CN105434724A - Traditional Chinese medicine composition for treating rhinitis disease and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rhinitis disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating rhinitis disease and a preparation method thereof. The traditional Chinese medicine composition is prepared from radix tetrastigme, wild panax notoginseng, balanophora spicata hayata and saffron crocus. The preparation method includes the steps that all raw materials are cleaned, aired, crushed and mixed in proportion, water is added for soaking the mixture, a steam distillation method is adopted for extracting volatile oil, the volatile oil is collected, ethyl alcohol is used as a solvent to conduct heating reflux extraction, filtering is conducted, vacuum concentration is conducted, liquid medicine absorbs resin through large pores, then elution is conducted through an ethanol solution, ethanol eluent is collected, concentration and drying are conducted, and traditional Chinese medicine extract is obtained. It is proved by experiment examples that the traditional Chinese medicine composition has a quite good curative effect on rhinitis, is free of toxic or side effect, wide in raw material source and low in cost and relieves the economic burden of patients.
Description
Technical field
The present invention relates to the field of Chinese medicines, specifically a kind ofly treat Chinese medicine composition of rhinitis disease and preparation method thereof.
Background technology
Rhinitis is the diseases associated with inflammation occurring in bronchia mucosal, clinical be cardinal symptom with ictal nasal obstruction, rhinocnesmus, sneeze, watery nasal discharge, headache and dizzy, hypomnesis and concha nasalis enlargement a kind of commonly encountered diseases, frequently-occurring disease, comprise allergic rhinitis and anallergic rhinitis, allergic rhinitis are bronchia mucosal inflammation that body causes for environment allergen, mainly contain IgE mediation, part is that non-IgE mediates.Anallergic rhinitis comprises six types such as acute and chronic sinusitis, infectious rhinitis, and all kinds of property rhinitis can be present in a patient simultaneously.Along with environmental pollution increase, rhythm of life are accelerated, cacorhinia sickness rate increases year by year, has a strong impact on people's quality of life.Though currently available technology has the routine of multiple treatment rhinitis to take orally or the medicine of external, mostly poor effect or take effect slow, Western medicine side effect is large simultaneously, and cure the symptoms, not the disease, curative effect is general.
Summary of the invention
The object of the present invention is to provide and a kind ofly treat Chinese medicine composition of rhinitis disease and preparation method thereof, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine composition for rhinitis disease, be prepared from by the raw material of following weight portion: Radix Apioris Fortunei (Radix Lespedezae Buergeri) 24 ~ 30 parts, wild Radix Notoginseng 28 ~ 32 parts, Rhizoma Atractylodis Macrocephalae spirit 8 ~ 12 parts, Stigma Croci 15 ~ 21 parts.
A preparation method for the Chinese medicine composition of described treatment rhinitis disease, concrete preparation process is as follows:
(1) each raw material is cleaned respectively, and dry under natural environment, make the water content of each raw material remain on 10 ~ 12%, take respectively according to proportioning, be ground into 30 ~ 60 object medical material, then mix homogeneously with pulverizer respectively;
(2) in the medical material of above-mentioned mixing, add the water soaking 6 ~ 8h of raw material 10 ~ 12 times, adopt extraction by steam distillation volatile oil, extraction time 3 ~ 4h, extraction time 3 ~ 4 times, collect volatile oil, obtain extract A;
(3) ethanol being 80 ~ 95% by the extract A volumetric concentration that step (2) obtains is solvent, heating and refluxing extraction, and extraction time is 2 ~ 3 times, each extraction time is 2 ~ 3h, each solvent load is 6 ~ 8 times of raw material gross weight, filters, obtains extract B;
(4) extract B that step (3) obtains is evaporated to relative density d=1.10 ~ 1.20, filter, medicinal liquid passes through macroporous adsorbent resin, use the alcoholic solution eluting of concentration 60 ~ 75% again, collect ethanol elution, concentrate drying, obtains Chinese medicine extract of the present invention.
As the further scheme of the present invention: described macroporous adsorbent resin is LSA-21 macroporous adsorbent resin, DM130 macroporous adsorbent resin or LSA-40 macroporous adsorbent resin.
