CN111870749A - Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument - Google Patents
Water circulation unfreezing unit, water circulation unfreezing system and cryoprecipitation preparation instrument Download PDFInfo
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- CN111870749A CN111870749A CN202010917894.6A CN202010917894A CN111870749A CN 111870749 A CN111870749 A CN 111870749A CN 202010917894 A CN202010917894 A CN 202010917894A CN 111870749 A CN111870749 A CN 111870749A
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 991
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 210000004369 blood Anatomy 0.000 claims abstract description 64
- 239000008280 blood Substances 0.000 claims abstract description 64
- 238000010257 thawing Methods 0.000 claims description 78
- 238000003860 storage Methods 0.000 claims description 68
- 239000007788 liquid Substances 0.000 claims description 52
- 239000004065 semiconductor Substances 0.000 claims description 9
- 238000002844 melting Methods 0.000 abstract description 12
- 230000008018 melting Effects 0.000 abstract description 12
- 238000012864 cross contamination Methods 0.000 abstract description 5
- 210000002381 plasma Anatomy 0.000 description 32
- 238000000034 method Methods 0.000 description 29
- 230000001276 controlling effect Effects 0.000 description 26
- 239000004023 fresh frozen plasma Substances 0.000 description 11
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- 208000002004 Afibrinogenemia Diseases 0.000 description 1
- 206010067787 Coagulation factor deficiency Diseases 0.000 description 1
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- 108010054218 Factor VIII Proteins 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
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- 206010051077 Post procedural haemorrhage Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0259—Apparatus for treatment of blood or blood constituents not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0286—Handling a large number of blood product units, e.g. storage cabinets, blood bank administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3327—Measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/366—General characteristics of the apparatus related to heating or cooling by liquid heat exchangers
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
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Abstract
The application provides a water cycle unit, water cycle system and cryoprecipitation preparation appearance of unfreezing, water cycle unit of unfreezing includes water bath and water cycle control device, and the water bath is used for the holding only a blood bag. The water circulation control device is connected with the water bath tank. The water circulation control device is connected with the water bath tank and forms the water route circulation to the temperature that can control water remains stable in order to promote melting of blood bag, because blood bag is held to water bath tank at most, compare in other mode of melting a plurality of blood bags simultaneously in same water bath tank, avoided taking place the plasma seepage because of one of them blood bag is damaged, and then make the condition of taking place cross contamination between the blood bag, improved the security of cryoprecipitation.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a water circulation unfreezing unit, a water circulation unfreezing system and a cryoprecipitation preparation instrument.
Background
Preparation of cryoprecipitate is one of the projects routinely performed by blood stations, and in the preparation of cryoprecipitate, a plurality of blood bags containing fresh frozen plasma are usually thawed at the same time to improve the efficiency of preparation of cryoprecipitate. However, it has been found through research that in the process of preparing a plurality of blood bags containing fresh frozen plasma at the same time, plasma may leak due to various reasons such as blood bag breakage, operator misoperation and the like during thawing, so that the blood bags are cross-contaminated, and the safety of cryoprecipitation is seriously affected.
Disclosure of Invention
The embodiment of the application provides a water circulation unfreezing unit, a water circulation unfreezing system and a cryoprecipitation preparation instrument to solve the technical problem of the safety of cryoprecipitation.
The embodiment of the application realizes the aim through the following technical scheme.
In a first aspect, an embodiment of the present application provides a water circulation thawing unit, which includes a water bath tank and a water circulation control device, wherein the water bath tank is used for accommodating only one blood bag. The water circulation control device is connected with the water bath tank.
In some embodiments, the water circulation control device comprises a water pump, a temperature regulator and a plurality of pipelines, the water inlet of the water bath tank is communicated with an external water supply unit through a pipeline, the water outlet of the water bath tank is communicated with an external drainage unit through a pipeline, the water outlet of the water bath tank is also communicated with the water inlet of the water bath tank through a pipeline to form water circulation, the water pump is arranged between the water outlet of the water bath tank and the water inlet of the water bath tank through a pipeline to provide power for the water circulation, and the temperature regulator is arranged between the water outlet of the water bath tank and the water inlet of the water bath tank through a pipeline and used for controlling the temperature of water in the water channel.
