antrum is little curved in dentation, and wriggle, contractile function is on the weak side; Without tenderness excitation.Check latter 3 hours namely to start to discharge contrast agent.
Detailed description of the invention
Embodiment 1:
The present embodiment provides a kind of contrast agent being applicable to intermingling cold and heat type irritable bowel syndrome, and be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; Described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Zingiberis 25 parts, Herba Asari 25 parts, Caulis et Folium Sinapis albee 12 parts, Rhizoma Coptidis 12 parts, Flos Primulae Vittatae 25 parts, little tackle all problems at once 12 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, exist everywhere 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, Fructus Aurantii Immaturus 12 parts, Concha Arcae (calcined) 12 parts, Fructus Mume 8 parts.
Described contrast agent preparation method is as follows:
(1) get above-mentioned raw material of Chinese medicine by weight to pulverize, cross 60 mesh sieves, add the distilled water of mixing Chinese medicine powder quality 5 times, decoct 1h, filter, obtain Aqueous extracts filtrate, Aqueous extracts concentrating under reduced pressure obtains water extracting liquid, 95% ethanol of its quality 4 times is added in residue, reflux 3h, extract 2 times, merge extractive liquid, filter, obtain alcohol extract, alcohol extract concentrating under reduced pressure, be recycled to without alcohol taste, mix with the water extracting liquid obtained above, further concentrating under reduced pressure, except desolventizing, dry, obtain and get dry extract, dry cream is placed in super micron mill to be pulverized, sieve, obtain 1000 object micropowders,
(2) join in dehydrated alcohol by lecithin, stirring and dissolving at 40 DEG C, add the Chinese crude drug micropowders that step (1) obtains in the solution obtained, rotary evaporation volatilizes solvent and obtains pro-liposome;
(3) aseptically, the pro-liposome that taking-up (2) obtains is sub-packed in cillin bottle, and the mist then injecting oxygen and carbon dioxide composition, to replace the air of cillin bottle head, seals and get final product.
Claims (2)
1. be applicable to a contrast agent for intermingling cold and heat type irritable bowel syndrome, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 10 ~ 25 parts, lecithin, middle drug carrier 45 ~ 70 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Zingiberis 20 ~ 30 parts, Herba Asari 20 ~ 30 parts, Caulis et Folium Sinapis albee 10 ~ 15 parts, Rhizoma Coptidis 10 ~ 15 parts, Flos Primulae Vittatae 20 ~ 30 parts, little tackle all problems at once 10 ~ 15 parts, Radix Et Caulis Acanthopanacis Senticosi 10 ~ 15 parts, exist everywhere 10 ~ 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 10 ~ 15 parts, Fructus Aurantii Immaturus 10 ~ 15 parts, Concha Arcae (calcined) 10 ~ 15 parts, Fructus Mume 5 ~ 10 parts.
2. be applicable to the contrast agent of intermingling cold and heat type irritable bowel syndrome as claimed in claim 1, be made up of liposome and the microvesicle be wrapped in described liposome, described liposome is made up of the component of following weight portion: 20 parts, lecithin, middle drug carrier 55 parts; It is characterized in that described middle drug carrier is formulated by the raw material of Chinese medicine of following parts by weight: in Rhizoma Zingiberis Recens 25 parts, Herba Asari 25 parts, Caulis et Folium Sinapis albee 12 parts, Rhizoma Coptidis 12 parts, Flos Primulae Vittatae 25 parts, little tackle all problems at once 12 parts, Radix Et Caulis Acanthopanacis Senticosi 12 parts, exist everywhere 12 parts, Rhizoma Atractylodis Macrocephalae (parched) 12 parts, Fructus Aurantii Immaturus 12 parts, Concha Arcae (calcined) 12 parts, Fructus Mume 8 parts.
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| CN104984366A (en) * | 2015-08-11 | 2015-10-21 | 刘子成 | Gastrointestinal tract contrast agent |
| CN105031670A (en) * | 2015-08-11 | 2015-11-11 | 青岛市中心医院 | Gastrointestinal tract contrast agent |
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| CN102861306A (en) * | 2012-09-06 | 2013-01-09 | 李承平 | Group of dark plum fruit combined tablets |
| CN104857533A (en) * | 2015-05-29 | 2015-08-26 | 乔芳霞 | Ultrasonic diagnosis contrast medium and preparation method thereof |
| CN104984366A (en) * | 2015-08-11 | 2015-10-21 | 刘子成 | Gastrointestinal tract contrast agent |
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Application publication date: 20160330 |