CN105434696A - Zhuang medicine composition for treating migraine - Google Patents
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Abstract
The invention discloses a Zhuang medicine composition for treating migraine. The composition comprises the following components in parts by weight: 10 to 50 parts of geum aleppicum, 10 to 50 parts of coffee senna, 10 to 50 parts of roughhaired holly root, 10 to 30 parts of screwtree root, 5 to 20 parts of xanthium, 10 to 30 parts of chloranthus spicatus, 6 to 20 parts of uncaria, 10 to 30 parts of dicliptera chinensis, 5 to 20 parts of ilex kudincha, and 10 to 30 parts of verbena. The preparation method comprises the following steps: (1) primary decoction: decocting the raw materials by strong fire until the water is boiling, then turning down the fire, boiling the raw materials by slow fire for 20 to 25 minutes, filtering the decoction, and saving the filtrate; (2) secondary decoction: adding water with a room temperature into the dregs, decocting the dregs by strong fire until the water is boiling, then turning down the fire, boiling the dregs by slow fire for 20 to 25 minutes, filtering, saving the filtrate, and finally merging the filtrates together. The Zhuang medicine composition has the functions of moving wind toxin, clearing heat toxin, relieving headache, and freeing collaterals, can well relieve the jumping pain, stabbing pain, swelling pain, dull pain of head, is capable of effectively relieving headache, and reducing the frequency of attack and happening rate of headache, and has the advantages of definite therapeutic effect, rapid effect, stability, safety, and no side or toxic effect.
Description
Technical field
The invention belongs to national medicine field, be specifically related to one and treat migrainous strong drug composition.
Background technology
Migraine is a kind of periodical attack nerve-dysfunction of blood vessel, with the inclined side of recurrent exerbation or bilatenal headache for feature, its painful area or forehead, volume temporo, top, mountain peak, top occipitalia or full head, headache character mostly is jumping pain, twinge, distending pain, dull pain, headache as wrapped up in, having a headache as split.Normal with symptoms such as Nausea and vomiting, phonophobia, photophobias, be common nervous system disease, sickness rate is high, recurrent exerbation, and the course of disease is longer, and normal delay is difficult, has a strong impact on the quality of life of patient.Jing Yue's complete work " carry: " with regard to polarization wind syndrome of head, unhealed, holds sputum wind-fire under the arm, strongly fragrant meridians of holding back, stagnation of QI-blood in being for a long time." point out that stagnation of QI-blood head meridians are migrainous basic pathogenesis.
Migraine is strengthened doctor and is called skilful Yin, strong literary composition: gyaeujin.Strong doctor thinks: migraine (skilful Yin) is because diseases caused by exogenous pathogenic factor or interior heresy poison of making block " skilful depressed place " (brain) Nei Long road, fiery road network network, make stagnation of QI-blood not smooth or obstructed and clinical a kind of disease that is primary symptom with conscious cephalic pain of occurring, its main pathogenesis is that stagnation of QI-blood is in skilful depressed place " (brain) Nei Long road, fiery road network network, belong to the sick category in sick, the fiery road of strong doctor's " skilful depressed place " (brain) by diseased region.
Clinical treatment migraine throws Western medicine more, control outbreak, but analgesic effect is not good enough based on analgesics, tranquilizer etc., and long-term prescription toxic and side effects is obvious, is difficult to radical cure.Strong doctor has original opinion and have accumulated abundant Couple herbs in treatment migraine (skilful Yin), and analgesic effect and Late curative effect are very good.Therefore, develop a kind of effect with dispelling wind poison, heat clearing away poison, only headache, Tong Tiaolong road, fiery road, good analgesic effect is had to head jumping pain, twinge, distending pain, dull pain etc., effectively can alleviate seizure frequency, reduce headache onset risk, determined curative effect, rapid, stable, safe strong drug composition, have great importance.