Compared with prior art, the invention has the beneficial effects as follows: prove through experimental example, Chinese medicine composition of the present invention has good therapeutic effect to rhinitis, has no side effect, and raw material sources are extensive, and cost is low, alleviates the financial burden of patient.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
The Chinese medicine composition for the treatment of rhinitis disease, is prepared from by the raw material of following weight portion: Radix Apioris Fortunei (Radix Lespedezae Buergeri) 24 parts, wild Radix Notoginseng 32 parts, Rhizoma Atractylodis Macrocephalae spirit 8 parts, Stigma Croci 21 parts.
In above-described embodiment, the preparation process of the Chinese medicine composition for the treatment of rhinitis disease is as follows:
(1) each raw material is cleaned respectively, and dry under natural environment, make the water content of each raw material remain on 10 ~ 12%, take respectively according to proportioning, be ground into 60 object medical material, then mix homogeneously with pulverizer respectively;
(2) in the medical material of above-mentioned mixing, add the water soaking 6h of raw material 10 times, adopt extraction by steam distillation volatile oil, extraction time 3h, extraction time 4 times, collect volatile oil, obtain extract A;
(3) ethanol being 95% by the extract A volumetric concentration that step (2) obtains is solvent, heating and refluxing extraction, and extraction time is 3 times, and each extraction time is 2h, and each solvent load is 6 times of raw material gross weight, filters, obtains extract B;
(4) extract B that step (3) obtains is evaporated to relative density d=1.10 ~ 1.20, filters, medicinal liquid is by LSA-21 macroporous adsorbent resin, use the alcoholic solution eluting of concentration 75% again, collect ethanol elution, concentrate drying, obtains Chinese medicine extract of the present invention.
Embodiment 2
The Chinese medicine composition for the treatment of rhinitis disease, is prepared from by the raw material of following weight portion: Radix Apioris Fortunei (Radix Lespedezae Buergeri) 27 parts, wild Radix Notoginseng 30 parts, Rhizoma Atractylodis Macrocephalae spirit 10 parts, Stigma Croci 18 parts.
In above-described embodiment, the preparation process of the Chinese medicine composition for the treatment of rhinitis disease is as follows:
(1) each raw material is cleaned respectively, and dry under natural environment, make the water content of each raw material remain on 10 ~ 12%, take respectively according to proportioning, be ground into 60 object medical material, then mix homogeneously with pulverizer respectively;
(2) in the medical material of above-mentioned mixing, add the water soaking 7 of raw material 11 times, adopt extraction by steam distillation volatile oil, extraction time 3.5h, extraction time 4 times, collect volatile oil, obtain extract A;
(3) ethanol being 95% by the extract A volumetric concentration that step (2) obtains is solvent, heating and refluxing extraction, and extraction time is 3 times, each extraction time is 2.5h, each solvent load is 7 times of raw material gross weight, filters, obtains extract B;
(4) extract B that step (3) obtains is evaporated to relative density d=1.10 ~ 1.20, filters, medicinal liquid is by DM130 macroporous adsorbent resin, use the alcoholic solution eluting of concentration 75% again, collect ethanol elution, concentrate drying, obtains Chinese medicine extract of the present invention.
Embodiment 3
The Chinese medicine composition for the treatment of rhinitis disease, is prepared from by the raw material of following weight portion: Radix Apioris Fortunei (Radix Lespedezae Buergeri) 30 parts, wild Radix Notoginseng 28 parts, Rhizoma Atractylodis Macrocephalae spirit 12 parts, Stigma Croci 15 parts.
In above-described embodiment, the preparation process of the Chinese medicine composition for the treatment of rhinitis disease is as follows:
(1) each raw material is cleaned respectively, and dry under natural environment, make the water content of each raw material remain on 10 ~ 12%, take respectively according to proportioning, be ground into 60 object medical material, then mix homogeneously with pulverizer respectively;
(2) in the medical material of above-mentioned mixing, add the water soaking 8h of raw material 12 times, adopt extraction by steam distillation volatile oil, extraction time 4h, extraction time 3 times, collect volatile oil, obtain extract A;
(3) ethanol being 95% by the extract A volumetric concentration that step (2) obtains is solvent, heating and refluxing extraction, and extraction time is 2 times, each extraction time is 32h, each solvent load is 8 times of raw material gross weight, filters, obtains extract B;
(4) extract B that step (3) obtains is evaporated to relative density d=1.10 ~ 1.20, filters, medicinal liquid is by LSA-40 macroporous adsorbent resin, use the alcoholic solution eluting of concentration 75% again, collect ethanol elution, concentrate drying, obtains Chinese medicine extract of the present invention.
