CN105399814A - Cryoprecipitated antihemophilic factor preparation instrument and application method thereof - Google Patents
Cryoprecipitated antihemophilic factor preparation instrument and application method thereof Download PDFInfo
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- CN105399814A CN105399814A CN201510756741.7A CN201510756741A CN105399814A CN 105399814 A CN105399814 A CN 105399814A CN 201510756741 A CN201510756741 A CN 201510756741A CN 105399814 A CN105399814 A CN 105399814A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 129
- 102100026735 Coagulation factor VIII Human genes 0.000 title claims abstract description 44
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title claims abstract description 44
- 238000000034 method Methods 0.000 title claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 113
- 238000005303 weighing Methods 0.000 claims abstract description 60
- 230000000603 anti-haemophilic effect Effects 0.000 claims abstract description 15
- 238000004260 weight control Methods 0.000 claims abstract description 11
- 230000000694 effects Effects 0.000 claims abstract description 8
- 210000002381 plasma Anatomy 0.000 claims description 96
- 239000004023 fresh frozen plasma Substances 0.000 claims description 26
- 210000004369 blood Anatomy 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 23
- 210000004027 cell Anatomy 0.000 claims description 21
- 238000005057 refrigeration Methods 0.000 claims description 20
- 229910000639 Spring steel Inorganic materials 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 8
- 239000000155 melt Substances 0.000 claims description 6
- 239000008399 tap water Substances 0.000 claims description 6
- 235000020679 tap water Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 238000010257 thawing Methods 0.000 description 6
- 239000002699 waste material Substances 0.000 description 3
- 201000003542 Factor VIII deficiency Diseases 0.000 description 2
- 208000009292 Hemophilia A Diseases 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 208000032668 Acquired afibrinogenaemia Diseases 0.000 description 1
- 208000002004 Afibrinogenemia Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 208000023661 Haematological disease Diseases 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000027276 Von Willebrand disease Diseases 0.000 description 1
- 201000007182 congenital afibrinogenemia Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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Abstract
The invention discloses a cryoprecipitated antihemophilic factor preparation instrument. The cryoprecipitated antihemophilic factor preparation instrument is characterized by being composed of three parts, i.e., a weight control part, a water temperature control and water circulation system part and a central control part, wherein the three parts are interconnected together, and the weight control part is divided into a weighing part and a control part. The cryoprecipitated antihemophilic factor preparation instrument disclosed by the invention not only can achieve the simultaneous batch preparation of cryoprecipitated antihemophilic factors, but also can implement single-bag operation, i.e., the implementation of batch preparation is not required, once a bag is completely prepared, the bag can be taken out, and then a next bag is put into the instrument to prepare, so that an effect of flow production is achieved, thereby greatly saving time.
Description
Technical field
The present invention relates to Cryoprecipitated antihemophilic factor preparation device field, be specially a kind of Cryoprecipitated antihemophilic factor preparation device, also relate to a kind of Cryoprecipitated Antihemophilic Factors simultaneously and prepare using method.
Background technology
Cryoprecipitated Antihemophilic Factors are isolated most blood plasma, and are solid-state component blood by the quick-frozen in 1 hour of remaining cold insoluble matter after referring to and adopting specific method the fresh frozen plasma in preservation period to be melted at 1 DEG C ~ 6 DEG C.Cryoprecipitated Antihemophilic Factors are mainly used in inpatient with haematological diseases, such as congenital or acquired afibrinogenemia, congenital or acquired blood coagulation factor VIII deficiency disease, von Willebrand disease, children and light-duty grownup's hemophilia A etc.Cryoprecipitated Antihemophilic Factors from whole blood, isolate fresh frozen plasma by blood collecting and supplying unit, and then prepare from fresh frozen plasma.The quality of Cryoprecipitated Antihemophilic Factors and the standardization of whole preparation process and stdn closely related.At present, the preparation process of Cryoprecipitated Antihemophilic Factors in blood station mainly still adopts manually-operated method, causes the quality product prepared to be difficult to reach the standard of national requirements, and production efficiency is low, time-consuming effort.
