CN105434883A - Pharmaceutical preparation for treating hepatic depression and blood deficiency-type hypomenorrhea - Google Patents

Pharmaceutical preparation for treating hepatic depression and blood deficiency-type hypomenorrhea Download PDF

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CN105434883A
CN105434883A CN201610004483.1A CN201610004483A CN105434883A CN 105434883 A CN105434883 A CN 105434883A CN 201610004483 A CN201610004483 A CN 201610004483A CN 105434883 A CN105434883 A CN 105434883A
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pharmaceutical preparation
radix
rhizoma
hypomenorrhea
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段希福
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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to a pharmaceutical preparation for treating hepatic depression and blood deficiency-type hypomenorrhea. The pharmaceutical preparation is prepared from the following medicinal raw materials: horehound, stellaria yunnanensis, conic gymnadenia tuber, siberian solomonseal rhizome, rose, rhizoma cyperi, hairy clovershrub root, barbary wolfberry fruit and auriculate swallowwort root; all the medicines are combined and compatible in a full prescription and jointly take effect of reinforcing qi, nourishing blood, tonifying kidney, soothing liver and regulating thoroughfare and conception vessels, so that liver qi is smooth, spleen qi is tonified, kidney qi is sthenic, and Ren channel is activated and Chong channel is vigorous; the pharmaceutical preparation aims at the hepatic depression and blood deficiency-type hypomenorrhea syndrome. Shown by a clinical observation experiment, an observation group of the pharmaceutical preparation disclosed by the invention is capable of obviously increasing the clinical cure rate and the obvious effect rate of hypomenorrhea in comparison with a control group, is capable of obviously improving clinical symptoms of a patient and has a better long-term effect; moreover, the clinical symptoms of the patient are not easy to relapse, and adverse reactions are few; the pharmaceutical preparation is safe and effective.

Description

A kind of pharmaceutical preparation for the treatment of hepatic depression and blood deficiency type hypomenorrhea
Technical field
The invention belongs to the field of Chinese medicines, relate to the medicine for the treatment of menoxenia, particularly relate to a kind of pharmaceutical preparation for the treatment of hepatic depression and blood deficiency type hypomenorrhea.
Background technology
Hypomenorrhea is that menstrual cycle is normal, and menstrual blood volume obviously reduces, or the deficiency of time 2 days of passing through, even drop namely.Ancient books has title " a small amount of menses and menstruating unsmoothly ", " few through water ", " very few through measuring ".It is generally acknowledged Hypomenorrhea in 20mL be hypomenorrhea.Hypomenorrhea is commonly encountered diseases, the frequently-occurring disease of gynecological, can cause amenorrhea, infertile, miscarriage etc.,
Cause the reason of hypomenorrhea a lot, what doctor trained in Western medicine was common is the disease such as uterine hypoplasia, hypogonadism and surgical injury, weight reducing etc. of going on a diet.The traditional Chinese medical science thinks that its pathogeny has dividing of deficiency and excess, and empty person mostly is damage of essence insufficiency of blood, and punching appoints the sea of blood hollow, the weary source of menses; Reality person mostly is in blood stasis and stops, and raw in phlegm-damp, the stagnant punching of expectorant stasis blocking appoints the sea of blood, hematogenous blockage.The hypomenorrhea that hepatic depression and blood deficiency causes is comparatively common.Psychentonia, feelings will freely do not cause the strongly fragrant resistance of conscience, fire-transformation impairment of YIN, deficiency of YIN-blood, sea of blood uterus virtual loss, so that few through row amount.
XIAOYAO POWDER comes from " formulary of peaceful benevolent dispensary ", be made up of Radix Bupleuri, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Atractylodis Macrocephalae (parched), Poria, Radix Glycyrrhizae Preparata, Herba Menthae and Rhizoma Zingiberis Recens compatibility, for the conventional side of soothing liver and strengthening spleen and Fuke Tiaojing, XIAOYAO POWDER plus-minus can be used for treating menoxenia, also the report once having and use the menoxenia of XIAOYAO POWDER treatment liver energy stagnation type is had in document, but clinical middle discovery is for it to hepatic depression and blood deficiency type hypomenorrhea, and curative effect is not remarkable.Therefore develop the pharmaceutical preparation that effect treats hypomenorrhea more to be significantly significant.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of pharmaceutical preparation its preparation method for the treatment of hepatic depression and blood deficiency type hypomenorrhea.
An object of the present invention is to provide a kind of pharmaceutical preparation for the treatment of hepatic depression and blood deficiency type hypomenorrhea.
