CN105399814B - Cryoprecipitated antihemophilic factor preparation device and its application method - Google Patents
Cryoprecipitated antihemophilic factor preparation device and its application method Download PDFInfo
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- CN105399814B CN105399814B CN201510756741.7A CN201510756741A CN105399814B CN 105399814 B CN105399814 B CN 105399814B CN 201510756741 A CN201510756741 A CN 201510756741A CN 105399814 B CN105399814 B CN 105399814B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
Abstract
A kind of Cryoprecipitated antihemophilic factor preparation device, it is characterised in that：The Cryoprecipitated antihemophilic factor preparation device is made of three parts：Weight control part, water temperature control and water circulation system part and central control portion interconnect between the three parts, and the Weight control part is divided into weighing section and control section.The present invention not only can batch prepare simultaneously, can also single bag of operation completed as long as there is one bag to prepare without waiting for preparing completions by the gross, so that it may with taking-up, and be put into next bag and prepared, realization continuous-flow type operation greatlys save the time.
Description
Technical field
The present invention relates to Cryoprecipitated antihemophilic factor preparation device field, specially a kind of Cryoprecipitated antihemophilic factor preparation device, together
When further relate to a kind of Cryoprecipitated Antihemophilic Factors and prepare application method.
Background technology
Cryoprecipitated Antihemophilic Factors refer to being melted the fresh frozen plasma in storage life at 1 DEG C~6 DEG C using specific method
After change, most blood plasma is isolated, and remaining cold insoluble matter is quick-frozen in solid component blood in 1h.Cryoprecipitate
Coagulation factor is mainly used for inpatient with haematological diseases, such as congenital or acquired afibrinogenemia, congenital or acquired
Platelet cofactor Ⅰ deficiency disease, von Willebrand disease, children and light-duty adult's hemophilia A etc..Cryoprecipitated Antihemophilic Factors are
Fresh frozen plasma is isolated from whole blood by blood collecting and supplying unit, is then prepared from fresh frozen plasma again.Cryoprecipitate
The quality of coagulation factor and the standardization of whole preparation process and standardization are closely related.Currently, Cryoprecipitated Antihemophilic Factors
Preparation process in blood station causes the product quality prepared to be extremely difficult to country mainly or using manually-operated method
Required standard, and production efficiency is low, time-consuming effort.
There are mainly two types of methods for the preparation of existing Cryoprecipitated Antihemophilic Factors：
1.4 DEG C of refrigerator defrosting+centrifugal process：
The fresh frozen plasma for being frozen into solid state is put into 4 DEG C of refrigerators and is stood, it is allowed slowly to melt naturally, about 15
Hour, it takes out when basic thawing still has a little rubble ice, centrifuges again.Upper plasma is isolated to transfering bag, stays in former bag
Lower layer's blood plasma and white depositions are cryoprecipitate, reach standard by the capacity of Weighing control cryoprecipitate.
2.1 DEG C~6 DEG C water-bath defrosting+siphonages：
By the fresh frozen plasma for being frozen into solid state be put into it is pre- be cooled in 1 DEG C~6 DEG C of water, the blood plasma of thawing passes through
Siphonage oozes transfering bag, and remaining white depositions are cryoprecipitate in former bag.Pass through Weighing control cryoprecipitate
Capacity reach standard.
Wherein Publication No. CN102389592A is prepared using water-bath freezing process and siphonage, uses two sets to weigh
System, the weight (i.e. upper weighing system) for fresh frozen plasma of weighing respectively and the real-time weight for flowing out to transfering bag (are called in the following text
Weight system), siphon is formed by peristaltic pump air-discharging.Because blood plasma can not weigh in water, a kind of lifting gear is needed
First " upper weighing system " the lift-off water surface, it is re-weighed, then blood plasma is dropped back in water and is thawed.
Secondly there are one Publication No. CN104623748A, it uses frozen air freezing process, therefore there are wind turbine, wind
The devices such as pipe.
The technical disadvantages of the following aspects existing for the above-mentioned published patent have：
One, the method weighed as a result of two step of two systems will respectively carry out fresh frozen plasma and transfering bag
It weighs.Weighing for fresh frozen plasma must carry out more than the water surface, need to put back in water again after having claimed and thaw, so using
Lifting gear is realized.And the running and comparing of lifting gear is time-consuming.Importantly, the setting of lifting gear, leads to cryoprecipitate
Preparation work can only carry out (current a batch can only prepare 15 bags) by the gross, as long as there is wherein one bag of cryoprecipitate not yet to make
It is standby to complete, after must all waiting for, the preparation work of next group cryoprecipitate could be carried out, this is also to cause working efficiency not
High factor.
