CN105461803A - Novel cryoprecipitated antihemophilic factor preparing instrument - Google Patents
Novel cryoprecipitated antihemophilic factor preparing instrument Download PDFInfo
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- CN105461803A CN105461803A CN201511029870.2A CN201511029870A CN105461803A CN 105461803 A CN105461803 A CN 105461803A CN 201511029870 A CN201511029870 A CN 201511029870A CN 105461803 A CN105461803 A CN 105461803A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
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Abstract
The invention discloses a novel cryoprecipitated antihemophilic factor preparing instrument. The novel cryoprecipitated antihemophilic factor preparing instrument is characterized by comprising an upper blood bag box and a lower blood bag box which are connected through a pipeline, a height difference exists between an upper blood bag and a lower blood bag, the upper blood bag and the lower blood bag are both connected with weighing mechanisms, and a melted water tank is arranged inside the upper blood bag and connected with a water circulating device. The automation degree is high, the influence of human factors is reduced, cryoprecipitation quality is improved correspondingly, the cryoprecipitation curative effect is improved, medical burden is relieved for patients, blood consumption of a blood station is reduced, and workers do not make contact with ice water any more during blood bag taking and placing so that the working environment is improved.
Description
Technical field
The present invention relates to a kind of novel Cryoprecipitated antihemophilic factor preparation device, belong to technical field of medical instruments.
Background technology
At present, along with the progress of science and technology, the mankind have broken away from heavy manual work gradually, transfer to plant and instrument to complete by more and more working, more like this at medical field.Present equipment and technology just towards automatization, the development of integrated and intelligent direction, also just towards this future development in the equipment use of blood station.The every composition carried out in blood station is prepared in business, and the equipment that cryoprecipitate preparation needs is more, and equipment comparatively disperses, operator need to shuttle between various equipment, operate personnel that are cumbersome, that take more, and be all handwork operation, labour intensity is very large.
Preparation cryoprecipitate is the project that blood station routine is carried out.Cryoprecipitate, as blood products, is rich in the VIII a large amount of factors, Fibrinogen, Fiberonectin and some other thrombin.Be mainly used in hemophilia A clinically, the treatment of Fibrinogen and the hemorrhagic diseases caused by deficiency of coagulation factors, and the treatment of disturbances of blood coagulation that operation, wound cause.Along with the supply of preparation increases and the clinical understanding to preparation, cryoprecipitate is by being merely applied to A type blood friend patient in the past, till now throughout the application of each clinical speciality section office, and going deep into along with the research to cryoprecipitate, cryoprecipitate preparation is more and more wide in clinical application, the technology of preparing of cryoprecipitate and principle: the method that cryoprecipitate adopts thing fixed is by the fresh frozen plasma (freshfrozenplas2ma in preservation period, FFP) after melting at 1 DEG C ~ 6 DEG C, isolate most blood plasma, and cold not melt material quick-frozen in 1h be solid-state component blood by remaining.Cryoprecipitate common method is prepared in blood station two kinds, and a kind of is FFP is positioned over the method that 4 DEG C of refrigerators slowly melt rear centrifugation; Another kind FFP is placed in the water-bath siphonage that rear siphon separation is melted in 4 DEG C of waters bath with thermostatic control.Two kinds of method contrasts, the cryoprecipitate quality that second method preparation is prepared than first method is higher than first method.
Adopt these two kinds of methods to there is hold facility many, preparation cycle is long, and loss of effective components is too much.Cryoprecipitate is not carried out in preparation process under cold chain environment, and preparation process exists potential safety hazard, does not meet relevant preparation environmental requirement, there is the defects such as operator will shuttle between different devices, and labour intensity is large in addition.
Summary of the invention
The object of the present invention is to provide a kind ofly provides a kind of above-mentioned defect that solves, and only needs an equipment can complete Cryoprecipitated Antihemophilic Factors preparation, alleviates labour intensity, the Cryoprecipitated antihemophilic factor preparation device that level of automation is high.