" Standards of Diagnosis and Treatment female section regulating menstruation door " institute's cloud: " a small amount of menses and menstruating unsmoothly, for void is puckery, deficiency syndrome should be treated by tonifying method, puckery, moisten it." liver controlling conveyance and dispersion, can regulate the mechanism of qi of the whole body, irritability bar reaches then conception vessel tonneau, thus uterus must be supported, normal through thing; As strongly fragrant impairing the liver of a specified duration, liver is lost bar and reaches, and QI-blood circulation is obstructed, and the sea of blood can not completely be full of, and causes few warp, then causes primary disease.
Inventor combines theory and the clinical experience of oneself of the sage of the past at all times, and sum up and think that irritability is relaxed, temper is good for, kidney qi is contained, abundant CHONG meridian with unobstructed REN meridian, then abundance of blood in CHONG meridian, many through water, the present invention is shown in that hepatopathy is not soothing the liver simply, sees puckery and namely attacks it, but with benefiting QI and nourishing blood, the kidney invigorating is soothing the liver, the road of Chong and Ren Meridians regulating for effecting a permanent cure, QI and blood is sufficient, internal organs peace and, rush Ren Tongsheng, then through water from logical.
The technical solution used in the present invention is as follows:
Treat a pharmaceutical preparation for hepatic depression and blood deficiency type hypomenorrhea, it is that medicinal raw material is made by Herba lagopsis supinae, Radix Stellariae Yunnanensis, Rhizoma Gymnadeniae, Rhizoma Polygonati, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae, Fructus Lycii, Radix cynanchi wilfordii.
Although although the indivedual single medicinal materials in prescription of the present invention have the effect for the treatment of menoxenia, be all not enough to that there is good clinical therapeutic efficacy.In order to the synergism of effective active composition in medicine, the present inventor is on the basis of secret prescription handed down in the family from generation to generation, test through long-term, a large amount of screening prescriptions, be preferably as follows technical scheme further: a kind of pharmaceutical preparation for the treatment of hepatic depression and blood deficiency type hypomenorrhea, it is characterized in that being made up of the medicinal raw material of following weight parts: Herba lagopsis supinae 10-20 part, Radix Stellariae Yunnanensis 20-40 part, Rhizoma Gymnadeniae 10-20 part, Rhizoma Polygonati 10-20 part, Flos Rosae Rugosae 8-18 part, Rhizoma Cyperi 7-15 part, Radix Campylotropis hirtellae 5-15 part, Fructus Lycii 15-25 part, Radix cynanchi wilfordii 6-16 part.
Further preferably, treat a pharmaceutical preparation for hepatic depression and blood deficiency type hypomenorrhea, it is characterized in that being made up of the medicinal raw material of following weight parts: Herba lagopsis supinae 12-17 part, Radix Stellariae Yunnanensis 26-32 part, Rhizoma Gymnadeniae 13-17 part, Rhizoma Polygonati 10-15 part, Flos Rosae Rugosae 10-15 part, Rhizoma Cyperi 7-12 part, Radix Campylotropis hirtellae 6-11 part, Fructus Lycii 20-25 part, Radix cynanchi wilfordii 10-15 part.
Further preferably, treat a pharmaceutical preparation for hepatic depression and blood deficiency type hypomenorrhea, it is characterized in that being made up of the medicinal raw material of following weight parts: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
Fang Zhong: the pungent micro-bitter cold of Herba lagopsis supinae, specially enters Liver Channel, kind nourshing blood and promoting blood circulation, the heat clearing away of cold energy; Radix Stellariae Yunnanensis is sweet flat, can strengthening spleen and nourishing blood, again the liver and the kidney tonifying, and two medicine 5 kidney-supplementing liver-boostings, benefiting QI and nourishing blood is monarch drug.Rhizoma Gymnadeniae Yishen Jianpi, regulates the flow of vital energy and blood, pain relieving; Rhizoma Polygonati boosting qi and nourishing yin, tonifying speen and tonifying kidney, with principal drug assistance, is ministerial drug.The sweet micro-hardship of Flos Rosae Rugosae, the strongly fragrant gas of energy soothing liver-QI gallbladder, spleen invigorating pathogenic fire reducing, energy removing blood stasis dissipating blood stasis of holding concurrently, the pungent micro-hardship of Rhizoma Cyperi is micro-sweet flat, and promoting QI circulation for relieving depression, regulating menstruation, two medicine 5 use, soothing the liver promoting QI circulation for relieving depression, regulating menstruation by adjusting the flow of blood is adjuvant drug.Radix Campylotropis hirtellae promoting blood flow to regulate menstruation, regulating QI to relieve pain, clearing away heat-damp and promoting diuresis; Fructus Lycii Gan Run and nourishing, doublely can bring down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating; Radix cynanchi wilfordii invigorating the liver and kidney, bone and muscle strengthening, strengthening the spleen and stomach, nourishing YIN and benefiting blood, spleen invigorating is pleasant, is also adjuvant drug.Full side closes 5, and play benefiting QI and nourishing blood altogether, the kidney invigorating is soothing the liver, the merit of Chong and Ren Meridians regulating, and irritability is relaxed, and temper is good for, and kidney qi is contained, and abundant CHONG meridian with unobstructed REN meridian, demonstrate,proves for hepatic depression and blood deficiency type hypomenorrhea.
