CN107343953A - A kind of preparation method for the oral liquid for treating winter cat fever - Google Patents
A kind of preparation method for the oral liquid for treating winter cat fever Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
- A61K36/264—Aristolochia (Dutchman's pipe)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of preparation method for the oral liquid for treating winter cat fever, a kind of preparation method for the oral liquid for treating winter cat fever, comprise the following steps:Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, the Chinese medicine composition includes the raw material of following parts by weight:Herba aristolochiae 25, Chinese ephedra 13, cassia twig 10 20, schizonepeta 8 12, windproof 58, Jehol Ligusticum Rhizome 58, the flower bud of lily magnolia 7 12, Bulbus Allii Fistulosi 20 30, the root of herbaceous peony 8 15, Radix Angelicae Sinensis 8 12, jujube 10 20, fresh ginger 8 15 and tussilago 8 12;Step 2, raw material powder is mixed to extraction with 60 70% ethanol solutions of 10 30 times of volumes, extraction is heated after terminating makes ethanol evaporation, obtains extract;Step 3, extract is added to 3 10 times of distilled water diluting, produce the oral liquid of the treatment winter cat fever.
Description
Technical field
The present invention relates to tcm field,
A kind of more particularly to preparation method for the oral liquid for treating winter cat fever.
Background technology
The winter climate cold multiple season dried, be flu.
Flu is generally divided into anemofrigid cold, anemopyretic cold by the traditional Chinese medical science
And summer-heat damp cold, winter typically multiple anemofrigid cold.
Anemofrigid cold it is more with generate heat, have pains all over,
The symptoms such as nasal obstruction, throat itch, cough.At present, at present, it is various that the medicament categories of flu are treated, can substantially divide four classes:
Antiallergy class, this kind of medicine contain chlorphenamine maleate or diphenhydramine composition,
Such as paracetamol caffein atificial cow-bezoar, sense health, Tylenol Cold, morning-night, crack, Tylenol children's cold liquid, children's quick-acting cold particle, tablet for treating common cold, GANMAOTONG piece, VC Lonicera and Forsythias piece,
New contac capsule capsule;
Antipyretics and analgesics, such as aspirin compound (APC), paracetamol (paracetamol),
Tylenol is (to acetyl
Amino phenols sustained release tablets), compound phenobarbital parenteral solution (antondin),
Bupleurum injection;
Antiviral class:Ribavirin, ACV, amantadine;
Chinese patent drug:Antitoxic bolus of honeysuckle flower and forsythia, SUNJU GANMAO PIAN, tablet of antelope's horn for common cold, KANGKAN KELI, heat-clearing and detoxicating oral liquid (or glue
Capsule), " Zhengcaihu Drink ", Yinhuang Particle, banlangen granules, banlangen keli, Shuanghuanglian oral liquid (or capsule, piece), Qingkailing granule (or capsule),
The clear pest capsule of antiviral oral liquor, lotus flower, HuoXiangZhengQiShui (or capsule).
Although the medicine for treating flu is numerous,
But the universal side effect of one side Western medicine is bigger, immunity is easily reduced, on the other hand existing Chinese patent drug in the prior art, is not felt also general lack of the specific aim to winter cold, fever from winter
The basic etiological analysis of heating is emitted,
And the traditional Chinese medicine ingredients oral liquid of dialectical treatment winter cold, fever.
The content of the invention
It is an object of the invention to solve at least the above and/or defect, and provide the advantages of at least will be described later.
It is a further object to provide a kind of preparation method for the oral liquid for treating winter cat fever,
The oral liquid of winter cat fever can be effectively treated.
To achieve the above object with some other purposes,
The present invention adopts the following technical scheme that
A kind of preparation method for the oral liquid for treating winter cat fever,
Comprise the following steps:
Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, the Chinese medicine composition includes following weight
The raw material of part:Herba aristolochiae 2-5, Chinese ephedra 1-3, cassia twig 10-20,
Schizonepeta 8-12, windproof 5-8, Jehol Ligusticum Rhizome 5-8, flower bud of lily magnolia 7-12, Bulbus Allii Fistulosi 20-30,
Root of herbaceous peony 8-15, Radix Angelicae Sinensis 8-12, jujube 10-20, fresh ginger 8-15 and tussilago 8-12;
Step 2, raw material powder mixed into extraction with the 60-70% ethanol solutions of 10-30 times of volume,
Extraction is heated after terminating to be made
Ethanol evaporation, obtain extract;
Step 3, extract is added to 3-10 times of distilled water diluting, produce the oral liquid of the treatment winter cat fever.