Novel Cryoprecipitated antihemophilic factor preparation device of the present invention, it is characterized in that, comprise the upper blood bag box and lower blood bag box that are connected by pipeline, difference of altitude is had between upper blood bag and lower blood bag, and upper blood bag is all connected Weighing mechanism with lower blood bag, upper blood bag inside is provided with thawing water tank, melts water tank and connects water circle device.
Described water circle device comprises water inlet pipe, water shoot, water tank, water pump, water refrigeration titanium bag, the water outlet of water refrigeration titanium bag is by threeway respectively with circulating pipe with melts water tank and be connected, and circulating pipe is back in water tank with the recirculated water of thawing water tank.
Be provided with vaporizer in water refrigeration titanium bag, melt in water tank and be provided with temperature sensor, in water tank, be provided with water level sensor.
One end of water inlet pipe is connected with bottom water tank, and the other end is connected with tap water; One end of water shoot is connected with bottom water tank, and in the other end access water drain, suction culvert and discharge pipe line are respectively equipped with entering water electromagnetic valve and drain solenoid valve; Circulation waterway is provided with magnetic valve, is provided with magnetic valve between water bag and thawing water tank.
Upper blood bag box is designed to bilayer structure, be positioned at above LOAD CELLS, melt water tank to be also positioned at above LOAD CELLS, melt water tank between upper blood bag box bilayer, melting water tank is fixed in LOAD CELLS mounting seat by support through upper blood bag box, upper blood bag box and water tank separate each other.
Described upper blood bag inside is provided with extruding gasbag, and extruding gasbag is positioned at the internal layer periphery of blood bag box, and be fixedly linked with upper blood bag box internal layer sidewall, the blood bag put into is wrapped up completely by air bag.
Melt the water-in of water tank in below, up, water outlet adopts the mode of overflow to water outlet, and the water of spilling flows directly in water tank.
Lower blood bag box is positioned at a side-lower of blood bag box, and the pipeline between upper blood bag box and lower blood bag box is provided with pinch valve, and the bottom of lower blood bag box is provided with lower LOAD CELLS.
The corner of the bottom of described thawing water tank is fillet structure.Can accomplish during cleaning not stay dead angle.
Extruding gasbag in upper blood bag box, includes the multiple air bags be arranged side by side.
Upper blood bag box and lower blood bag box include the multiple blood bags be arranged side by side and weigh box.
The present invention compared with prior art, has following beneficial effect:
1, level of automation is high, reduces the impact of human factor, the corresponding raising of quality of cryoprecipitate.
2, improve the curative effect of cryoprecipitate.
3, the medical burden of patient is alleviated.
4, blood station blood using amount has been saved.
5, staff can not contact with frozen water when getting blood letting bag again, improves Working environment.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Fig. 2 is extruding gasbag place of the present invention structural representation;
Fig. 3 is blood bag box and lower blood bag box connection diagram in the present invention;
In figure: 1, water shoot; 2, water inlet pipe; 3, water tank; 4, support; 5, upper blood bag box; 6, water tank is melted; 7, upper LOAD CELLS; 8, water refrigeration titanium bag; 9, water pump; 10, Mini-size inflation pump; 11, minipump; 12, extruding gasbag; 13, lower blood bag box; 14, pinch valve.
Embodiment
Below in conjunction with drawings and Examples, the present invention is further illustrated:
Cryoprecipitated antihemophilic factor preparation device as shown in Figure 1-2, there is cabinet, cabinet is provided with cabinet door or upper cover, water circle device, upper LOAD CELLS 7, lower LOAD CELLS, extruding gasbag 12, the medium of extruding gasbag 12 is gas, water, wet goods, also has upper blood bag box 5, lower blood bag box 13, temperature transmitter, refrigeration compressor set and Controlling System.
