CN105412905A - Medical foam disinfector long in bacteriostatic time and preparation method thereof - Google Patents
Medical foam disinfector long in bacteriostatic time and preparation method thereof Download PDFInfo
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- CN105412905A CN105412905A CN201510911768.9A CN201510911768A CN105412905A CN 105412905 A CN105412905 A CN 105412905A CN 201510911768 A CN201510911768 A CN 201510911768A CN 105412905 A CN105412905 A CN 105412905A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a medical foam disinfectant long in bacteriostatic time. The medical foam disinfectant is prepared from chlorhexidine acetate, water-soluble alpha-terpineol, a plantain extract, glycerin, grape seed essential oil, a fibroin peptide, a poria cocos extract, a sanguisorba extract, moxa leaf oil, glycine betaine cocoate, tocopherol and lavender essential oil. The invention further provides a preparation method of the disinfectant. The prepared foam disinfectant is used for disinfecting the hand skin of a user, the escherichia coli killing rate is up to 99.7-100% within 15 seconds, the staphylococcus aureus killing rate is up to 99.6-99.999%, the pseudomonas aeruginosa killing rate is up to 99.97-99.999%, the mycobacterium tuberculosis killing rate is up to 99.1-99.9%, the influenza virus killing rate is up to 98.4-99.8%, the candida albicans killing rate is up to 99.8-99.999%, the medical foam disinfectant is long in bacteriostatic time, is used for skin wounds, promotes wound healing and improves the wound healing rate.
Description
Technical field
The present invention relates to medical foam disinfectant of a kind of antibacterial time length and preparation method thereof, belong to foamaseptic technical field.
Background technology
Medical antiseptic solution, need great broad-spectrum antibacterial, bactericidal action, hospital's dealing every day flow of the people is larger, patient, medical worker and family members are in working, in the processes such as medical and inspection, contact with each other chance more, the quantity of hand antibacterial can constantly increase, if effectively disinfect not in time, the probability of bacteria infection is very large, especially for surgical staff, the preoperative hand disinfection that carries out is for the hospital infection preventing patient with operation, and cause thus cause a disease, lethal etc. play vital effect, therefore, strong to Medical antiseptic solution demand fulfillment bacteriostasis, the feature that bactericidal range is wide, because the time of operation needs, medical disinfectant, also needs the effect meeting long-acting bacteriostatic.
The technical problem that existing disinfectant or disinfectant solution exist is summarized as follows:
(1) antibacterial kind is single, all cannot play sterilization functions to antibacterial, fungus, virus simultaneously;
(2) the antibacterial time is short;
(3) having certain stimulation to hand skin, use repeatedly, there is dry, decortication phenomenon in skin;
(4) function singleness.
Summary of the invention
For solving the technical problem existed in prior art, the invention provides medical foam disinfectant of a kind of antibacterial time length and preparation method thereof, to realize following goal of the invention:
(1) foamaseptic prepared of the present invention, carries out disinfection to people's hand skin, reaches 99.7-100% in 15s to colibacillary killing rate; 99.6-99.999% is reached to staphylococcus aureus killing rate; 99.97-99.999% is reached to Pseudomonas aeruginosa killing rate; 99.1-99.9% is reached to tubercule bacillus killing rate; Infected by influenza killing rate reaches 98.4-99.8%; 99.8-99.999% is reached to Candida albicans killing rate;
(2) foamaseptic prepared of the present invention, the antibacterial time is long, compares and makes merely to disinfect in alcohol, and its antibacterial timeliness increases 2.7-3.4 doubly; After 12 hours, 90.4-95.2% is reached to colibacillary suppression ratio; 85.4-94.9% is reached to staphylococcus aureus suppression ratio; 88.4-93.2% is reached to P. aeruginosa suppression ratio; 90.1-92.9% is reached to tubercule bacillus suppression ratio; Infected by influenza suppression ratio reaches 84.5-90.9%; 89.2-93.7% is reached to Candida albicans suppression ratio;
(3) foamaseptic prepared of the present invention, non-stimulated to hand skin, has skin care, increases the effect of moisture of skin;
(4) disinfectant of the present invention, for skin injury, promotes wound healing, improves wound healing rate.
for solving above technical problem, the technical scheme that the present invention takes is as follows:
The medical foam disinfectant that the antibacterial time is long, comprises chlorhexidine acetate, water solublity alpha-terpineol, Herba Plantaginis extract, glycerol, Semen Vitis viniferae quintessence oil, fibroin peptide, Poria extract, Radix Sangusorbae extract, Oleum Folium Artemisiae Argyi, coco-betaine, tocopherol, Herba Lysimachiae foenum-graeci quintessence oil.
