CN105409974A - Bactericidal composition containing fluxapyroxad and SYP-Z048 - Google Patents
Bactericidal composition containing fluxapyroxad and SYP-Z048 Download PDFInfo
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- CN105409974A CN105409974A CN201510999150.2A CN201510999150A CN105409974A CN 105409974 A CN105409974 A CN 105409974A CN 201510999150 A CN201510999150 A CN 201510999150A CN 105409974 A CN105409974 A CN 105409974A
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- syp
- acid amides
- bactericidal composition
- azoles bacterium
- fluorine azoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Abstract
The invention discloses a bactericidal composition containing fluxapyroxad and SYP-Z048. The effective components of the bactericidal composition are fluxapyroxad and SYP-Z048, a weight ratio of fluxapyroxad to SYP-Z048 is 1:10-10:1, and the weight sum of fluxapyroxad and SYP-Z048 accounts for 5-80% of that of the bactericidal composition; according to the actual applicative requirements, the bactericidal composition can be prepared into one of an emulsion in water, a micron emulsion, a suspending agent, wettable powder and water dispersible granules. The bactericidal composition has obvious synergistic effect for botrytis cinerea and powdery mildew of cucumber, simultaneously reduces an application amount of a pesticide, reduces residual quantity of the pesticide on plants, mitigates pollution on environment, delays disease drug-resistance generation, and increases usage life of the pesticide.
Description
Technical field
The bactericidal composition that the present invention relates to is with fluorine azoles bacterium acid amides and SYP-Z048 for active ingredient, for preventing and treating graw mold of tomato, powdery mildew of cucumber.
Background technology
The resistance problem of agricultural disease is a global problem, is the emphasis problem that agricultural science and technology worker pays close attention to always.Along with the continuity year in year out of disease chemical control, the increase of Pesticide use amount and not scientifical use agricultural chemicals, germ resistance is day by day serious, and the germ kind producing resistance is on the increase.Meanwhile, the use agricultural chemicals of high strength, causes Practice for Pesticide Residue in Agricultural Products to exceed standard, environmental pollution and the increase of peasant's drug cost etc., is unfavorable for agricultural sustainable development.Therefore, the bactericide agricultural chemicals of efficient, the low toxicity of research and development, environmental protection has positive effect to agricultural sustainable development.
Fluorine azoles bacterium acid amides, chemical name: 3-(difluoromethyl)-1-methyl-N-(3,4,5-trifluoro [1, the two benzene of 1-]-2-base))-1H-pyrazole-4-carboxamide, fluorine azoles bacterium acid amides is succinate dehydrogenase inhibitors, has potent selectivity bactericidal action to cereal, soybean, corn, oil crop and banana, tomato, grape etc., for preventing and treating sigatoka, powdery mildew of cucumber, graw mold of tomato etc.
SYP-Z048, chemical name: N-methyl-3-(4-chlorine) phenyl-5-methyl-5-pyridine-3-methyl-oxazoline SYP-Z048 is sterol synthesis inhibition bactericide, effectively can be controlled the occurrence and infection of the not disease of leaf on the ground, also may be used for spraying by root application.SYP-Z048 has the bactericidal activity of wide spectrum, has protection and therapeutic action and good interior absorption, to gray mold, powdery mildew excellent effect simultaneously.
The mixture of different pesticide species is the common methods of control agricultural pest.Being screened by formulation of pesticide, filter out rational formula, can effectively improve actual control efficiency, reduce dosage, reduce costs, delay the drug-fast generation of damage by disease and insect, is the important means that agricultural synthesis is administered.The recipe determination of the present inventor to fluorine azoles bacterium acid amides and SYP-Z048 conducts in-depth research, find that fluorine azoles bacterium acid amides and SYP-Z048 carry out mixture and have obvious synergistic effect in certain mixed ratio scope to multiple fungi, after further study, the present invention is completed.
Composition and the application of fluorine azoles bacterium acid amides and SYP-Z048 there is no report at present.
Summary of the invention
The technical problem that the present invention solves be to provide a kind of efficient, low toxicity and the lasting period long, effectively can prevent and treat a kind of bactericidal composition containing fluorine azoles bacterium acid amides and SYP-Z048 of agricultural fungal evil.