Two, the setting of peristaltic pump makes the conduit between blood bag often be pullled during wriggling, and operating personnel is needed to keep
It aside observes, will be pulled back by the conduit pullled, otherwise cause conduit rupture, it is extremely dangerous.
Three, whole operation is completed in cabinet, and whole set equipment volume is caused to be doted on greatly in this way.Two sets of refrigeration systems are provided with,
A set of air cooling in cabinet, a set of water in water bath freeze.And the air cooling role in cabinet is not
Greatly, so that power is doubled instead, largely cause the waste of electric energy.
Four, the air thawing method preparation time used is very long, a hour more than 10, can not promptly prepare.One equipment
A batch can only be prepared within one day, cannot achieve the purpose being prepared on a large scale.And cryoprecipitate product quality prepared by air thawing is not
Height, coagulation factor therein can be inactivated because preparation time is long.Wind after refrigeration can cause a large amount of energy by in/out air tube
Amount loss, and by refrigeration to wind and heating come realize that the temperature of blood plasma unfreezing is constant can be very inaccurate.Generally, empty
Gas freezing process prepares cryoprecipitate and already belongs to filtering technique.
Invention content
For the above Cryoprecipitated Antihemophilic Factors preparation the drawbacks of, the present invention provide Cryoprecipitated antihemophilic factor preparation device,
GIS structures can not be influenced in the case where not contacting measurand, realize the real time temperature for observing GIS steadily in the long term, protect
The safe operation of card system.
The technical solution adopted by the present invention to solve the technical problems is：
A kind of Cryoprecipitated antihemophilic factor preparation device, it is characterised in that：The Cryoprecipitated antihemophilic factor preparation device is by three big portions
It is grouped as：Weight control part, water temperature control and water circulation system part and central control portion, phase between the three parts
Interconnection is connected together, and the Weight control part is divided into weighing section and control section, the water temperature control and water circulation system
Include mainly lower header (15), water pump (16), refrigeration compressor (17), radiator fan (18), temperature sensor (20), water-level gauge
(21), heating device (22) and upper water box (23), the lower header (15) are located at the back side of Cryoprecipitated antihemophilic factor preparation device, institute
It states radiator fan (18) to be located at below lower header (15), the left side of the radiator fan (18) is equipped with vent window (5), described to dissipate
The right side of Hot-air fan (18) is equipped with the refrigeration compressor (17) being connected with water pump (16), and the central control portion includes mainly
Touch screen operation platform (11) and electric control box (19).
Further, the touch screen operation platform (11) is located at the top of Cryoprecipitated antihemophilic factor preparation device, the electric-controlled
Case (19) processed is located at the front of lower header (15).
Further, control section includes mainly：Pinch valve (4) prepares position independent operation advance key (6), prepares position independence
Display screen (7) prepares position independent operation button return key (8) and batch preparation manipulation button (9), the Cryoprecipitated Antihemophilic Factors
Preparing instrument front is equipped with control panel, and the control panel is equipped with multigroup control unit, and described control unit is only by preparing position
Vertical operation advance key (6) prepares position separate display screens (7) and prepares position independent operation button return key (8) composition, in multigroup control
The top of unit processed is equipped with batch preparation manipulation button (9).
Further, the weighing section includes：Pinch valve (4), box of weighing (10), weighing sensor (24), spring steel ball
(25), fixed plate (26), Upper gasket (27), lower gasket (28), fixed plate screw hole (29) and box fixing groove (30) of weighing, it is described
Pinch valve (4) is screwed on the front of Cryoprecipitated antihemophilic factor preparation device, and the box of weighing (10) is located at pinch valve
(4) lower part, the box fixing groove (30) of weighing are located at the lower part for box (10) of weighing, and the box of weighing (10) is solid by box of weighing
Determine slot (30) to be stuck on spring steel ball (25), the spring steel ball (25) is located at the both sides of fixed plate (26), the fixed plate
(26) it is screwed on weighing sensor (24) by fixed plate screw hole (29), the fixed plate (26) and weighing and sensing
Upper gasket (27) is equipped among device (24), the weighing sensor (24) is screwed in Cryoprecipitated antihemophilic factor preparation device
Main body rack on, weighing sensor (24) between the main body rack of Cryoprecipitated antihemophilic factor preparation device be equipped with lower gasket
(28)。
Further, the connection type described in the three parts is to be welded to connect or screw connection.
