CN105412291B - The proheparin that relaxes is preparing the application in treatment diabetic neuropathy and complication medicine - Google Patents
The proheparin that relaxes is preparing the application in treatment diabetic neuropathy and complication medicine Download PDFInfo
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- CN105412291B CN105412291B CN201510906503.XA CN201510906503A CN105412291B CN 105412291 B CN105412291 B CN 105412291B CN 201510906503 A CN201510906503 A CN 201510906503A CN 105412291 B CN105412291 B CN 105412291B
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- diabetic neuropathy
- neuropathy
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- 208000032131 Diabetic Neuropathies Diseases 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 208000002249 Diabetes Complications Diseases 0.000 title description 2
- 206010012655 Diabetic complications Diseases 0.000 title description 2
- 239000000284 extract Substances 0.000 claims abstract description 25
- 208000019423 liver disease Diseases 0.000 claims abstract description 14
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 12
- 238000002360 preparation method Methods 0.000 claims abstract description 10
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- 241000334160 Isatis Species 0.000 claims abstract description 7
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- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 2
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- 210000004185 liver Anatomy 0.000 description 1
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- 230000001376 precipitating effect Effects 0.000 description 1
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- 230000009023 proprioceptive sensation Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000000453 second toe Anatomy 0.000 description 1
- 208000037118 sensory ataxia Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 201000001862 viral hepatitis Diseases 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510906503.XA CN105412291B (en) | 2015-12-09 | 2015-12-09 | The proheparin that relaxes is preparing the application in treatment diabetic neuropathy and complication medicine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510906503.XA CN105412291B (en) | 2015-12-09 | 2015-12-09 | The proheparin that relaxes is preparing the application in treatment diabetic neuropathy and complication medicine |
Publications (2)
Publication Number | Publication Date |
---|---|
CN105412291A CN105412291A (en) | 2016-03-23 |
CN105412291B true CN105412291B (en) | 2019-08-20 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201510906503.XA Active CN105412291B (en) | 2015-12-09 | 2015-12-09 | The proheparin that relaxes is preparing the application in treatment diabetic neuropathy and complication medicine |
Country Status (1)
Country | Link |
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CN (1) | CN105412291B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109793847A (en) * | 2019-04-09 | 2019-05-24 | 伍治明 | A kind of composite isatis root acupoint injection therapy liquid and preparation method thereof and application method |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1186091C (en) * | 2002-11-01 | 2005-01-26 | 贵州瑞和制药有限公司 | Chinese medicine injection and its production process |
CN1813984B (en) * | 2005-12-14 | 2011-08-31 | 贵州瑞和制药有限公司 | Chinese medicine preparation for treating liver disease and preparing method |
CN100558348C (en) * | 2006-06-16 | 2009-11-11 | 贵州益佰制药股份有限公司 | YINZHIHUANG ZHIJI and preparation method |
CN103550281B (en) * | 2013-11-12 | 2015-11-18 | 庞会心 | The pharmaceutical composition of a kind of prevention and therapy diabetes and complication thereof and preparation thereof |
-
2015
- 2015-12-09 CN CN201510906503.XA patent/CN105412291B/en active Active
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Publication number | Publication date |
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CN105412291A (en) | 2016-03-23 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20190716 Address after: 551200 Camphor Rock, Gujiao Town, Longli County, Guizhou Province Applicant after: GUIZHOU RUIHE PHARMACEUTICAL Co.,Ltd. Address before: 551200 Wangchengpo, Guanshan Street Office, Longli County, Guizhou Province Applicant before: LONGLI PHARMACEUTICAL FACTORY, GUIZHOU RUIHE PHARMACEUTICAL CO.,LTD. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Application of Shuganning in the preparation of drugs for diabetic neuropathy and complications Effective date of registration: 20200901 Granted publication date: 20190820 Pledgee: Agricultural Bank Chinese Limited by Share Ltd. Longli County branch Pledgor: GUIZHOU RUIHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020980005621 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230925 Granted publication date: 20190820 Pledgee: Agricultural Bank Chinese Limited by Share Ltd. Longli County branch Pledgor: GUIZHOU RUIHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020980005621 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Application of Shuganning in the preparation of drugs for the treatment of diabetes neuropathy and complications Effective date of registration: 20231011 Granted publication date: 20190820 Pledgee: Agricultural Bank Chinese Limited by Share Ltd. Longli County branch Pledgor: GUIZHOU RUIHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2023520000056 |