CN105410913B - A kind of preparation method of oligochitosan oral cavity cleaning lozenge - Google Patents
A kind of preparation method of oligochitosan oral cavity cleaning lozenge Download PDFInfo
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- CN105410913B CN105410913B CN201510862857.9A CN201510862857A CN105410913B CN 105410913 B CN105410913 B CN 105410913B CN 201510862857 A CN201510862857 A CN 201510862857A CN 105410913 B CN105410913 B CN 105410913B
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- China
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- alginate
- chitosan oligosaccharide
- lozenge
- moringa powder
- oligochitosan
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- 239000007937 lozenge Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 19
- 210000000214 mouth Anatomy 0.000 title claims abstract description 18
- 238000004140 cleaning Methods 0.000 title claims abstract description 17
- RQFQJYYMBWVMQG-IXDPLRRUSA-N chitotriose Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)[C@@H](CO)O1 RQFQJYYMBWVMQG-IXDPLRRUSA-N 0.000 claims abstract description 57
- 235000011347 Moringa oleifera Nutrition 0.000 claims abstract description 35
- 241000220215 Moringa Species 0.000 claims abstract description 34
- 239000000843 powder Substances 0.000 claims abstract description 34
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 31
- 229920000615 alginic acid Polymers 0.000 claims abstract description 31
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229940072056 alginate Drugs 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000005520 cutting process Methods 0.000 claims abstract description 5
- 239000012528 membrane Substances 0.000 claims abstract description 5
- 238000010297 mechanical methods and process Methods 0.000 claims abstract description 3
- 238000000265 homogenisation Methods 0.000 claims description 4
- 239000000737 potassium alginate Substances 0.000 claims description 3
- 235000010408 potassium alginate Nutrition 0.000 claims description 3
- MZYRDLHIWXQJCQ-YZOKENDUSA-L potassium alginate Chemical compound [K+].[K+].O1[C@@H](C([O-])=O)[C@@H](OC)[C@H](O)[C@H](O)[C@@H]1O[C@@H]1[C@@H](C([O-])=O)O[C@@H](O)[C@@H](O)[C@H]1O MZYRDLHIWXQJCQ-YZOKENDUSA-L 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 229940112822 chewing gum Drugs 0.000 description 4
- 235000015218 chewing gum Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229920001542 oligosaccharide Polymers 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000001408 fungistatic effect Effects 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000002482 oligosaccharides Chemical class 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 244000179886 Moringa oleifera Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- -1 amine group oligosaccharides Chemical class 0.000 description 1
- 244000037640 animal pathogen Species 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229940046011 buccal tablet Drugs 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 230000007661 gastrointestinal function Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000010220 ion permeability Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- VJQYLJSMBWXGDV-UHFFFAOYSA-N tiadinil Chemical group N1=NSC(C(=O)NC=2C=C(Cl)C(C)=CC=2)=C1C VJQYLJSMBWXGDV-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The present invention provides a kind of preparation method of oligochitosan oral cavity cleaning lozenge, oligochitosan oral cavity cleaning lozenge is made of the moringa powder of the chitosan oligosaccharide of 5~10 weight %, the alginate of 70~85 weight % and 10~20 weight %, and this method includes:(1) chitosan oligosaccharide, alginate and moringa powder are uniformly mixed;(2) pure water is added in into the mixture that step (1) obtains, the weight ratio of water and mixture is 1:20~1:50,20~40min is stirred under the conditions of 20 DEG C~60 DEG C;(3) chitosan oligosaccharide, alginate and the moringa powder homogenate obtained step (2) is packed into lyophilized plate, and homogenate layer thickness is controlled in 3~30mm, makes its surface uniform using Mechanical Method;(4) lyophilized plate that step (3) is filled to chitosan oligosaccharide, alginate and moringa powder homogenate is put into freeze drier, 20~50min of precooling under the conditions of 20~40 DEG C, then freeze-drying is vacuumized, until the water content of membrane after lyophilized is in 4~8 weight %;(5) piece containing chitosan oligosaccharide, alginate and moringa powder prepared by step (4) is formed into lozenge by the method for cross cutting.
Description
Technical field
The invention belongs to the technology of preparing of buccal tablet in field of food, in particular it relates to a kind of oligochitosan oral cavity
Clean the preparation method of lozenge.