Further, the spring steel ball (25) is six, and the spring steel ball (25) is inserted in fixed plate in a manner of agreeing with
(26) both sides.
The invention also includes a kind of method preparing single packet Cryoprecipitated Antihemophilic Factors using Cryoprecipitated antihemophilic factor preparation device,
Its step are as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to fill
Connecting pipe between full blood bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature that water-bath is thawed, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water passes through pore of intaking
(12) enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature
The water in lower header (15) is set to reach setting under the collaborative work of sensor (20), refrigeration compressor (17) and heating device (22)
Temperature；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting, lower header (15) are made a sound
In chilled water pumped by water pump (16) in the water bath (2) of upper water box (23), passing through such cycle up and down and maintain setting
Temperature will be frozen into solid fresh frozen plasma and be proceeded as follows after being taken out in low temperature environment：
The first step：Plasma bags and transfering bag are put into togerther in box of weighing (10), weighing below box of weighing (10) is passed through
Sensor (24) is weighed, and operation preparation position independent operation advance key (6), which confirms, completes this step operation, and it is complete simultaneously to carry out batch
It at operation, prepares position separate display screens (7) and operation is prompted, if there is maloperation, can press and prepare position independent operation button
Return key (8) cancels the maloperation；
Second step：Plasma bags and transfering bag are taken out from box of weighing, plasma bags are put into water bath (2) and are thawed,
Transfering bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), in order to make mixed and disorderly blood in order
Bag conduit, can be used fixing buckle (3) that conduit is fixed, and presses preparation position independent operation advance key (6) and confirms this step operation of completion；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, from high-order plasma bags stream
To the transfering bag of low level, when the residue capacity in plasma bags reaches user preset value, start pinch valve (4) clamp blood bag it
Between connecting conduit, and pass through sound-light alarm remind operating personnel prepare complete；
Step 5：Operating personnel in water bath the plasma bags for having formed cryoprecipitate and have been flowed into the transfering bag one of blood plasma
It rises and takes out, heat seal disconnects, and just preparation process is completed.
The invention also includes a kind of more packet Cryoprecipitated Antihemophilic Factors are prepared using Cryoprecipitated antihemophilic factor preparation device batch
Method, its step are as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to fill
Connecting pipe between full blood bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature that water-bath is thawed, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water passes through pore of intaking
(12) enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature
The water in lower header (15) is set to reach setting under the collaborative work of sensor (20), refrigeration compressor (17) and heating device (22)
Temperature；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting, lower header (15) are made a sound
In chilled water pumped by water pump (16) in the water bath (2) of upper water box (23), passing through such cycle up and down and maintain setting
Temperature will be frozen into solid fresh frozen plasma and be proceeded as follows after being taken out in low temperature environment：
The first step：Being put into togerther in box of weighing (10) with the plasma bags and transfering bag criticized, pass through below box of weighing (10)
Weighing sensor (24) weigh, operation preparation position independent operation advance key (6) confirm complete this step operation, by batch make
Standby operation button (9) carries out batch and is completed at the same time operation to more bags of plasma procedures, preparation position separate display screens (7) to operate into
Row prompt can press preparation position independent operation button return key (8) and cancel the maloperation if there is maloperation；
Second step：Being taken out from box of weighing with the plasma bags and transfering bag criticized, plasma bags are put into solution in water bath (2)
Freeze, transfering bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), it is miscellaneous in order to make in order
Random blood bag conduit can be used fixing buckle (3) that conduit is fixed, and presses batch preparation manipulation button (9) batch confirmation and completes this
Step operation；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, from high-order plasma bags stream
To the transfering bag of low level, when the residue capacity in plasma bags reaches user preset value, start pinch valve (4) clamp blood bag it
Between connecting conduit, and pass through sound-light alarm remind operating personnel prepare complete；
Step 5：Operating personnel in water bath the plasma bags for having formed cryoprecipitate and have been flowed into the transfering bag one of blood plasma
It rises and takes out, heat seal disconnects, and just preparation process is completed.
