CN108420829B - Detumescence granulation promoting paste for pets - Google Patents

Abstract

The invention belongs to the technical field of external ointment, and particularly relates to swelling-diminishing and tissue-regeneration-promoting ointment for pets and a preparation method thereof. The swelling-diminishing and tissue-regeneration-promoting paste is prepared from the following raw materials: 10-15g of vaseline, 0.25-0.5g of erythromycin powder, 5-8mL of 1% iodine tincture, 3-5g of slaked lime and 5-10g of borneol. The swelling-diminishing and tissue-regeneration-promoting ointment is prepared by mixing borneol, erythromycin, slaked lime and 1% iodine tincture according to a certain proportion, taking vaseline as a matrix, enabling the borneol to fully exert the pain-relieving and tissue-promoting effects of the borneol, enabling the slaked lime to exert the putrefaction-removing and convergence effects of the slaked lime, and enabling the iodine tincture and the erythromycin to inhibit bacteria and diminish inflammation, and is prepared into an ointment for applying suppurative wounds, wherein the raw materials are mutually matched to generate a synergistic effect.

Description

Detumescence granulation promoting paste for pets

Technical Field

The invention belongs to the technical field of external ointment, and particularly relates to swelling-diminishing and tissue-regeneration-promoting ointment for pets and a preparation method thereof.

Background

The wounds of the pets are caused by a plurality of reasons, and the pets are all suppurative and wounded due to the reasons of putting a frame between the pets and biting, postoperative infection, suppuration and wound, sharp object scratch and the like. The self-nursing cognitive abilities of dogs and cats are poor, wounds are often scratched and licked seriously by the pets, the untimely treatment of the wounds can cause important influences on various aspects of life such as appetite and actions of the pets, if the large-area suppurative infection is not treated in time, bacteremia and even septicemia can be formed, and the life is threatened, so that good medicines are needed for treatment.

It can be found that only the literature of using external ointment to cure animal trauma is Zhang Wen Jian, Su Qing Ping with trauma No. 1 to cure injured horses, Song Jade and self-made trauma medicine to cure male mules impacted by the tractor to shoulder blades, all three people use camphor, rhubarb and white sugar in certain proportion to make "trauma No. 1" to paint on the trauma of big livestock, there is a few literature of using external ointment to cure suppurative trauma of pets, and the patents of related internal ointment are few.

Chinese patent with application number 201210271976.3 discloses a compound neomycin sulfate composition for treating pet suppurative sore and a preparation method thereof, wherein the composition is prepared by uniformly mixing the following components in parts by weight: 1-3 parts of neomycin sulfate, 3-5 parts of erythromycin thiocyanate, 1-2 parts of trimethoprim lactate, 1-3 parts of hexadecyl trimethylammonium bromide, 3-5 parts of menthol, 50-70 parts of liquid paraffin, 7-9 parts of glycerol, 0.4 part of ethylparaben, 1-3 parts of essence, 80-113 parts of distilled water and the like. The invention has the beneficial effects that: the formula is reasonable, the preparation is simple, the curative effect is very obvious, and clinical application proves that the traditional Chinese medicine composition has special effect on treating pet suppurative sore. However, the composition has more related components, and the clinical medication principle of the antibacterial drug is violated, namely: infection can be controlled by an anti-infective agent without the need for combinations. In addition, the organism is very easy to generate drug resistance to neomycin and sulfonamide synergists, neomycin sulfate in the patent is the most toxic to aminoglycoside drugs, and the sulfonamide synergists are easy to cause folic acid uptake obstacle of young animals and are used with caution.

The Chinese patent with the application number of 201310316508.8 discloses a compound medicine for treating wounds which are difficult to heal, various wounds and suppurative diseases. Mainly comprises ascorbic acid, riboflavin, dragon's blood, stone honey, erythromycin, pseudo-ginseng and borneol. The wound disinfectant is mainly used for sterilizing and disinfecting wounds of multiple wounds such as abscesses, ulcers and incised wounds and removing pollutants, and can effectively accelerate wound healing. However, the components related to the compound medicine, such as dragon's blood, are expensive; the effect of ascorbic acid on skin ulcer is undetermined, ascorbic acid is an acidic drug, is not suitable to be combined with a basic drug riboflavin, and can influence mutual drug effect, and the ascorbic acid and erythromycin have obvious incompatibility in clinical intravenous medication.