For solving the problem, the technical solution adopted in the present invention is: a kind of bactericidal composition containing fluorine azoles bacterium acid amides and SYP-Z048, active ingredient is fluorine azoles bacterium acid amides and SYP-Z048, the weight ratio of fluorine azoles bacterium acid amides and SYP-Z048 is 1:10 ~ 10:1, fluorine azoles bacterium acid amides and SYP-Z048 weight summation in the composition percentage by weight are 5% ~ 80%, and all the other are agriculturally allow to use and acceptable insecticides adjuvant.
Bactericidal composition of the present invention according to well known to a person skilled in the art method, can be configured to the one in aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules.
Bactericidal composition of the present invention is also containing the auxiliary agent of preparation needed for pesticidal preparations, auxiliary agent is the mixing of one or more in solvent, emulsifier, wetting agent, stabilizing agent, dispersant, thickener, pH adjusting agent, defoamer, antifreezing agent, packing agent etc., be known substance, various auxiliary agents conventional in pesticidal preparations, can change to some extent according to different situations, be not particularly limited.
Bactericidal composition of the present invention, for preventing and treating graw mold of tomato, powdery mildew of cucumber.
A kind of bactericidal composition containing fluorine azoles bacterium acid amides and SYP-Z048 provided by the invention, usually adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
A kind of bactericidal composition containing fluorine azoles bacterium acid amides and SYP-Z048 provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, obvious synergy or summation action is shown in certain ratio range, the control efficiency of composition to germ is significantly improved than single dose, reduce the using dosage of agricultural chemicals, decrease times for spraying, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope.
2, bactericidal composition provided by the invention, two kinds of effective ingredient mechanism of action are not quite identical, can overcome the shortcoming that long-term single use easily produces resistance, extend the service life of medicament, to the comprehensive regulation important in inhibiting of germ resistance.
3, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and it applies huge economic benefit and social benefit.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Embodiment 1:16.5% fluorine azoles bacterium acid amides SYP-Z048 suspending agent.
Concrete operation step is: first mixed by other auxiliary agent, in clipper, shear-mixed is even, then adds fluorine azoles bacterium acid amides and SYP-Z048, in ball crusher, grind 2 ~ 3h, make a diameter all at below 5mm, 16.5% fluorine azoles bacterium acid amides SYP-Z048 suspending agent can be obtained.
Embodiment 2:18% fluorine azoles bacterium acid amides SYP-Z048 aqueous emulsion.
Concrete operation step is: first fluorine azoles bacterium acid amides and SYP-Z048, trimethylbenzene, Sorbitan fatty acid ester are mixed, and dissolves and becomes uniform oil phase.Again part water and other auxiliary agents are mixed, dissolve and become uniform aqueous phase.Then oil phase is added aqueous phase while high-speed stirred in a kettle., slowly add water to and reach phase inversion point, carry out high speed shear afterwards, and add remaining water, shear about 30min, 18% fluorine azoles bacterium acid amides SYP-Z048 aqueous emulsion can be obtained.
Embodiment 3:12% fluorine azoles bacterium acid amides SYP-Z048 microemulsion.
Concrete operation step is: first fluorine azoles bacterium acid amides and SYP-Z048 fatty acid methyl ester are dissolved completely, and then add other auxiliary agent, mix, finally add water, after fully stirring, can obtain 12% fluorine azoles bacterium acid amides SYP-Z048 microemulsion.
Embodiment 4:10% fluorine azoles bacterium acid amides SYP-Z048 wetting powder.
Concrete operation step is: fluorine azoles bacterium acid amides and SYP-Z048, other auxiliary agent are fully stirred in stirred tank, mixes, can obtain 10% fluorine azoles bacterium acid amides SYP-Z048 wetting powder after airslide disintegrating mill is pulverized.
Embodiment 5:40% fluorine azoles bacterium acid amides SYP-Z048 water dispersible granules.
Concrete operation step is: fluorine azoles bacterium acid amides and SYP-Z048, other auxiliary agent will be had to mix, pulverize with micro jet, add after mediating after carrying out granulation, drying, screening in fluidized-bed granulation dryer, 40% fluorine azoles bacterium acid amides SYP-Z048 water dispersible granules can be obtained.
Embodiment 6:24% fluorine azoles bacterium acid amides SYP-Z048 suspending agent.