In some embodiments, the water inlet of the water pump is communicated with the external water supply unit through a pipeline, the water outlet of the water pump is communicated with the water inlet of the water bath tank through a pipeline, the water outlet of the water bath tank is communicated with the external drainage unit through a pipeline, and the water outlet of the water bath tank is also communicated with the water inlet of the water pump through a pipeline to form water circulation.
In some embodiments, the water inlet of the temperature regulator is communicated with the external water supply unit through a pipeline, the water outlet of the temperature regulator is communicated with the water inlet of the water bath tank, the water outlet of the water bath tank is communicated with the external water drainage unit through a pipeline, and the water outlet of the water bath tank is also communicated with the water inlet of the temperature regulator through a pipeline to form water circulation.
In some embodiments, the water circulation control device further comprises a control valve assembly, the control valve assembly is arranged between the plurality of pipelines and used for controlling the on-off of a water path from the external water supply unit to the water inlet of the water bath tank and controlling the on-off of the water path from the water outlet of the water bath tank to the external water drainage unit.
In some embodiments, the water circulation control device further comprises a control valve assembly, the control valve assembly is arranged among the plurality of pipelines and used for controlling the on-off of a water path from the external water supply unit to the water inlet of the water bath box, controlling the on-off of a water path from the water outlet of the water bath box to the external drainage unit and controlling the on-off of a water path from the water outlet of the water bath box to the water inlet of the water pump.
In some embodiments, the water circulation control device includes: the temperature control device comprises a water pump, a temperature regulator, a control valve assembly and a plurality of pipelines, wherein the temperature regulator is used for controlling the temperature of water in a water path. The water inlet of the temperature regulator is communicated with an external water supply unit through a pipeline, the water outlet of the temperature regulator is communicated with the water inlet of the water bath box, the water outlet of the water bath box is communicated with an external drainage unit through a pipeline, the water outlet of the water bath box is also communicated with the water inlet of the temperature regulator through a pipeline to form water circulation, and the water pump is arranged between the water outlet of the water bath box and the water inlet of the temperature regulator through a pipeline to provide power for the water circulation. The control valve assembly is arranged among the pipelines and used for controlling the on-off of a water path from the external water supply unit to the water inlet of the temperature regulator, controlling the on-off of a water path from the water outlet of the water bath box to the external drainage unit and controlling the on-off of a water path from the water outlet of the water bath box to the water inlet of the temperature regulator.
In some embodiments, the control valve assembly includes a first solenoid valve, a second solenoid valve, and a third solenoid valve. The first end of the first electromagnetic valve is communicated with an external water supply unit through a pipeline, and the second end of the first electromagnetic valve is communicated with a water inlet of the temperature regulator through a pipeline. The first end of the second electromagnetic valve is communicated with the external drainage unit through a pipeline, the second end of the second electromagnetic valve is communicated with the first end of the third electromagnetic valve through a pipeline, and the second end of the third electromagnetic valve is communicated with the water outlet of the water bath box through a pipeline. The second end of the first solenoid valve is also in communication with the second end of the second solenoid valve. The water pump is installed between the water inlet of the temperature regulator and the external water supply unit through a pipeline, the water inlet of the water pump is communicated with the external water supply unit through a pipeline, the water outlet of the water pump is communicated with the water inlet of the temperature regulator through a pipeline, and the water outlet of the water bath box is communicated with the water inlet of the water pump through a pipeline to form water circulation.
In some embodiments, the water circulation thawing unit further comprises a water storage tank, the water storage tank is respectively communicated with a water inlet of the water pump and a water outlet of the water bath tank through pipelines, the water storage tank is respectively communicated with an external water supply unit and an external drainage unit through pipelines, the control valve assembly is used for controlling the on-off of a water path from the external water supply unit to the water storage tank, controlling the on-off of the water path from the water storage tank to the external drainage unit, controlling the on-off of the water path from a water outlet of the water bath tank to the water inlet of the water pump, controlling the on-off of the water path from the water storage tank to the water inlet of the water pump and controlling the on-off of.