The preparation of existing Cryoprecipitated Antihemophilic Factors mainly contains two kinds of methods:
1.4 DEG C of refrigerator defrosting+centrifuging:
The fresh frozen plasma being frozen into solid state is put into 4 DEG C of refrigerators to leave standstill, allow it naturally slowly melt, about 15 hours, still have during a little rubble ice until basic thawing and take out, heavy centrifugal.Isolate upper plasma to transfering bag, lower floor's blood plasma and the white depositions of staying former bag are cryoprecipitate, reach standard by the capacity of Weighing control cryoprecipitate.
2.1 DEG C ~ 6 DEG C water-baths are thawed+siphonage:
The fresh frozen plasma being frozen into solid state is put into the water being chilled to 1 DEG C ~ 6 DEG C in advance, the blood plasma of thawing oozes transfering bag by syphonic effect, and white depositions remaining in former bag is cryoprecipitate.Standard is reached by the capacity of Weighing control cryoprecipitate.
Wherein publication number is that CN102389592A uses water-bath freezing process and siphonage to be prepared, it adopts two cover weighing systems, the weight (namely going up weighing system) of fresh frozen plasma of weighing respectively and flow out to the real-time weight (namely descending weighing system) of transfering bag, forms siphon by peristaltic pump air-discharging.Because blood plasma cannot be weighed in water, so need a kind of lifting device first " upper weighing system " lift-off water surface, then weigh, then blood plasma is fallen in backwater thaw.
Secondly also have a publication number to be its use frozen air freezing process of CN104623748A, therefore there is the device such as blower fan, airduct.
The technical disadvantages of the following aspects that above-mentioned disclosed patent exists has:
One, owing to have employed the method that two cover system two steps are weighed, weigh to fresh frozen plasma and transfering bag respectively.Weighing of fresh frozen plasma must be carried out more than the water surface, needs again to put back in water to thaw, so realize with lifting device after having claimed.And the running and comparing of lifting device is time-consuming.The more important thing is, the setting of lifting device, cause the preparation work of cryoprecipitate can only carry out (a collection of at present can only prepare 15 bags) by the gross, as long as there is wherein one bag of cryoprecipitate not yet to prepare, all required etc. to be done after, just can carry out the preparation work of next batch cryoprecipitate, this is also the factor causing working efficiency not high.
Two, the setting of peristaltic pump makes the conduit between blood bag be pullled in wriggling process of being everlasting, and needs operator to keep and aside observes, pull back, otherwise cause conduit rupture by by the conduit pullled, very dangerous.
Three, whole operating in cabinet completes, and causes whole set equipment volume to be doted on greatly like this.Be provided with two cover refrigeration systems, a set of for the air cooling in cabinet, a set of to the water refrigeration in water bath.And air cooling role in cabinet is little, makes power double on the contrary, cause the waste of electric energy in a large number.
Four, the air thawing method preparation time adopted is very long, more than 10 hour, cannot promptly prepare.An equipment can only be prepared a collection of in one day, cannot realize the object of preparation in enormous quantities.And cryoprecipitate quality product prepared by air thawing is not high, thrombin meeting is wherein inactivation because preparation time is long.Wind after refrigeration can cause a large amount of energy waste by in/out air tube, and can very out of true by the homo(io)thermism that the refrigeration of wind and heating realized to blood plasma unfreezing.Generally, air thawing legal system belongs to filtering technique for cryoprecipitate.