Further, in Chinese medicine composition of the present invention, the function of each crude drug and function cure mainly as described below.
Herba lagopsis supinae: [nature and flavor] acrid in the mouth; Micro-hardship; Cold in nature.[return through] returns Liver Channel.[function cures mainly] nourshing blood and promoting blood circulation; Clearing away heat-damp and promoting diuresis.Main menoxenia; The stagnant stomachache of the stasis of blood in puerperal; Blood deficiency is dizzy; It is unsuccessful partly to penetrate; Traumatic injury; Edema; Dysuria; Conjunctival congestion and swelling pain; Carbuncle sore; Chilblain; Toothache; Erythra pruritus.
Radix Stellariae Yunnanensis: be the root of pinkwort Yunnan Herba stellariae mediae.[nature and flavor] are sweet; Property is put down.[return through] liver; Spleen; Kidney channel.[function cures mainly] strengthening spleen and nourishing blood; The liver and the kidney tonifying; Detumescence.Main anemia; Spirit is deficient; Dizzy nervous; Tinnitus dim eyesight; Hectic fever; Seminal emission; Menoxenia; Leukorrhagia; Fracture; Mastitis.
Rhizoma Gymnadeniae: [nature and flavor] are sweet; Flat.[return through] lung; Spleen; Stomach warp.[function cures mainly] relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.
Rhizoma Polygonati: [nature and flavor] are sweet is flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Flos Rosae Rugosae: [nature and flavor] sweet, micro-hardship, temperature.[return through] returns liver, spleen channel.[function cures mainly] promoting QI circulation for relieving depression, and blood, pain relieving.For stomachache due to hyperactive liver-QI attacking the stomach, lack of appetite vomiting and nausea, menoxenia, falls and flutters the pain of injury.[function cures mainly] regulates the flow of vital energy resolving depression and blood dissipating blood stasis.Treating the liver peratodynia, new lingering pathogenic wind numbness, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, acute mastitis, toxic swelling.
Rhizoma Cyperi: [nature and flavor] pungent, micro-hardship, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Radix Campylotropis hirtellae: [nature and flavor] are puckery, micro-hardship, tepor.[function cures mainly] promoting blood flow to regulate menstruation; Regulating QI to relieve pain; Clearing away heat-damp and promoting diuresis.Main menoxenia; Amenorrhea; Dysmenorrhea; Leucorrhea; Dysentery; Gastric abscess; Traumatic hemorrhage; Impetigo; Burn due to hot liquid or fire." Yunnan Chinese herbal medicine " carries: " regulating menstruation and activating blood, regulating QI to relieve pain.Control amenorrhea, dysmenorrhea, redly to collapse, leucorrhea, stomachache, digestive tract ulcer." modern medicine study confirmation, Radix Campylotropis hirtellae has method stasis of blood tissue regeneration promoting, promoting blood flow to regulate menstruation, hemostasis, the effect of removing toxic substances.
Fructus Lycii: [nature and flavor] are sweet is flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.
Radix cynanchi wilfordii: Radix cynanchi wilfordii, heat-insulating mechanism, Radix Cynanchi Auriculati, white Radix Polygoni Multiflori, mountain Fructus Trichosanthis.[nature and flavor] sweet in the mouth; Micro-hardship; Slightly warm in nature.[return through] spleen; Stomach; Kidney channel.[function cures mainly] invigorating the liver and kidney; Bone and muscle strengthening; Strengthening the spleen and stomach; Removing toxic substances.Main Liver and kidney two is empty; Feel dizzy; Insomnia forgetfulness; Early whitening of beard and hair; Sexual impotence; Seminal emission; The acid of waist knee joint is climbed; Spleen insufficiency; Distension and fullness in the abdomen; Ren is for depressed; Have loose bowels; Puerperal, breast was few; Lymphogranuloma inguinale sore.
