CN105435137A - A traditional Chinese medicine preparation for treating trigeminal neuralgia - Google Patents
A traditional Chinese medicine preparation for treating trigeminal neuralgia Download PDFInfo
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Abstract
A traditional Chinese medicine preparation for treating trigeminal neuralgia is disclosed. Raw material medicines of the preparation comprise 20-30 g of giant typhonium rhizome, 10-20 g of stiff silkworm, 10-20 g of baical skullcap root, 10-20 g of spica schizonepetae, 10-20 g of kudzu vine root, 10-20 g of Chinese thorowax root, 10-20 g of divaricate saposhnikovia root, 10-20 g of mulberry leaf, 8-12 g of manchurian wildginger, 8-15 g of twotoothed achyranthes root, 8-12 g of hedyotis, 8-12 g of tall gastrodia tuber, 8-12 g of fresh ginger, 8-12 g of amur cork-tree and 8-12 g of long pepper. The medicines are compatible, complement each other, and have functions of dispelling wind, relieving pain, removing heat from the liver, purging fire, promoting circulation of blood, relieving swelling, expelling wind and dredging collaterals. Clinical application shows that the preparation has advantages of low prices, definite curative effects, no side or toxic effects, a high curative rate, and the like when the preparation is used for treating the trigeminal neuralgia. The preparation deserves clinical trial and popularization.
Description
Technical field
The invention belongs to the field of Chinese medicines, one can treat prosopalgic Chinese medicine preparation specifically.
Background technology
Trigeminal neuralgia refers to the severe pain occurring repeated relapsing, transience in nervi trigeminus distributed areas.Show as during outbreak with lower jaw on buccal and tongue significantly acutely shock by electricity sample, acupuncture sample, lancinate sample or tear sample pain, last for several seconds or 1 ~ 2 minute, burst is only prominent, and the intermission is completely normal.Patient's bicker, the wing of nose, buccal or tongue are sensitizing range, touch and can bring out, and are called trigger point or trigger point.Because of pain, several cases can occur that facial muscle reflexive is twitched, bicker is led to Ipsilateral and trismus dolorificus.Pain can cause due to any stimulation of oral cavity or face, grow up and old people common, within more than 40 years old, patient accounts for 70% ~ 80%, and women is more than male, and majority is Unilateral.
Trigeminal neuralgia clinically touching difficulty is healed, aggravation, the course of disease extends, and clinical treatment generally adopts the medicines such as carbamazepine, phenytoin Sodium, tramadol, but said medicine treatment disadvantage needs long-term taking, once drug withdrawal, pain is shown effect very soon, and due to Long-term taking medicine, some patients there will be erythra, hematuria, granulocytopenia, simple thrombocytopenia causes hematopathy, the side effect such as hypomnesis, liver function injury; Paralysis nerve block, frequently temperature control coagulate the technology such as art, x radiation x and can postpone pain, but relapse rate is up to 64%, and easily cause becoming deaf, the complication such as blind, ataxia, the object of radical cure cannot be reached.
Summary of the invention
Instant invention overcomes the technical deficiency existed in treatment trigeminal neuralgia at present, provide a kind of determined curative effect, taking convenience, cheap, have no side effect and the high Chinese medicine preparation of cure rate.
The technical solution adopted in the present invention is: one treats prosopalgic Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 20-30 gram, Bombyx Batryticatus 10-20 gram, Radix Scutellariae 10-20 gram, Herba Schizonepetae 10-20 gram, Radix Puerariae 10-20 gram, Radix Bupleuri 10-20 gram, Radix Saposhnikoviae 10-20 gram, Folium Mori 10-20 gram, Herba Asari 8-12 gram, Radix Achyranthis Bidentatae 8-15 gram, Herba Hedyotidis Diffusae 8-12 gram, Rhizoma Gastrodiae 8-12 gram, Rhizoma Zingiberis Recens 8-12 gram, Cortex Phellodendri 8-12 gram, Fructus Piperis Longi 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 20 grams, Bombyx Batryticatus 10 grams, Radix Scutellariae 10 grams, Herba Schizonepetae 10 grams, Radix Puerariae 10 grams, Radix Bupleuri 10 grams, Radix Saposhnikoviae 10 grams, 10 grams, Folium Mori, Herba Asari 8 grams, Radix Achyranthis Bidentatae 8 grams, Herba Hedyotidis Diffusae 8 grams, 8 grams, Rhizoma Gastrodiae, 8 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 8 grams, Fructus Piperis Longi 8 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 25 grams, Bombyx Batryticatus 15 grams, Radix Scutellariae 15 grams, Herba Schizonepetae 15 grams, Radix Puerariae 15 grams, Radix Bupleuri 15 grams, Radix Saposhnikoviae 15 grams, 15 grams, Folium Mori, Herba Asari 10 grams, Radix Achyranthis Bidentatae 12 grams, Herba Hedyotidis Diffusae 10 grams, 10 grams, Rhizoma Gastrodiae, 10 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 10 grams, Fructus Piperis Longi 10 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 30 grams, Bombyx Batryticatus 20 grams, Radix Scutellariae 20 grams, Herba Schizonepetae 20 grams, Radix Puerariae 20 grams, Radix Bupleuri 20 grams, Radix Saposhnikoviae 20 grams, 20 grams, Folium Mori, Herba Asari 12 grams, Radix Achyranthis Bidentatae 15 grams, Herba Hedyotidis Diffusae 12 grams, 12 grams, Rhizoma Gastrodiae, 12 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 12 grams, Fructus Piperis Longi 12 grams.
