CN105412766A - Pharmaceutical composition for treating chronic diarrhea - Google Patents
Pharmaceutical composition for treating chronic diarrhea Download PDFInfo
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- CN105412766A CN105412766A CN201510934651.2A CN201510934651A CN105412766A CN 105412766 A CN105412766 A CN 105412766A CN 201510934651 A CN201510934651 A CN 201510934651A CN 105412766 A CN105412766 A CN 105412766A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
The invention relates to a pharmaceutical composition for treating chronic diarrhea. The pharmaceutical composition is composed of the following traditional Chinese medicine raw materials in parts by weight: 9-15 parts of dry root of codonopsis pilosula, 11-20 parts of whole herb of pteris multifida, 27-34 parts of seed kernel of euryale ferox, 4-7 parts of dry root of aucklandia lappa, 8-13 parts of dry root of cichorium intybus, 8-13 parts of dry fruit of alpinia oxyphylla, 8-13 parts of flower bud of magnolia officinalis, 8-13 parts of dry rhizome of cimicifuga heracleifolia, 4-7 parts of shell of papaver somniferum and 5-10 parts of dry root of glycyrrhiza uralensis. The pharmaceutical composition has the efficacies of clearing heat, detoxifying, tonifying qi, nourishing blood, tonifying the spleen, warming the middle-warmer, dispelling cold and relieving pain, has the advantages of being capable of treating both symptoms and root causes, remarkable in curative effect and low in relapse rate after the disease is cured for the chronic diarrhea and is very suitable for treating the chronic diarrhea.
Description
Technical field
The invention belongs to technical field of Chinese medicine, be specifically related to a kind of pharmaceutical composition for the treatment of chronic diarrhea.
Background technology
Diarrhoea refers to that defecation frequency is significantly more than the frequency be on ordinary days accustomed to, and excrement matter is thin, and every day, Fecal wastes was more than 200g, or containing non-digest food or pus and blood.Chronic diarrhea refers to the diarrhoea of the course of disease more than two months or the intermission recurrent diarrhoea within 2-4 week.Chronic diarrhea is multiple disease clinically, although this disease can not threaten to the life security of patient, long-term diarrhoea can cause harmful effect to the orthobiosis of patient, work, study, therefore should treat in time after the state of an illness is made a definite diagnosis.Current treatment takes racecadotril to treat more, and its pharmacological action is mainly active by retardance enkephalin, to produce defencive function to endogenous enkephalins, prevents degraded from occurring, extends the physiologically active of endogenous enkephalins with this; Meanwhile, racecadotril effectively can control water, electrolytical secretion, to produce anti-diarrhea effect.But this medicine production cost is high, therapeutic effect is also undesirable not.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide a kind of pharmaceutical composition for the treatment of chronic diarrhea of side effect evident in efficacy, with low cost, almost non-toxic.
The object of the present invention is achieved like this:
Treat a pharmaceutical composition for chronic diarrhea, be made up of the traditional Chinese medicinal material raw materials of following weight portion: Radix Codonopsis 9-15 part, Herba Pteridis Multifidae 11-20 part, Semen Euryales 27-34 part, Radix Aucklandiae 4-7 part, root of Herba Cichorii 8-13 part, Fructus Alpiniae Oxyphyllae 8-13 part, Flos Magnoliae Officinalis 8-13 part, Rhizoma Cimicifugae 8-13 part, Pericarpium Papaveris 4-7 part, Radix Glycyrrhizae 5-10 part.
Preferably, the pharmaceutical composition for the treatment of chronic diarrhea is made up of the traditional Chinese medicinal material raw materials of following weight portion as mentioned above: Radix Codonopsis 11-13 part, Herba Pteridis Multifidae 14-16 part, Semen Euryales 29-32 part, Radix Aucklandiae 5-6 part, root of Herba Cichorii 9-11 part, Fructus Alpiniae Oxyphyllae 9-11 part, Flos Magnoliae Officinalis 9-11 part, Rhizoma Cimicifugae 9-11 part, Pericarpium Papaveris 5-6 part, Radix Glycyrrhizae 7-9 part.