In order to express pharmaceutical preparation of the present invention better, pharmaceutical preparation of the present invention can add various customary adjuvant required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc. make the conventional peroral dosage form of any one with the pharmaceutical preparation preparation method of routine, such as, tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.Preferably the peroral dosage form of pharmaceutical preparation of the present invention is tablet, capsule or granule, most preferably is capsule.
Present invention also offers a kind of preparation method for the treatment of the pharmaceutical preparation of hepatic depression and blood deficiency type hypomenorrhea, the present inventor finds under study for action, by optimized fabrication method, can when remaining valid medicine, remove impurity or the part without drug effect, reduce impurity to the interference of therapeutic effect, make this pharmaceutical preparation more effective, and reduce the consumption of medicine thus.
A kind of preparation method for the treatment of the pharmaceutical preparation of hepatic depression and blood deficiency type hypomenorrhea provided by the invention, mainly comprises the following steps:
(1) Herba lagopsis supinae, Radix Stellariae Yunnanensis, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae are pulverized, the ethanol water of 50% of 3-8 times amount is added after crossing 80 mesh sieves, adopt ultrasonic extraction 1-3 time, extraction conditions comprises: ultrasonic power is 160-180W, Extracting temperature is 35-40 DEG C, and extraction time is 30-40min; Ultrasonic extraction is complete, gets filtrate, concentrating under reduced pressure drying obtains extract A;
(2) get Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Lycii, Radix cynanchi wilfordii pulverizing, add 5-10 times of water soaking 3-4 hour, decoct extraction twice, timing from during boiling, each 1.5-2.0 hour; Merge extractive liquid, filter, relative density 1.03-1.07 is recorded when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 35%, leaves standstill after 24 hours, centrifugal 20 minutes (rotating speed is 3000r/min), discard lower sediment thing, obtain supernatant, after being concentrated into relative density 1.05-1.10 (60 DEG C record), spraying dry obtains extract B;
(3) by extract A extract B mix homogeneously, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
The present invention relatively and prior art, has following clear superiority:
Selected by invention medicine, medical material compatibility is suitable, meets Chinese medicine and pharmacy and modern medicine theory, and comprehensively, medication is thoughtful in legislation, plays special effect, play benefiting QI and nourishing blood altogether, the kidney invigorating is soothing the liver, the merit of Chong and Ren Meridians regulating, and irritability is relaxed, temper is good for, and kidney qi is contained, and abundant CHONG meridian with unobstructed REN meridian, demonstrate,proves for hepatic depression and blood deficiency type hypomenorrhea.Clinical observation finds, observation group uses the rear cure rate of invention formulation treatment, effective percentage high, is significantly higher than matched group.
Traditional Chinese medicine preparation of the present invention has Mutiple Targets, too many levels, multi-level comprehensive regulation effect, and side effect is less, and patient compliance is better, taking convenience, can effectively alleviate patient's burden and misery, the object for the treatment of both the principal and secondary aspects of a disease can be reached, wide popularization and application on clinic.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
Preparation method:
(1) Herba lagopsis supinae, Radix Stellariae Yunnanensis, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae are pulverized, the ethanol water of 50% of 3-8 times amount is added after crossing 80 mesh sieves, adopt ultrasonic extraction 1-3 time, extraction conditions comprises: ultrasonic power is 160-180W, Extracting temperature is 35-40 DEG C, and extraction time is 30-40min; Ultrasonic extraction is complete, gets filtrate, concentrating under reduced pressure drying obtains extract A;
(2) get Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Lycii, Radix cynanchi wilfordii pulverizing, add 5-10 times of water soaking 3-4 hour, decoct extraction twice, timing from during boiling, each 1.5-2.0 hour; Merge extractive liquid, filter, relative density 1.03-1.07 is recorded when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 35%, leaves standstill after 24 hours, centrifugal 20 minutes (rotating speed is 3000r/min), discard lower sediment thing, obtain supernatant, after being concentrated into relative density 1.05-1.10 (60 DEG C record), spraying dry obtains extract B;
(3) by extract A extract B mix homogeneously, capsule is made according to galenic pharmacy routine techniques.
This enforcement prepares capsule, and every containing crude drug 1.4g.
Embodiment 2 capsule
Prescription: Herba lagopsis supinae 12 parts, Radix Stellariae Yunnanensis 25 parts, Rhizoma Gymnadeniae 13 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 10 parts, Rhizoma Cyperi 7 parts, Radix Campylotropis hirtellae 10 parts, Fructus Lycii 25 parts, Radix cynanchi wilfordii 10 parts.