The instructions of taking of above-mentioned Chinese medicine preparation is: after being mixed by the raw material Chinese medicine of above-mentioned weight proportion, add water and decoct altogether, boil 30 minutes, leaching medicinal liquid; Medicinal residues add water and decoct, boil 40 minutes, leaching medicinal liquid.Merge 2 medicinal liquids, point morning, late 2 decoction being taken warmly, every day 1 dose.It within 10 days, was 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
Rhizoma Typhonii, acrid in the mouth, sweet, warm in nature; Return stomach, Liver Channel.There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of detoxicating and resolving stagnation of pathogens.
Bombyx Batryticatus, salty in the mouth, pungent, property is put down; Return liver, lung meridian.There is expelling wind for relieving convulsion, effect of dissipating phlegm and resolving masses.
Radix Scutellariae, bitter in the mouth, cold in nature; Return lung, gallbladder, stomach, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication.
Herba Schizonepetae, acrid in the mouth, slightly warm in nature; Return lung, Liver Channel.Have the loose wind that induces sweat, rash disappears effect of skin ulcer.
Radix Puerariae, sweet in the mouth, pungent, cold in nature; Attach to the lung and stomach meridians.Have and deliver rash, yang invigorating antidiarrheal, effect of promoting the production of body fluid to quench thirst.
Radix Bupleuri, bitter in the mouth, pungent, cold nature; Return liver, gallbladder meridian.Having induces sweat brings down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, effect of elevate a turnable ladder yang-energy.
Radix Saposhnikoviae, acrid in the mouth, sweet, slightly warm in nature; Return bladder, liver, spleen channel.There is expelling pathogenic wind from the body surface, effect of removing dampness to relieve pain.
Folium Mori, bitter in the mouth, sweet, cold in nature; Return lung, Liver Channel.There is dispelling wind and heat pathogens, effect of liver heat removing and eyesight improving.
Herba Asari, acrid in the mouth, warm in nature; Return lung, kidney channel.There is wind-expelling pain-stopping, expelling cold and relieving exterior syndrome, warming the lung to resolve fluid-retention, effect of a surname's clearing the nasal passage.
Radix Achyranthis Bidentatae, bitter in the mouth, acid, property is put down; Return liver, kidney channel.There is blood circulation promoting and blood stasis dispelling, the liver and the kidney tonifying, bone and muscle strengthening, relieving stranguria by diuresis, effect of conducting blood to flow downwards.
Herba Hedyotidis Diffusae, sweet in the mouth, micro-hardship, cold in nature; Return stomach, intestinal warp.There is heat-clearing and toxic substances removing, effect of dampness removing eliminating carbuncle.
Rhizoma Gastrodiae, sweet in the mouth, property is put down; Return Liver Channel.There is relieving spasm by subduing liver-wind, effect of suppressing liver-YANG.
Rhizoma Zingiberis Recens, acrid in the mouth, slightly warm in nature; Return lung, spleen channel.There is relieving the exterior syndrome by diaphoresis, warming middle-JIAO to stop vomiting, effect of warming the lung to relieve cough.
Cortex Phellodendri, bitter in the mouth, cold in nature; Return kidney, bladder, large intestine channel.There is heat clearing and damp drying, effect of eliminating fire and detoxication.
Fructus Piperis Longi, acrid in the mouth, warm in nature; Return stomach, large intestine channel.There is warming spleen and stomach for dispelling cold, effect of therapeutic method to keep the adverse QI flowing downwards pain relieving.