In the present invention's preferred embodiment, the pharmaceutical composition of described treatment chronic diarrhea is made up of the traditional Chinese medicinal material raw materials of following weight portion: Radix Codonopsis 12 parts, Herba Pteridis Multifidae 15 parts, Semen Euryales 30 parts, the Radix Aucklandiae 06 part, root of Herba Cichorii 10 parts, Fructus Alpiniae Oxyphyllae 10 parts, Flos Magnoliae Officinalis 10 parts, Rhizoma Cimicifugae 10 parts, Pericarpium Papaveris 5 parts, 8 parts, Radix Glycyrrhizae.
Further preferably, the pharmaceutical composition of any one treatment chronic diarrhea above-mentioned, it is solid orally ingestible; Described solid orally ingestible comprises granule, capsule.
In addition, it should be noted that, the traditional Chinese medicinal material raw materials that pharmaceutical composition of the present invention adopts in preparation process has following source: the dry root of Campanulaceae Radix Codonopsis Codonopsispilosula (Franch.) Nannf. selected by Radix Codonopsis; Herba Pteridis Multifidae selects the dry herb of Pteridaceae plant Herba Pteridis Multifidae PterismultifidaPoir.; The dry mature kernal of nymphaeaceae plant Gorgon euryale EuryaleferoxSalisb. selected by Semen Euryales; The Radix Aucklandiae selects the dry root of feverfew Radix Aucklandiae AucklandialappaDecne.; Root of Herba Cichorii selects the dry root of feverfew Herba Cichorii CichoriumintybusL.; Fructus Alpiniae Oxyphyllae selects the dry fruit of zingiberaceous plant Fructus Alpiniae Oxyphyllae AlpiniaoxyphyllaMiq.; Flos Magnoliae Officinalis selects the dry flower of Magnoliacea plant Cortex Magnoliae Officinalis MagnoliaofficinalisRehd.etWils.; The dry rhizome of ranunculaceae plant C.heracleifolia CimicifugaheracleifoliaKom. selected by Rhizoma Cimicifugae; Pericarpium Papaveris selects the drying and ripening shell of Papaveraceae poppy Semen Papaveris PapaversomniferumL.; Radix Glycyrrhizae selects the dry root of glycyrrhizic legume GlycyrrhizauralensisFisch..
Pharmaceutical composition of the present invention has heat-clearing and toxic substances removing, benefiting QI and nourishing blood, spleen reinforcing warming middle-JIAO, effect that cold expelling relieves the pain, the treatment for chronic diarrhea has treating both the principal and secondary aspects of a disease, evident in efficacy, to control recurrence rate after healing low, and the advantage such as side effect is little, production cost is low, be applicable to very much the chronic spleen-deficient diarrhoea for the treatment of.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: Radix Codonopsis 1.2kg, Herba Pteridis Multifidae 1.5kg, Semen Euryales 3.0kg, Radix Aucklandiae 0.6kg, root of Herba Cichorii 1.0kg, Fructus Alpiniae Oxyphyllae 1.0kg, Flos Magnoliae Officinalis 1.0kg, Rhizoma Cimicifugae 1.0kg, Pericarpium Papaveris 0.5kg, Radix Glycyrrhizae 0.8kg.
The preparation technology of capsule: the above-mentioned traditional Chinese medicinal material raw materials taking recipe quantity, adds the water of 12 times amount, soaks 12h, then decocts three times, and first time decocts 2h, leaches medicinal liquid stand-by; Second time adds the water of 9 times amount, decocts 1.5h, leaches medicinal liquid stand-by; Add the water of 8 times amount for the third time, decoct 1.5h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; Filtrate is concentrated into thick paste, and low-temperature bake about 7h fully dry, pulverize the powder that gets dry extract; By dried cream powder: dextrin is that the weight ratio of 1:0.5 adds adjuvant, common process is granulated, and is sub-packed in capsule after granulate, and every capsules, by the crude drug amount powder charge being equivalent to 11 grams, is used
60co irradiation bomb irradiation sterilization, obtains capsule preparations.
Embodiment 2
Crude drug prescription: Radix Codonopsis 1.0kg, Herba Pteridis Multifidae 1.6kg, Semen Euryales 3.3kg, Radix Aucklandiae 0.7kg, root of Herba Cichorii 1.3kg, Fructus Alpiniae Oxyphyllae 1.3kg, Flos Magnoliae Officinalis 0.8kg, Rhizoma Cimicifugae 0.8kg, Pericarpium Papaveris 0.6kg, Radix Glycyrrhizae 0.9kg.
