CN105412536A - 一种鼻炎灵丸及其制备方法 - Google Patents
一种鼻炎灵丸及其制备方法 Download PDFInfo
- Publication number
- CN105412536A CN105412536A CN201510879029.6A CN201510879029A CN105412536A CN 105412536 A CN105412536 A CN 105412536A CN 201510879029 A CN201510879029 A CN 201510879029A CN 105412536 A CN105412536 A CN 105412536A
- Authority
- CN
- China
- Prior art keywords
- pill
- powder
- extracting solution
- water
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 22
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000012907 honey Nutrition 0.000 claims abstract description 8
- 206010028748 Nasal obstruction Diseases 0.000 claims abstract description 6
- 206010039101 Rhinorrhoea Diseases 0.000 claims abstract description 6
- 230000001154 acute effect Effects 0.000 claims abstract description 6
- 201000009151 chronic rhinitis Diseases 0.000 claims abstract description 6
- 208000010753 nasal discharge Diseases 0.000 claims abstract description 6
- 201000009240 nasopharyngitis Diseases 0.000 claims abstract description 6
- 239000000284 extract Substances 0.000 claims description 21
- 241000628997 Flos Species 0.000 claims description 10
- 239000009670 cang er zi wan Substances 0.000 claims description 8
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 201000009890 sinusitis Diseases 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 7
- 238000001035 drying Methods 0.000 abstract description 5
- 235000013399 edible fruits Nutrition 0.000 abstract description 5
- 235000017089 Scutellaria baicalensis Nutrition 0.000 abstract description 2
- 240000004534 Scutellaria baicalensis Species 0.000 abstract description 2
- 241000159213 Zygophyllaceae Species 0.000 abstract description 2
- 230000008961 swelling Effects 0.000 abstract description 2
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 abstract 1
- 240000004307 Citrus medica Species 0.000 abstract 1
- 241000218394 Magnolia liliiflora Species 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 241001506766 Xanthium Species 0.000 abstract 1
- 238000007670 refining Methods 0.000 abstract 1
- 235000009165 saligot Nutrition 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 238000002137 ultrasound extraction Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 230000004345 fruit ripening Effects 0.000 description 3
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 244000241838 Lycium barbarum Species 0.000 description 2
- 235000015459 Lycium barbarum Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 235000015170 shellfish Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 241001644297 Fritillaria delavayi Species 0.000 description 1
- 241001644295 Fritillaria przewalskii Species 0.000 description 1
- 241001644290 Fritillaria unibracteata Species 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 240000005819 Magnolia denudata Species 0.000 description 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 description 1
- 244000280293 Mentha haplocalyx Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000005070 ripening Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