Summary of the invention
For the drawback of the preparation of above Cryoprecipitated Antihemophilic Factors, the invention provides Cryoprecipitated antihemophilic factor preparation device, it when not contacting measurand, can not affect GIS structure, realize the real time temperature observing GIS steadily in the long term, ensure the safe operation of system.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of Cryoprecipitated antihemophilic factor preparation device, it is characterized in that: described Cryoprecipitated antihemophilic factor preparation device is made up of three parts: weight control part, water temperature controls and water circulation system part and central control portion, interconnect between described three parts, described weight control part is divided into weight control part to be divided into weighing section and control section, described water temperature controls and water circulation system mainly comprises lower header (15), water pump (16), refrigeration compressor (17), radiator fan (18), temperature sensor (20), water level gauge (21), heating unit (22) and upper water box (23), described lower header (15) is positioned at the back side of Cryoprecipitated antihemophilic factor preparation device, described radiator fan (18) is positioned at below lower header (15), the left side of described radiator fan (18) is provided with vent window (5), the right side of described radiator fan (18) is provided with the refrigeration compressor (17) be connected with water pump (16), described central control portion mainly comprises touch screen operation platform (11) and electric control box (19).
Further, described touch screen operation platform (11) is positioned at the top of Cryoprecipitated antihemophilic factor preparation device, and described electric control box (19) is positioned at the right on of lower header (15).
Further, control section mainly comprises: pinch valve (4), preparation position independent operation advance key (6), preparation position separate display screens (7), preparation position independent operation button return key (8) and batch preparation manipulation button (9), described Cryoprecipitated antihemophilic factor preparation device front is provided with control panel, described control panel is provided with organizes control unit more, described control unit is by preparing an independent operation advance key (6), preparation position separate display screens (7) and preparation position independent operation button return key (8) composition, batch preparation manipulation button (9) is provided with on the top of many row's control units.
Further, described weighing section comprises: pinch valve (4), to weigh box (10), LOAD CELLS (24), spring steel ball (25), retaining plate (26), Upper gasket (27), lower gasket (28), retaining plate screw hole (29) and box pickup groove (30) of weighing, described pinch valve (4) is screwed on the front of Cryoprecipitated antihemophilic factor preparation device, described box of weighing (10) is positioned at the bottom of pinch valve (4), described box pickup groove (30) of weighing is positioned at the bottom of box of weighing (10), described box of weighing (10) is stuck on spring steel ball (25) by box pickup groove (30) of weighing, described spring steel ball (25) is positioned at the both sides of retaining plate (26), described retaining plate (26) is screwed in LOAD CELLS (24) by retaining plate screw hole (29), Upper gasket (27) is provided with in the middle of described retaining plate (26) and LOAD CELLS (24), described LOAD CELLS (24) is screwed on the main body rack of Cryoprecipitated antihemophilic factor preparation device, lower gasket (28) is provided with between LOAD CELLS (24) and the main body rack of Cryoprecipitated antihemophilic factor preparation device.
Further, the mode of connection described in described three parts is for being welded to connect or screw connection.
Further, described spring steel ball (25) is six, and described spring steel ball (25) is inserted in the both sides of retaining plate (26) in the mode of agreeing with.
The present invention also comprises a kind of method using Cryoprecipitated antihemophilic factor preparation device to prepare single bag Cryoprecipitated Antihemophilic Factors, and its step is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: plasma bags is put into box of weighing (10) together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: plasma bags and transfering bag are taken out from box of weighing, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press preparation position independent operation advance key (6) and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
The present invention also comprises a kind of method using Cryoprecipitated antihemophilic factor preparation device batch to prepare many bags Cryoprecipitated Antihemophilic Factors, and its step is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: put into box of weighing (10) with the plasma bags criticized together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, press batch preparation manipulation button (9) to many bags of plasma procedure, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: take out from box of weighing with the plasma bags criticized and transfering bag, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press batch preparation manipulation button (9) batch and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
Present invention employs water-bath thaw preparation cryoprecipitate technology, by structure and the flow scheme design of exquisiteness, achieve following breakthrough:
1. not only can prepare by batch simultaneously, also can single bag of operation, need not wait for and having prepared by the gross, as long as there is one bag of preparation to complete, just can take out, and put into next bag and be prepared, realize continuous-flow type operation, greatly save time;
2. use a set of weighing system, realize object by two step weighting methods; Do not need lifting device, preparation speed is fast, prepares a collection of 20 bags of cryoprecipitates and only needs 50 minutes;
3. a set of refrigeration system of a needs, carries out refrigeration constant temperature to preset temp to the water in water bath, greatly reduces energy waste.By air-discharging in advance, realize siphon, without the need to arranging the device of other exclusion air;
4. cabinet is not set, adopts open-sky technique, facilitate staff.Deft design, small volume can realize in enormous quantities;
5. can shift to an earlier date starting up's refrigeration by setting-up time, make staff can carry out cryoprecipitate preparation work immediately once going to work, saving the waiting time to water refrigeration.