In some embodiments, the control valve assembly comprises a first solenoid valve, a second solenoid valve, a third solenoid valve and a fourth solenoid valve, wherein a first end of the first solenoid valve is communicated with the external water supply unit through a pipeline, a second end of the first solenoid valve is communicated with the water inlet of the water storage tank through a pipeline, a first end of the second solenoid valve is communicated with the external drainage unit through a pipeline, and a second end of the second solenoid valve is communicated with the water outlet of the water storage tank through a pipeline; the water outlet of the water storage tank is communicated with the first end of the fourth electromagnetic valve through a pipeline, the second end of the fourth electromagnetic valve is communicated with the water inlet of the water pump through a pipeline, the second end of the fourth electromagnetic valve is also communicated with the first end of the third electromagnetic valve through a pipeline, and the second end of the third electromagnetic valve is communicated with the water outlet of the water bath tank through a pipeline.
In some embodiments, the temperature regulator is a semiconductor refrigerator. And/or the water circulation unfreezing unit further comprises a liquid level sensor, the liquid level sensor is arranged in the water bath tank, and the liquid level sensor is used for detecting the water level in the water bath tank. And/or the water circulation unfreezing unit further comprises a temperature sensor, the temperature sensor is arranged in the water bath tank, and the temperature sensor is used for detecting the temperature of water in the water bath tank. And/or the water circulation thawing unit further comprises a filter, wherein the first end of the filter is communicated with the external water supply unit through a pipeline, and the second end of the filter is communicated with the control valve assembly through a pipeline.
In a second aspect, an embodiment of the present application provides a water circulation thawing system, which includes a plurality of water circulation thawing units according to any of the above embodiments, and the plurality of water circulation thawing units are independent of each other.
In a third aspect, an embodiment of the present application provides a cryoprecipitation preparation apparatus, where the cryoprecipitation preparation apparatus includes the water circulation thawing system of any one of the above embodiments, a plurality of placing units, and a plurality of exhausting units, where the placing units are used to place empty bags of external duplex bags, the placing units correspond to water bath boxes in the water circulation thawing system one to one and form a height difference, and a height of the water bath boxes from the ground is higher than a height of the placing units from the ground; the exhaust unit is arranged between the water bath tank and the placing unit and used for clamping the conduit of the external duplex bag to exhaust.
The water circulation unit that unfreezes, among water circulation system and the cryoprecipitation preparation appearance of unfreezing, the blood bag is placed and is melted in the water bath incasement, water circulation controlling means is connected with the water bath case and is formed a confined water route circulation, and can control the temperature of water and remain stable in order to promote melting of blood bag, because blood bag is held to the water bath case at most, compare in other mode of melting a plurality of blood bags simultaneously in same water bath incasement, avoided taking place the plasma seepage because of one of them blood bag is damaged, and then make the condition of taking place cross contamination between the blood bag, the security of cryoprecipitation has been improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic structural diagram of a water circulation thawing unit provided in an embodiment of the present application.
Fig. 2 is a block schematic diagram of the water circulation defrosting unit of fig. 1.
Fig. 3 is a schematic structural diagram of a water circulation defrosting unit according to another embodiment of the present application.
Fig. 4 is a block schematic diagram of the water circulation defrosting unit of fig. 3.
Fig. 5 is a schematic structural diagram of a water circulation defrosting unit according to another embodiment of the present application.
Fig. 6 is a block schematic diagram of the water circulation defrosting unit of fig. 5.
Fig. 7 is a schematic structural diagram of a water circulation defrosting system according to still another embodiment of the present application.
Fig. 8 is a schematic structural diagram of a water circulation defrosting system according to still another embodiment of the present application.