- A61K36/575—Magnolia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Botany (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种鼻炎灵丸及其制备方法，其特征在于取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成粗粉，置循环超声提取器中，加入水，锗粉，吐温60，超声取提，射流喷雾干燥，制得纳米提取粉，炼蜜泛丸，制得鼻炎灵丸，用于治疗祛风清热，消肿通窍。用于鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎，疗效显著优于市售鼻炎灵丸，取得了良好效果。
Description
技术领域
本发明涉及中药领域，具体涉及一种鼻炎灵丸及其制备方法。
背景技术
鼻炎灵丸祛风清热，消肿通窍。用于鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎。市售鼻炎灵丸由于组方和工艺原因，疗效不甚理想，制剂采用传统工艺制备，存在疗效低的缺点。
发明内容
本发明为克服上述不足，提供一种疗效高的鼻炎灵丸及其制备方法。
发明实施方案如下：
取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，6～8g锗粉，6～8g吐温60，选择超声频率50～60KHz，压力0.4～0.6Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度38～48℃，压力0.02～0.04Mpa，流速每秒400～600米，得纳米提取粉；每100g纳米提取粉用炼蜜20-30g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
上述实施方案所提到的原材料标准如下：
蒺藜：中国药典2005年版一部标准。本品为蒺藜科植物蒺藜TribulusterrestrisL.的干燥成熟果实。秋季果实成熟时采割植株，晒干，打下果实，除去杂质。
香橼：中国药典2005年版一部标准。本品为芸香科植物构橼CitrusmedicaL．或香圆CitruswilsoniiTanaka的干燥成熟果实。秋季果实成熟时采收，趁鲜切片，晒干或低温干燥。香圆亦可整个或对剖两半后，晒干或低温干燥。
地骨皮：中国药典2005年版一部标准。本品为茄科植物枸杞LyciumchinenseMill.或宁夏枸杞LyciumbarbarumL.的干燥根皮。春初或秋后采挖根部，洗净，剥取根皮，晒干。
苍耳子：中国药典2005年版一部标准。本品为菊科植物苍耳XanthiumsibiricumPatr.的干燥成熟带总苞的果实。秋季果实成熟时采收，干燥，除去梗、叶等杂质。
辛夷：中国药典2005年版一部标准。本品为木兰科植物望春花MagnoliabiondiiPamp.、玉兰MagnoliadenudataDesr.或武当玉兰MagnoliasprengeriPamp．的干燥花蕾。冬末春初花未开放时采收．除去枝梗，阴干。
黄芩：中国药典2005年版一部标准。本品为唇形科植物黄芩ScutellariabaicalensisGeorgi的干燥根。春、秋二季采挖，除去须根及泥沙，晒后撞去粗皮，晒干。
薄荷：中国药典2005年版一部标准。本品为唇形科植物薄荷MenthahaplocalyxBriq.的干燥地上部分。夏、秋二季茎叶茂盛或花开至三轮时，选晴天，分次来割，晒干或阴干。
川贝母：中国药典2005年版一部标准。本品为百合科植物川贝母FritillariacirrhosaD．Don。暗紫贝母FritillariaunibracteataHsiaoetK．C．Hsia、甘肃贝母FritillariaprzewalskiiMaxim．或梭砂贝母FritillariadelavayiFranch．的干燥鳞茎。前三者按性状不同分别习称“松贝”和“青贝”，后者习称“炉贝”。夏、秋二季或积雪融化时采挖，除去须根、粗皮及泥沙，晒干或低温干燥。
锗粉：二氧化锗：CAS号:1310-53-8：行业标准：百灵威科技有限公司；
吐温60：中国药典2010年版二部标准；
以上鼻炎灵丸所用到的原材料均可从医药公司购买得到，并不限于典型生产厂家，只要满足质量标准均可用来实施本发明方案。
上述发明实施方案所提到的关键设备如下：
循环超声机：超声频率20～100KHz,
（典型生产厂家:北京弘祥隆生物技术开发有限公司）
射流喷雾干燥机：进风温度范围30～70℃，射流速度范围每秒300～900米；
（典型生产厂家:北京奈诺生物科技有限公司）
以上鼻炎灵丸所用到的原材料均可从医药公司购买得到，只要满足国家标准均可用来实施本发明方案。
上述发明方案中所用术语为药学专用术语，如“减压”等皆遵从中国药典规定和相关药学规范。
本发明中的单位g也可以是其它重量份，不影响本发明方案的实施。
本发明方案中所述的设备市场均有销售，并不限于典型生产厂家，只要技术指标能够达到要求，均可用来实现本发明。
具体实施方式
本发明的具体实施例1
取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，6g锗粉，6g吐温60，选择超声频率50KHz，压力0.4Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度38℃，压力0.02Mpa，流速每秒400米，得纳米提取粉；每100g纳米提取粉用炼蜜20g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
本发明的具体实施例2
取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，8g锗粉，8g吐温60，选择超声频率60KHz，压力0.6Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度48℃，压力0.04Mpa，流速每秒600米，得纳米提取粉；每100g纳米提取粉用炼蜜30g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
本发明的具体实施例3
取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，7g锗粉，7g吐温60，选择超声频率55KHz，压力0.5Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度43℃，压力0.03Mpa，流速每秒500米，得纳米提取粉；每100g纳米提取粉用炼蜜25g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
以上实施例说明，采用本发明实施方案的极端条件和优化条件均能制成鼻炎灵丸。下面以实施例3制得的鼻炎灵丸考察本发明的实际效果：
（一）实施例3鼻炎灵丸与市售鼻炎灵丸治疗鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎临床疗效观察
1病例情况
统计门诊和住院病例，共观察鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎病例102例，平均年龄42岁。将患者分为两组，试验组服用实施例3鼻炎灵丸，对照组服用传统鼻炎灵丸。
2疗效评定标准
依据中药新药临床研究指导原则中医证候疗效判定标准：
治愈：中医临床症状、体征消失或基本消失，证候积分减少≥95%。