The clinical efficacy of Chinese medicine composition of the present invention
1, diagnostic criteria and case selection
With reference to the sick diagnostic criteria of rhinitis that otolaryngology branch of Chinese Medical Association formulates, select confirmation to have manifest symptom or sign, meet diagnostic criteria rhinitis disease (comprising perennially and seasonal allergic rhinitis) patient.Selected case is diagnosed as the patient of rhinitis disease by hals,Nasen und Ohrenheilkunde outpatient service.Age, the course of disease reached 15 years most at 10 ~ 50 years old, and patient is divided into 2 groups at random, was respectively 100 examples, and between each group, the situations such as the state of an illness, clinical symptoms and age are suitable, have comparability.
(1) symptom: have a stuffy nose, suppurate, hyposmia or disappearance, and how with headache, dizzy, feeling of fullness in the head;
(2) sign: often flow out with purulent secretion in nasal meatus;
(3) auxiliary examination: do x-ray inspection according to state of an illness some cases, gets rid of other pathological changes of nose.
2, Therapeutic Method
Treatment group: A group uses the Liquid traditional Chinese medicine compositions in the embodiment of the present invention 2, collunarium, three times on the one, 2, nostril, two weeks courses for the treatment of;
Matched group: B group uses triamcinolone acetonide nasal spray, and nasal cavity sprays into, every day 2 times, each every nostril 1 is skimmed, and often lifting is 50 μ g, and 2 lift 100 μ g, 2 weeks courses for the treatment of;
Matched group: C group uses numb imperial nasal drop (containing meticortelone and ephedrine hydrochloride 1%), three times on the one, 2, nostril, two weeks courses for the treatment of.
3, clinical observation
Each case all after acceptance treatment every day examine in detail, and record cardinal symptom and the signs such as the situation of change, particularly sneeze of sings and symptoms, watery nasal discharge, nasal obstruction, rhinocnesmus and nasal mucosa at 1d, 6d, lld, 14d.The various untoward reaction that in therapeutic process, close observation and itemized record occur and change.
4, clinical efficacy criterion
Clinical cure: clinical symptoms, sign disappear, follow up a case by regular visits to six months without recurrence;
Effective: nasal obstruction alleviates, pus tears reduce, headache alleviates;
Invalid: clinical symptoms, sign has no significant change.
5, therapeutic outcome
| Group | Total number of cases | Effective number of cases | Effective number of cases | Invalid number of cases | Total effective rate |
| Treatment group A | 100 | 92 | 7 | 1 | 99 |
| Treatment group B | 100 | 75 | 15 | 10 | 90 |
| Treatment group C | 100 | 55 | 20 | 25 | 75 |
Interpretation of result: A group and matched group B:P0.05; A group and C group: P0.01; B group and C group: P0.01.Show from above to show and find out that total effective rate of the present invention is 99%; The total effective rate of triamcinolone acetonide nasal spray is 90%; The imperial nasal drop total effective rate of fiber crops is 75%.A group is obviously greater than matched group B, matched group C, and Chinese medicine composition of the present invention and matched group B are all better than numb imperial nasal drop.But matched group B and matched group C is all containing glucocorticoid, topical application side effect is comparatively large, easily makes skin mucosa atrophy degeneration, telangiectasis, thus skin mucosa resistance is declined, and concurrent bacterial infects.Chinese medicine composition of the present invention is without above-mentioned untoward reaction, and clinical efficacy is fine, instant effect, and general medication can alleviate nasal obstruction and rhinocnesmus for 3 times, and the symptoms such as watery nasal discharge, continuous use 3 days, symptom disappears substantially, is used in conjunction one week, symptom basic controlling.
Model case
Case 1: week certain, man, 12 years old, suffers from rhinitis more than 2 years, increases the weight of for cardinal symptom, spring and autumn with rhinocnesmus, snivel.During serious attack, a large amount of clear water sample nasal mucus outflow, can not consciously drip from nostril sometimes.Use Chinese medicine composition of the present invention liquid sprays, three times on the one, 2, nostril, use 2 days, rhinocnesmus basic controlling, snivel obviously alleviates, and is used in conjunction 7 days symptom basic controlling, and continue medication 7 days, symptom all controls.