It thaws present invention employs water-bath and prepares the technology of cryoprecipitate, by exquisite structure and flow scheme design, realize
It breaks through below：
1. not only can batch prepare simultaneously, can also single bag operate, without waiting for completion is prepared by the gross, as long as there is one bag
It prepares and completes, so that it may to take out, and be put into next bag and be prepared, realize continuous-flow type operation, greatly save the time；
2. a set of weighing system of use realizes purpose by two step weight methods；Lifting gear is not needed, preparation speed is fast,
It prepares a collection of 20 bags of cryoprecipitates and only needs 50 minutes；
3. a set of refrigeration system of needs, to the water in water bath freeze and constant temperature is to preset temperature, greatly reduce
Energy loss.By advance air-discharging, siphon is realized, it is not necessary that the device of other exclusion air is arranged；
4. being not provided with cabinet, using open-sky technique, facilitate staff.Deft design, small size may be implemented large quantities of
Amount；
5. starting up's refrigeration can be shifted to an earlier date with setting time, make the working of staff one that can carry out cryoprecipitate preparation immediately
Work, saves the stand-by period freezed to water.
Description of the drawings
The oblique view of Fig. 1 Cryoprecipitated antihemophilic factor preparation devices
The side view of Fig. 2 Cryoprecipitated antihemophilic factor preparation devices
The dorsal view of Fig. 3 Cryoprecipitated antihemophilic factor preparation devices
The Weighing module side view of Fig. 4 Cryoprecipitated antihemophilic factor preparation devices
The Weighing module top view of Fig. 5 Cryoprecipitated antihemophilic factor preparation devices
The Weighing module of Fig. 6 Cryoprecipitated antihemophilic factor preparation devices and box connection figure of weighing
Touch operation screen 1；Water bath 2；Fixing buckle 3；Pinch valve 4；Vent window 5；Prepare position independent operation advance key 6；System
Standby position separate display screens 7；Prepare position independent operation button return key 8；Batch preparation manipulation button 9；It weighs box 10；Touch screen is grasped
Make platform 11；Water inlet pore 12；Drain tube holes 13；Spilling water pore 14；Lower header 15；Water pump 16；Refrigeration compressor 17；Radiator fan
18；Electric control box 19；Temperature sensor 20；Water-level gauge 21；Heating device 22；Upper water box 23；Weighing sensor 24；Spring steel
Pearl 25；Fixed plate 26；Upper gasket 27；Lower gasket 28；Fixed plate screw hole 29；It weighs box fixing groove 30.
Specific implementation mode
To make the objectives, technical solutions, and advantages of the present invention clearer, With reference to embodiment and join
According to attached drawing, the invention will be further described.
As shown in figures 1 to 6, the present invention is broadly divided into three parts：(1) Weight control part, the control of (2) water temperature and water follow
Loop system and (3) central control portion.Interconnect between three parts, used mode be welded to connect or
Screw connection.
Wherein, Weight control part is divided into weighing section and control section, and wherein control section includes mainly：Pinch valve
(4), prepare position independent operation advance key (6), prepare position separate display screens (7), prepare position independent operation button return key (8) and
It is independent to be equipped with multigroup preparation position on the positive control panel of Cryoprecipitated antihemophilic factor preparation device for batch preparation manipulation button (9)
Advance key (6) is operated, position separate display screens (7) are prepared and prepares one control of position independent operation button return key (8) composition is single
Member is equipped with batch preparation manipulation button (9) at the middle part of control panel, for controlling in batches, on the other hand, weighing sections subpackage
It includes：Pinch valve (4), box of weighing (10), weighing sensor (24), spring steel ball (25), fixed plate (26), Upper gasket (27), under
Gasket (28), fixed plate screw hole (29) and box fixing groove (30) of weighing, weighing section primary structure are shown in attached drawing 4~6.Pinch valve
(4) it is screwed, box of weighing (10) is stuck in 6 of fixed plate (26) both sides by the box fixing groove (30) of weighing of box body lower part
On spring steel ball (25).Spring steel ball (25) is inserted in the both sides of fixed plate (26) in a manner of agreeing with.Spring steel ball (25) can press
Under, it can be bounced after release.Fixed plate (26) is screwed in by fixed plate screw hole (29) on weighing sensor (24),
Fixed plate (26) and addition Upper gasket (27) among weighing sensor (24).Weighing sensor (24) is screwed in cryoprecipitate
On the main body rack of coagulation factor preparing instrument, lower gasket (28) is added among the two.