Water circle device comprise water inlet pipe 2, water shoot 1, water tank 3, water pump 9, water refrigeration titanium bag 8, water refrigeration titanium bag 8 water outlet by threeway respectively with circulating pipe with melts water tank 6 and is connected, circulating pipe is back in water tank 3 with the recirculated water of thawing water tank 6.Be provided with vaporizer in water refrigeration titanium bag 8, melt in water tank 6 and be provided with temperature sensor, in water tank 3, be provided with water level sensor.One end of water inlet pipe 2 is connected with bottom water tank 3, and the other end is connected with tap water; One end of water shoot 1 is connected with bottom water tank, and in the other end access water drain, water inlet pipe 2 and water shoot 1 are respectively equipped with entering water electromagnetic valve and drain solenoid valve; Circulating pipe is provided with magnetic valve, is provided with magnetic valve between water refrigeration titanium bag 8 and thawing water tank 6.Upper blood bag box 5 is designed to bilayer structure, be positioned at above LOAD CELLS 7, melting water tank 6 is also positioned at above LOAD CELLS 7, melt water tank 6 between upper blood bag box 5 bilayer, melting water tank 6 is fixed in the mounting seat of upper LOAD CELLS 7 by support 4 through upper blood bag box, upper blood bag box 5 is complete independence with water tank 3 each other, without any contact.Extruding gasbag 12 is positioned at the internal layer periphery of blood bag box 5, is fixedly linked with internal layer sidewall, and the blood bag put into is extruded air bag 12 and wraps up completely.Melt the water-in of water tank 6 in below, up, water outlet adopts the mode of overflow to water outlet, and the water of spilling flows directly in water tank 3, and advantage maintains the water level homeostasis all the time of melting in water tank 6.Lower blood bag box 13 is positioned at a side-lower of blood bag box 5, pinch valve 14 is between upper blood bag box 5 and lower blood bag box 13, the bottom of lower blood bag box 13 is provided with lower LOAD CELLS, and Controlling System is arranged on the sidepiece of cabinet, and refrigeration compressor set is positioned at the inner bottom part of cabinet.
The temperature sensor melted in water tank 6 connects temperature transmitter, and temperature transmitter, upper LOAD CELLS, lower LOAD CELLS, refrigeration compressor set are connected with Controlling System respectively by circuit with water circle device.Described extruding gasbag 12 includes the multiple air bags be arranged side by side.Described upper blood bag box 5 and lower blood bag box 13 include be arranged side by side multiple.The corner of the bottom of described thawing water tank 6 is fillet structure.Can accomplish during cleaning not stay dead angle.
During use, by entering water electromagnetic valve to water filling in water tank 3, the magnetic valve on circulating pipe is opened, and is detected by water level sensor, stops water filling after reaching the water level of needs.Water in water tank 3 is driven by water pump 9, is back in water tank 3 again through water refrigeration titanium bag 8, circulating pipe, and the vaporizer in water refrigeration titanium bag 8 circulates, and makes the water for cooling in water tank 3.After reaching the temperature of needs, fresh frozen plasma bag is joined bag with sky and puts into upper blood bag box 5 and lower blood bag box 13 respectively, fresh frozen plasma bag and the empty connecting hose joined between bag are placed in pinch valve 14.The closed electromagnetic valve of circulating pipe, recirculated water is transferred to melt in water tank 6 and continues circulation.When refrigerated plasma melts, due to the effect of extruding gasbag 12, the blood plasma of thawing flows in empty connection bag, and in fresh frozen plasma bag, the remaining cold material that do not melt is cryoprecipitate, it is placed in fast cryogenic refrigerator and saves backup.
For the weight produced, two steps are adopted to weigh, the first step whole blood bag is weighed by upper weighing sensor 7, related data is stored after weighing, second step is weighed and is weighed in real time in thaw process by lower-weighing sensor, the data that the data weighed in real time with second step and the first step store contrast, after Data Comparison reaches the numerical value of setting, notice pinch valve 14 is energized work by Controlling System, pinch valve 14 closes, by fresh frozen plasma bag and the empty connecting hose clamped closed joined between bag, the blood plasma in pipeline is made to stop circulation.
Cryoprecipitated antihemophilic factor preparation device can realize automatic loading water and drain function, automatic siphon process is achieved by extruding gasbag 12, the impact of human factor is decreased in cryoprecipitate preparation process, in preparation process, adopt two step automatic Weighings, weighing tolerance range is high, and level of automation is high, and integral device can complete Cryoprecipitated Antihemophilic Factors preparation easily.After siphonic process terminates, the recirculated water melted in water tank 6 is transferred in water tank 3, can not contact again, alleviate labour intensity when staff takes out cryoprecipitate blood bag with frozen water.