Preparation method: with reference to embodiment 1.
Embodiment 3 capsule
Prescription: Herba lagopsis supinae 17 parts, Radix Stellariae Yunnanensis 32 parts, Rhizoma Gymnadeniae 10 parts, Rhizoma Polygonati 15 parts, Flos Rosae Rugosae 15 parts, Rhizoma Cyperi 12 parts, Radix Campylotropis hirtellae 6 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 10 parts.
Preparation method: with reference to embodiment 1.
Embodiment 4 capsule
Prescription: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 20 parts, Rhizoma Gymnadeniae 20 parts, Rhizoma Polygonati 15 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 15 parts, Radix Campylotropis hirtellae 10 parts, Fructus Lycii 18 parts, Radix cynanchi wilfordii 12 parts.
Preparation method: with reference to embodiment 1.
Embodiment 5 capsule
Prescription: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
Preparation method: with reference to embodiment 1.
Embodiment 6 capsule
Prescription: Herba lagopsis supinae 20 parts, Radix Stellariae Yunnanensis 40 parts, Rhizoma Gymnadeniae 10 parts, Rhizoma Polygonati 15 parts, Flos Rosae Rugosae 15 parts, Rhizoma Cyperi 15 parts, Radix Campylotropis hirtellae 11 parts, Fructus Lycii 25 parts, Radix cynanchi wilfordii 15 parts.
Preparation method: with reference to embodiment 1.
Embodiment 7 capsule
Prescription: Herba lagopsis supinae 16 parts, Radix Stellariae Yunnanensis 32 parts, Rhizoma Gymnadeniae 13 parts, Rhizoma Polygonati 15 parts, Flos Rosae Rugosae 10 parts, Rhizoma Cyperi 8 parts, Radix Campylotropis hirtellae 9 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 10 parts.
Preparation method: with reference to embodiment 1.
Embodiment 8 tablet
Prescription: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
Preparation method:
(1) Herba lagopsis supinae, Radix Stellariae Yunnanensis, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae are pulverized, the ethanol water of 50% of 3-8 times amount is added after crossing 80 mesh sieves, adopt ultrasonic extraction 1-3 time, extraction conditions comprises: ultrasonic power is 160-180W, Extracting temperature is 35-40 DEG C, and extraction time is 30-40min; Ultrasonic extraction is complete, gets filtrate, concentrating under reduced pressure drying obtains extract A;
(2) get Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Lycii, Radix cynanchi wilfordii pulverizing, add 5-10 times of water soaking 3-4 hour, decoct extraction twice, timing from during boiling, each 1.5-2.0 hour; Merge extractive liquid, filter, relative density 1.03-1.07 is recorded when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 35%, leaves standstill after 24 hours, centrifugal 20 minutes (rotating speed is 3000r/min), discard lower sediment thing, obtain supernatant, after being concentrated into relative density 1.05-1.10 (60 DEG C record), spraying dry obtains extract B;
(3) by extract A extract B mix homogeneously, tablet is made according to galenic pharmacy routine techniques.
Embodiment 9 granule
Prescription: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
Preparation method:
(1) Herba lagopsis supinae, Radix Stellariae Yunnanensis, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae are pulverized, the ethanol water of 50% of 3-8 times amount is added after crossing 80 mesh sieves, adopt ultrasonic extraction 1-3 time, extraction conditions comprises: ultrasonic power is 160-180W, Extracting temperature is 35-40 DEG C, and extraction time is 30-40min; Ultrasonic extraction is complete, gets filtrate, concentrating under reduced pressure drying obtains extract A;
(2) get Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Lycii, Radix cynanchi wilfordii pulverizing, add 5-10 times of water soaking 3-4 hour, decoct extraction twice, timing from during boiling, each 1.5-2.0 hour; Merge extractive liquid, filter, relative density 1.03-1.07 is recorded when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 35%, leaves standstill after 24 hours, centrifugal 20 minutes (rotating speed is 3000r/min), discard lower sediment thing, obtain supernatant, after being concentrated into relative density 1.05-1.10 (60 DEG C record), spraying dry obtains extract B;
(3) by extract A extract B mix homogeneously, granule is made according to galenic pharmacy routine techniques.