Motherland's medical science is thought, trigeminal neuralgia belongs to " wind syndrome of head " category, trigeminal neuralgia by affection by exopathogenic cold-wind, wind heat are attacked, exopathogen attacks impatency passages through which vital energy circulates, coagulation of QI-blood and causing, the heresy of diseases caused by exogenous pathogenic factor seek through on go against one's superiors to disturb key and cause primary disease clearly.Gallbladder stagnation of liver-QI heat stagnation fire-transformation of a specified duration, burning hot pneumatic wind-fire folder expectorant disturbs sun clearly and does not open up and fall ill.All YANG-meridians meeting into the head, all pathogens hinder in meridians, and QI and blood must not be declared logical, stagnation of QI and blood may bring about pain.In Chinese medicine preparation of the present invention, Rhizoma Typhonii, Bombyx Batryticatus, Radix Scutellariae, Fructus Piperis Longi share can expelling wind and relieving convulsion, suppressing the hyperactive liver to relieve the wind syndrome, detoxicating and resolving stagnation of pathogens, clearing away heat-fire; Herba Schizonepetae, Radix Puerariae, Radix Bupleuri, Radix Saposhnikoviae, Rhizoma Zingiberis Recens, Herba Asari share and can rise evacuation meridians, dispelling wind expelling pathogenic factors from the exterior, wind-expelling pain-stopping; Rhizoma Gastrodiae, Radix Achyranthis Bidentatae, Folium Mori share can the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling, suppressing liver-YANG; Cortex Phellodendri, Herba Hedyotidis Diffusae are share can heat-clearing and toxic substances removing, eliminating carbuncle pain relieving.All medicines share, and play the body resistance strengthening and constitution consolidating altogether, expel wind to dredge collateral, blood circulation promoting and blood stasis dispelling, relieving pain of dysmenorrhea, the merit of clearing away heat-fire, the cold and heat of patient's body, deficiency and excess, good and evil, lifting multidirectionally can be regulated after taking, comprehensive conditioning internal organs SHAO YIN network, QI and blood, negative and positive, treating both the principal and secondary aspects of a disease, makes facial QI and blood passages through which vital energy circulates thereupon unobstructed, stasis blocking is dispelled, muscle arteries and veins must be supported, and trigeminal nerve function recovers thereupon, and pain is eliminated naturally.
For investigating clinical efficacy and the safety of medicine of the present invention further, we have selected 80 routine patients and carry out clinical trial, wherein man 42 example, female 38 example.Age 18-80 year, average 50 years old; The shortest person of the course of disease 2 weeks, most elder reaches 25 years.All patients are diagnosed as trigeminal neuralgia by practical neurological, and the symptomatic trigeminal neuralgia that outer intracranial tumor, inflammatory reaction, vascular malformation etc. cause is got rid of.80 routine patients are divided into treatment group and observation group at random, often organize each 40 examples.Two groups of patients before age, sex and treatment in the clinical data such as pain scores, durante dolors and panic attacks frequency without significant difference (P > 0.05), there is comparability.
Therapeutic Method:
Treatment group takes Chinese medicine preparation of the present invention, according to above-mentioned pharmaceutical methods, adds water and decocts rear merging 2 medicinal liquids altogether, point morning, late 2 decoction being taken warmly, every day 1 dose.It within 10 days, was 1 course for the treatment of.The oral Carbamazepine Tablets of matched group, each 0.2g, every day 3 times.
Criterion of therapeutical effect:
Cure: headache and double disease disappear completely, drug withdrawal half a year to 1 is year without recidivist.
Take a turn for the better: headache and double disease disappear substantially, and drug withdrawal has recurrence half a year to 1 year, but recurrent number is less, pain relief.
Invalid: after treatment, pain symptom is without improvement.
Efficacy result:
1. Clinical efficacy comparison:
After treatment, treatment group cures 30 examples, and take a turn for the better 8 examples, invalid 2 examples, effective percentage 95.0%, matched group cures 18 examples, and take a turn for the better 12 examples, invalid 10 examples, effective percentage 75.0%, treatment group effective percentage, apparently higher than matched group, compares between group and has significant difference (P < 0.05).Detailed annotation the results are shown in Table 1.
Table 1: Clinical efficacy comparison after two groups of treatments
| Group | Number of cases | Cure n (%) | Improvement n (%) | Invalid n (%) | Effective percentage n (%) |
| Treatment group | 40 | 30(75.0) | 8(20.0) | 2(5.0) | 38(95.0) |
| Matched group | 40 | 18(45.0) | 12(30.0) | 10(25.0) | 30(75.0) |
2. pain improvement situation compares:
Treatment group pain scores, durante dolors and panic attacks frequency etc. are obviously better than matched group, compare and have significant difference (P < 0.05) between group.Detailed annotation the results are shown in Table 2.