The preparation technology of capsule: the above-mentioned traditional Chinese medicinal material raw materials taking recipe quantity, adds the water of 11 times amount, soaks 16h, then decocts three times, and first time decocts 2h, leaches medicinal liquid stand-by; Second time adds the water of 9 times amount, decocts 1.5h, leaches medicinal liquid stand-by; Add the water of 8 times amount for the third time, decoct 1.5h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; Filtrate is concentrated into thick paste, and low-temperature bake about 7h fully dry, pulverize the powder that gets dry extract; By dried cream powder: dextrin is that the weight ratio of 1:0.5 adds adjuvant, common process is granulated, and is sub-packed in capsule after granulate, and every capsules, by the crude drug amount powder charge of 10 grams, is used
60co irradiation bomb irradiation sterilization, obtains capsule preparations.
Embodiment 3
Crude drug prescription: Radix Codonopsis 1.5kg, Herba Pteridis Multifidae 1.5kg, Semen Euryales 2.7kg, Radix Aucklandiae 0.5kg, root of Herba Cichorii 1.0kg, Fructus Alpiniae Oxyphyllae 1.3kg, Flos Magnoliae Officinalis 1.0kg, Rhizoma Cimicifugae 1.3kg, Pericarpium Papaveris 0.7kg, Radix Glycyrrhizae 1.0kg.
The preparation technology of capsule: the above-mentioned traditional Chinese medicinal material raw materials taking recipe quantity, adds the water of 12 times amount, soaks 15h, then decocts three times, and first time decocts 1.5h, leaches medicinal liquid stand-by; Second time adds the water of 8 times amount, decocts 1h, leaches medicinal liquid stand-by; Add the water of 8 times amount for the third time, decoct 0.8h, leach medicinal liquid stand-by; Merge three decocting liquids, filter, collect filtrate; Filtrate is concentrated into thick paste, and low-temperature bake about 7h fully dry, pulverize the powder that gets dry extract; By dried cream powder: dextrin is that the weight ratio of 1:0.5 adds adjuvant, common process is granulated, and is sub-packed in capsule after granulate, and every capsules, by the crude drug amount powder charge of 10 grams, is used
60co irradiation bomb irradiation sterilization, obtains capsule preparations.
Embodiment 4 Chinese medicine capsules is to the effectiveness study of spleen-deficient Chronic Diarrhea Patients
Chronic spleen-deficient diarrhea patient 62 example is as object of study, and all patients are all made a definite diagnosis in conjunction with sings and symptoms by x-ray inspection, main manifestations is that body is thin and weak, chronic diarrhea is not healed, lusterless complexion, diet reduce, arteries and veins is unable, tired unable, tongue in vain, just rare.Be divided into test group and matched group at random, each 31 examples, test group man 17 example, female 14 example, 21 ~ 58 years old age, the mean age (37.5 ± 7.3) year, patient's times of defecation 3 ~ 6 times/d, average time (4.2 ± 0.6) is secondary/d; Matched group man 18 example, female 13 example, 21 ~ 59 years old age, the mean age (38.3 ± 6.9) year, patient's times of defecation 4 ~ 6 times/d, average time (4.4 ± 0.7) is secondary/d.The physical data of two groups of patients compares, and no significant difference has comparability.
Matched group adopts Racecadotril granules (the accurate word H20050411 of traditional Chinese medicines, Baili Pharmaceutical Co., Ltd., Sichuan Prov.) treatment, 20mg/ time, 3 times/d; The Chinese medicine capsules that test group adopts the embodiment of the present invention 1 to prepare, each 3, every day sooner or later respectively once.Two groups of equal continued treatments of patient one month.After treatment terminates, evaluate two groups of curative effects by following curative effect determinate standard:
Effective: diarrhoea, stomachache, the complexion of patient, the transference cure such as weak, arteries and veins is unable, appetite recovers normal, and x-ray inspection and lab testing are all without exception;
Effective: diarrhoea, stomachache, the complexion of patient, weak, arteries and veins is unable etc., and symptom is significantly improved, appetite is obviously recovered;
Invalid: diarrhoea, stomachache, the complexion of patient, weak, arteries and veins is unable etc., and symptom is not improved or aggravates.