Embodiment 10 clinical observation test example
1 data and method
1.1 physical data: observe in January, 2014 to 2014 year December and go to a doctor in my institute's Out-patient Clinic of Department of Gynecology and be diagnosed as patient 118 example that Hypomenorrhea card belongs to syndrome of stagnation of liver qi and blood deficiency, be divided into observation group and matched group to observe at random, often organize 59 routine.Observation group age 18-40 year, 24.2 ± 4.8 years old mean age, matched group age 18-39 year, average 24.9 ± 5.1 years old; Observation group's course of disease is the longest 2.5 years, the shortest 6 months, and average 1.05 ± 0.68 years, the matched group course of disease was the longest 2.5 years, the shortest 5 months, average 1.06 ± 0.71 years; 11 examples that observation group's state of an illness is slight, moderate 29 example, severe 19 example; 12 examples that the matched group state of an illness is slight, moderate 30 example, severe 17 example, two groups of physical data compare no difference of science of statistics (P > 0.05), have comparability.
1.2 diagnostic criterias: the diagnostic criteria of writing the hypomenorrhea of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " of " Gynecology of Chinese Medicine " and Ministry of Health of the People's Republic of China promulgation in 2002 according to Zhang Yuzhen etc.
Hypomenorrhea: hypomenorrhea refers to that menstrual cycle is normal, and menstrual blood loss comparatively constant obviously reduces, and even drop is namely clean, or through line time less than 2 days, through the menopathy that amount is also few.
Standards of Chinese Medical Syndrome Differentiation: with reference to the related content of " guideline of clinical investigations of new Chinese medicine treatment menoxenia " that Ministry of Health of the People's Republic of China promulgates for 2002, formulate hepatic depression and blood deficiency: through measuring obvious minimizing, light through color, matter is thick, two sides of body are done swollen, dizzy weak, distending pain of the breast, insomnia, pale tongue with white fur, stringy and thready pulse.
1.3 exclusion standards: have cryptorrhea, luteal phase defect, uterine cavity organic disease person; There are the Chronic consumptions persons such as hyperthyroidism, tuberculosis, severe anemia; There is oral hormone in 3 months, use contraceptive person; Untoward reaction person is there is in drug administration process; Not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or statistical disposition person.
1.4 Therapeutic Method:
Observation group: the capsule that menstruation brings into use the embodiment of the present invention 1 to prepare on the 5th day, every day 2 times, each 2-4 grain, withdraws during menstrual onset, is a course for the treatment of, takes 3 months continuously with 3 months.
Matched group: menstruation brings into use ease pill, 2 days twice on the 5th day, each 16-32 ball (every 8 balls are equivalent to crude drug 3g), withdraws during menstrual onset, is a course for the treatment of with 3 months, continuously treatment 3 menstrual cycle.
1.5 treatment fore-and-aft observing indexs:
1.5.1 change--menstrual blood volume color, the matter for the treatment of front and back menstruation, pass through the time, menstrual cycle.
1.5.2 symptom score before and after treatment.Standard: slight: less than 8 points, moderate: 8.5 ~ 12.5 points; Severe: more than 13 points.Cardinal symptom standards of grading: spanomenorrhea 1/3 or less than 2d, whole menstrual cycle 7 ~ 10 pieces of paper washers 5 points; Reduce 1/2, share paper washer 3 ~ 6 pieces 6 points; Menstruation drop is namely clean, with paper washer 1 ~ 2 piece 7 points.Do swollen 2 points with two sides of body, dizzy weak 2 points, premenstrual distending pain of the breast 1 point, has a sleepless night 1 point, through the thick companion's clot of matter 0.5 point.
1.5.3 the observation of adverse effect during medication: with or without occurring untoward reaction and record during observing medication, as gastrointestinal upset, anaphylaxis, vaginal bleeding time prolongation etc.As the person that occurs serious adverse reaction, discontinue medication immediately, exit this research.
1.5.4 following up a case by regular visits to property observation: treatment is followed up a case by regular visits to after terminating rear third time menstrual onset, record related symptoms is observed.
1.6 statistical methods: adopt SPSS16.0 statistical software to calculate.Each numerical value with represent, measurement data adopts t inspection, and enumeration data adopts χ 2inspection, with P < 0.05 for difference has statistical significance.
2 results
2.1 criterions of therapeutical effect: according to " guideline of clinical investigations of new Chinese medicine treatment menoxenia ", draft following criterion of therapeutical effect: recovery from illness: treat rear menstrual cycle, recover normal through amount, other transference cures, drug withdrawal 3 non-recidivists of menstrual cycle.Effective: menstrual blood volume increases by 1/3, and other transference cures alleviate, integration reduces more than 70% before comparatively treating, and drug withdrawal 3 menstrual cycle are without recidivist.Effective: treat rear menstrual cycle, through amount, comparatively treat front improvement menstrual period, other symptoms alleviate before comparatively treating, integration reduces 30 ~ 69% before comparatively controlling.Invalid: treatment after menstrual cycle, through amount and menstrual period without improvement, integration comparatively treat before reduce less than 30%.