Technical background
Chitosan oligosaccharide is the oligosaccharide for being broken to form chitosan main chain using particular form, is uniquely contained in nature
The basic amine group oligosaccharides of positive charge, bioactivity are the manyfolds of chitosan.Chitosan oligosaccharide is water-soluble fabulous and is easily absorbed
It utilizes, in human body internal absorption factor nearly 100%.The molecular structure of chitosan oligosaccharide uniqueness makes it have multiple biological activities, such as has suppression
The growth of tumour cell processed enhances immunity of organisms, strengthens liver function, prevents gastric ulcer, and adjustment blood pressure reduces blood glucose and blood
Fat adsorbs cholesterol and antibacterial action etc., and chitosan oligosaccharide, which also has, adjusts pH value of human body and fungistatic effect.
Based on the multiple biological activities using chitosan oligosaccharide, food and beverage containing chitosan oligosaccharide etc. there are many.In recent years, shell
The bacteriostasis of oligosaccharides causes extensive concern, as the natural antiseptic agent of milk beverage, can play the work(of its bacteriostatic preservative
Can, at the same can also play enhancing host body health effect etc. (research of chitosan oligosaccharide bacteriostasis, food industry is scientific and technological,
2009,1:88-90).Numerous studies show chitosan oligosaccharide to pathogenic bacteria such as staphylococcus aureus and Escherichia coli and are harmful to micro- life
Object has detailed inhibitory action, meanwhile, the suppression to different microorganisms of the chitosan oligosaccharide of different molecular weight ranges and various dose
There is also differents for bacterium effect.Protonated amino positively charged is the structure base that chitosan oligosaccharide has bacteriostatic activity on chitosan oligosaccharide molecule
Plinth;Some researches show that chitosan oligosaccharide can directly inhibit the activity of thalline β -1,3- dextranase, by improving microbial cell film
Ion permeability, and then inhibit its bioactivity.Chitosan oligosaccharide can also cause the film rupture of travelling microbial cell, and then realize
Its fungistatic effect.In addition, the bacteriostatic activity of chitosan oligosaccharide has broad spectrum activity, various plants pathogen, food microorganisms can be inhibited
And the growth of human body and other animal pathogens.Therefore, chitosan oligosaccharide can be as the preservative of food and beverage, while chitosan oligosaccharide
Also there is anti-inflammatory and eliminate the unusual smell and other effects, hygienic material or food hygiene raw material etc. can be used as.Such as the toothpaste containing chitosan oligosaccharide can be bright
Aobvious fungistatic effect for improving toothpaste etc.;Bactericidal composition (application number 201310680506) containing chitosan oligosaccharide discloses one kind and contains
The composition of tiadinil and chitosan oligosaccharide can effectively realize bactericidal effect.A kind of health food containing chitosan oligosaccharide and its preparation
Method (application number 201210586860) discloses a kind of health food containing chitosan oligosaccharide and preparation method thereof, is prepared with chitosan oligosaccharide
For improving the health food of gastrointestinal function.It is few that oligochitosan chewing gum (application number 200910073477.1) discloses a kind of shell
Chitosan oligosaccharide is pressed in the addition conventional chewing gum constitutive material of whole raw material components and stirred equal by sugared chewing gum and preparation method thereof
Even, routinely production technology is produced, and is made it have effectively preventing saprodontia, is removed the effect of oral peculiar smell, product form
It is little with conventional chewing gum composition difference.It is few that chitosan oligosaccharide oral cavity cleaning tablet (application number 201010500093.6) discloses a kind of shell
Sugared cleaning tablet of oral cavity and preparation method thereof is formulated by materials such as chitosan oligosaccharide, xylitol and D-sorbites, but product mouthfeel is not
Ideal, edible and carrying are also convenient for.Studying and developing the chitosan oligosaccharide product that preparation process is simple and product is easy to carry has weight
Want practical value.
The content of the invention
The present invention is intended to provide a kind of preparation method of oligochitosan oral cavity cleaning lozenge, with the sterilizing of chitosan oligosaccharide, it is antibacterial, disappear
It is scorching and based on eliminating the unusual smell and other effects, using chitosan oligosaccharide, alginate and moringa powder as raw material, by being sufficiently mixed and being freeze-dried
Technology, prepare it is easy to carry, beneficial to the chitosan oligosaccharide lozenge for preserving and helping oral hygiene.Contain abundant plant in moringa powder
Calcium can form flocculate after being mixed in the solution with alginate, beneficial to the sustained release of chitosan oligosaccharide, the oral cavity prepared is clear
Clean lozenge can persistently play a role.