显效：中医临床症状、体征明显改善，证候积分减少≥70%。
有效：中医临床症状、体征均有好转，证候积分减少≥30%。
无效：中医临床症状、体征均均无明显改善或者加重，证候积分减少＜30%。
计算公式：[（治疗前积分－治疗后积分）÷治疗前积分]×100%。
3临床观察结果
表1实施例3鼻炎灵丸和市售鼻炎灵丸临床疗效对比
上述临床疗效观察结果表明，本发明制备的鼻炎灵丸在治疗鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎时,疗效显著高于市售鼻炎灵丸，p＜0.05。
Claims (3)
1.一种治疗鼻渊、鼻塞、鼻流浊涕等急、慢性鼻炎的中药，其特征是取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，6～8g锗粉，6～8g吐温60，选择超声频率50～60KHz，压力0.4～0.6Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度38～48℃，压力0.02～0.04Mpa，流速每秒400～600米，得纳米提取粉；每100g纳米提取粉用炼蜜20-30g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
2.根据权利要求1所述中药的制备方法，其特征是取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，6～8g锗粉，6～8g吐温60，选择超声频率50～60KHz，压力0.4～0.6Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度38～48℃，压力0.02～0.04Mpa，流速每秒400～600米，得纳米提取粉；每100g纳米提取粉用炼蜜20-30g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
3.根据权利要求1所述中药的制备方法，其特征是取蒺藜21g,香橼63g,地骨皮42g,苍耳子(微炒)210g,辛夷168g,黄芩42g,薄荷40g,川贝母42g,粉碎成40目粗粉，置循环超声提取器中，加入6280g水，7g锗粉，7g吐温60，选择超声频率55KHz，压力0.5Mpa提取30分钟，用80目筛过滤，得提取液；取提取液置射流喷雾干燥机中，控制进风温度43℃，压力0.03Mpa，流速每秒500米，得纳米提取粉；每100g纳米提取粉用炼蜜25g加适量的水泛丸，干燥，制成水蜜丸，制得鼻炎灵丸。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879029.6A CN105412536A (zh) | 2015-12-05 | 2015-12-05 | 一种鼻炎灵丸及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879029.6A CN105412536A (zh) | 2015-12-05 | 2015-12-05 | 一种鼻炎灵丸及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105412536A true CN105412536A (zh) | 2016-03-23 |
Family
ID=55491383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510879029.6A Pending CN105412536A (zh) | 2015-12-05 | 2015-12-05 | 一种鼻炎灵丸及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105412536A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236721A (zh) * | 2016-08-31 | 2016-12-21 | 太极集团浙江东方制药有限公司 | 一种归芍六君丸的制备方法 |
-
2015
- 2015-12-05 CN CN201510879029.6A patent/CN105412536A/zh active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236721A (zh) * | 2016-08-31 | 2016-12-21 | 太极集团浙江东方制药有限公司 | 一种归芍六君丸的制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105232704A (zh) | 防治牛瘤胃胀气的药物及其制备方法 | |
| CN113730479A (zh) | 一种具有保健功能的组合物及其制备方法与用途 | |
| WO2016183784A1 (zh) | 一种用于治疗过敏性鼻炎的中药 | |
| CN105412536A (zh) | 一种鼻炎灵丸及其制备方法 | |
| CN114392339A (zh) | 一种用于胆囊炎胆结石息肉的组合物及其用途与制备方法 | |
| CN105362766A (zh) | 一种防风通圣丸及其制备方法 | |
| CN105381303A (zh) | 一种金银花感冒颗粒及其制备方法 | |
| CN105796855A (zh) | 一种治疗急性支气管炎的中药 | |
| CN104547066A (zh) | 一种感冒退热颗粒及其制备方法 | |
| CN105362588A (zh) | 一种复方白带丸及其制备方法 | |
| CN104383516A (zh) | 一种少阳感冒颗粒及其制备方法 | |
| CN105456746A (zh) | 一种复方鱼腥草片及其制备方法 | |
| CN104474089A (zh) | 一种五味香连丸及其制备方法 | |
| CN105456599A (zh) | 一种香连化滞丸及其制备方法 | |
| CN106309608A (zh) | 一种枇杷叶的炮制方法 | |
| CN104399007A (zh) | 一种清胰利胆颗粒及其制备方法 | |
| CN105343676A (zh) | 一种清热解毒片及其制备方法 | |
| CN103518930A (zh) | 一种橄榄润喉糖及其制备方法 | |
| CN104383401A (zh) | 一种小儿麻甘颗粒及其制备方法 | |
| CN105343681A (zh) | 一种止咳橘红胶囊及其制备方法 | |
| CN104383083A (zh) | 一种和肝利胆颗粒及其制备方法 | |
| CN104398935A (zh) | 一种化痔片及其制备方法 | |
| CN104524265A (zh) | 一种茵白肝炎颗粒及其制备方法 | |
| CN110623114A (zh) | 茵陈茶的制备方法 | |
| CN104398951A (zh) | 一种胃痛定片及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160323 |
|
| WD01 | Invention patent application deemed withdrawn after publication |