Concrete operation step is: first mixed by other auxiliary agent, in clipper, shear-mixed is even, then adds fluorine azoles bacterium acid amides and SYP-Z048, in ball crusher, grind 2 ~ 3h, make a diameter all at below 5mm, 24% fluorine azoles bacterium acid amides SYP-Z048 suspending agent can be obtained.
Embodiment 7:55% fluorine azoles bacterium acid amides SYP-Z048 wetting powder.
Concrete operation step is: fluorine azoles bacterium acid amides and SYP-Z048, other auxiliary agent are fully stirred in stirred tank, mixes, can obtain 55% fluorine azoles bacterium acid amides SYP-Z048 wetting powder after airslide disintegrating mill is pulverized.
Embodiment 8: indoor bioassay.
Graw mold of tomato test surveys standard method NY/T1156.2-2006 with reference to raw, adopt pastille medium therapy: the liquid 6mL getting each single dose and mixture series concentration, add in the PDA medium of the 54mL being cooled to 45 DEG C, make the pastille culture medium flat plate of required final concentration.Then produce 6mm diameter mycelia block from the cultivation object bacteria colony edge of 7 days, move on each serial pastille medium, mycelia faces down, and each process repeats for 4 times.Be disposed, the constant temperature biochemical cultivation case being placed in 25 ± 1 DEG C is cultivated.
Take out culture medium flat plate after 3 days, measure each process colony diameter by right-angled intersection method, calculate the mycelial growth inhibition rate of each process.Be independent variable x according to the logarithm value of drug concentration (mg/L), with the probit value of corrected mortality for dependent variable y, set up virulence regression equation formula respectively, adopt DPS software to calculate the EC of single dose and each proportioning mixture
50and mixture co-toxicity coefficient.Co-toxicity coefficient (CTC) >=120 shows as synergistic effect; Co-toxicity coefficient (CTC)≤80 shows as antagonism; 80 < co-toxicity coefficient (CTC) < 120 show as summation action.Actual measurement toxicity index (ATI)=(standard agent EC
50/ reagent agent EC
50) × 100.Theoretical toxicity index (the TTI)=percentage composition of A (in the toxicity index × mixture of the A)+percentage composition of B (in the toxicity index × mixture of B).Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100.
Table 1, fluorine azoles bacterium acid amides and SYP-Z048 are to the indoor joint toxicity measuring result of graw mold of tomato germ.
As can be seen from Table 1, it is 125.78,122.56,124.90,128.28,129.05,126.36 and 130.60 that fluorine azoles bacterium acid amides and SYP-Z048 combine graw mold of tomato germ CTC value with 10:1,5:1,3:1,1:1,1:3,1:5 and 1:10 respectively, illustrates that fluorine azoles bacterium acid amides and SYP-Z048 combination have synergistic effect to graw mold of tomato germ.
Powdery mildew of cucumber test adopts field Cucumis sativus stem leaf spray-on process dispenser (having water membrane to be advisable with blade surface), spraying process is carried out on May 5th, 2015, chemical sprayer tool adopts manual sprayer (liquid capacity is about 2.0L), every 10 days spray medicines once, and continuous spraying 2 times.Often process selects climing 20 blades of uniform melon of falling ill as efficacy of medicine observing object, and each process repeats for 3 times.
Investigation method:
0 grade: without scab;
1 grade: lesion area accounts for less than 5% of whole leaf area;
3 grades: lesion area accounts for the 6%-15% of whole leaf area;
5 grades: lesion area accounts for the 16%-25% of whole leaf area;
7 grades: lesion area accounts for the 26%-50% of whole leaf area;
9 grades: lesion area accounts for more than 50% of whole leaf area.
According to survey data, calculate disease index and the control efficiency of each process.
Disease index presses formulae discovery, and result of calculation retains 2 significant digits:
When carrying out drug combination toxicity test, this test adopts Wadley method to calculate the coefficient of synergism (SR) of mixture, evaluates the synergy type of mixture.