Summary of the invention
The present invention to solve technical problem be to provide a kind of effect with dispelling wind poison, heat clearing away poison, only headache, Tong Tiaolong road, fiery road, good analgesic effect is had to head jumping pain, twinge, distending pain, dull pain, effectively can alleviate migraine frequency, reduce headache onset risk, determined curative effect, rapid, stable, the safe migrainous strong drug composition for the treatment of.
The present invention solves the problems of the technologies described above by the following technical programs:
One treats migrainous strong drug composition, its raw material, with parts by weight, comprises Herba Diclipterae Chinensis 10 ~ 50 parts, Herba cassiae occidentalis 10 ~ 50 parts, Radix Ilicis Asprellae 10 ~ 50 parts, Radix Helicteris 10 ~ 30 parts, Fructus Xanthii 5 ~ 20 parts, chu lan tree 10 ~ 30 parts, Ramulus Uncariae Cum Uncis 6 ~ 20 parts, Herba Diclipterae Chinensis 10 ~ 30 parts, Folium Ilicis 5 ~ 20 parts, Herba Verbenae 10 ~ 30 parts.Its preparation method comprises the following steps: take above-mentioned raw materials by weight respectively and clean, soak 15 ~ 30 minutes; Head is decocted: intense fire decocts to boiling, changes slow fire boiling 20 ~ 25 minutes, is leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 20 ~ 25 minutes, medicine juice is leached; Head is decocted and decocts gained medicine juice with two and merge.
The dosage form of described strong drug composition is decoction.
Herba Diclipterae Chinensis, be loaded in " the strong medicine primary colors collection of illustrative plates of China ", strong Goheuhenzloh by name, derives from leaf, the root of Verbenaceae Folium Isatidis wood ClerodendrumcyrtophyllumTurcz.; Nature and flavor: bitter, cold; Effect: clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Cure mainly: the high heat of cold, headache, mumps, sore throat, erysipelas, hematodiarrhoea etc.
Herba cassiae occidentalis, be loaded in " the strong medical science of China ", strong Duhheundoi by name, derives from the stem and leaf of leguminous plant Herba cassiae occidentalis CassiaoccidentalisL.; Nature and flavor: bitter, cold; Effect: relieving cough and asthma, liver heat removing and eyesight improving, removing toxic substances pain relieving, under rushing down; Cure mainly: cough with asthma, eyes are red, migraine, furuncle swelling toxin, constipation with dry stool etc.
Radix Ilicis Asprellae, be loaded in " the strong medical science of China ", strong Raggodiemjcaengh by name, derives from the root of holly plant Folium Mume Ilicis Purpureae Ilexasprella (Hook.etArn) Champ.exBenth.; Nature and flavor: bitter, sweet, cold; Effect: removing summer-heat pyretic toxicity, blood stasis dispelling poison, detumescence, Tong Longlu, Huo Lu; Cure mainly: heating, hematodiarrhoea, headache, throat pain, traumatic injury, Tianjin wound is thirsty.
Radix Helicteris, be loaded in " the strong medical science of China ", strong Lwgrazndei by name, derives from the root of Sterculiaceae plant Radix Helicteris HelicteresangustifoliaL.; Nature and flavor: pungent, micro-hardship are cool; Effect: removing summer-heat pyretic toxicity, reducing swelling and alleviating pain, except noxious dampness, dispel the wind poison; Cure mainly: eruptive disease, hot anemogenous headache, measles, pig's head is fertile, carbuncle etc.
Fructus Xanthii, be loaded in " the strong medicine primary colors collection of illustrative plates of China ", strong Gocangh ' wjcauj by name, derives from the fruit of feverfew Herba Xanthii XanthiumsibiricumPatr.exWidder; Nature and flavor: bitter, sweet, acrid, warm; Effect: dispersing wind and cold, airway, wind-damp dispelling, antipruritic; Cure mainly: wind syndrome of head is had a headache, arthralgia chiefly caused by damp pathogen, skin pruritus etc.
