CN105434692A - 一种亚麻籽油复方保健喷雾剂及制备方法 - Google Patents
一种亚麻籽油复方保健喷雾剂及制备方法 Download PDFInfo
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Abstract
本发明所述的一种亚麻籽油复方保健喷雾剂及制备方法，由亚麻籽油、蜂胶、茶籽油、藿香油为纯天然药食同源材料通过常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，利用它们的协同作用，制成促进消化营养脾胃的功能性保健食品，产品安全、无副作用，具有显著保健功效，可长期服用，具有很好的市场开发前景。
Description
技术领域
本发明提供一种亚麻籽油复方保健喷雾剂及制备方法，用于提高人体脾胃消化功能，属于保健食品技术领域。
背景技术
在我国中医理论认为脾胃为受纳升降之官，主要负责食物的消化、吸收、传送、输出，将糟粕排出体外，将气血精微物质输送到五脏六腑、四肢百骸、五官九窍、皮脉肉筋骨，以供机体活动之需。然而生活中的饮食不节、过食肥腻、忧思过度、偏食偏嗜、饥饱不均等都可能伤及脾胃。随着社会的发展和科技的进步，人们的生活条件得到很大的改善：食物的品种日益增多，人们的饮食结构也发生很大的变化。但随之而来的是，人们脾胃的负担加重，导致各种各样的脾胃问题，如脾胃虚弱、脾胃虚寒、脾胃湿热等。具体临床表现为：胃酸，胃胀，胃疼，胃焖，胃灼热，胃吵杂，胃烦躁，泛酸，吐酸，恶心，口水多，呕吐，肠鸣，肠胀气，不明原因腹泻或便秘等等。常用西药治疗，副作用大，现有的中药效果不明显。
发明内容
本发明提供一种亚麻籽油复方保健喷雾剂，促进消化营养脾胃，具有明显的临床疗效。
本发明还公开了一种亚麻籽油复方保健喷雾剂的制备方法，工艺简单、容易操作,生产成本低廉，适用于工业化生产。
本发明所述的一种亚麻籽油复方保健喷雾剂，其特征在于是由以下药物按重量份数比制成的：
亚麻籽油25~45、蜂胶10~25、茶籽油10~25、藿香油1~3。
本发明所述的一种亚麻籽油复方保健喷雾剂的制备方法，包括以下步骤：
按比例称取上述原料；亚麻籽油、茶籽油、藿香油混合调配成调和油后，再与蜂胶制成油相混合物，再按常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，即得。
【用法用量】口服；2次/日；10~15ml/次。
【适应症】脾胃虚弱、脾胃虚寒、脾胃湿热、脾胃滞胀等症；促进消化营养脾胃。
本发明的保健作用分析：
亚麻籽油：含有VE，一种强有效的自由基清除剂,有延缓衰老和抗氧化的作用。亚麻籽中含有类黄酮23mg/100g。类黄酮化合物有降血脂,抗动脉粥样硬化的良好作用。亚麻籽油中的不饱和脂肪酸的含量很高,其碘值也较高,保存时须采取添加抗氧剂或充氮密闭的办法。亚麻籽油的非皂化物为8.26%,说明在亚麻籽油中还存在数量可观的高级脂肪醇,甾醇和羟类等。亚麻籽中含丰富的矿物元素。钾含量最高,比高钾食物橙子、花生仁、虾米的含量高出很多。钾与维持人体正常血压有关,亚麻籽中锌的含量也较高,锌为人体必需的微量元素,对维持人体正常的生理功能具有重要作用。
蜂胶：含有黄酮化合物包括黄酮类、黄酮醇类和双氢黄酮类等，约占蜂胶的4.13%，具有多方面的生理和药理作用，能帮助人体防治多种疾病，使机体各种功能正常化、增强化。蜂胶中的黄酮类化合物，其品种之多、含量之高超过了一般的植物药。对治疗冠心病有效的许多中草药都含有黄酮类化合物。
茶籽油：茶籽油中不饱和脂肪酸高达90%以上，油酸达到80-83%，亚油酸达到7-13%，并富含蛋白质和维生素A、B、D、E等，尤其是它所含的丰富的亚麻酸是人体必需而又不能合成的。经测试，茶叶籽油的油酸及亚油酸含量均高于橄榄油。
藿香油：内含黄酮、有机酸、生物碱、甾醇类、三萜烯类及各种维生素等140多种生物活性成分。具有止呕吐，治霍乱腹痛，驱逐肠胃充气，清暑等作用。
本发明以亚麻籽油为主，稳定安全，具有人体免疫力和延缓衰老功能，促进消化营养脾胃，加入茶籽油、藿香油和蜂胶协同配伍增强了这种功效，上述各药相互作用，治疗脾胃虚寒、脾胃滞胀等症。通过舌下粘膜直接吸收入血液，服用方便，避免被胃酸的分解破坏，也不会被肝脏酶的代谢，保持药效同时也减轻了药物对胃肠道和肝脏的毒副作用。
通过选择160例脾胃虚弱、脾胃虚寒、脾胃湿热、脾胃滞胀等症患者作为临床观察对象，口服本发明保健品进行临床观察显示，本发明对各种因素引起的脾胃问题都具有很好的调理作用。
以下实验表明本发明的促进消化营养脾胃作用：
选择脾胃虚弱、脾胃虚寒、脾胃湿热、脾胃滞胀等症患者共200例作为临床观察对象，年龄在18-50岁之间，男、女各半。