Below the further improvement to technique scheme:
In weight content, each raw material comprises: chlorhexidine acetate 0.2-0.7%, water solublity alpha-terpineol 0.6-2.0%, Herba Plantaginis extract 7-10%, glycerol 15-19%, Semen Vitis viniferae quintessence oil 2-5%, fibroin peptide 3-6%, Poria extract 5-8%, Radix Sangusorbae extract 6-8%, Oleum Folium Artemisiae Argyi 2-4.5%, emulsifying agent 0.2-0.5%, coco-betaine 2-3.1%, tocopherol 1-2%, Herba Lysimachiae foenum-graeci quintessence oil 2.0-3.5%, surplus are deionized water.
Described Poria extract is buff powder, and pachyman content is 45%, moisture < 4%, ash < 7%, fineness 100 order.
Described Radix Sangusorbae extract, granularity is 200 orders, containing tannin 17%, containing triterpene saponin 3.5%, Quercetin 2.5%.
Described Herba Plantaginis extract, the content of aucubin is 98%.
Described Oleum Folium Artemisiae Argyi, the index of refraction of 25 DEG C is the relative density of 1.4680,25 DEG C is 0.90, and the content of Folium Artemisiae Argyi alcohol is 99.0wt%.
Described fibroin peptide, molecular weight is 700, pH value 6, Glycine Levels 40wt%, alanine content 20wt%, serine content 25wt%.。
The preparation method of the medical foam disinfectant that a kind of antibacterial time is long, comprise dissolving, described dissolving, chlorhexidine acetate, fibroin peptide, Radix Sangusorbae extract, Oleum Folium Artemisiae Argyi, tocopherol are joined in glycerol, speed of agitator is 600r/ minute, is heated to 45 DEG C, is incubated 20 minutes, add Semen Vitis viniferae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, mixing, obtain A liquid.
Described dissolving, adds in deionized water by water solublity alpha-terpineol, Herba Plantaginis extract, Poria extract, and speed of agitator is 800r/ minute, and temperature is 35 DEG C, is incubated 15 minutes, obtains B liquid.
Described method, comprises mixing, described mixing, B liquid is slowly joined in A liquid, rate of addition is 80g/ minute, and temperature is 40 DEG C, and speed of agitator is 850r/ minute, after dropwising, add emulsifying agent, coco-betaine, rotating speed is 1200r/ minute, stirs 10 minutes, leave standstill, obtain foamaseptic of the present invention.
compared with prior art, beneficial effect of the present invention is:
(1) foamaseptic prepared of the present invention, carries out disinfection to people's hand skin, reaches 99.7-100% in 15s to colibacillary killing rate; 99.6-99.999% is reached to staphylococcus aureus killing rate; 99.97-99.999% is reached to Pseudomonas aeruginosa killing rate; 99.1-99.9% is reached to tubercule bacillus killing rate; Infected by influenza killing rate reaches 98.4-99.8%; 99.8-99.999% is reached to Candida albicans killing rate;
(2) foamaseptic prepared of the present invention, the antibacterial time is long, compares and makes merely to disinfect in alcohol, and its antibacterial timeliness increases 2.7-3.4 doubly; After 12 hours, be 90.4-95.2% to colibacillary suppression ratio; Be 85.4-94.9% to staphylococcus aureus suppression ratio; Be 88.4-93.2% to P. aeruginosa suppression ratio; Be 90.1-92.9% to tubercule bacillus suppression ratio; Infected by influenza suppression ratio is 84.5-90.9%; Be 89.2-93.7% to Candida albicans suppression ratio;
(3) foamaseptic prepared of the present invention, non-stimulated to hand skin, there is skin care, increase the effect of moisture of skin, after 100 people use product of the present invention 20 times, all do not occur xerosis cutis, allergy, the symptom such as dry and cracked, and moisture of skin increases by more than 5%, skin smooth, moisten, have 97 people, moisture of skin, smoothness, to moisten degree be 3 people without significant change;
(4) disinfectant of the present invention, for skin injury, promotes wound healing, improve wound healing rate, 3d after medication, wound healing rate is 5.75-5.96%, 5d after medication, wound healing rate is 18.4-20.9%, 7d after medication, and wound healing rate is 42.1-43.8%, 10d after medication, wound healing rate is 73.2-75.6%, 14d after medication, and wound healing rate is 98.3-99.4%.