Chu lan tree, be loaded in " Guangxi book on Chinese herbal medicine a collection of selected materials ", strong Goginhsuzlanz by name, derives from the stem and leaf of Chloranthaceae plant chu lan tree Chloranthusspicatus (Thunb.) Mak.; Nature and flavor: bitter, micro-pungent are flat; Effect: Tong Longlu, promoting blood circulation to remove blood stasis pain relieving; Cure mainly: rheumatic arthralgia, migraine, epersalgia cough, injury and bone fracture, stubborn dermatitis etc.
Ramulus Uncariae Cum Uncis, be loaded in " the strong medical science of China ", strong Godayezgouhdwngz by name, derives from the dry stem and branch with belt hook of Rubiaceae evergreen woody climber Ramulus Uncariae macrophyllae UncariamacrophyllaWall.; Nature and flavor: sweet, bitter, cold; Effect: clearing liver-fire for calming endogenous wind, dispelling wind poison, only knots; Cure mainly: liver-heat is attacked the dizziness in skilful depressed place, headache, cramp etc.
Herba Diclipterae Chinensis, be loaded in " the strong medical science of China ", strong Byaekdaepma by name, derives from the herb of acanthaceous plant Herba Diclipterae Chinensis Diclipterachinensis (L.) Nees.; Nature and flavor: bitter, cold; Effect: heat clearing away poison, except noxious dampness, liver heat removing and eyesight improving, tonneau water channel, eliminating pathogenic heat from blood to cure dysentery, rash dissipating rashes; Cure mainly: discharge dysentery, damp and hot skin infection, smelly yellow fluid of suppurating, inflamed eyes pain, dizziness headache, bitter taste is deaf, discharging fresh blood stool, pyretic stranguria, macule etc.
Folium Ilicis, be loaded in " the strong medicine primary colors collection of illustrative plates of China ", strong Gocazdaeng by name, derives from the leaf of holly plant Folium Ilicis IlexkudingchaC.J.Tseng.; Nature and flavor: bitter, sweet, cool; Effect: heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst; Cure mainly: calentura excessive thirst, heatstroke, laryngopharynx swelling and pain, headache, conjunctival congestion, toothache etc.
Herba Verbenae, be loaded in " the strong medical science of China ", strong Rumbienmax by name, derives from herb or the whole herb with root of Verbenaceae Herba Verbenae VerbenaofficinalisL.; Nature and flavor: bitter, acrid, cold; Effect: relieving heat toxin, except blood stasis, Tong Longlu, waterway; Cure mainly: jaundice, acute filthy disease, headache, pyretic toxicity carbuncle, imperial road is obstructed, traumatic injury, tympanites, gonorrhea, miasma disease etc.
According to the prescription combination principle of strong doctor's male and female main side band, public medicine is the medicine for the treatment of YIN syndrome, and female medicine is the medicine for the treatment of YANG syndrome, and principal agent is the medicine for chief complaint or the cause of disease, side medicine helps principal agent to treat the ancillary drug of main disease, and band medicine is the medicine guiding other drug to arrive sick institute or mediation flavour of a drug.In side, Herba Diclipterae Chinensis, Radix Ilicis Asprellae, chu lan tree heat-clearing and toxic substances removing blood stasis dispelling are principal agent; Herba cassiae occidentalis, Radix Helicteris, Folium Ilicis removing toxic substances pain relieving, Fructus Xanthii, Ramulus Uncariae Cum Uncis dispelling wind and relieving, Herba Verbenae blood stasis dispelling detoxifies, and is side medicine altogether; Herba Diclipterae Chinensis priming is to head, very good to the headache of migraine especially liver-heat, is priming; Chu lan tree, Fructus Xanthii are again public medicine, and all the other are female medicine.Full side's male and female main side band share, altogether the effect on long memorial pathogenic wind toxic, heat clearing away poison, only headache, Tong Tiaolong road, fiery road.