临床表现症状：胃酸，胃胀，胃疼，胃焖，胃灼热，胃吵杂，胃烦躁，泛酸，吐酸，恶心，舌淡苔白，脉虚弱。
治疗方法：口服本发明实施例制备保健品；2次/日；10~15ml/次。
效果判断：临床表现全部消除且随访1年未复发者为痊愈；随访1年虽复发但较前减轻者为有效；其它为无效。
治疗结果：痊愈160例，占80%；有效30例，占15%；无效10例，占5%。
上述临床观察显示，本发明的药物对各种因素引起的脾胃问题都具有很好的调理作用，总有效率达95%。
以下药效试验进一步证明，本发明可促进脾虚小鼠胃肠蠕动，促进大鼠胃液分泌。临床试验表明，经常服用本发明可清火气并促进消化，具体实验如下:
1、本发明对正常小鼠胃排空及肠推进的影响
取小鼠30只，雌雄兼用，体重18~22g，按体重随机分空白对照组、亚麻籽油对照组、本发明实施例1~实施例3组；各组小鼠每日灌胃给药1次，连续3d，本发明实施例1~实施例3给药剂量为(相当于生药量)40g生药/Kg，亚麻籽油对照组40g生药/Kg，空白对照组给予相同体积生理盐水，末次给药前禁食12h，给药后2h灌胃0.04%酚红溶液(含1.5%梭甲基纤维素)0.25m1,20min处死动物，同时取出胃及小肠，将小肠平铺于白纸上。胃置于30m10.5mo1/L的NaOH溶液中，沿胃大弯剪开胃，充分洗下胃内容物，取5m1离心(3000r/min,10min)取上清液用722分光光度计于560nm比色测其吸光度，然后计算胃酚红残留率，以胃酚红残留率为指标评价胃排空速度，小肠推进率则以酚红在小肠中移行距离占小肠全长的百分比来评价。结果见表1
表1本发明对正常小鼠胃排空及肠推进的影响
结论：本发明实施例1~实施例3及亚麻籽油对照组对正常小鼠胃排空及肠推进的均有影响，并且本发明高于亚麻籽油对照组，也表明了本发明的协同作用。
2、本发明对肾上腺素负荷小鼠的胃排空及小肠推进的影响
取小鼠40只，体重18~22g，雌雄兼用，按体重随机分空白对照组、亚麻籽油对照组、本发明实施例1~实施例3组。各组小鼠每日灌胃给药1次，连续3d，亚麻籽油对照组、本发明实施例1~实施例3给药剂量为(相当于生药量)40生药·kg，空白对照组给予相同体积生理盐水，末次给药前禁食12h,给药后1.75h，除空白组外，各组小鼠皮下注射肾上腺素0.5mg/kg,15min后灌胃酚红溶液，20min后处死动物，同时取出胃及小肠，将小肠平铺于白纸上。胃置于30m10.5mo1/L的NaOH溶液中，沿胃大弯剪开胃，充分洗下胃内容物，取5m1离心(3000r/min,10min)取上清液用722分光光度计于560nm比色测其吸光度，然后计算胃酚红残留率，以胃酚红残留率为指标评价胃排空速度，小肠推进率则以酚红在小肠中的移行距离占小肠全长的百分比来评价。
结果见表2
表2本发明对肾上腺素负荷小鼠胃排空及肠推进的影响
由以上结果可知，本发明实施例1~实施例3对正常小鼠胃排空有明显促进作用，与空白对照组相比有显著性差异;对肾上腺素负荷小鼠胃排空亦有促进作用，与亚麻籽油相比有显著性差异。
3、本发明对大鼠胃液分泌的影响
取体重180~220大鼠30只，雌雄各半，按体重随机分空白对照组、亚麻籽油对照组、本发明实施例1~实施例3。各组大鼠每日灌胃给药1次，连续3d，亚麻籽油对照组、本发明实施例1~实施例3给药剂量为(相当于生药量)20生药·Kg，空白对照组给予相同体积生理盐水，末次给药前各大鼠禁食不禁水36h,给药2h后乙醚麻醉后行幽门结扎术，于十二指肠给药1次，缝合腹壁切口，覆盖伤口，3h后，拆线开腹结扎责门取胃，倾出胃内容物，离心后记录胃液总量。吸取上清液2m1，加蒸馏水20m1，加酚红指示剂2滴，用20mmol/LNaOH中和滴定，记录NaOH溶液消耗量，计算总酸度和总酸排出量，结果见表3
表3本发明对大鼠胃液分泌的影响
由上表可知，本发明实施例1~实施例3组大鼠胃液分泌量及总酸排出量增加，与空白组相比有显著性差异，与亚麻籽油相比有显著性差异。
本发明能明显促进大鼠胃酸分泌和增加胃蛋白酶活性；可增加小肠推进率，说明本发明有增加肠蠕动和促消化作用；可增加未成年小鼠体重，说明具有促进生长作用；该产品可明显增加小鼠肝组织中RNA和DNA及蛋白含量，说明本品具有促进小鼠肝核酸、蛋白质合成和促生长的作用。
本发明的积极效果在于：亚麻籽油、蜂胶、茶籽油、藿香油为纯天然药食同源材料，利用它们的协同作用，制成促进消化营养脾胃的功能性保健食品，产品安全、无副作用，具有显著保健功效，可长期服用，具有很好的市场开发前景。
具体实施方式
通过以下实施例进一步举例描述本发明，并不以任何方式限制本发明，在不背离本发明的技术解决方案的前提下，对本发明所作的本领域普通技术人员容易实现的任何改动或改变都将落入本发明的权利要求范围之内。
实施例1