Fig. 9 is a schematic structural diagram of a cryoprecipitation preparation apparatus provided in an embodiment of the present application.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the embodiments described are only a few embodiments of the present application and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application. It should be noted that, unless otherwise explicitly stated or limited, the term "communicate" in the description of the present invention should be interpreted broadly, and may be fixed, detachable, direct or indirect via intermediary media, and those skilled in the art may specifically understand the meaning of the above terms in the present invention.
The cryoprecipitate is prepared by melting fresh frozen plasma of about 150mL or 200mL in a storage period at 1-6 ℃ by a specific method, separating most of the plasma, and remaining 40-50mL of insoluble substances, wherein the main components of the cryoprecipitate are factor VIII and fibrinogen, and the cryoprecipitate is mainly used for treating patients with hemophilia, postoperative hemorrhage, severe trauma, disseminated intravascular coagulation, fibrinogen and coagulation factor deficiency.
The existing preparation methods of the cryoprecipitate mainly comprise two methods: the centrifugal method and the water bath siphoning method are adopted. The centrifugation method is that the blood bag filled with fresh frozen plasma is placed in the environment with the temperature of 4 +/-2 ℃ for melting, the blood bag is taken out in time when a little crushed ice exists in the plasma, the blood bag is placed in a centrifuge for centrifugation in the environment with the temperature of 4 +/-2 ℃, the upper layer of plasma is separated to a communicated empty bag, and the remaining lower layer of 40-50mL is the cryoprecipitate. The water bath siphon method comprises placing blood bag containing fresh frozen plasma in 4 deg.C environment, flowing the melted plasma out of the bag by siphon effect when the frozen plasma is melted, and collecting the rest 40-50mL of the blood as cryoprecipitate.
In the preparation of cryoprecipitate using the above two methods, a plurality of blood bags containing fresh frozen plasma are usually thawed at the same time to improve the efficiency of the preparation of cryoprecipitate. However, it has been found that in the process of preparing a plurality of blood bags containing fresh frozen plasma at the same time, plasma may leak due to various reasons such as blood bag breakage, operator misoperation and the like during thawing, so that the blood bags are cross-contaminated, and the safety and effectiveness of cryoprecipitate and plasma are seriously affected.
Based on this, please refer to fig. 1 and fig. 2, an embodiment of the present application provides a water circulation thawing unit 100, the water circulation thawing unit 100 includes a water bath 10 and a water circulation control device 101, and the water circulation control device 101 is connected to the water bath 10. The water bath 10 is used to house only one blood bag 60. The water circulation control device 101 is used to form a water circuit with the water bath tank 10, and can control the temperature of water to be kept stable to promote the melting of the blood bag 60 in the water bath tank 10.
The use of the water bath 10 for accommodating only one blood bag 60 means that one water bath 10 is used for thawing at most one blood bag 60 at the same time during the cryoprecipitation process for preparing each blood bag 60. The volume of the water bath 10 is designed according to the volume of the blood bag 60 and the volume of water required to melt the volume of blood plasma so that the volume of the water bath 10 is not so large as to occupy an excessive space of the water circulation thawing unit 100.
In the water circulation unit 100 that unfreezes of this application embodiment, blood bag 60 is placed and is melted in water bath 10, water circulation controlling means 101 is connected with water bath 10 and is formed the water circuit circulation, and can control the temperature of water and keep stable in order to promote melting of blood bag 60, because water bath 10 holds a blood bag 60 at most, compare in other modes of melting a plurality of blood bags 60 simultaneously in same water bath 10, avoided taking place the plasma seepage because of one of them blood bag 60 is damaged, and then make the condition of taking place cross contamination between blood bag 60, the security that has improved the cryoprecipitation. The direction indicated by the thick arrow in fig. 2 is the flow direction of water.