This patent can realize automatic loading water and drain function: water inlet pipe is connected with tap water pipe line, the entering water electromagnetic valve that the suction culvert of equipment is installed, when equipment energising start, water level sensor detect anhydrous in water tank after, opened by entering water electromagnetic valve, water tank is intake, when the water level in water tank reaches behind the position of setting, entering water electromagnetic valve is closed by water level sensor, and water tank stops upper water.After water temperature reaches set(ting)value, the water in water tank is transferred to and is melted in water tank, carries out water-bath thawing to blood bag, and after siphon completes, the water melted in water tank is all emptying, transfers in water tank.When needing the water bled off in water tank, opened by the drain solenoid valve on discharge pipe line, by emptying for the water in water tank, after water is emptying, drain solenoid valve is closed by water level sensor.Entering water electromagnetic valve and the mutual self-locking of drain solenoid valve.
Automatic weighing function: be the weight produced, two steps are adopted to weigh, it is whole blood bag weighed by upper weighing sensor that the first step weighs mode, related data is stored after weighing, second step is weighed and is weighed in real time in thaw process by lower-weighing sensor, the data that the data weighed in real time with second step and the first step store contrast, after Data Comparison reaches the numerical value of setting, notice pinch valve 14 is energized work by Controlling System, pinch valve 14 is closed closed, by fresh frozen plasma bag and the empty connecting hose clamped closed joined between bag, the blood plasma in pipeline is made to stop circulation.
The design of temperature controlling system: the temperature control principle that equipment melts water in water tank is linked together by associated refrigeration assembly by pipeline by refrigeration compressor set, vaporizer carries out energy exchange, vaporizer is placed in water refrigeration titanium bag, water in water refrigeration titanium bag is ceaselessly circulated by water pump, recirculated water is by carrying out energy exchange with vaporizer, and the result of energy exchange is the water for cooling that will melt in water tank.Due to heat-eliminating medium glassware for drinking water, to have good heat conductivity and specific heat of water to hold comparatively large, and therefore glassware for drinking water has good temperature stability, and homogeneity has good performance in the accurate control realizing temperature, is to realize the conventional heat-eliminating medium that temperature accurately controls.By at the temperature sensor melting the setting of water tank inside, the change of temperature is passed to temperature controller.Temperature controller controls the working order of corresponding refrigeration compressor set according to the temperature range of setting.By temperature sensor and temperature controller, working state control is carried out to refrigeration compressor set, combination adopt specific heat capacity comparatively systemic circulation water as thawing heat-eliminating medium, the accurate control of circulation thawing water temperature can be realized.
Extruding type automatic siphon: siphon will meet following two conditions: will have a height fall between first, two bags, drop is greater than the height of a blood bag; Second, two blood bags are necessary for vacuum state.First condition easily meets.Second condition, because the operation in producing process and blood bag enter air in producing process, can not form vacuum, when relying on vacuum siphon when producing, effective siphon can not be formed, in this case, often need to carry out human intervention, blood plasma is extruded in satellite bag and forms siphon.Due to human intervention, effective constituent is run off; In the process of human intervention, staff needs contact low temperature frozen water in addition, impacts the healthy of operator.For head it off adds extruding gasbag in a device.Extruding gasbag carries out inflation/deflation by Mini-size inflation pump 10, minipump 11 pairs of extruding gasbags, swells to the extruding of blood bag surrounding after airbag aeration, and similar hand extruding blood bag forms liquid stream.
Claims (9)
1. a novel Cryoprecipitated antihemophilic factor preparation device, it is characterized in that, comprise the upper blood bag box and lower blood bag box that are connected by pipeline, difference of altitude is had between upper blood bag and lower blood bag, and upper blood bag is all connected Weighing mechanism with lower blood bag, upper blood bag inside is provided with thawing water tank, melts water tank and connects water circle device.