Preferably, in the preparation method of the oral liquid of described treatment winter cat fever,
5-8% maltitol is added in step 3 into the oral liquid for the treatment of winter cat fever.
Preferably, in the preparation method of the oral liquid of described treatment winter cat fever,
Leach extraction method is substep extraction in step 2, and specific method is:
Step 2.1, extract for the first time, extraction temperature is 30-50 DEG C, extraction time 30-40 minutes, is filtrated to get the first leaching liquor;
Step 2.2, extracting for second, the trapped substance for extracting filtering for the first time is mixed to second of extraction of progress with ethanol, extraction temperature is 60-80 DEG C,
Extraction time 20-30 minutes, it is filtrated to get the second leaching liquor;
Step 2.3, the first leaching liquor mixed with the second leaching liquor, being heated to 80-85 DEG C makes ethanol evaporation, produces described
Extract.
The present invention comprises at least following beneficial effect:
First, the present invention utilize the traditional Chinese medical science five-element and dialectical theory, it is believed that the cause of disease of winter cold, fever be cold-evil visitor in fur fleshy exterior, causing lung to lose, a surname is respectful, checks and defends normal a surname of gas and send out, strongly fragrant and generate heat.Perverse trend stasis channels and collaterals, the not smooth event head-body-pain of qi and blood prevalence,
The symptoms such as nasal obstruction, throat itch, cough.Treat suitable inducing diaphoresis, Wen Jing dispel cold it is evil, enrich blood, stimulate the menstrual flow, complement controls pain, facilitaing lung gas.Based on principles above, the present invention utilizes following traditional Chinese medicine composition for treating winter cold, fever:
Herba aristolochiae, dispersing wind and cold, inducing diaphoresis;Chinese ephedra, facilitaing lung gas, loosing the interspaces of skin and muscles, dispersing wind and cold;Cassia twig, inducing sweat and dispelling exogenous evils, Wen Jing activate yang;Schizonepeta, throat, refresh oneself;It is windproof, dispersing superficial exopathogens, expelling wind and clearing away cold, analgesic;
Jehol Ligusticum Rhizome, deliver cold dispelling, only parietal headache;The flower bud of lily magnolia, dispersing wind and cold, clearing the nasal passage;Bulbus Allii Fistulosi root, cold dispelling activates yang, inducing sweat and dispelling exogenous evils;The root of herbaceous peony, blood-nourishing, harmonizing yingfen and weifen;Radix Angelicae Sinensis, and blood are enriched blood;Jujube, help ying blood,
Harmonizing yingfen and weifen;Fresh ginger, help and defend gas sweating;Tussilago, moistening lung to lower qi
Secondly, by the way that the Chinese medicine composition that can effectively treat winter cat fever is carried out into substep alcohol steep,
The oral liquid of prepared treatment winter cat fever is not only drunk conveniently, and be advantageous to the absorption of effective ingredient, effectively treat winter cat fever.
Further advantage, target and the feature of the present invention embodies part by following explanation,
Part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Embodiment
The present invention is elaborated below,
To make those of ordinary skill in the art to implement according to this after referring to this specification.
A kind of preparation method for the oral liquid for treating winter cat fever,
Comprise the following steps:Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, the Chinese medicine composition includes the raw material of following parts by weight:Herba aristolochiae 2-5, Chinese ephedra 1-3, cassia twig 10-20,
Schizonepeta 8-12, windproof 5-8, Jehol Ligusticum Rhizome 5-8, flower bud of lily magnolia 7-12, Bulbus Allii Fistulosi 20-30,
Root of herbaceous peony 8-15, Radix Angelicae Sinensis 8-12, jujube 10-20, fresh ginger 8-15 and tussilago 8-12;
Step 2, raw material powder mixed into extraction with the 60-70% ethanol solutions of 10-30 times of volume,
Heating makes ethanol evaporation after extraction terminates, and obtains extract;
Step 3, extract is added to 3-10 times of distilled water diluting, produce the oral liquid of the treatment winter cat fever.
The present invention utilizes the traditional Chinese medical science five-element and dialectical theory,
Think that the cause of disease of winter cold, fever is cold-evil visitor in fur fleshy exterior, causing lung to lose, a surname is respectful, checks the normal a surname hair for defending gas, strongly fragrant and generate heat.Perverse trend stasis channels and collaterals, the not smooth event symptom such as head-body-pain, nasal obstruction, throat itch, cough of qi and blood prevalence.