The present invention has following remarkable result:
The present invention has effect that clear and definite dispelling wind is malicious, heat clearing away is malicious, stop headache, Tong Tiaolong road, fiery road, good analgesic effect is had to head jumping pain, twinge, distending pain, dull pain etc., effectively can alleviate seizure frequency, reduce headache onset risk, determined curative effect, rapidly, stable, safely, have no side effect.
Detailed description of the invention
Below by embodiment, the invention will be further described, but not as any restriction to scope.
Embodiment 1:
1. strong drug composition comprises the raw material of following weight portion:
Herba Diclipterae Chinensis 50g, Herba cassiae occidentalis 30g, Radix Ilicis Asprellae 10g, Radix Helicteris 10g, Fructus Xanthii 5g, chu lan tree 20g, Ramulus Uncariae Cum Uncis 12g, Herba Diclipterae Chinensis 30g, Folium Ilicis 12g, Herba Verbenae 20g.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 15 ~ 30 minutes; Head is decocted: intense fire decocts to boiling, changes slow fire boiling 20 ~ 25 minutes, decocts to 200ml, leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 20 ~ 25 minutes, decoct to 200ml, medicine juice leached; Head is decocted and decocts gained medicine juice with two and merge, altogether 400ml.Described strong drug composition is decoction.
3. administrated method: oral, above-mentioned decoction every day 1 dose, every agent 400ml, points 2 times sooner or later, each 200ml decoction being taken warmly 7 days is a course for the treatment of, takes 3 courses for the treatment of continuously, has a rest 2 days between the course for the treatment of.
4. judging basis:
Diagnostic criteria: migrainous diagnostic criteria in the 2nd edition " International Classification of headache illness " that Western medicine diagnose standard reference International Headache association promulgates for 2004: patients is headache periodicity, repeatability outbreak, and all through head CT inspection, get rid of intracranial organic disease.
Inclusive criteria: include case in and all meet the following conditions: 1. meet the diagnostic criteria of doctor trained in Western medicine migraine; 2. the diagnostic criteria of traditional Chinese medical science headache due to blood stasis card is met; 3. each duration of seizure >=4h; 4. seizure frequency >=1 time/month; 5. this pain was not used analgesic and other Analgesic techniques or was used nonresponder; 6. 18 ~ 65 years old age.
Rejecting standard: 1. pregnancy women; 2. the severe primary disease patients such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system are merged; 3. psychotic; 4. this pain had used treatment migraine remedy and responder; Though 5. have headache, as the Symptoms of other diseases, as patients such as hypertension, cerebral trauma and intracranial organic diseases; 6. the migraine of the specific type such as ophthalmoplegia type, hemiplegia type.
Criterion of therapeutical effect: with reference to the migraine curative effect determinate standard evaluation in " new Chinese medicine guideline of clinical investigations ", clinical cure: terminate the course for the treatment of without ictal cephalagra, drug withdrawal is not fallen ill for 1 month; Effective: after treatment, integration reduces more than 50%; Effective: after treatment, integration reduces 21%-50%; Invalid: after treatment, integration reduces less than 20%.
5. model case:
Lee so-and-so, man, 35 years old, people from Nanning City, migraine recurrent exerbation 3 years, increased the weight of 1 week.Based on head both sides jumping pain, distending pain.After taking this strong drug composition by above-mentioned administrated method, cephalagra disappears, and follows up a case by regular visits to and has no recurrence half a year.
Huang, female, 42 years old, people from Wuzhou, migraine recurrent exerbation 8 months.Within every 30 ~ 60 minutes, show effect once, based on right side distending pain in the head, pain and forehead.After taking this strong drug composition by above-mentioned administrated method, cephalagra disappears, and follows up a case by regular visits to and has no recurrence in 3 months.