Can be found out by the test statistics result of table 1, the complete obvious effective rate of matched group is 29.0%, and total effective rate is 67.7%; The complete obvious effective rate of test group is 51.6%, and total effective rate is 93.5%.Obviously, the curative effect of test group is obviously better than matched group, and especially in obvious effective rate, test group is significantly better than matched group.
Table 1 liang group patient clinical comparitive study (example)
| Group | Case load | Effective | Effectively | Invalid | Effectively total |
| Matched group | 31 | 9(29.0％) | 12(38.7％) | 10(32.3％) | 21(67.7％) |
| Test group | 31 | 16(51.6％) | 13(41.9％) | 2(6.5％) | 29(93.5％) |
Claims (7)
1. treat a pharmaceutical composition for chronic diarrhea, it is characterized in that: be made up of the traditional Chinese medicinal material raw materials of following weight portion: Radix Codonopsis 9-15 part, Herba Pteridis Multifidae 11-20 part, Semen Euryales 27-34 part, Radix Aucklandiae 4-7 part, root of Herba Cichorii 8-13 part, Fructus Alpiniae Oxyphyllae 8-13 part, Flos Magnoliae Officinalis 8-13 part, Rhizoma Cimicifugae 8-13 part, Pericarpium Papaveris 4-7 part, Radix Glycyrrhizae 5-10 part.
2. treat the pharmaceutical composition of chronic diarrhea according to claim 1, it is characterized in that: be made up of the traditional Chinese medicinal material raw materials of following weight portion: Radix Codonopsis 11-13 part, Herba Pteridis Multifidae 14-16 part, Semen Euryales 29-32 part, Radix Aucklandiae 5-6 part, root of Herba Cichorii 9-11 part, Fructus Alpiniae Oxyphyllae 9-11 part, Flos Magnoliae Officinalis 9-11 part, Rhizoma Cimicifugae 9-11 part, Pericarpium Papaveris 5-6 part, Radix Glycyrrhizae 7-9 part.
3. treat the pharmaceutical composition of chronic diarrhea according to claim 2, it is characterized in that: be made up of the traditional Chinese medicinal material raw materials of following weight portion: Radix Codonopsis 12 parts, Herba Pteridis Multifidae 15 parts, Semen Euryales 30 parts, the Radix Aucklandiae 06 part, root of Herba Cichorii 10 parts, Fructus Alpiniae Oxyphyllae 10 parts, Flos Magnoliae Officinalis 10 parts, Rhizoma Cimicifugae 10 parts, Pericarpium Papaveris 5 parts, 8 parts, Radix Glycyrrhizae.
4. according to claim 1 or 2 or 3, treat the pharmaceutical composition of chronic diarrhea, it is characterized in that: described pharmaceutical composition is solid orally ingestible.
5. treat the pharmaceutical composition of chronic diarrhea according to claim 4, it is characterized in that: described solid orally ingestible comprises granule, capsule.
6. the application of the traditional Chinese medicinal material raw materials compositions of claim 1 or 2 or 3 in the medicine of preparation treatment chronic diarrhea.
7. application according to claim 6, is characterized in that, described chronic diarrhea is chronic spleen-deficient diarrhoea.
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| CN201510934651.2A CN105412766A (en) | 2015-12-15 | 2015-12-15 | Pharmaceutical composition for treating chronic diarrhea |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491748A (en) * | 2016-12-17 | 2017-03-15 | 郑州郑先医药科技有限公司 | A kind of treat Chinese and western medicinal composition of chronic diarrhea and preparation method thereof |
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| CN101185746A (en) * | 2007-12-11 | 2008-05-28 | 叶明伟 | Orally-administered traditional Chinese medicine for treating insufficiency of the spleen qi type diarrhea |
| CN101195023A (en) * | 2007-12-11 | 2008-06-11 | 叶志群 | Orally taken Chinese medicine for treating children's lax |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185746A (en) * | 2007-12-11 | 2008-05-28 | 叶明伟 | Orally-administered traditional Chinese medicine for treating insufficiency of the spleen qi type diarrhea |
| CN101195023A (en) * | 2007-12-11 | 2008-06-11 | 叶志群 | Orally taken Chinese medicine for treating children's lax |
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| Title |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106491748A (en) * | 2016-12-17 | 2017-03-15 | 郑州郑先医药科技有限公司 | A kind of treat Chinese and western medicinal composition of chronic diarrhea and preparation method thereof |
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Application publication date: 20160323 |