Accompanying drawing explanation
The oblique drawing of Fig. 1 Cryoprecipitated antihemophilic factor preparation device
The side-view of Fig. 2 Cryoprecipitated antihemophilic factor preparation device
The rear view of Fig. 3 Cryoprecipitated antihemophilic factor preparation device
The Weighing module side-view of Fig. 4 Cryoprecipitated antihemophilic factor preparation device
The Weighing module top view of Fig. 5 Cryoprecipitated antihemophilic factor preparation device
The Weighing module of Fig. 6 Cryoprecipitated antihemophilic factor preparation device and box interface chart of weighing
Touch operation screen 1; Water bath 2; Clip 3; Pinch valve 4; Vent window 5; Preparation position independent operation advance key 6; Preparation position separate display screens 7; Preparation position independent operation button return key 8; Batch preparation manipulation button 9; To weigh box 10; Touch screen operation platform 11; Water inlet pore 12; Drain tube holes 13; Spilling water pore 14; Lower header 15; Water pump 16; Refrigeration compressor 17; Radiator fan 18; Electric control box 19; Temperature sensor 20; Water level gauge 21; Heating unit 22; Upper water box 23; LOAD CELLS 24; Spring steel ball 25; Retaining plate 26; Upper gasket 27; Lower gasket 28; Retaining plate screw hole 29; To weigh box pickup groove 30.
Embodiment
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with embodiment, also with reference to accompanying drawing, the invention will be further described.
As shown in figures 1 to 6, the present invention is mainly divided into three parts: (1) weight control part, (2) water temperature control and water circulation system and (3) central control portion.Interconnect between three parts, the mode adopted is for being welded to connect or screw connection.
Wherein, weight control part is divided into weight control part to be divided into weighing section and control section, and wherein control section mainly comprises: pinch valve (4), preparation position independent operation advance key (6), preparation position separate display screens (7), preparation position independent operation button return key (8) and batch preparation manipulation button (9), the control panel in Cryoprecipitated antihemophilic factor preparation device front is provided with many groups preparation position independent operation advance key (6), preparation position separate display screens (7) and preparation position independent operation button return key (8) composition control unit, batch preparation manipulation button (9) is provided with at the middle part of control panel, control for batch, on the other hand, its weighing section comprises: pinch valve (4), to weigh box (10), LOAD CELLS (24), spring steel ball (25), retaining plate (26), Upper gasket (27), lower gasket (28), retaining plate screw hole (29) and box pickup groove (30) of weighing, accompanying drawing 4 ~ 6 is shown in by weighing section primary structure.Pinch valve (4) is screwed, and box of weighing (10) is stuck on 6 spring steel balls (25) of retaining plate (26) both sides by the box pickup groove (30) of weighing of box body bottom.Spring steel ball (25) is inserted in the both sides of retaining plate (26) in the mode of agreeing with.Spring steel ball (25) can be depressed, and can upspring after unclamping.Retaining plate (26) is screwed in LOAD CELLS (24) by retaining plate screw hole (29), adds Upper gasket (27) in the middle of retaining plate (26) and LOAD CELLS (24).LOAD CELLS (24) is screwed on the main body rack of Cryoprecipitated antihemophilic factor preparation device, adds lower gasket (28) in the middle of both.