Disclosure of Invention

The invention aims to provide swelling-diminishing and tissue-promoting paste for pets and a preparation method thereof, aiming at the defects of the prior art. The swelling-diminishing and tissue-regeneration-promoting ointment is prepared by mixing borneol, erythromycin, slaked lime and 1% iodine tincture according to a certain proportion, taking vaseline as a matrix, enabling the borneol to fully exert the pain-relieving and tissue-promoting effects of the borneol, enabling the slaked lime to exert the putrefaction-removing and convergence effects of the slaked lime, and enabling the iodine tincture and the erythromycin to inhibit bacteria and diminish inflammation, and is prepared into an ointment for applying suppurative wounds, wherein the raw materials are mutually matched to generate a synergistic effect.

In order to realize the purpose of the invention, the following technical scheme is adopted:

the swelling-diminishing and tissue-regeneration-promoting paste for the pets is prepared from the following raw materials: 10-15g of vaseline, 0.25-0.5g of erythromycin powder (equivalent to 25-50 ten thousand units), 5-8mL of 1% iodine tincture, 3-5g of slaked lime and 5-10g of borneol.

A method for preparing the detumescence myogenic ointment for pets comprises the following steps:

(1) grinding slaked lime into powder in a mortar for later use;

(2) grinding Borneolum Syntheticum into powder;

(3) and (2) placing vaseline in a clean container, adding the prepared slaked lime powder, borneol powder, erythromycin powder and 1% iodine tincture into the vaseline, fully stirring, and filling into a sealed bottle for later use.

The detumescence granulation promoting ointment has reasonable formula, vaseline is used as the matrix of the traditional Chinese medicine ointment, the chemical property is relatively stable, no incompatibility exists, the release property and the penetrability of the contained medicine are ideal, no irritation or allergy exists, the process for preparing the ointment is simple, and the operation is easy.

The slaked lime has the functions of drying, stopping bleeding, astringing to remove the necrotic tissue, relieving pain, sterilizing, diminishing inflammation and the like, and is economical and convenient.

Iodine has strong bactericidal action, is effective to fungi, protozoon, virus and bacterial spore, has direct and reliable local use effect, and iodine tincture is used as a medicine which is effective, economical and wide in application.

Erythromycin has strong antibacterial activity on gram-positive bacteria, has inhibiting effect on some gram-negative bacteria, spirochetes, mycoplasma pneumoniae, rickettsia, chlamydia and the like, and has particularly good effect on diseases infected by staphylococcus or streptococcus.

Borneol is a common adjuvant drug in traditional Chinese medicine, and the traditional Chinese medicine believes that the borneol has the effects of inducing resuscitation, refreshing mind, clearing heat, relieving pain and promoting tissue regeneration; the modern medicine considers that the borneol has the effects of resisting inflammation, easing pain, resisting bacteria and viruses, protecting heart and brain, bidirectionally regulating nervous system, improving the biological utilization of other medicines and the like, and the analgesic effect is more obvious than the anti-inflammatory effect; the borneol can promote the medicine to penetrate through a biological membrane barrier so as to achieve the optimal absorption and distribution of the medicine in the organism, and in clinical application, the dosage of other medicines can be reduced, the medicine effect is increased, and the medicine toxicity and side effects are reduced; borneol is bitter in property, slightly cold and cool in property, is applied to the compatibility of traditional Chinese medicines for treating diseases from old times, particularly has stronger bacteriostatic action on staphylococcus aureus and other bacteria, and has the strongest antibacterial activity of oil. The "Ben Cao Yan Yi" considers that its action characteristics are "weak in one trip and active in assistant and guide".

The invention has the beneficial effects that:

the swelling-diminishing and granulation-promoting ointment is prepared by mixing borneol, erythromycin, slaked lime and 1% iodine tincture according to a certain proportion, taking vaseline as a matrix, enabling the borneol to fully exert the pain-relieving and granulation-promoting effects of the borneol, enabling the slaked lime to exert the putrefaction-removing and convergence effects of the slaked lime, and enabling the iodine tincture and the erythromycin to inhibit bacteria and diminish inflammation. The detumescence and granulation promoting ointment has the advantages of simple formula, convenient material acquisition, low price of each medicine, complete preparation, preservation at normal temperature, no difference in clinical application effect and accordance with clinical medication guidelines of veterinarians in China.

Drawings

FIG. 1 is the operation of debridement before applying the swelling-reducing and granulation-promoting ointment prepared in example 2;

FIG. 2 is a diagram of the effect of applying the swelling-diminishing and tissue-promoting ointment for 5 days;

FIG. 3 is the acquired effect chart of applying swelling-eliminating granulation-promoting ointment 9;

fig. 4 is a picture of the complete healing after applying detumescence granulation promoting ointment for 15 days.