Embodiment 2:
1. strong drug composition comprises the raw material of following weight portion:
Herba Diclipterae Chinensis 30g, Herba cassiae occidentalis 50g, Radix Ilicis Asprellae 30g, Radix Helicteris 20g, Fructus Xanthii 20g, chu lan tree 10g, Ramulus Uncariae Cum Uncis 20g, Herba Diclipterae Chinensis 20g, Folium Ilicis 20g, Herba Verbenae 30g.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 15 ~ 30 minutes; Head is decocted: intense fire decocts to boiling, changes slow fire boiling 20 ~ 25 minutes, decocts to 200ml, leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 20 ~ 25 minutes, decoct to 200ml, medicine juice leached; Head is decocted and decocts gained medicine juice with two and merge, altogether 400ml.Described strong drug composition is decoction.
3. administrated method: oral, above-mentioned decoction every day 1 dose, every agent 400ml, point 2 times sooner or later, each 200ml decoction being taken warmly, 7 days be a course for the treatment of, take 4 courses for the treatment of continuously, have a rest 2 days between the course for the treatment of.
4. judging basis:
Diagnostic criteria: migrainous diagnostic criteria in the 2nd edition " International Classification of headache illness " that Western medicine diagnose standard reference International Headache association promulgates for 2004: patients is headache periodicity, repeatability outbreak, and all through head CT inspection, get rid of intracranial organic disease.
Inclusive criteria: include case in and all meet the following conditions: 1. meet the diagnostic criteria of doctor trained in Western medicine migraine; 2. the diagnostic criteria of traditional Chinese medical science headache due to blood stasis card is met; 3. each duration of seizure >=4h; 4. seizure frequency >=1 time/month; 5. this pain was not used analgesic and other Analgesic techniques or was used nonresponder; 6. 18 ~ 65 years old age.
Rejecting standard: 1. pregnancy women; 2. the severe primary disease patients such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system are merged; 3. psychotic; 4. this pain had used treatment migraine remedy and responder; Though 5. have headache, as the Symptoms of other diseases, as patients such as hypertension, cerebral trauma and intracranial organic diseases; 6. the migraine of the specific type such as ophthalmoplegia type, hemiplegia type.
Criterion of therapeutical effect: with reference to the migraine curative effect determinate standard evaluation in " new Chinese medicine guideline of clinical investigations ", clinical cure: terminate the course for the treatment of without ictal cephalagra, drug withdrawal is not fallen ill for 1 month; Effective: after treatment, integration reduces more than 50%; Effective: after treatment, integration reduces 21%-50%; Invalid: after treatment, integration reduces less than 20%.
5. model case:
Chen, female, 56 years old, people from Mashan County, migraine recurrent exerbation 5 years.Based on right side head twinge, night bitterly very.After taking this strong drug composition by above-mentioned administrated method, migraine disappears completely, follows up a case by regular visits to and has no recurrence in 3 months.
Lin, female, 18 years old, people from Cenxi City, migraine recurrent exerbation 1 year.Show effect 1 time weekly, each headache about continues 6 hours, based on a two temporo side and temple place distending pain.After taking this strong drug composition by above-mentioned administrated method, migraine disappears, and follows up a case by regular visits to and has no recurrence half a year.
Embodiment 3:
1. strong drug composition comprises the raw material of following weight portion:
Herba Diclipterae Chinensis 10g, Herba cassiae occidentalis 10g, Radix Ilicis Asprellae 50g, Radix Helicteris 30g, Fructus Xanthii 12g, chu lan tree 30g, Ramulus Uncariae Cum Uncis 6g, Herba Diclipterae Chinensis 10g, Folium Ilicis 5g, Herba Verbenae 10g.
2. strong drug composition preparation method:
Take above-mentioned raw materials respectively by weight, raw material is cleaned, pour medicine pot into, soak 15 ~ 30 minutes; Head is decocted: intense fire decocts to boiling, changes slow fire boiling 20 ~ 25 minutes, decocts to 200ml, leached by medicine juice; Two decoct: rejoin normal-temperature water paramount go out 0.5 ~ 1 centimetre, medical material plane, intense fire decoct to medicinal liquid boiling after change slow fire boiling into 20 ~ 25 minutes, decoct to 200ml, medicine juice leached; Head is decocted and decocts gained medicine juice with two and merge, altogether 400ml.Described strong drug composition is decoction.