Table 2: after two groups of treatments, pain improvement situation compares
| Group | Number of cases | Pain scores (dividing) | Durante dolors (s) | Panic attacks frequency (times/day) |
| Treatment group | 40 | 1.4±0.5 | 2.3±0.9 | 0.6±0.3 |
| Matched group | 40 | 3.6±1.1 | 3.8±1.5 | 1.9±0.5 |
3. bad should be compared
Adding up untoward reaction in two groups of patient treatments, there is not untoward reaction in treatment group., there are drowsiness 11 examples, gastrointestinal dysfunction 5 example, erythra, hematuria 2 example, leukopenia 4 example in dizzy 7 examples of matched group.
Result shows, Chinese medicine preparation of the present invention effectively can improve body's immunity, dredge facial QI and blood passages through which vital energy circulates, trifacial physiological function is made to recover normal, thus reaching the object for the treatment of both the principal and secondary aspects of a disease, drug price of the present invention is cheap, evident in efficacy, to have no side effect and cure rate is higher, there is clinical expansion use value.
Detailed description of the invention
Embodiment 1: one treats prosopalgic Chinese medicine preparation, chooses Rhizoma Typhonii 20 grams, Bombyx Batryticatus 10 grams, Radix Scutellariae 10 grams, Herba Schizonepetae 10 grams, Radix Puerariae 10 grams, Radix Bupleuri 10 grams, Radix Saposhnikoviae 10 grams, 10 grams, Folium Mori, Herba Asari 8 grams, Radix Achyranthis Bidentatae 8 grams, Herba Hedyotidis Diffusae 8 grams, 8 grams, Rhizoma Gastrodiae, 8 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 8 grams, Fructus Piperis Longi 8 grams.
Embodiment 2: one treats prosopalgic Chinese medicine preparation, chooses Rhizoma Typhonii 25 grams, Bombyx Batryticatus 15 grams, Radix Scutellariae 15 grams, Herba Schizonepetae 15 grams, Radix Puerariae 15 grams, Radix Bupleuri 15 grams, Radix Saposhnikoviae 15 grams, 15 grams, Folium Mori, Herba Asari 10 grams, Radix Achyranthis Bidentatae 12 grams, Herba Hedyotidis Diffusae 10 grams, 10 grams, Rhizoma Gastrodiae, 10 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 10 grams, Fructus Piperis Longi 10 grams.
Embodiment 3: one treats prosopalgic Chinese medicine preparation, chooses Rhizoma Typhonii 30 grams, Bombyx Batryticatus 20 grams, Radix Scutellariae 20 grams, Herba Schizonepetae 20 grams, Radix Puerariae 20 grams, Radix Bupleuri 20 grams, Radix Saposhnikoviae 20 grams, 20 grams, Folium Mori, Herba Asari 12 grams, Radix Achyranthis Bidentatae 15 grams, Herba Hedyotidis Diffusae 12 grams, 12 grams, Rhizoma Gastrodiae, 12 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 12 grams, Fructus Piperis Longi 12 grams.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
Permitted certain, female, 60 years old.Suddenly there is right side toothache without under obvious inducement before 1 year in patient, after intermittent in cheek portion, right side gradually, acupuncture sample pain; Provocative pains such as having a meal, drink water, wash one's face, brush teeth or the pain increased; outbreak continues about 5-7 minute, normally cannot carry out life daily routines, go to a doctor in local hospital during outbreak; be diagnosed as " trigeminal neuralgia "; and give oral carbamazepine, there is the symptoms such as dizzy in patient, withdrawal; once row four closed treatings, DeGrain.Take medicine of the present invention after being introduced to treat, after 1 course for the treatment of, patient pain alleviates, and attack times and persistent period reduce; Continue to take to 2 courses for the treatment of, patient pain disappears, and has no outbreak.Follow up a case by regular visits to half a year without recurrence.
Case 2
Zhao, man, 62 years old.Patient had a toothache without the prominent sense right side of obvious inducement before 3 years, do not note at the beginning, rear toothache develops into whole cheek all pains gradually, pain as pinprick, and duration of seizure continues at about 7 minutes, have impact on normal life, day after day often to have a meal, drink water, wash one's face, brushing teeth all can cause violent pain.Go to a doctor to local hospital, be diagnosed as second and third pain trifacial, after taking carbamazepine medicine, occur allergy at once, go out the symptoms such as skin pimple, dizziness, so take closed treating 3 times, but DeGrain.Take medicine of the present invention after being introduced to treat, after 1 course for the treatment of, patient pain alleviates, and attack times and persistent period reduce; Continue to take to 3 courses for the treatment of, patient pain disappears, and has no outbreak.Follow up a case by regular visits to half a year without recurrence.