Case 2: Feng, female 43 years old, suffers from allergic rhinitis more than 6 years, with nasal obstruction, sneeze for cardinal symptom, rise morning and increase the weight of, continuous sneeze about 1 minute during serious attack, use Chinese medicine powder of the present invention, three times on the one, a nostril spray twice, use 1 day, nasal obstruction basic controlling, sneeze obviously alleviates, and is used in conjunction 5 days symptom basic controlling, continue medication 7 days, symptom all controls.
Case 3: Lu, man 30 years old, suffer from rhinitis more than 5 years, swell as cardinal symptom with rhinocnesmus, nasal obstruction, turbinate mucosa, spring and autumn increases the weight of.During serious attack, impact is breathed, and is forced to dehisce to breathe for cardinal symptom, uses Chinese medicine composition liquid preparation of the present invention, three times on the one, and 2, nostril, uses 1 day, and rhinocnesmus, having a stuffy nose obviously alleviates.Be used in conjunction 7 days symptoms substantially to control, nasal mucosa swelling obviously improves.Continue medication 7 days, symptom all controls.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
Claims (3)
1. treat a Chinese medicine composition for rhinitis disease, it is characterized in that, be prepared from by the raw material of following weight portion: Radix Apioris Fortunei (Radix Lespedezae Buergeri) 24 ~ 30 parts, wild Radix Notoginseng 28 ~ 32 parts, Rhizoma Atractylodis Macrocephalae spirit 8 ~ 12 parts, Stigma Croci 15 ~ 21 parts.
2. a preparation method for the Chinese medicine composition for the treatment of rhinitis disease as claimed in claim 1, it is characterized in that, concrete preparation process is as follows:
(1) each raw material is cleaned respectively, and dry under natural environment, make the water content of each raw material remain on 10 ~ 12%, take respectively according to proportioning, be ground into 30 ~ 60 object medical material, then mix homogeneously with pulverizer respectively;
(2) in the medical material of above-mentioned mixing, add the water soaking 6 ~ 8h of raw material 10 ~ 12 times, adopt extraction by steam distillation volatile oil, extraction time 3 ~ 4h, extraction time 3 ~ 4 times, collect volatile oil, obtain extract A;
(3) ethanol being 80 ~ 95% by the extract A volumetric concentration that step (2) obtains is solvent, heating and refluxing extraction, and extraction time is 2 ~ 3 times, each extraction time is 2 ~ 3h, each solvent load is 6 ~ 8 times of raw material gross weight, filters, obtains extract B;
(4) extract B that step (3) obtains is evaporated to relative density d=1.10 ~ 1.20, filter, medicinal liquid passes through macroporous adsorbent resin, use the alcoholic solution eluting of concentration 60 ~ 75% again, collect ethanol elution, concentrate drying, obtains Chinese medicine extract of the present invention.
3. the preparation method of the Chinese medicine composition for the treatment of rhinitis disease according to claim 2, is characterized in that, described macroporous adsorbent resin is LSA-21 macroporous adsorbent resin, DM130 macroporous adsorbent resin or LSA-40 macroporous adsorbent resin.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125564A (en) * | 2018-09-19 | 2019-01-04 | 方小龙 | A kind of Chinese medicine with antibiotic effect |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585227A (en) * | 2013-10-31 | 2014-02-19 | 济南星懿医药技术有限公司 | Application of ligularia purdomii extract in preparation of drug for treatment of leukemia |
| CN103751349A (en) * | 2013-12-26 | 2014-04-30 | 广西天天乐药业股份有限公司 | Traditional Chinese medicine composition for treating rhinitis and preparation method of composition |
| CN104306646A (en) * | 2014-10-13 | 2015-01-28 | 徐艳 | Soft capsule for treating nasosinusitiss as well as preparation method and application of soft capsule |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585227A (en) * | 2013-10-31 | 2014-02-19 | 济南星懿医药技术有限公司 | Application of ligularia purdomii extract in preparation of drug for treatment of leukemia |
| CN103751349A (en) * | 2013-12-26 | 2014-04-30 | 广西天天乐药业股份有限公司 | Traditional Chinese medicine composition for treating rhinitis and preparation method of composition |
| CN104306646A (en) * | 2014-10-13 | 2015-01-28 | 徐艳 | Soft capsule for treating nasosinusitiss as well as preparation method and application of soft capsule |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125564A (en) * | 2018-09-19 | 2019-01-04 | 方小龙 | A kind of Chinese medicine with antibiotic effect |
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