Treat suitable inducing diaphoresis, Wen Jing dispel cold it is evil, enrich blood, stimulate the menstrual flow, complement controls pain, facilitaing lung gas.Based on principles above, the present invention utilizes following traditional Chinese medicine composition for treating winter cold, fever:Herba aristolochiae, dispersing wind and cold, inducing diaphoresis;Chinese ephedra,
Facilitaing lung gas, loosing the interspaces of skin and muscles, dispersing wind and cold;Cassia twig, inducing sweat and dispelling exogenous evils, Wen Jing activate yang;Schizonepeta, throat, refresh oneself;It is windproof, dispersing superficial exopathogens, expelling wind and clearing away cold, analgesic;Jehol Ligusticum Rhizome, deliver cold dispelling, only parietal headache;
The flower bud of lily magnolia, dispersing wind and cold, clearing the nasal passage;Bulbus Allii Fistulosi root, cold dispelling activates yang, inducing sweat and dispelling exogenous evils;The root of herbaceous peony, blood-nourishing, harmonizing yingfen and weifen;Radix Angelicae Sinensis, and blood are enriched blood;Jujube, help ying blood, harmonizing yingfen and weifen;Fresh ginger, help and defend gas
Sweating;Tussilago, moistening lung to lower qi
Chinese medicine composition of the invention by can will effectively treat winter cat fever carries out substep alcohol steep,
Make institute
The oral liquid of the treatment winter cat fever of preparation is not only drunk conveniently,
And be advantageous to the absorption of effective ingredient, effectively treat winter cat fever.
In the preparation method of the oral liquid of described treatment winter cat fever,
5-8% maltitol is added in step 3 into the oral liquid for the treatment of winter cat fever.
In the preparation method of the oral liquid of described treatment winter cat fever,
Leach extraction method is substep extraction in step 2, and specific method is:Step 2.1, extract for the first time,
Extraction temperature is 30-50 DEG C, extraction time 30-40 minutes, is filtrated to get the first leaching liquor;
Step 2.2, extracting for second, the trapped substance for extracting filtering for the first time is mixed to second of extraction of progress with ethanol, extraction temperature is 60-80 DEG C,
Extraction time 20-30 minutes, it is filtrated to get the second leaching liquor;
Step 2.3, the first leaching liquor mixed with the second leaching liquor, being heated to 80-85 DEG C makes ethanol evaporation, produces the extract.
Substep extraction can be such that effective ingredient more fully discharges,
Improve curative effect of medication.
Although embodiment of the present invention is disclosed as above,
But it is not restricted to listed utilization in specification and embodiment, it can be applied to various suitable the field of the invention completely, for those skilled in the art, other modification is easily achieved, therefore under the universal limited without departing substantially from claim and equivalency range
The present invention is not limited to specific details.
Claims (3)
1. a kind of preparation method for the oral liquid for treating winter cat fever, it is characterised in that comprise the following steps:Step 1, extraction, by Chinese medicine composition drying and crushing, obtain raw material powder, the Chinese medicine composition includes the raw material of following parts by weight:Herba aristolochiae 2-5, Chinese ephedra 1-3, cassia twig 10-20, schizonepeta 8-12, windproof 5-8, Jehol Ligusticum Rhizome 5-8, flower bud of lily magnolia 7-12, Bulbus Allii Fistulosi 20-30, root of herbaceous peony 8-15, Radix Angelicae Sinensis 8-12, jujube 10-20, fresh ginger 8-15 and tussilago 8-12;Step 2, raw material powder is mixed to extraction with the 60-70% ethanol solutions of 10-30 times of volume, extraction is heated after terminating makes ethanol evaporation, obtains extract;Step 3, extract is added to 3-10 times of distilled water diluting, produce the oral liquid of the treatment winter cat fever.
2. the preparation method of the oral liquid for the treatment of winter cat fever as claimed in claim 1, it is characterised in that add 5-8% maltitol in step 3 into the oral liquid for the treatment of winter cat fever.
3. the preparation method of the oral liquid for the treatment of winter cat fever as claimed in claim 1, it is characterised in that leach extraction method is substep extraction in step 2, and specific method is:Step 2.1, extract for the first time, extraction temperature is 30-50 DEG C, extraction time 30-40 minutes, is filtrated to get the first leaching liquor;Step 2.2, extract for second, the trapped substance for extracting filtering for the first time is mixed to second of extraction of progress with ethanol, extraction temperature is 60-80 DEG C, extraction time 20-30 minutes, is filtrated to get the second leaching liquor;Step 2.3, the first leaching liquor mixed with the second leaching liquor, being heated to 80-85 DEG C makes ethanol evaporation, produces the extract.
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