Detailed description of the invention
Below the preferred embodiments of the present invention are described, should be appreciated that preferred embodiment described herein is only for instruction and explanation of the present invention, is not intended to limit the present invention.
the medical foam disinfectant that the embodiment 1 one kinds antibacterial time is long
in weight content, comprise following component:
Chlorhexidine acetate 0.3%, water solublity alpha-terpineol 2%, Herba Plantaginis extract 7%, glycerol 15%, Semen Vitis viniferae quintessence oil 2%, fibroin peptide 3%, Poria extract 5%, Radix Sangusorbae extract 6%, Oleum Folium Artemisiae Argyi 2%, emulsifying agent 0.2%, coco-betaine 2%, tocopherol 1%, Herba Lysimachiae foenum-graeci quintessence oil 2%, surplus are deionized water.
Described Poria extract, buff powder, pachyman content is 45%, moisture < 4%, ash < 7%, fineness 100 order,
Described Radix Sangusorbae extract, powder, granularity is 200 orders, containing tannin 17%, containing triterpene saponin 3.5%, Quercetin 2.5%.
Described Herba Plantaginis extract, the content of aucubin is 98%.
Described emulsifying agent, be the mixture of op-10 and trimethyl silicane alkoxy silane ester, mass ratio is 2:1;
Described Oleum Folium Artemisiae Argyi, the index of refraction of 25 DEG C is the relative density of 1.4680,25 DEG C is 0.90, and the content of Folium Artemisiae Argyi alcohol is 99.0wt%;
Described fibroin peptide, molecular weight is 700, pH value 6, Glycine Levels 40wt%, alanine content 20wt%, serine content 25wt%.；
Described Semen Vitis viniferae quintessence oil, in weight content, comprises Palmic acid 8.28%, stearic acid 2.34%, oleic acid 16%, linoleic acid 66%;
Described Herba Lysimachiae foenum-graeci quintessence oil is light yellow working fluid, and 20 DEG C of relative densities are 0.895,20 DEG C of refraction indexs is 1.4620, and linalool content is 40%, and linalyl acetate content is 35%;
Described water solublity alpha-terpineol, mass percentage is 89%, and relative density is 0.925, and refraction coefficient is 1.495.
the medical foam disinfectant that the embodiment 2 one kinds antibacterial time is long
each raw material, with embodiment 1, only changes the proportioning of each raw material, as follows:
in weight content, comprise following raw material components:
Chlorhexidine acetate 0.5%, water solublity alpha-terpineol 1.0%, Herba Plantaginis extract 8%, glycerol 17%, Semen Vitis viniferae quintessence oil 3%, fibroin peptide 4%, Poria extract 7%, Radix Sangusorbae extract 7%, Oleum Folium Artemisiae Argyi 3.4%, emulsifying agent 0.4%, coco-betaine 2.5%, tocopherol 1.2%, Herba Lysimachiae foenum-graeci quintessence oil 2.8%, surplus are deionized water.
the medical foam disinfectant that the embodiment 3 one kinds antibacterial time is long
each raw material, with embodiment 1, only changes the proportioning of each raw material, as follows:
in weight content, comprise following raw material components:
Chlorhexidine acetate 0.7%, water solublity alpha-terpineol 1.0%, Herba Plantaginis extract 10%, glycerol 19%, Semen Vitis viniferae quintessence oil 5%, fibroin peptide 6%, Poria extract 8%, Radix Sangusorbae extract 8%, Oleum Folium Artemisiae Argyi 4.5%, emulsifying agent 0.5%, coco-betaine 3.1%, tocopherol 2%, Herba Lysimachiae foenum-graeci quintessence oil 3.5%, surplus are deionized water.
the preparation method of the medical foam disinfectant that the embodiment 4 one kinds antibacterial time is long
(1) weigh
According to formula, take each raw material components;
(2) dissolve
Join in glycerol by chlorhexidine acetate, fibroin peptide, Radix Sangusorbae extract, Oleum Folium Artemisiae Argyi, tocopherol, speed of agitator is 600r/ minute, is heated to 45 DEG C, is incubated 20 minutes, adds Semen Vitis viniferae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, mixing, obtain A liquid;
Add in deionized water by water solublity alpha-terpineol, Herba Plantaginis extract, Poria extract, speed of agitator is 800r/ minute, and temperature is 35 DEG C, is incubated 15 minutes, obtains B liquid;
(3) mix
Slowly joined by B liquid in A liquid, rate of addition is 80g/ minute, and temperature is 40 DEG C, and speed of agitator is 850r/ minute, after dropwising, add emulsifying agent, coco-betaine, rotating speed is 1200r/ minute, stir 10 minutes, leave standstill, obtain foamaseptic of the present invention.
the effect test of disinfectant solution prepared by embodiment 5 the present invention
Disinfectant solution prepared by the present invention is liquid, includes 40-45%(volume ratio) foam, sterilization evenly, lastingly.
