CN105435167A - Preparation method for oral liquid used for treating cold and fever in winter - Google Patents

Preparation method for oral liquid used for treating cold and fever in winter Download PDF

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CN105435167A
CN105435167A CN201510915352.4A CN201510915352A CN105435167A CN 105435167 A CN105435167 A CN 105435167A CN 201510915352 A CN201510915352 A CN 201510915352A CN 105435167 A CN105435167 A CN 105435167A
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parts
winter
oral liquid
lixiviate
fever
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覃俊
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
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    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

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Abstract

The invention discloses a preparation method for an oral liquid used for treating cold and fever in winter. The preparation method for the oral liquid comprises the following steps: step 1, drying and crushing a traditional Chinese medicine composition so as to obtain raw material powder, wherein the traditional Chinese medicine comprises the following bulk drugs by weight: 2 to 5 parts of Herba Aristolochiae, 1 to 3 parts of ephedra stem, 10 to 20 parts of cassia twig, 8 to 12 parts of catnip, 5 to 8 parts of divaricate saposhnikovia root, 5 to 8 parts of Rhizoma Ligustici, 7 to 12 parts of lily magnolia, 20 to 30 parts of fistular onion bulb, 8 to 15 parts of white peony root, 8 to 12 parts of Chinese angelica, 10 to 20 parts of jujube, 8 to 15 parts of fresh ginger and 8 to 12 parts of Flos Farfarae; step 2, mixing the raw material powder with an ethanol solution having a concentration of 60 to70% and accounting for 10 to 30 times of the volume of the raw material powder and carrying out extraction, and after completion of extraction, carrying out heating to evaporate ethanol so as to obtain an extractive substance; and step 3, diluting the extractive substance to 3 to 10 times with distilled water so as to obtain the oral liquid used for treating cold and fever in winter.