2.2 observation of curative effect
2.2.1 two groups of patient's comparitive study: observation group's recovery from illness 22 example, effective 27 examples, effective 9 examples, invalid 1 example, obvious effective rate 83.05%, total effective rate 98.31%; Matched group recovery from illness 12 example, effective 18 examples, effective 20 examples, invalid 12 examples, obvious effective rate 46.9%, total effective rate 78.1%, observation group compares with matched group obvious effective rate, total effective rate, difference has statistical significance (P < 0.05), illustrates that clinical cure rate and the obvious effective rate of hypomenorrhea significantly can improve compared with matched group in observation group.In table 1.
Table 1 liang group patient comparitive study (n%, example)
Note: compare with matched group, * P < 0.05.
2.2.2 two groups of symptom integral compare: treat between front two groups of clinical symptoms total mark groups and compare not statistically significant (P > 0.05), illustrate that two groups have homogeneity comparability before the treatment.After different Therapeutic Method, two groups of clinical symptoms total marks more all have remarkable statistical significance (P < 0.01) before the treatment with between group after treatment, illustrate that two kinds of Therapeutic Method all have obvious therapeutic effect for the clinical symptoms of hypomenorrhea patient; And treatment after between clinical symptoms total mark observation group and matched group group the poor opposite sex there is statistical significance (P < 0.05), observation group's more effective clinical symptoms improving patient compared with matched group is described.
When following up a case by regular visits to after treatment is finished, clinical symptoms total mark compares with clinical symptoms total mark after treatment, compare in observation group's group and have statistical significance (P < 0.05), illustrate that observation group patient compares clinical symptoms and is improved when following up a case by regular visits to after treatment.Compare not statistically significant (P > 0.05) in matched group group, illustrate that the patient of matched group clinical symptoms after drug withdrawal has bounce-back.Can illustrate that observation group compares with matched group and has better late result accordingly, and the clinical symptoms of patient not easily recurs, and also demonstrates pharmaceutical preparation of the present invention and can treat hepatic depression and blood deficiency type hypomenorrhea, make body obtain good recovery.In table 2.
Table 2 is treated the two groups of symptom integral in front and back and is compared
Note: compare with before treatment, * P < 0.05, * * P < 0.01, compares with after treatment of control group, #p < 0.05, compares with after treatment of control group when following up a case by regular visits to, △p < 0.05.
2.2.3 the observation of adverse effect during medication: have 1 routine patient to occur slight gastrointestinal reaction during observation group's patient medication.5 routine patients are had to occur slight gastrointestinal reaction during matched group patient medication, as Nausea and vomiting, upper abdomen dull pain; Have 2 routine patients to occur menorrhagia, observation group compares with matched group, and difference has statistical significance, and observation group's less adverse effect, patient compliance is better.
Therapeutic outcome shows: observation group can significantly improve clinical cure rate and the obvious effective rate of hypomenorrhea compared with matched group; Significantly can improve the clinical symptoms of patient, there is better late result, and the clinical symptoms of patient not easily recurs, untoward reaction is few, one pharmaceutical preparation safely and effectively, for Chinese medicine hypomenorrhea provides new method, obtained research and development further.
Model case: Wang, female, 25 years old, on April 12nd, 2014 went to a doctor.Within nearly, amount in the period, 1 obviously reduces, light through color, matter is thick, and menstrual cycle is normal, usually often has two sides of body to do swollen, dizzy weak, premenstrual distending pain of the breast, receive can, sleep not good enough, pale tongue with white fur, stringy and thready pulse.Deny sexual life history and special medical history.Last menstrual period is on April 3rd, 2014.Look into estrogen six levels all normal, Gynaecological B ultrasound shows that uterus and double accessory show no obvious abnormalities.Tcm diagnosis is hypomenorrhea, and dialectical is hepatic depression and blood deficiency.The capsule using the embodiment of the present invention 1 to prepare, every day 2 times, each 3, takes 3 menstrual cycle altogether, and menstrual blood volume is normal, follows up a case by regular visits to and does not recur again.