As shown in figure 3, water temperature control and water circulation system include mainly lower header (15), water pump (16), refrigeration compressor
(17), radiator fan (18), temperature sensor (20), water-level gauge (21), heating device (22) and upper water box (23).
Central control portion includes mainly touch screen operation platform (11) and electric control box (19).
The step of preparing single packet Cryoprecipitated Antihemophilic Factors using Cryoprecipitated antihemophilic factor preparation device is as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to fill
Connecting pipe between full blood bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature that water-bath is thawed, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water passes through pore of intaking
(12) enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature
The water in lower header (15) is set to reach setting under the collaborative work of sensor (20), refrigeration compressor (17) and heating device (22)
Temperature；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting, lower header (15) are made a sound
In chilled water pumped by water pump (16) in the water bath (2) of upper water box (23), passing through such cycle up and down and maintain setting
Temperature will be frozen into solid fresh frozen plasma and be proceeded as follows after being taken out in low temperature environment：
The first step：Plasma bags and transfering bag are put into togerther in box of weighing (10), weighing below box of weighing (10) is passed through
Sensor (24) is weighed, and operation preparation position independent operation advance key (6), which confirms, completes this step operation, and it is complete simultaneously to carry out batch
It at operation, prepares position separate display screens (7) and operation is prompted, if there is maloperation, can press and prepare position independent operation button
Return key (8) cancels the maloperation；
Second step：Plasma bags and transfering bag are taken out from box of weighing, plasma bags are put into water bath (2) and are thawed,
Transfering bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), in order to make mixed and disorderly blood in order
Bag conduit, can be used fixing buckle (3) that conduit is fixed, and presses preparation position independent operation advance key (6) and confirms this step operation of completion；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, from high-order plasma bags stream
To the transfering bag of low level, when the residue capacity in plasma bags reaches user preset value, start pinch valve (4) clamp blood bag it
Between connecting conduit, and pass through sound-light alarm remind operating personnel prepare complete；
Step 5：Operating personnel in water bath the plasma bags for having formed cryoprecipitate and have been flowed into the transfering bag one of blood plasma
It rises and takes out, heat seal disconnects, and just preparation process is completed.
The step of preparing more packet Cryoprecipitated Antihemophilic Factors using Cryoprecipitated antihemophilic factor preparation device batch is as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to fill
Connecting pipe between full blood bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature that water-bath is thawed, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water passes through pore of intaking
(12) enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature
The water in lower header (15) is set to reach setting under the collaborative work of sensor (20), refrigeration compressor (17) and heating device (22)
Temperature；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting, lower header (15) are made a sound
In chilled water pumped by water pump (16) in the water bath (2) of upper water box (23), passing through such cycle up and down and maintain setting
Temperature will be frozen into solid fresh frozen plasma and be proceeded as follows after being taken out in low temperature environment：
The first step：Being put into togerther in box of weighing (10) with the plasma bags and transfering bag criticized, pass through below box of weighing (10)
Weighing sensor (24) weigh, operation preparation position independent operation advance key (6) confirm complete this step operation, by batch make
Standby operation button (9) carries out batch and is completed at the same time operation to more bags of plasma procedures, preparation position separate display screens (7) to operate into
Row prompt can press preparation position independent operation button return key (8) and cancel the maloperation if there is maloperation；
Second step：Being taken out from box of weighing with the plasma bags and transfering bag criticized, plasma bags are put into solution in water bath (2)
Freeze, transfering bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), it is miscellaneous in order to make in order
Random blood bag conduit can be used fixing buckle (3) that conduit is fixed, and presses batch preparation manipulation button (9) batch confirmation and completes this
Step operation；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, from high-order plasma bags stream
To the transfering bag of low level, when the residue capacity in plasma bags reaches user preset value, start pinch valve (4) clamp blood bag it
Between connecting conduit, and pass through sound-light alarm remind operating personnel prepare complete；
Step 5：Operating personnel in water bath the plasma bags for having formed cryoprecipitate and have been flowed into the transfering bag one of blood plasma
It rises and takes out, heat seal disconnects, and just preparation process is completed.
Although above schematically illustrate some specific embodiments to illustrate and describe the present invention, be not meant to the present invention only
It is confined to one of the various details.On the contrary, can be without departing from the present invention in the scope and range for being equivalent to claims
Various modifications are made in various details in spiritual ground.