The preparation method of a kind of oligochitosan oral cavity cleaning lozenge of the present invention, which is characterized in that oligochitosan oral cavity cleaning contains
The ingredient of piece includes 5~10 weight % chitosan oligosaccharides, 70~85 weight % alginates and 10~20 weight % moringa powders, preparation side
Method comprises the following steps:
(1) by chitosan oligosaccharide, alginate and moringa powder according to 5%~10%:70%~85%:10%~20% ratio
It is mixed;
(2) pure water into the chitosan oligosaccharide, alginate and Moringa powder mixture that step (1) obtains, the water with it is described
The weight ratio of mixture is 1:20~1:50,20min~40min is stirred under the conditions of 20 DEG C~60 DEG C, using high-pressure homogenization skill
Art makes it be thoroughly mixed to form homogenate;
(3) chitosan oligosaccharide, alginate and the moringa powder homogenate obtained step (2) is packed into lyophilized plate, is homogenized layer thickness control
It makes in 3mm~30mm, makes its surface uniform using Mechanical Method;
(4) lyophilized plate that step (3) is filled to chitosan oligosaccharide, alginate and moringa powder homogenate is put into freeze drier, and -20
DEG C~-40 DEG C under the conditions of precooling 20min~50min, then vacuumize and be freeze-dried, until the water content of membrane after lyophilized
Control is in 4~8 weight %;
(5) piece containing chitosan oligosaccharide, alginate and moringa powder prepared by step (4) is contained by the method formation of cross cutting
Piece.
Preferably, in the step (1), alginate can be sodium alginate or potassium alginate.
Preferably, in the step (1), the molecular weight of alginate can be controlled in 30000Da~300000Da.
Preferably, in the step (1), moringa powder can be the powder formed after dry leaf of Moringa directly crushes, can also
It is the powder formed after leaf of Moringa water extract is spray-dried.
Preferably, in the step (1), the grain size of moringa powder can be in the mesh of 100 mesh~1000.
A kind of preparation method of oligochitosan oral cavity cleaning lozenge provided by the invention, for preparing contains chitosan oligosaccharide, alginic acid
The lozenge for oral cleaning of salt and moringa powder can be eaten by modes such as buccal or chewings, the advantage is that preparation process is held
Easily, product carrying portable, long shelf-life and chitosan oligosaccharide therein have controlled-release effect etc..By the molecular weight for selecting alginate
The rate of release of chitosan oligosaccharide, the machine of lozenge is can control by the proportional amount for controlling moringa powder in the lozenge of controllable oral cleaning
Tool intensity.
Specific embodiment
The present invention is specifically described below by embodiment, it is worth mentioning that, embodiment is simply to the present invention
A kind of explanation of the preparation method of oligochitosan oral cavity cleaning lozenge, can not represent the whole of patent of the present invention, less be understood that
For limiting the scope of the invention, in the case where not departing from the precondition of design of essence of the invention, can also make several
Adjustment improves, and all belongs to the scope of protection of the present invention.
Embodiment 1
(1) after accurately weighing chitosan oligosaccharide 80g, molecular weight as 300000Da sodium alginates 800g and the directly crushing of dry leaf of Moringa
Moringa powder 120g (300 mesh), be uniformly mixed.
(2) pure water 50kg is added in into the mixture that step (1) obtains, 40min is stirred at 30 DEG C, uses high-pressure homogenization
Machine is processed to 2 Xun Huans, up to no solid content exists and forms homogenate.
(3) chitosan oligosaccharide, alginate and the moringa powder homogenate obtained step (2) is packed into lyophilized plate, is homogenized layer thickness control
It makes in 10mm, is flattened its surface using transfer roller.
(4) lyophilized plate that step (3) is filled to chitosan oligosaccharide, alginate and moringa powder homogenate is put into freeze drier ,-
Precooling 40min under the conditions of 30 DEG C, then vacuumizes and is freeze-dried, until the water content of membrane after lyophilized is controlled in 4.5 weights
Measure %.
(5) the method shape that the freeze-drying tablet containing chitosan oligosaccharide, alginate and moringa powder prepared by step (4) is passed through into cross cutting
Into lozenge.
Embodiment 2
(1) accurate chitosan oligosaccharide 100g, the molecular weight of weighing is that the potassium alginate 800g of 200000Da and fresh leaf of Moringa water carry
Moringa powder 100g (500 mesh) after the spray drying taken is uniformly mixed.