Referring to fig. 3 and 4, the water circulation control device 101 may include a water pump 24, a temperature regulator 26, and a plurality of pipes 20, wherein the water inlet of the water bath tank 10 is communicated with an external water supply unit (not shown) through the pipes 20, the water outlet of the water bath tank 10 is communicated with an external water discharge unit (not shown) through the pipes 20, and the water outlet of the water bath tank 10 is further communicated with the water inlet of the water bath tank 10 through the pipes 20 to form a water circulation. The water pump 24 is arranged between the water outlet of the water bath box 10 and the water inlet of the water bath box 10 through the pipeline 20 to provide power for water circulation. The temperature regulator 26 is arranged between the water outlet of the water bath box 10 and the water inlet of the water bath box 10 through the pipeline 20, and the temperature regulator 26 is used for controlling the temperature of the water in the waterway.
The external water supply unit may be a tap water source, for example, the water inlet of the water bath case 10 is connected to a tap of a tap water pipe through a pipe 20, and since tap water sprayed from the tap water pipe has pressure, water of the external water supply unit can flow to the water inlet of the water bath case 10 through the pipe 20, so that water supply of the water bath case 10 can be realized. The external drainage unit may be an underground drainage channel, for example, the water outlet of the water bath box 10 communicates with the inlet of the underground drainage channel through the pipe 20, so that drainage of the water bath box 10 can be achieved.
The water pump 24 pumps the water discharged from the water outlet of the water bath 10 into the pipe 20 and re-delivers the water into the inlet of the water bath 10, thus continuously pumping and forming a water circulation effect. When the blood bag 60 containing the fresh frozen plasma is placed in the water bath 10 for dissolution, the temperature of the water in the water bath 10 is decreased from the original 4 ℃ + -2 ℃, and in order to rapidly dissolve the fresh frozen plasma, it is preferable to rapidly increase the temperature of the water in the water bath 10 back to 4 ℃ + -2 ℃. The water pump 24 is used to pump the water discharged from the water bath 10 back into the water bath 10 after the temperature of the water is adjusted by the temperature adjuster 26 during the water circulation.
The position of the water pump 24 can be adjusted according to actual conditions, for example, the water inlet of the water pump 24 can be communicated with an external water supply unit through the pipeline 20, the water outlet of the water pump 24 can be communicated with the water inlet of the water bath box 10 through the pipeline 20, the water outlet of the water bath box 10 can be communicated with an external drainage unit through the pipeline 20, and the water outlet of the water bath box 10 can also be communicated with the water inlet of the water pump 24 through the pipeline 20 to form water circulation. Because the water pump 24 can be from the low eminence of carrying with water, can open the water pump 24 when the water pressure of outside water supply unit is on the low side, even water bath 10 sets up in the position higher than outside water supply unit relative ground, does not influence outside water supply unit and for water bath 10 delivery water yet, be favorable to the place position of water bath 10 to carry out adaptability adjustment and arrange according to the actual space of hydrologic cycle thawing unit 100.
The thermostat 26 can selectively heat or cool the water in the water circuit to maintain the water in the water bath 10 in a stable temperature range. Since plasma needs to be thawed in an environment of 4 ℃ ± 2 ℃, the temperature regulator 26 may be set to a corresponding temperature to change the temperature of the water passing through the temperature regulator 26. The temperature regulator 26 may be a semiconductor refrigerator, and compared to a compressor, the semiconductor refrigerator has a current positive and negative direction that respectively performs cooling and heating to control the temperature, and the cooling and heating are faster to be switched, and the semiconductor refrigerator has a lower working power, so that the semiconductor refrigerator is more suitable for the case that the water bath 10 melts one blood bag 60. In addition, the semiconductor refrigerator can realize temperature adjustment without using a refrigerant.