Claims (8)
1. a kind of Cryoprecipitated antihemophilic factor preparation device, it is characterised in that：The Cryoprecipitated antihemophilic factor preparation device is by three parts
Composition：Weight control part, water temperature control and water circulation system part and central control portion, between the three parts mutually
It links together, the Weight control part is divided into weighing section and control section, the water temperature control and water circulation system master
To include lower header (15), water pump (16), refrigeration compressor (17), radiator fan (18), temperature sensor (20), water-level gauge
(21), heating device (22) and upper water box (23), the lower header (15) are located at the back side of Cryoprecipitated antihemophilic factor preparation device, institute
It states radiator fan (18) to be located at below lower header (15), the left side of the radiator fan (18) is equipped with vent window (5), described to dissipate
The right side of Hot-air fan (18) is equipped with the refrigeration compressor (17) being connected with water pump (16), and the central control portion includes mainly
Touch screen operation platform (11) and electric control box (19).
2. Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterised in that：The touch screen operation platform (11)
Positioned at the top of Cryoprecipitated antihemophilic factor preparation device, the electric control box (19) is located at the front of lower header (15).
3. Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterised in that：The control of the Weight control part
System part includes mainly：Pinch valve (4), preparation position independent operation advance key (6), preparation position separate display screens (7), preparation position are only
Vertical operation button return key (8) and batch preparation manipulation button (9), the Cryoprecipitated antihemophilic factor preparation device front are equipped with control
Panel, the control panel are equipped with multigroup control unit, and described control unit is by preparing position independent operation advance key (6), system
Standby position separate display screens (7) and preparation position independent operation button return key (8) form, and are equipped with and criticize on the top of multigroup control unit
Measure preparation manipulation button (9).
4. according to any Cryoprecipitated antihemophilic factor preparation devices of claim 1-3, it is characterised in that：The weighing sections subpackage
It includes：Pinch valve (4), box of weighing (10), weighing sensor (24), spring steel ball (25), fixed plate (26), Upper gasket (27), under
Gasket (28), fixed plate screw hole (29) and box fixing groove (30) of weighing, the pinch valve (4) are screwed in cryoprecipitate
On the front of coagulation factor preparing instrument, the box of weighing (10) is located at the lower part of pinch valve (4), the box fixing groove (30) of weighing
Lower part positioned at box of weighing (10), the box of weighing (10) are stuck in by box fixing groove (30) of weighing on spring steel ball (25), institute
The both sides that spring steel ball (25) is located at fixed plate (26) are stated, the fixed plate (26) is solid with screw by fixed plate screw hole (29)
It is scheduled on weighing sensor (24), the fixed plate (26) is intermediate equipped with Upper gasket (27), the title with weighing sensor (24)
Retransmit sensor (24) be screwed on the main body rack of Cryoprecipitated antihemophilic factor preparation device, weighing sensor (24) with
Lower gasket (28) is equipped between the main body rack of Cryoprecipitated antihemophilic factor preparation device.
5. Cryoprecipitated antihemophilic factor preparation device according to claim 4, it is characterised in that：Company described in the three parts
It is to be welded to connect or screw connection to connect mode.
6. Cryoprecipitated antihemophilic factor preparation device according to claim 5, it is characterised in that：The spring steel ball (25) is six
A, the spring steel ball (25) is inserted in the both sides of fixed plate (26) in a manner of agreeing with.
7. a kind of Cryoprecipitated antihemophilic factor preparation device using described in claim 6 prepares the side of single packet Cryoprecipitated Antihemophilic Factors
Method, its step are as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to be full of blood
Connecting pipe between bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, water-bath is set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature of defrosting, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water by intake pore (12) into
Enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature sensor
(20), the water in lower header (15) is made to reach set temperature under the collaborative work of refrigeration compressor (17) and heating device (22)；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting is made a sound, in lower header (15)
Chilled water is pumped by water pump (16) into the water bath (2) of upper water box (23), and set temperature is maintained by such cycle up and down,
Solid fresh frozen plasma will be frozen into proceed as follows after taking out in low temperature environment：
The first step：Plasma bags and transfering bag are put into togerther in box of weighing (10), the weighing and sensing below box of weighing (10) is passed through
Device (24) is weighed, and operation preparation position independent operation advance key (6), which confirms, completes this step operation, carries out batch and is completed at the same time behaviour
Make, prepare position separate display screens (7) and operation is prompted, if there is maloperation, can press and prepare the return of position independent operation button
Key (8) cancels the maloperation；
Second step：Plasma bags and transfering bag are taken out from box of weighing, plasma bags are put into water bath (2) and are thawed, transfer
Bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), in order to which the blood bag for making mixed and disorderly in order is led
Pipe, fixes conduit using fixing buckle (3), presses preparation position independent operation advance key (6) and confirms that completing this walks operation；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, and is flow to from high-order plasma bags low
The transfering bag of position, when the residue capacity in plasma bags reaches user preset value, startup pinch valve (4) clamps between blood bag
Connecting conduit, and remind operating personnel to prepare by sound-light alarm and complete；
Step 5：Operating personnel together take the plasma bags for having formed cryoprecipitate in water bath with the transfering bag for having been flowed into blood plasma
Go out, heat seal disconnects, and just preparation process is completed.