Case 3
Bai, female, 56 years old.There is severity pain without obvious inducement right face before 4 years in patient, in sample or the acupuncture sample of lancinating, each outbreak continues about 5 minutes, outbreak every day for several times, speak, brush teeth, feed etc. all can cause panic attacks, and the gap phase, without any symptom, without giddy, has a headache.Be " trigeminal neuralgia " at hospital diagnosis, oral carbamazepine treatment, pain can obviously be alleviated or disappear, but recurs again in a few days, is difficult to effect a radical cure.Upon somebody's introduction, patient takes medicine of the present invention and treats, and after 1 course for the treatment of, patient pain alleviates, and attack times and persistent period reduce; Continue to take to 3 courses for the treatment of, patient pain disappears, and has no outbreak.Follow up a case by regular visits to half a year without recurrence.
Claims (4)
1. treat a prosopalgic Chinese medicine preparation, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Rhizoma Typhonii 20-30 gram, Bombyx Batryticatus 10-20 gram, Radix Scutellariae 10-20 gram, Herba Schizonepetae 10-20 gram, Radix Puerariae 10-20 gram, Radix Bupleuri 10-20 gram, Radix Saposhnikoviae 10-20 gram, Folium Mori 10-20 gram, Herba Asari 8-12 gram, Radix Achyranthis Bidentatae 8-15 gram, Herba Hedyotidis Diffusae 8-12 gram, Rhizoma Gastrodiae 8-12 gram, Rhizoma Zingiberis Recens 8-12 gram, Cortex Phellodendri 8-12 gram, Fructus Piperis Longi 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 20 grams, Bombyx Batryticatus 10 grams, Radix Scutellariae 10 grams, Herba Schizonepetae 10 grams, Radix Puerariae 10 grams, Radix Bupleuri 10 grams, Radix Saposhnikoviae 10 grams, 10 grams, Folium Mori, Herba Asari 8 grams, Radix Achyranthis Bidentatae 8 grams, Herba Hedyotidis Diffusae 8 grams, 8 grams, Rhizoma Gastrodiae, 8 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 8 grams, Fructus Piperis Longi 8 grams.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 25 grams, Bombyx Batryticatus 15 grams, Radix Scutellariae 15 grams, Herba Schizonepetae 15 grams, Radix Puerariae 15 grams, Radix Bupleuri 15 grams, Radix Saposhnikoviae 15 grams, 15 grams, Folium Mori, Herba Asari 10 grams, Radix Achyranthis Bidentatae 12 grams, Herba Hedyotidis Diffusae 10 grams, 10 grams, Rhizoma Gastrodiae, 10 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 10 grams, Fructus Piperis Longi 10 grams.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the raw material of following weight portion:
Rhizoma Typhonii 30 grams, Bombyx Batryticatus 20 grams, Radix Scutellariae 20 grams, Herba Schizonepetae 20 grams, Radix Puerariae 20 grams, Radix Bupleuri 20 grams, Radix Saposhnikoviae 20 grams, 20 grams, Folium Mori, Herba Asari 12 grams, Radix Achyranthis Bidentatae 15 grams, Herba Hedyotidis Diffusae 12 grams, 12 grams, Rhizoma Gastrodiae, 12 grams, Rhizoma Zingiberis Recens, Cortex Phellodendri 12 grams, Fructus Piperis Longi 12 grams.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492089A (en) * | 2016-12-23 | 2017-03-15 | 曾凡跃 | One kind treats trifacial Chinese medicine |
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| CN101073646A (en) * | 2006-05-16 | 2007-11-21 | 霍承宝 | Method for treating tic douloureux |
| CN102342994A (en) * | 2011-10-18 | 2012-02-08 | 文登市口腔医院 | Traditional Chinese medicine for treating trigeminal neuralgia |
| CN102961607A (en) * | 2012-10-26 | 2013-03-13 | 郗光敏 | Traditional Chinese medicine for treating trigeminal neuralgia |
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2014
- 2014-08-27 CN CN201410427110.6A patent/CN105435137A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101073646A (en) * | 2006-05-16 | 2007-11-21 | 霍承宝 | Method for treating tic douloureux |
| CN102342994A (en) * | 2011-10-18 | 2012-02-08 | 文登市口腔医院 | Traditional Chinese medicine for treating trigeminal neuralgia |
| CN102961607A (en) * | 2012-10-26 | 2013-03-13 | 郗光敏 | Traditional Chinese medicine for treating trigeminal neuralgia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492089A (en) * | 2016-12-23 | 2017-03-15 | 曾凡跃 | One kind treats trifacial Chinese medicine |
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