Description

A kind of preparation method for the treatment of the oral liquid of cat fever in winter
Technical field
The present invention relates to tcm field, particularly relate to a kind of preparation method for the treatment of the oral liquid of cat fever in winter.
Background technology
Winter climate is cold dry, is the multiple season of flu.The traditional Chinese medical science flu be generally divided into anemofrigid cold, anemopyretic cold and summer-heat damp cold, winter general multiple anemofrigid cold.
Anemofrigid cold is many with symptoms such as heating, ache all over the body, nasal obstruction, throat itch, coughs.At present, at present, the medicament categories for the treatment of flu is various, substantially can divide four classes:
Antiallergic class, this kind of medicine all containing chlorphenamine maleate or diphenhydramine composition, as paracetamol caffein atificial cow-bezoar, GANKANG, Tylenol Cold, paracetamol, KUAIKE, paracetamol children's cold liquid, wean quick acting cold granules, tablet for treating common cold, GANMAOTONG sheet, VC YINQIAO sheet, New contac capsule capsule;
Antipyretics and analgesics, as aspirin compound (APC), acetaminophen (acetaminophen), tylenol (acetaminophen extended release tablets), compound phenobarbital injection (antondin), injection of Radix Bupleuri;
Antiviral class: ribavirin, acyclovir, amantadine;
Chinese patent medicine: antitoxic bolus of honeysuckle flower and forsythia, SUNJU GANMAO PIAN, tablet of antelope horn for common cold, KANGKAN KELI, QINGRE JIEDU KOUFUYE (or capsule), " Zhengcaihu Drink ", Yinhuang Particle, Radix Isatidis granule, SHUANGHUANGLIAN KOUFUYE (or capsule, sheet), Qingkailing granule (or capsule), antivirus oral liquid, the clear pestilence capsule of Flos Nelumbinis, HUOXIANG ZHENGQI SHUI (or capsule).
Although the medicine for the treatment of flu is numerous, but the general side effect of Western medicine is larger on the one hand, easy reduction immunity, existing Chinese patent medicine generally lacks the specific aim to cold, fever in winter on the other hand, in prior art, also not from the basic etiological analysis of cold, fever in winter, and the Chinese medicine ingredients oral liquid of dialectical treatment cold, fever in winter.
Summary of the invention
An object of the present invention is to solve at least the problems referred to above and/or defect, and the advantage will illustrated at least is below provided.
Another object of the present invention is to provide a kind of preparation method for the treatment of the oral liquid of cat fever in winter, can be effectively treated cat fever in winter oral liquid.
Other objects with some for achieving the above object, the present invention adopts following technical scheme
Treat a preparation method for the oral liquid of cat fever in winter, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Herba Aristolochiae 2-5, Herba Ephedrae 1-3, Ramulus Cinnamomi 10-20, Herba Schizonepetae 8-12, Radix Saposhnikoviae 5-8, Rhizoma Ligustici 5-8, Flos Magnoliae 7-12, Bulbus Allii Fistulosi 20-30, Radix Paeoniae Alba 8-15, Radix Angelicae Sinensis 8-12, Fructus Jujubae 10-20, fresh ginger 8-15 and Flos Farfarae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 3-10 doubly, obtain described treatment cat fever in winter oral liquid.
Preferably, in the preparation method of the oral liquid of described treatment cat fever in winter, in step 3 to treatment cat fever in winter oral liquid in add the maltose alcohol of 5-8%.
Preferably, in the preparation method of the oral liquid of described treatment cat fever in winter, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
The present invention at least comprises following beneficial effect: first, and the present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of cold, fever in winter is for cold-evil visitor is in fur flesh table, causes impaired depurative descending of lung QI, checks normal a surname defending gas and send out, strongly fragrant and generate heat.Pathogen stasis meridians, the popular smooth event head-body-pain of QI and blood, the symptom such as nasal obstruction, throat itch, cough.Treatment should be induced sweat, warming the meridian dispels cold heresy, enrich blood, stimulate the menstrual flow, complement controls pain, lung qi dispersing gas.Based on above principle, the present invention utilizes following traditional Chinese medicine composition for treating cold, fever in winter: Herba Aristolochiae, dispersing wind and cold, induces sweat; Herba Ephedrae, lung qi dispersing gas, loosing the interspaces of skin and muscles, dispersing wind and cold; Ramulus Cinnamomi, relieving the exterior syndrome by diaphoresis, warming the meridian for promoting the flow of YANG QI; Herba Schizonepetae, throat, refresh oneself; Radix Saposhnikoviae, dispelling exopathogens from superficies of the body, expelling wind and cold, pain relieving; Rhizoma Ligustici, delivers cold expelling, only parietal headache; Flos Magnoliae, dispersing wind and cold, clearing the nasal passage; Bulbus Allii Fistulosi root, dispelling cold and activating YANG, relieving the exterior syndrome by diaphoresis; The Radix Paeoniae Alba, nourishes blood, harmonizing yingfen and weifen; Radix Angelicae Sinensis, and blood is enriched blood; Fructus Jujubae, tonification nutrient blood, harmonizing yingfen and weifen; Fresh ginger, helps and defends gas diaphoresis; Flos Farfarae, nourishing the lung to keep the adverse QI downward
Secondly, by can effectively treat cat fever in winter Chinese medicine composition carry out substep alcohol steep, the oral liquid of prepared treatment cat fever in winter is not only drunk conveniently, and is conducive to the absorption of effective ingredient, effectively treatment cat fever in winter.
Part is embodied by explanation below by other advantage of the present invention, target and feature, part also will by research and practice of the present invention by those skilled in the art is understood.
Detailed description of the invention
Below the present invention is elaborated, can implement according to this after consulting this description to make those of ordinary skill in the art.
Treat a preparation method for the oral liquid of cat fever in winter, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Herba Aristolochiae 2-5, Herba Ephedrae 1-3, Ramulus Cinnamomi 10-20, Herba Schizonepetae 8-12, Radix Saposhnikoviae 5-8, Rhizoma Ligustici 5-8, Flos Magnoliae 7-12, Bulbus Allii Fistulosi 20-30, Radix Paeoniae Alba 8-15, Radix Angelicae Sinensis 8-12, Fructus Jujubae 10-20, fresh ginger 8-15 and Flos Farfarae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 3-10 doubly, obtain described treatment cat fever in winter oral liquid.
The present invention utilizes the traditional Chinese medical science five elements and dialectical theory, thinks that the cause of disease of cold, fever in winter is for cold-evil visitor is in fur flesh table, causes impaired depurative descending of lung QI, checks normal a surname defending gas and send out, strongly fragrant and generate heat.Pathogen stasis meridians, the popular smooth event head-body-pain of QI and blood, the symptom such as nasal obstruction, throat itch, cough.Treatment should be induced sweat, warming the meridian dispels cold heresy, enrich blood, stimulate the menstrual flow, complement controls pain, lung qi dispersing gas.Based on above principle, the present invention utilizes following traditional Chinese medicine composition for treating cold, fever in winter: Herba Aristolochiae, dispersing wind and cold, induces sweat; Herba Ephedrae, lung qi dispersing gas, loosing the interspaces of skin and muscles, dispersing wind and cold; Ramulus Cinnamomi, relieving the exterior syndrome by diaphoresis, warming the meridian for promoting the flow of YANG QI; Herba Schizonepetae, throat, refresh oneself; Radix Saposhnikoviae, dispelling exopathogens from superficies of the body, expelling wind and cold, pain relieving; Rhizoma Ligustici, delivers cold expelling, only parietal headache; Flos Magnoliae, dispersing wind and cold, clearing the nasal passage; Bulbus Allii Fistulosi root, dispelling cold and activating YANG, relieving the exterior syndrome by diaphoresis; The Radix Paeoniae Alba, nourishes blood, harmonizing yingfen and weifen; Radix Angelicae Sinensis, and blood is enriched blood; Fructus Jujubae, tonification nutrient blood, harmonizing yingfen and weifen; Fresh ginger, helps and defends gas diaphoresis; Flos Farfarae, nourishing the lung to keep the adverse QI downward
The present invention by can effectively treat cat fever in winter Chinese medicine composition carry out substep alcohol steep, the oral liquid of prepared treatment cat fever in winter is made not only to drink conveniently, and be conducive to the absorption of effective ingredient, effectively treatment cat fever in winter.
In the preparation method of the oral liquid of described treatment cat fever in winter, in step 3 to treatment cat fever in winter oral liquid in add the maltose alcohol of 5-8%.
In the preparation method of the oral liquid of described treatment cat fever in winter, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
Substep lixiviate can make effective ingredient more fully discharge, and improves curative effect of medication.
Although embodiment of the present invention are open as above, but it is not restricted to listed in description and embodiment utilization, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore do not deviating under the general concept that claim and equivalency range limit, the present invention is not limited to specific details.