8. a kind of Cryoprecipitated antihemophilic factor preparation device batch using described in claim 6 prepares more packet Cryoprecipitated Antihemophilic Factors
Method, its step are as follows：
Step 1：Prepare the preparation of the fresh frozen plasma of cryoprecipitate：
After fresh frozen plasma separation is completed, the air in plasma bags is all discharged in transfering bag, and blood plasma is allowed to be full of blood
Connecting pipe between bag, is put into low temperature environment and freezes；
Step 2：Be switched on pre-temperature：After booting is powered, water-bath is set by the touch operation screen (1) on touch screen operation platform (11)
The target temperature of defrosting, temperature range are：1 DEG C~6 DEG C, and start pre-temperature process, tap water by intake pore (12) into
Enter lower header (15), by water-level gauge (21), water pump (16) and drain tube holes (13) co- controlling inflow, in temperature sensor
(20), the water in lower header (15) is made to reach set temperature under the collaborative work of refrigeration compressor (17) and heating device (22)；
Step 3：After the water temperature of touch operation screen (1) display reaches set temperature, prompting is made a sound, in lower header (15)
Chilled water is pumped by water pump (16) into the water bath (2) of upper water box (23), and set temperature is maintained by such cycle up and down,
Solid fresh frozen plasma will be frozen into proceed as follows after taking out in low temperature environment：
The first step：Being put into togerther in box of weighing (10) with the plasma bags and transfering bag criticized, pass through the title below box of weighing (10)
It retransmits sensor (24) to weigh, operation preparation position independent operation advance key (6), which confirms, completes this step operation, and behaviour is prepared by batch
Make button (9) to more bags of plasma procedures, carries out batch and be completed at the same time operation, prepare position separate display screens (7) and operation is carried
Show, if there is maloperation, preparation position independent operation button return key (8) can be pressed and cancel the maloperation；
Second step：Being taken out from box of weighing with the plasma bags and transfering bag criticized, plasma bags are put into water bath (2) and are thawed,
Transfering bag is placed in box of weighing (10), and connecting conduit between two bags is caught in pinch valve (4), it is mixed and disorderly in order to make in order
Blood bag conduit fixes conduit using fixing buckle (3), presses batch preparation manipulation button (9) batch and confirms that completing this step operates；
Step 4：Refrigerated plasma in water bath (2) passes through siphonage while melting, and is flow to from high-order plasma bags low
The transfering bag of position, when the residue capacity in plasma bags reaches user preset value, startup pinch valve (4) clamps between blood bag
Connecting conduit, and remind operating personnel to prepare by sound-light alarm and complete；
Step 5：Operating personnel together take the plasma bags for having formed cryoprecipitate in water bath with the transfering bag for having been flowed into blood plasma
Go out, heat seal disconnects, and just preparation process is completed.
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| CN110615837A (en) * | 2019-08-28 | 2019-12-27 | 青岛海特生物医疗有限公司 | Cold precipitation preparation instrument |
| CN110841122B (en) * | 2019-10-31 | 2022-08-30 | 深圳市迈思特生物医学工程有限公司 | Method and device for preparing cryoprecipitate |
| CN110812550A (en) * | 2019-11-27 | 2020-02-21 | 深圳市普特生物医学工程有限公司 | Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument |
| CN111560065B (en) * | 2020-06-29 | 2023-06-16 | 山东中保康医疗器具有限公司 | Cryoprecipitated coagulation factor preparation instrument and application method thereof |
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