(1) foamaseptic prepared of the present invention, carries out disinfection to people's hand skin, reaches 99.7-100% in 15s to colibacillary killing rate; 99.6-99.999% is reached to staphylococcus aureus killing rate; 99.97-99.999% is reached to Pseudomonas aeruginosa killing rate; 99.1-99.9% is reached to tubercule bacillus killing rate; Infected by influenza killing rate reaches 98.4-99.8%; 99.8-99.999% is reached to Candida albicans killing rate;
The killing effect of table 1 pair antibacterial, fungus, virus
(2) foamaseptic prepared of the present invention, the antibacterial time is long, compares and makes merely to disinfect in alcohol, and its antibacterial timeliness increases 2.7-3.4 doubly; After 12 hours, 90.4-95.2% is reached to colibacillary suppression ratio; 85.4-94.9% is reached to staphylococcus aureus suppression ratio; 88.4-93.2% is reached to P. aeruginosa suppression ratio; 90.1-92.9% is reached to tubercule bacillus suppression ratio; Infected by influenza suppression ratio reaches 84.5-90.9%; 89.2-93.7% is reached to Candida albicans suppression ratio;
The fungistatic effect of table 2 foamaseptic of the present invention after 12 hours
(3) foamaseptic prepared of the present invention, non-stimulated to hand skin, there is skin care, increase the effect of moisture of skin, after 100 people use product of the present invention 20 times, all do not occur xerosis cutis, allergy, the symptom such as dry and cracked, and moisture of skin increases by more than 5%, skin smooth, moisten, have 97 people, moisture of skin, smoothness, to moisten degree be 3 people without significant change.
(4) foamaseptic prepared of the present invention, for wound, has the effect promoting wound healing,
Test method is: healthy white rabbit, body weight 2.0 ~ 2.5kg, male and female are regardless of, by the hair of family rabbit back 3cm × 3cm, then with the sodium sulfide of 8%, hair is to the greatest extent de-, after routine disinfection, with 2% lignocaine local anesthesia, the skin holostrome of excision diameter 2cm × 2cm 1 piece, every only all have 2 wounds, causes surgical wound model.
Administering mode: after cleaning with distilled water, disinfectant of the present invention is sprayed directly on to skin wound surface, after dry, by animal sub-cage rearing, every day timed drug administrations once, model group not administration.
Observation index: (1) wound surface area and Wound healing rate.After administration, the 3rd, 5,7,10,14d measuring the maximum major diameter on skin wound surface and wide footpath with ruler, after there is epithelium, the edge of creeping with epithelium is for boundary is for measuring.Calculate: wound area=maximum major diameter × to large wide footpath; Wound healing rate=(original area-do not heal area)/original area/100%.
The standard of curative effect evaluation: (1) fully recovers: wound surface epithelium covers completely, without cicatrix.(2) effective: wound surface reduces 75%, granulation tissue is fresh, remission.(3) take a turn for the better: wound surface 25%, granulation tissue comparatively fresh, symptom is improved.(4) invalid: though wound surface is comparatively front fresh, to reduce less than 25% granulation growth seldom.
Table 3 disinfectant of the present invention is to the effect of wound wound healing rate
Upon administration the 2nd, 3,4,6,7,8,15d, observe wound infection, start to form a scab, form a scab completely, decrustation completely, new epithelize time of occurrence and the healing state of recovery time etc. completely, in table 4.
The effect that table 4 disinfectant of the present invention forms a scab to trauma wounds
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the medical foam disinfectant that the antibacterial time is long, is characterized in that: comprise chlorhexidine acetate, water solublity alpha-terpineol, Herba Plantaginis extract, glycerol, Semen Vitis viniferae quintessence oil, fibroin peptide, Poria extract, Radix Sangusorbae extract, Oleum Folium Artemisiae Argyi, coco-betaine, tocopherol, Herba Lysimachiae foenum-graeci quintessence oil.