As shown in Figure 3, water temperature control and water circulation system mainly comprise lower header (15), water pump (16), refrigeration compressor (17), radiator fan (18), temperature sensor (20), water level gauge (21), heating unit (22) and upper water box (23).
Central control portion mainly comprises touch screen operation platform (11) and electric control box (19).
The step that use Cryoprecipitated antihemophilic factor preparation device prepares single bag Cryoprecipitated Antihemophilic Factors is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: plasma bags is put into box of weighing (10) together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: plasma bags and transfering bag are taken out from box of weighing, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press preparation position independent operation advance key (6) and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
The step that use Cryoprecipitated antihemophilic factor preparation device batch prepares many bags Cryoprecipitated Antihemophilic Factors is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: put into box of weighing (10) with the plasma bags criticized together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, press batch preparation manipulation button (9) to many bags of plasma procedure, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: take out from box of weighing with the plasma bags criticized and transfering bag, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press batch preparation manipulation button (9) batch and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
Although schematically illustrating some specific embodiments to illustrate and describing the present invention above, and do not mean that the present invention is only confined to wherein each kind of details.On the contrary, the present invention's spirit can not be departed from the category being equivalent to claims and scope in various details, various amendment is made.
Claims (8)
1. a Cryoprecipitated antihemophilic factor preparation device, it is characterized in that: described Cryoprecipitated antihemophilic factor preparation device is made up of three parts: weight control part, water temperature controls and water circulation system part and central control portion, interconnect between described three parts, described weight control part is divided into weight control part to be divided into weighing section and control section, described water temperature controls and water circulation system mainly comprises lower header (15), water pump (16), refrigeration compressor (17), radiator fan (18), temperature sensor (20), water level gauge (21), heating unit (22) and upper water box (23), described lower header (15) is positioned at the back side of Cryoprecipitated antihemophilic factor preparation device, described radiator fan (18) is positioned at below lower header (15), the left side of described radiator fan (18) is provided with vent window (5), the right side of described radiator fan (18) is provided with the refrigeration compressor (17) be connected with water pump (16), described central control portion mainly comprises touch screen operation platform (11) and electric control box (19).
2. Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that: described touch screen operation platform (11) is positioned at the top of Cryoprecipitated antihemophilic factor preparation device, described electric control box (19) is positioned at the right on of lower header (15).
3. Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that: control section mainly comprises: pinch valve (4), preparation position independent operation advance key (6), preparation position separate display screens (7), preparation position independent operation button return key (8) and batch preparation manipulation button (9), described Cryoprecipitated antihemophilic factor preparation device front is provided with control panel, described control panel is provided with organizes control unit more, described control unit is by preparing an independent operation advance key (6), preparation position separate display screens (7) and preparation position independent operation button return key (8) composition, batch preparation manipulation button (9) is provided with on the top of many row's control units.
4. according to the arbitrary described Cryoprecipitated antihemophilic factor preparation device of claim 1-3, it is characterized in that: described weighing section comprises: pinch valve (4), to weigh box (10), LOAD CELLS (24), spring steel ball (25), retaining plate (26), Upper gasket (27), lower gasket (28), retaining plate screw hole (29) and box pickup groove (30) of weighing, described pinch valve (4) is screwed on the front of Cryoprecipitated antihemophilic factor preparation device, described box of weighing (10) is positioned at the bottom of pinch valve (4), described box pickup groove (30) of weighing is positioned at the bottom of box of weighing (10), described box of weighing (10) is stuck on spring steel ball (25) by box pickup groove (30) of weighing, described spring steel ball (25) is positioned at the both sides of retaining plate (26), described retaining plate (26) is screwed in LOAD CELLS (24) by retaining plate screw hole (29), Upper gasket (27) is provided with in the middle of described retaining plate (26) and LOAD CELLS (24), described LOAD CELLS (24) is screwed on the main body rack of Cryoprecipitated antihemophilic factor preparation device, lower gasket (28) is provided with between LOAD CELLS (24) and the main body rack of Cryoprecipitated antihemophilic factor preparation device.