3. administrated method: oral, above-mentioned decoction every day 1 dose, every agent 400ml, point 2 times sooner or later, each 200ml decoction being taken warmly, 7 days be a course for the treatment of, take 3 courses for the treatment of continuously.
4. judging basis:
Diagnostic criteria: migrainous diagnostic criteria in the 2nd edition " International Classification of headache illness " that Western medicine diagnose standard reference International Headache association promulgates for 2004: patients is headache periodicity, repeatability outbreak, and all through head CT inspection, get rid of intracranial organic disease.
Inclusive criteria: include case in and all meet the following conditions: 1. meet the diagnostic criteria of doctor trained in Western medicine migraine; 2. the diagnostic criteria of traditional Chinese medical science headache due to blood stasis card is met; 3. each duration of seizure >=4h; 4. seizure frequency >=1 time/month; 5. this pain was not used analgesic and other Analgesic techniques or was used nonresponder; 6. 18 ~ 65 years old age.
Rejecting standard: 1. pregnancy women; 2. the severe primary disease patients such as cardiovascular, cerebrovascular, liver, kidney, hemopoietic system are merged; 3. psychotic; 4. this pain had used treatment migraine remedy and responder; Though 5. have headache, as the Symptoms of other diseases, as patients such as hypertension, cerebral trauma and intracranial organic diseases; 6. the migraine of the specific type such as ophthalmoplegia type, hemiplegia type.
Criterion of therapeutical effect: with reference to the migraine curative effect determinate standard evaluation in " new Chinese medicine guideline of clinical investigations ", clinical cure: terminate the course for the treatment of without ictal cephalagra, drug withdrawal is not fallen ill for 1 month; Effective: after treatment, integration reduces more than 50%; Effective: after treatment, integration reduces 21%-50%; Invalid: after treatment, integration reduces less than 20%.
5. model case:
Zhang, man, 29 years old, people from Guilin City, migraine recurrent exerbation more than 1 year.Based on both sides head dull pain.Follow up a case by regular visits to after taking this strong drug composition by above-mentioned administrated method and have no recurrence in 3 months.
Yang, female, 26 years old, people from Binyang County, migraine recurrent exerbation 7 months.Left side headache, in twinge sample.After taking this strong drug composition by above-mentioned administrated method, migraine disappears, and follows up a case by regular visits to and has no recurrence in 3 months.
Claims (2)
1. the migrainous strong drug composition for the treatment of, it is characterized in that: its raw material, with parts by weight, comprises Herba Diclipterae Chinensis 10 ~ 50 parts, Herba cassiae occidentalis 10 ~ 50 parts, Radix Ilicis Asprellae 10 ~ 50 parts, Radix Helicteris 10 ~ 30 parts, Fructus Xanthii 5 ~ 20 parts, chu lan tree 10 ~ 30 parts, Ramulus Uncariae Cum Uncis 6 ~ 20 parts, Herba Diclipterae Chinensis 10 ~ 30 parts, Folium Ilicis 5 ~ 20 parts, Herba Verbenae 10 ~ 30 parts.
2. one as claimed in claim 1 treats migrainous strong drug composition, it is characterized in that: the dosage form of described strong drug composition is decoction.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1850268A (en) * | 2006-03-01 | 2006-10-25 | 贵州圣泉药业有限公司 | Semen caesalpiniae Chinese medicine preparation for treating cold, its preparing method and quality control method |
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| 田兴秀主编: "《中国苗族医学》", 31 August 2013, 贵州科技出版社 * |
| 魏铁力等: "祛风活血治头痛", 《上海中医药杂志》 * |
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Application publication date: 20160330 |