Wadley method: the synergistic effect evaluating pharmacy mix according to coefficient of synergism (SR), namely SR<0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR>1.5 is synergistic function.Coefficient of synergism (SR) calculates by formula (1), (2):
In formula:
X1-------------mixture EC
50theoretical value, unit is milligrams per liter (mg/L);
P
a------------percentage composition of A in-mixture, unit is percentage (%);
P
b------------percentage composition of B in-mixture, unit is percentage (%);
The EC of A in A---------------mixture
50value, unit is milligrams per liter (mg/L);
The EC of B in B---------------mixture
50value, unit is milligrams per liter (mg/L).
In formula:
The coefficient of synergism of SR-------------mixture;
The EC of X1-------------mixture
50theoretical value, unit is milligrams per liter (mg/L);
The EC of X2-------------mixture
50measured value, unit is milligrams per liter (mg/L).
Table 2, fluorine azoles bacterium acid amides and SYP-Z048 are to the synergy of powdery mildew of cucumber germ
As can be seen from Table 2, fluorine azoles bacterium acid amides and SYP-Z048 composite in the scope of 1:10-10:1, synergistic effect is shown as to powdery mildew of cucumber.
Embodiment 9: fluorine azoles bacterium acid amides and SYP-Z048 composition are for preventing and treating graw mold of tomato field trial.
Test site is positioned at Ma An town, Huizhou, adopts spray-on process.Adopt 20% fluorine azoles bacterium amide suspending agents, 25% SYP-Z048 missible oil medicament in contrast, 9 chemicals treatment are established in test altogether, each process repeats for 4 times, the sick number of sheets of tomato is investigated before dispenser, within after dispenser 7 days, 15 days, respectively investigate a control efficiency, record the disease number of sheets, calculate control efficiency, result of the test is as shown in table 3.
Table 3, fluorine azoles bacterium acid amides and SYP-Z048 combination control graw mold of tomato result of the test
As can be seen from Table 3, example of formulations 1-7, the effect of control graw mold of tomato is better than the process of each contrast single dose.Fluorine azoles bacterium acid amides is described and SYP-Z048 is composite can improve control efficiency, reduces the using dosage of agricultural chemicals, decrease the impact of agricultural chemicals on environment, reduce drug cost.
Embodiment 10: fluorine azoles bacterium acid amides and SYP-Z048 composition are used for preventing and treating powdery mildew of cucumber field trial.
Test site is positioned at Ma An town, Huizhou, adopts spray-on process.Adopt 20% fluorine azoles bacterium amide suspending agents, 25% SYP-Z048 missible oil medicament in contrast, 9 chemicals treatment are established in test altogether, each process repeats for 4 times, the sick number of sheets of cucumber is investigated before dispenser, within after dispenser 7 days, 15 days, respectively investigate a control efficiency, record the disease number of sheets, calculate control efficiency, result of the test is as shown in table 4.
The combination of table 4, fluorine azoles bacterium acid amides and SYP-Z048 prevents and treats powdery mildew of cucumber result of the test
As can be seen from Table 4, example of formulations 1-7, the effect of preventing and treating powdery mildew of cucumber is better than the process of each contrast single dose.Fluorine azoles bacterium acid amides is described and SYP-Z048 is composite can improve control efficiency, reduces the using dosage of agricultural chemicals, decrease the impact of agricultural chemicals on environment, reduce drug cost.
Claims (3)
1. one kind contains the bactericidal composition of fluorine azoles bacterium acid amides and SYP-Z048, it is characterized in that: active ingredient is fluorine azoles bacterium acid amides and SYP-Z048, the weight ratio of fluorine azoles bacterium acid amides and SYP-Z048 is 1:10 ~ 10:1, and fluorine azoles bacterium acid amides and SYP-Z048 weight summation in the composition percentage by weight are 5% ~ 80%.
2. a kind of bactericidal composition containing fluorine azoles bacterium acid amides and SYP-Z048 according to claim 1, is characterized in that: the formulation of described bactericidal composition is the one of aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules.
3. a kind of application of bactericidal composition in control graw mold of tomato, powdery mildew of cucumber containing fluorine azoles bacterium acid amides and SYP-Z048 described in claim 1.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631465A (en) * | 2007-02-05 | 2010-01-20 | 巴斯夫欧洲公司 | Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101631465A (en) * | 2007-02-05 | 2010-01-20 | 巴斯夫欧洲公司 | Fungicidal mixtures comprising substituted 1-methylpyrazol-4-ylcarboxanilides |
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Application publication date: 20160323 |