The position of the temperature regulator 26 can be adjusted according to actual conditions, for example, the water inlet of the temperature regulator 26 can be communicated with an external water supply unit through the pipeline 20, the water outlet of the temperature regulator 26 can be communicated with the water inlet of the water bath box 10, the water outlet of the water bath box 10 is communicated with an external drainage unit through the pipeline 20, and the water outlet of the water bath box 10 is also communicated with the water inlet of the temperature regulator 26 through the pipeline 20 to form water circulation. Thus, when water is supplied from the external water supply unit, the temperature regulator 26 can refrigerate and reduce the temperature of the water supplied from the external water supply unit to 4 ℃ +/-2 ℃ and then the water enters the water bath tank 10, so that the process before the water enters the water bath tank 10 is fully utilized, and the preparation efficiency of the cryoprecipitate is improved. In addition, the thermostat 26 heats the water discharged from the water bath 10 to a temperature lower than 4 ℃. + -. 2 ℃ and returns the heated water to the water bath 10 during the water circulation, so that the water in the water bath 10 can be maintained in a stable temperature range.
For another example, the water inlet of the temperature regulator 26 may be communicated with the water outlet of the water bath tank 10 through the pipe 20, the water outlet of the temperature regulator 26 may be communicated with the external drainage unit through the pipe 20, the water outlet of the temperature regulator 26 may be communicated with the water inlet of the water bath tank 10 through the pipe 20 to form a water circulation, and the water inlet of the water bath tank 10 is communicated with the external water supply unit through the pipe 20. When the water is supplied from the external water supply unit, the water can directly enter the water bath 10 through the pipe 20, and when the water in the water bath 10 reaches a desired volume and circulates, the thermostat 26 starts to heat the water discharged from the water bath 10 to a temperature lower than 4 ℃ ± 2 ℃ and returns to the water bath 10.
The water circulation control device 101 may include a control valve assembly 30, the control valve assembly 30 being disposed between the plurality of pipes 20. For example, the control valve assembly 30 may be disposed between the external water supply unit and the water inlet of the water bath 10, and is used to control the on/off of the water path between the external water supply unit and the water inlet of the water bath 10, so that the water path may be connected during the water inlet process of the water circulation thawing unit 100 to facilitate the water of the external water supply unit to flow into the water bath 10, and the water path may be disconnected during the water circulation process and the water discharge process of the water circulation thawing unit 100 to prevent the water in the water bath 10 from flowing out to the external water discharge unit.
For example, the control valve assembly 30 may be disposed between the water outlet of the water bath tank 10 and the external drainage unit, and is used to control the on/off of the water path between the water outlet of the water bath tank 10 and the external drainage unit, so as to disconnect the water path during the water inlet process and the water circulation process of the water circulation thawing unit 100 to prevent the water in the water bath tank 10 from flowing out to the external drainage unit, and connect the water path during the drainage process of the water circulation thawing unit 100 to drain the water.
For example, the control valve assembly 30 may be disposed between the water outlet of the water bath box 10 and the water inlet of the water pump 24, and is used to control the on/off of the water path between the water outlet of the water bath box 10 and the water inlet of the water pump 24, so that the water path may be cut off during the water inlet process of the water circulation thawing unit 100 to prevent water from entering the water bath box 10 from the water outlet of the water bath box 10, and water may be prevented from directly entering the water bath box 10 without being adjusted in temperature by the temperature adjuster 26 under the condition that the water inlet of the temperature adjuster 26 is communicated with an external water supply unit through the pipeline 20; the control valve assembly 30 may also communicate with the waterway during the water circulation and the water discharge of the water circulation/thawing unit 100.
Besides, the control valve assembly 30 can adjust and control the on/off of the water path according to the positions of the structures such as the water bath 10, the water pump 24, the temperature regulator 26, the external water supply unit, the external drainage unit and the like. For example, the water inlet of the temperature regulator 26 may be communicated with an external water supply unit through the pipe 20, the water outlet of the temperature regulator 26 may be communicated with the water inlet of the water bath box 10 through the pipe 20, the water outlet of the water bath box 10 may be communicated with an external drainage unit through the pipe 20, the water outlet of the water bath box 10 may also be communicated with the water inlet of the temperature regulator 26 through the pipe 20 to form water circulation, and the water pump 24 is disposed between the water outlet of the water bath box 10 and the water inlet of the temperature regulator 26 through the pipe 20 to provide power for the water circulation. When the external water supply unit supplies water, the water pump 24 does not need to be started, and when the water circulates, the water pump 24 needs to be started to provide power for water circulation. The control valve assembly 30 is used for controlling the on-off of the water path from the external water supply unit to the water inlet of the temperature regulator 26, the control valve assembly 30 is also used for controlling the on-off of the water path from the water outlet of the water bath box 10 to the external water drainage unit, and the control valve assembly 30 is also used for controlling the on-off of the water path from the water outlet of the water bath box 10 to the water inlet of the temperature regulator 26.