(2) pure water 30kg is added in into the mixture that step (1) obtains, 30min is stirred at 40 DEG C, uses high-pressure homogenization
Machine is processed to 3 Xun Huans, forms homogenate.
(3) chitosan oligosaccharide, alginate and the moringa powder homogenate obtained step (2) is packed into lyophilized plate, is homogenized layer thickness control
It makes in 10mm, is flattened its surface using transfer roller.
(4) lyophilized plate that step (3) is filled to chitosan oligosaccharide, alginate and moringa powder homogenate is put into freeze drier, and -40
Then precooling 20min under the conditions of DEG C is vacuumized and is freeze-dried, until the water content of membrane after lyophilized is controlled in 5 weight %.
(5) the method shape that the freeze-drying tablet containing chitosan oligosaccharide, alginate and moringa powder prepared by step (4) is passed through into cross cutting
Into lozenge.
Claims (4)
1. a kind of preparation method of oligochitosan oral cavity cleaning lozenge, which is characterized in that oligochitosan oral cavity cleans lozenge by 5~10 weights
Measure the moringa powder composition of the chitosan oligosaccharide of %, the alginate of 70~85 weight % and 10~20 weight %, the preparation method bag
Include following steps:
(1) chitosan oligosaccharide, alginate and moringa powder are uniformly mixed in the ratio;
(2) add in pure water into the chitosan oligosaccharide, alginate and Moringa powder mixture that step (1) obtains, the water with it is described
The weight ratio of mixture is 1:20~1:50,20min~40min is stirred under the conditions of 20 DEG C~60 DEG C, using high-pressure homogenization skill
Art makes it be thoroughly mixed to form homogenate;
(3) chitosan oligosaccharide, alginate and the moringa powder homogenate obtained step (2) is packed into lyophilized plate, and homogenate layer thickness control exists
3mm~30mm makes its surface uniform using Mechanical Method;
(4) lyophilized plate that step (3) is filled to chitosan oligosaccharide, alginate and moringa powder homogenate is put into freeze drier, -20 DEG C
Precooling 20min~50min under the conditions of~-40 DEG C, then vacuumizes and is freeze-dried, until the water content of membrane after lyophilized exists
4~8 weight %;
(5) piece containing chitosan oligosaccharide, alginate and moringa powder prepared by step (4) is formed into lozenge by the method for cross cutting.
A kind of 2. preparation method of oligochitosan oral cavity cleaning lozenge as described in claim 1, it is characterised in that the step (1)
Middle alginate can be sodium alginate or potassium alginate.
A kind of 3. preparation method of oligochitosan oral cavity cleaning lozenge as described in claim 1, it is characterised in that the step (1)
The molecular weight of middle alginate can be controlled in 10000Da~300000Da.
A kind of 4. preparation method of oligochitosan oral cavity cleaning lozenge as described in claim 1, it is characterised in that the step (1)
The particle size range of middle moringa powder can be in the mesh of 100 mesh~1000.
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CN201510862857.9A CN105410913B (en) | 2015-12-01 | 2015-12-01 | A kind of preparation method of oligochitosan oral cavity cleaning lozenge |
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CN105410913A CN105410913A (en) | 2016-03-23 |
CN105410913B true CN105410913B (en) | 2018-06-01 |
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EP1531832B1 (en) * | 2002-06-28 | 2009-04-15 | Glykos Finland Oy | Therapeutic compositions for use in prophylaxis or treatment of diarrheas |
CN101181293A (en) * | 2007-12-07 | 2008-05-21 | 武乾鹰 | Oral health lozenge for preventing tooth decay |
CN101972215A (en) * | 2010-10-09 | 2011-02-16 | 苗辉 | Chitosan oligosaccharide oral cavity cleaning tablet |
CN102579379B (en) * | 2011-12-29 | 2016-08-10 | 北京科信必成医药科技发展有限公司 | A kind of medicament slow release preparation and preparation method thereof |
CN104305202A (en) * | 2014-11-06 | 2015-01-28 | 河北考力森生物科技有限公司 | Ultrafine moringa oleifera powder compressed buccal tablet, and preparation method thereof |
CN104473822A (en) * | 2014-12-02 | 2015-04-01 | 东莞市荷花食品有限公司 | Mouthwash tablet containing plant extract and preparation method of mouthwash tablet |
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