Claims (3)

1. treat a preparation method for the oral liquid of cat fever in winter, it is characterized in that, comprise the following steps:
Step 1, lixiviate, by Chinese medicine composition drying and crushing, obtain raw material powder, described Chinese medicine composition comprises the raw material of following weight portion: Herba Aristolochiae 2-5, Herba Ephedrae 1-3, Ramulus Cinnamomi 10-20, Herba Schizonepetae 8-12, Radix Saposhnikoviae 5-8, Rhizoma Ligustici 5-8, Flos Magnoliae 7-12, Bulbus Allii Fistulosi 20-30, Radix Paeoniae Alba 8-15, Radix Angelicae Sinensis 8-12, Fructus Jujubae 10-20, fresh ginger 8-15 and Flos Farfarae 8-12;
Step 2, by the 60-70% alcoholic solution mixing lixiviate of raw material powder with 10-30 times of volume, lixiviate terminates post-heating makes ethanol evaporation, obtains extract;
Step 3, by extract adding distil water dilution 3-10 doubly, obtain described treatment cat fever in winter oral liquid.
2. the preparation method of the oral liquid for the treatment of cat fever in winter as claimed in claim 1, is characterized in that, in step 3 to treatment cat fever in winter oral liquid in add the maltose alcohol of 5-8%.
3. the preparation method of the oral liquid for the treatment of cat fever in winter as claimed in claim 1, is characterized in that, in step 2, leach extraction method is substep extraction, and concrete grammar is:
Step 2.1, first time lixiviate, extraction temperature is 30-50 DEG C, extraction time 30-40 minute, filters and obtains the first lixiviating solution;
Step 2.2, second time lixiviate, mixed with ethanol by the trapped substance of first time lixiviate filtration and carry out second time lixiviate, extraction temperature is 60-80 DEG C, extraction time 20-30 minute, filters and obtains the second lixiviating solution;
Step 2.3, the first lixiviating solution to be mixed with the second lixiviating solution, be heated to 80-85 DEG C and make ethanol evaporation, obtain described extract.
CN201510915352.4A 2015-12-10 2015-12-10 Preparation method for oral liquid used for treating cold and fever in winter Pending CN105435167A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107184924A (en) * 2017-04-14 2017-09-22 陆群英 Treat the preparation method of the oral liquid of deficiency of Yin flu

Citations (1)

* Cited by examiner, † Cited by third party
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