Claims (10)

1. treat the pharmaceutical preparation of hepatic depression and blood deficiency type hypomenorrhea for one kind, it is characterized in that by Herba lagopsis supinae, Radix Stellariae Yunnanensis, Rhizoma Gymnadeniae, Rhizoma Polygonati, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae, Fructus Lycii, Radix cynanchi wilfordii be that medicinal raw material is made, the weight of each medicinal raw material is as follows: Herba lagopsis supinae 10-20 part, Radix Stellariae Yunnanensis 20-40 part, Rhizoma Gymnadeniae 10-20 part, Rhizoma Polygonati 10-20 part, Flos Rosae Rugosae 8-18 part, Rhizoma Cyperi 7-15 part, Radix Campylotropis hirtellae 5-15 part, Fructus Lycii 15-25 part, Radix cynanchi wilfordii 6-16 part.
2. pharmaceutical preparation as claimed in claim 1, is characterized in that being made up of the medicinal raw material of following weight parts: Herba lagopsis supinae 12-17 part, Radix Stellariae Yunnanensis 26-32 part, Rhizoma Gymnadeniae 13-17 part, Rhizoma Polygonati 10-15 part, Flos Rosae Rugosae 10-15 part, Rhizoma Cyperi 7-12 part, Radix Campylotropis hirtellae 6-11 part, Fructus Lycii 20-25 part, Radix cynanchi wilfordii 10-15 part.
3. pharmaceutical preparation as claimed in claim 2, is characterized in that being made up of the medicinal raw material of following weight parts: Herba lagopsis supinae 15 parts, Radix Stellariae Yunnanensis 30 parts, Rhizoma Gymnadeniae 15 parts, Rhizoma Polygonati 12 parts, Flos Rosae Rugosae 12 parts, Rhizoma Cyperi 9 parts, Radix Campylotropis hirtellae 8 parts, Fructus Lycii 20 parts, Radix cynanchi wilfordii 15 parts.
4. the pharmaceutical preparation as described in as arbitrary in claim 1-3, is characterized in that described pharmaceutical preparation is peroral dosage form.
5. pharmaceutical preparation as claimed in claim 4, is characterized in that described middle peroral dosage form is tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, sucks agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution or plaster etc.
6. pharmaceutical preparation as claimed in claim 5, is characterized in that described middle peroral dosage form is tablet, capsule or granule.
7. pharmaceutical preparation as claimed in claim 6, is characterized in that described middle peroral dosage form most preferably is capsule.
8. the pharmaceutical preparation as described in as arbitrary in claim 1-3, is characterized in that the preparation method of described pharmaceutical preparation mainly comprises the following steps:
(1) Herba lagopsis supinae, Radix Stellariae Yunnanensis, Flos Rosae Rugosae, Rhizoma Cyperi, Radix Campylotropis hirtellae are pulverized, the ethanol water of 50% of 3-8 times amount is added after crossing 80 mesh sieves, adopt ultrasonic extraction 1-3 time, extraction conditions comprises: ultrasonic power is 160-180W, Extracting temperature is 35-40 DEG C, and extraction time is 30-40min; Ultrasonic extraction is complete, gets filtrate, concentrating under reduced pressure drying obtains extract A;
(2) get Rhizoma Gymnadeniae, Rhizoma Polygonati, Fructus Lycii, Radix cynanchi wilfordii pulverizing, add 5-10 times of water soaking 3-4 hour, decoct extraction twice, timing from during boiling, each 1.5-2.0 hour; Merge extractive liquid, filter, relative density 1.03-1.07 is recorded when being concentrated into 60 DEG C, adding ethanol makes alcohol content be 35%, leaves standstill after 24 hours, centrifugal 20 minutes (rotating speed is 3000r/min), discard lower sediment thing, obtain supernatant, after being concentrated into relative density 1.05-1.10 (60 DEG C record), spraying dry obtains extract B;
(3) by extract A extract B mix homogeneously, this composition is independent or mix with medicine acceptable carrier, makes pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
9. the purposes of the arbitrary described medicine of claim 1-3 in the medicine of preparation treatment hypomenorrhea.
10. the purposes of the arbitrary described medicine of claim 1-3 in the medicine of preparation treatment hepatic depression and blood deficiency type hypomenorrhea.
CN201610004483.1A 2016-01-04 2016-01-04 Pharmaceutical preparation for treating hepatic depression and blood deficiency-type hypomenorrhea Withdrawn CN105434883A (en)

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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
杨建宇等: "《国医大师治疗妇科病经典医案》", 30 April 2013, 中原出版传媒集团 中原农民出版社 *
赵素丽: "小柴胡汤临证新用", 《实用中医药杂志》 *

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