称取亚麻籽油25g、茶籽油10g、藿香油3g混合调配成调和油后，再与蜂胶10g制成油相混合物，再按常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，即得。
实施例2
称取亚麻籽油35g、茶籽油15g、藿香油4g混合调配成调和油后，再与15g蜂胶制成油相混合物，再按常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，即得。
实施例3
称取亚麻籽油45g、茶籽油25g、藿香油5g混合调配成调和油后，再与蜂胶25克制成油相混合物，再按常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，即得。
Claims (3)
1.一种亚麻籽油复方保健喷雾剂，其特征在于是由以下药物按重量份数比制成的：
亚麻籽油25~45、蜂胶10~25、茶籽油10~25、藿香油3~5。
2.权利要求1所述的一种亚麻籽油复方保健喷雾剂的制备方法，包括以下步骤：
按比例称取上述原料；亚麻籽油、茶籽油、藿香油混合调配成调和油后，再与蜂胶制成油相混合物，再按常规的口腔喷雾剂制备方法添加辅料制成口腔喷雾剂，即得。
3.权利要求1所述的亚麻籽油复方保健喷雾剂在促进消化营养脾胃的医用用途。
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101091708A (zh) * | 2006-06-22 | 2007-12-26 | 沈阳东宇药业有限公司 | 一种降血脂的组合物及其制备方法 |
| CN101278994A (zh) * | 2007-04-06 | 2008-10-08 | 王洪飞 | 青刺果口腔护理软胶囊 |
| US20130089618A1 (en) * | 2011-10-06 | 2013-04-11 | Peggy Mary Miller | Linseed Salve |
| CN103689129A (zh) * | 2013-12-05 | 2014-04-02 | 明光市鸿远油脂有限公司 | 一种具有化湿醒脾功效的保健芝麻油 |
| CN104288345A (zh) * | 2013-07-15 | 2015-01-21 | 湘北威尔曼制药股份有限公司 | 一种辅助降血脂的中药组合物及其制备方法 |
| US20150056312A1 (en) * | 2004-04-15 | 2015-02-26 | Woodstream Corporation | Insecticidal compositions and methods of using same |
| CN104705544A (zh) * | 2013-12-13 | 2015-06-17 | 明光市昊昊蜂业有限公司 | 一种蜂胶保健品 |
-
2015
- 2015-12-30 CN CN201511007617.7A patent/CN105434692A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150056312A1 (en) * | 2004-04-15 | 2015-02-26 | Woodstream Corporation | Insecticidal compositions and methods of using same |
| CN101091708A (zh) * | 2006-06-22 | 2007-12-26 | 沈阳东宇药业有限公司 | 一种降血脂的组合物及其制备方法 |
| CN101278994A (zh) * | 2007-04-06 | 2008-10-08 | 王洪飞 | 青刺果口腔护理软胶囊 |
| US20130089618A1 (en) * | 2011-10-06 | 2013-04-11 | Peggy Mary Miller | Linseed Salve |
| CN104288345A (zh) * | 2013-07-15 | 2015-01-21 | 湘北威尔曼制药股份有限公司 | 一种辅助降血脂的中药组合物及其制备方法 |
| CN103689129A (zh) * | 2013-12-05 | 2014-04-02 | 明光市鸿远油脂有限公司 | 一种具有化湿醒脾功效的保健芝麻油 |
| CN104705544A (zh) * | 2013-12-13 | 2015-06-17 | 明光市昊昊蜂业有限公司 | 一种蜂胶保健品 |
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