2. the medical foam disinfectant that a kind of antibacterial time according to claim 1 is long, it is characterized in that: in weight content, each raw material comprises: chlorhexidine acetate 0.2-0.7%, water solublity alpha-terpineol 0.6-2.0%, Herba Plantaginis extract 7-10%, glycerol 15-19%, Semen Vitis viniferae quintessence oil 2-5%, fibroin peptide 3-6%, Poria extract 5-8%, Radix Sangusorbae extract 6-8%, Oleum Folium Artemisiae Argyi 2-4.5%, emulsifying agent 0.2-0.5%, coco-betaine 2-3.1%, tocopherol 1-2%, Herba Lysimachiae foenum-graeci quintessence oil 2.0-3.5%, surplus are deionized water.
3. the medical foam disinfectant that a kind of antibacterial time according to claim 2 is long, it is characterized in that: described Poria extract, is buff powder, pachyman content is 45%, moisture < 4%, ash < 7%, fineness 100 order.
4. the medical foam disinfectant that a kind of antibacterial time according to claim 2 is long, it is characterized in that: described Radix Sangusorbae extract, granularity is 200 orders, containing tannin 17%, containing triterpene saponin 3.5%, Quercetin 2.5%.
5. the medical foam disinfectant that a kind of antibacterial time according to claim 2 is long, it is characterized in that: described Herba Plantaginis extract, the content of aucubin is 98%.
6. the medical foam disinfectant that a kind of antibacterial time according to claim 2 is long, is characterized in that: described Oleum Folium Artemisiae Argyi, and the index of refraction of 25 DEG C is the relative density of 1.4680,25 DEG C is 0.90, and the content of Folium Artemisiae Argyi alcohol is 99.0wt%.
7. the medical foam disinfectant that a kind of antibacterial time according to claim 2 is long, it is characterized in that: described fibroin peptide, molecular weight is 700, pH value 6, Glycine Levels 40wt%, alanine content 20wt%, serine content 25wt%.
8. the preparation method of the medical foam disinfectant of an antibacterial time length, it is characterized in that: comprise dissolving, described dissolving, chlorhexidine acetate, fibroin peptide, Radix Sangusorbae extract, Oleum Folium Artemisiae Argyi, tocopherol are joined in glycerol, speed of agitator is 600r/ minute, is heated to 45 DEG C, is incubated 20 minutes, add Semen Vitis viniferae quintessence oil, Herba Lysimachiae foenum-graeci quintessence oil, mixing, obtain A liquid.
9. the preparation method of the medical foam disinfectant that a kind of antibacterial time according to claim 8 is long, it is characterized in that: described dissolving, water solublity alpha-terpineol, Herba Plantaginis extract, Poria extract are added in deionized water, speed of agitator is 800r/ minute, temperature is 35 DEG C, be incubated 15 minutes, obtain B liquid.
10. the preparation method of the medical foam disinfectant that a kind of antibacterial time according to claim 8 is long, is characterized in that: comprise mixing, described mixing, B liquid is slowly joined in A liquid, rate of addition is 80g/ minute, and temperature is 40 DEG C, and speed of agitator is 850r/ minute, after dropwising, add emulsifying agent, coco-betaine, rotating speed is 1200r/ minute, stirs 10 minutes, leave standstill, obtain foamaseptic of the present invention.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510911768.9A CN105412905A (en) | 2015-12-11 | 2015-12-11 | Medical foam disinfector long in bacteriostatic time and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510911768.9A CN105412905A (en) | 2015-12-11 | 2015-12-11 | Medical foam disinfector long in bacteriostatic time and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1182927A1 (en) * | 1999-05-19 | 2002-03-06 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
| CN104208107A (en) * | 2014-08-14 | 2014-12-17 | 广东省食品工业研究所 | Poria cocos extract, and preparation method and application thereof |
| CN104207970A (en) * | 2014-03-21 | 2014-12-17 | 郭健 | Medical skin-care disinfection hand-cleaning liquid and preparation method thereof |
-
2015
- 2015-12-11 CN CN201510911768.9A patent/CN105412905A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1182927A1 (en) * | 1999-05-19 | 2002-03-06 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
| CN104207970A (en) * | 2014-03-21 | 2014-12-17 | 郭健 | Medical skin-care disinfection hand-cleaning liquid and preparation method thereof |
| CN104208107A (en) * | 2014-08-14 | 2014-12-17 | 广东省食品工业研究所 | Poria cocos extract, and preparation method and application thereof |
Non-Patent Citations (3)
| Title |
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| 孔阳等: "车前草提取物抗菌活性的研究", 《中国酿造》 * |
| 张鹏等: "艾叶油作为天然抗菌剂的研究进展", 《广东化工》 * |
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