Detailed Description

For further disclosure, but not limitation, the present invention is described in further detail below with reference to examples.

Example 1

The swelling-diminishing and tissue-regeneration-promoting paste for the pets is prepared from the following raw materials: 10g of vaseline, 0.5g of erythromycin powder, 5mL of 1% iodine tincture, 5g of slaked lime and 5g of borneol.

The preparation method of the external ointment comprises the following steps:

(1) grinding slaked lime into powder in a mortar for later use;

(2) grinding Borneolum Syntheticum into powder;

(3) and (2) placing vaseline in a clean container, adding the prepared slaked lime powder, borneol powder, erythromycin powder and 1% iodine tincture into the vaseline, fully stirring, and filling into a sealed bottle for later use.

Example 2

The swelling-diminishing and tissue-regeneration-promoting paste for the pets is prepared from the following raw materials: 12g of vaseline, 0.35g of erythromycin powder, 6mL of 1% iodine tincture, 4g of slaked lime and 8g of borneol.

The preparation method of the external ointment comprises the following steps:

(1) grinding slaked lime into powder in a mortar for later use;

(2) grinding Borneolum Syntheticum into powder;

(3) and (2) placing vaseline in a clean container, adding the prepared slaked lime powder, borneol powder, erythromycin powder and 1% iodine tincture into the vaseline, fully stirring, and filling into a sealed bottle for later use.

Example 3

The swelling-diminishing and tissue-regeneration-promoting paste for the pets is prepared from the following raw materials: 15g of vaseline, 0.25g of erythromycin powder, 8mL of 1% iodine tincture, 3g of slaked lime and 10g of borneol.

The preparation method of the external ointment comprises the following steps:

(1) grinding slaked lime into powder in a mortar for later use;

(2) grinding Borneolum Syntheticum into powder;

(3) and (2) placing vaseline in a clean container, adding the prepared slaked lime powder, borneol powder, erythromycin powder and 1% iodine tincture into the vaseline, fully stirring, and filling into a sealed bottle for later use.

Examples of formulations according to the invention are given below:

clinical curative effect observation of more than 100 cases of dogs and cats suffering from trauma, suppuration, wound and the like is carried out by the swelling-diminishing and tissue-regeneration-promoting ointment prepared in example 2 in the Mollier pet hospital in Sanming City, Fujian province, and the like, so that good healing effect is obtained.

One typical case is now described as follows:

after four young cats are born in an Anna cat, 3 years old, female, 5 months old in 2018, because nursing care is not enough for the female cat and nursing care is not enough for the young cats, the mammary gland of the female cat is caked, the mammary gland is inflamed and swollen, finally, the mammary gland of the female cat is ruptured in a large area, and two pairs of breast heads on the right side of the mammary gland are ruptured (as shown in figure 1). The treatment method comprises the following steps:

after blood biochemical and blood routine examination, anaesthetizing, shaving the skin of an affected part, thoroughly cleaning the wound surface, scraping clean the suppurative necrosis area by using a surgical scissors matched with a blade until the fresh wound surface is exposed, and uniformly coating the detumescence and granulation promoting ointment with the thickness of about 1-2mm on all the wound surfaces after the wound surfaces are washed clean because the ulcerated area is very large and a suture operation cannot be adopted. The Elizabeth ring is worn by a sick cat to prevent the sick cat from licking a wound, the antiphlogistic drug Kutkuo and the Kotken are injected subcutaneously for five consecutive days, the wound part is cleaned every 3 days, the detumescence granulation promoting ointment is smeared, and the wound surface is healed in a large area after four times of dressing change (as shown in figure 2, figure 3 and figure 4).

The above description is only a preferred embodiment of the present invention, and all equivalent changes and modifications made in accordance with the claims of the present invention should be covered by the present invention.

Claims (1)

1. The detumescence granulation promoting ointment for pets is characterized in that: the feed consists of the following raw materials: 10-15g of vaseline, 0.25-0.5g of erythromycin powder, 5-8mL of 1% iodine tincture, 3-5g of slaked lime and 5-10g of borneol;

the method for the detumescence myogenic ointment for the pets comprises the following steps:

(1) grinding slaked lime into powder in a mortar for later use;

(2) grinding Borneolum Syntheticum into powder;

(3) and (2) placing vaseline in a clean container, adding the prepared slaked lime powder, borneol powder, erythromycin powder and 1% iodine tincture into the vaseline, fully stirring, and filling into a sealed bottle for later use.

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