5. Cryoprecipitated antihemophilic factor preparation device according to claim 4, is characterized in that: the mode of connection described in described three parts is for being welded to connect or screw connection.
6. Cryoprecipitated antihemophilic factor preparation device according to claim 5, is characterized in that: described spring steel ball (25) is six, and described spring steel ball (25) is inserted in the both sides of retaining plate (26) in the mode of agreeing with.
7. use the Cryoprecipitated antihemophilic factor preparation device described in claim 6 to prepare a method for single bag Cryoprecipitated Antihemophilic Factors, its step is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: plasma bags is put into box of weighing (10) together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: plasma bags and transfering bag are taken out from box of weighing, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press preparation position independent operation advance key (6) and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
8. use the batch of the Cryoprecipitated antihemophilic factor preparation device described in claim 6 to prepare a method for many bags Cryoprecipitated Antihemophilic Factors, its step is as follows:
Step one: the preparation of the fresh frozen plasma of preparation cryoprecipitate:
After fresh frozen plasma has been separated, the air in plasma bags is all discharged in transfering bag, and allows blood plasma be full of connecting tube between blood bag, put into low temperature environment frozen;
Step 2: the pre-temperature of start: after start energising, by the target temperature that touch operation screen (1) the setting water-bath on touch screen operation platform (11) is thawed, its temperature range is: 1 DEG C ~ 6 DEG C, and start pre-temperature process, tap water enters lower header (15) by water inlet pore (12), by water level gauge (21), water pump (16) and drain tube holes (13) co-controlling flooding quantity, in temperature sensor (20), the water in lower header (15) is made to reach design temperature under the collaborative work of refrigeration compressor (17) and heating unit (22),
Step 3: after the water temperature that touch operation screen (1) shows reaches design temperature, to sound prompting, chilled water in lower header (15) passes through water pump (16) pump in the water bath (2) of upper water box (23), maintaining design temperature by circulation about this kind, proceeding as follows being frozen into after solid-state fresh frozen plasma is taken out from low temperature environment:
The first step: put into box of weighing (10) with the plasma bags criticized together with transfering bag, weighed by the LOAD CELLS (24) of box of weighing (10) below, operation preparation position independent operation advance key (6) has confirmed this step operation, press batch preparation manipulation button (9) to many bags of plasma procedure, carry out batch complete operation simultaneously, preparation position separate display screens (7) is pointed out operation, if there is mishandle, preparation position independent operation button return key (8) can be pressed and cancel this mishandle;
Second step: take out from box of weighing with the plasma bags criticized and transfering bag, plasma bags is put into water bath (2) thaw, transfering bag is placed in box of weighing (10), and linking conduit between two bags is snapped in pinch valve (4), in order to make mixed and disorderly blood bag conduit in order, can use clip (3) that conduit is fixed, press batch preparation manipulation button (9) batch and confirmed this step operation;
Step 4: the refrigerated plasma in water bath (2) melts and passes through syphonic effect, the transfering bag of low level is flow to from the plasma bags of a high position, when the residue capacity in plasma bags reaches user preset value, start the linking conduit between pinch valve (4) clamping blood bag, and remind operator to prepare by sound and light alarm;
Step 5: operator take out the plasma bags forming cryoprecipitate in water bath together with flowing into the transfering bag of blood plasma, and heat seal disconnects, and just preparation process completes.
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| CN111560065A (en) * | 2020-06-29 | 2020-08-21 | 山东中保康医疗器具有限公司 | Cryoprecipitated blood coagulation factor preparation instrument and use method thereof |
| CN111870749A (en) * | 2019-11-27 | 2020-11-03 | 深圳市普特生物医学工程有限公司 | Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument |
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