2. novel Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that, described water circle device comprises water inlet pipe, water shoot, water tank, water pump, water refrigeration titanium bag, the water outlet of water refrigeration titanium bag is by threeway respectively with circulating pipe with melts water tank and be connected, and circulating pipe is back in water tank with the recirculated water of thawing water tank.
3. novel Cryoprecipitated antihemophilic factor preparation device according to claim 2, is characterized in that, is provided with vaporizer, melts in water tank and be provided with temperature sensor, be provided with water level sensor in water tank in water refrigeration titanium bag.
4. novel Cryoprecipitated antihemophilic factor preparation device according to claim 2, is characterized in that, one end of water inlet pipe is connected with bottom water tank, and the other end is connected with tap water; One end of water shoot is connected with bottom water tank, and in the other end access water drain, suction culvert and discharge pipe line are respectively equipped with entering water electromagnetic valve and drain solenoid valve; Circulation waterway is provided with magnetic valve, is provided with magnetic valve between water bag and thawing water tank.
5. novel Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that, upper blood bag box is designed to bilayer structure, be positioned at above LOAD CELLS, melt water tank to be also positioned at above LOAD CELLS, melt water tank between upper blood bag box bilayer, melt water tank and be fixed in LOAD CELLS mounting seat by support through upper blood bag box, upper blood bag box and water tank separate each other.
6. novel Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that, described upper blood bag inside is provided with extruding gasbag, and extruding gasbag is positioned at the internal layer periphery of blood bag box, be fixedly linked with upper blood bag box internal layer sidewall, the blood bag put into is wrapped up completely by air bag.
7. novel Cryoprecipitated antihemophilic factor preparation device according to claim 2, is characterized in that, melts the water-in of water tank in below, and up, water outlet adopts the mode of overflow to water outlet, and the water of spilling flows directly in water tank.
8. novel Cryoprecipitated antihemophilic factor preparation device according to claim 1, it is characterized in that, lower blood bag box is positioned at a side-lower of blood bag box, and the pipeline between upper blood bag box and lower blood bag box is provided with pinch valve, and the bottom of lower blood bag box is provided with lower LOAD CELLS.
9. novel Cryoprecipitated antihemophilic factor preparation device according to claim 1, is characterized in that, the corner of the bottom of described thawing water tank is fillet structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511029870.2A CN105461803A (en) | 2015-12-31 | 2015-12-31 | Novel cryoprecipitated antihemophilic factor preparing instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511029870.2A CN105461803A (en) | 2015-12-31 | 2015-12-31 | Novel cryoprecipitated antihemophilic factor preparing instrument |
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| CN105461803A true CN105461803A (en) | 2016-04-06 |
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| CN201511029870.2A Withdrawn CN105461803A (en) | 2015-12-31 | 2015-12-31 | Novel cryoprecipitated antihemophilic factor preparing instrument |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111560065A (en) * | 2020-06-29 | 2020-08-21 | 山东中保康医疗器具有限公司 | Cryoprecipitated blood coagulation factor preparation instrument and use method thereof |
| CN111870749A (en) * | 2019-11-27 | 2020-11-03 | 深圳市普特生物医学工程有限公司 | Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument |
| CN114164196A (en) * | 2021-12-08 | 2022-03-11 | 山东中保康医疗器具有限公司 | Preparation process of cryoprecipitated blood coagulation factor |
-
2015
- 2015-12-31 CN CN201511029870.2A patent/CN105461803A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870749A (en) * | 2019-11-27 | 2020-11-03 | 深圳市普特生物医学工程有限公司 | Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument |
| CN111560065A (en) * | 2020-06-29 | 2020-08-21 | 山东中保康医疗器具有限公司 | Cryoprecipitated blood coagulation factor preparation instrument and use method thereof |
| CN111560065B (en) * | 2020-06-29 | 2023-06-16 | 山东中保康医疗器具有限公司 | Cryoprecipitated coagulation factor preparation instrument and application method thereof |
| CN114164196A (en) * | 2021-12-08 | 2022-03-11 | 山东中保康医疗器具有限公司 | Preparation process of cryoprecipitated blood coagulation factor |
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Application publication date: 20160406 |