In the process of using the water circulation thawing unit 100, a user can close the water path between the water outlet of the water bath box 10 and the external drainage unit, close the water path between the water outlet of the water bath box 10 and the water inlet of the temperature regulator 26, and keep the water path between the external water supply unit and the water inlet of the temperature regulator 26 communicated, at this time, water in the external water supply unit enters the pipeline 20, and water with the temperature regulated by the temperature regulator 26 enters the water bath box 10. When the water in the water bath box 10 is accumulated to a proper position, a user can close the water path from the external water supply unit to the water inlet of the temperature regulator 26 to stop the inflow of water, and keep the water path from the water outlet of the water bath box 10 to the external drainage unit closed, the water path from the water outlet of the water bath box 10 to the water inlet of the temperature regulator 26 is communicated, so that the water outlet of the water bath box 10 is communicated with the water inlet of the temperature regulator 26 through the pipeline 20 to form a closed loop, the water pump 24 is arranged between the water outlet of the water bath box 10 and the water inlet of the temperature regulator 26 to provide power for water circulation, at the moment, the water in the water bath box 10 is discharged from the water outlet, flows into the pipeline 20 and flows to the water pump 24, the water is pumped by the water pump 24 and is re-delivered into the water bath box 10, and thus the water circulation. The temperature regulator 26 can change the temperature of the water, and the water with the changed temperature can be pumped by the water pump 24 to enter the water bath box 10 again and be mixed with the water in the water bath box 10, so that the temperature of the whole water in the water bath box 10 is changed, and the temperature of the water in the water bath box 10 is kept at 4 +/-2 ℃. The direction indicated by the thick arrow in fig. 4 is the flow direction of water.
In some embodiments, the control valve assembly 30 includes a first solenoid valve 31, a second solenoid valve 32, and a third solenoid valve 33, a first end of the first solenoid valve 31 is communicated with the external water supply unit through the pipe 20, a second end of the first solenoid valve 31 is communicated with the water inlet of the thermostat 26 through the pipe 20, a first end of the second solenoid valve 32 is communicated with the external water discharge unit through the pipe 20, a second end of the second solenoid valve 32 is communicated with a first end of the third solenoid valve 33 through the pipe 20, a second end of the third solenoid valve 33 is communicated with the water outlet of the water bath tank 10 through the pipe 20, and a second end of the first solenoid valve 31 is further communicated with a second end of the second solenoid valve 32.
The first electromagnetic valve 31, the second electromagnetic valve 32 and the third electromagnetic valve 33 work in a mutual cooperation mode, for example, when the water circulation thawing unit 100 is in a water inlet process, the first electromagnetic valve 31 is communicated with a water channel where the first electromagnetic valve 31 is located, and the second electromagnetic valve 32 and the third electromagnetic valve 33 are both closed; when the water circulation thawing unit 100 is in the water circulation process, the first electromagnetic valve 31 and the second electromagnetic valve 32 are both closed, and the third electromagnetic valve 33 is communicated with the water path; when the water circulation thawing unit 100 is in the water discharging process, the first solenoid valve 31 closes the water path, and the second solenoid valve 32 and the third solenoid valve 33 are both communicated with the water path.
The first solenoid valve 31, the second solenoid valve 32 and the third solenoid valve 33 are solenoid valves of the same type, for example, solenoid valves of the type of direct-acting solenoid valve, step-by-step direct-acting solenoid valve, pilot-operated solenoid valve, etc., wherein the two solenoid valves of the first solenoid valve 31 and the third solenoid valve 33 can be replaced by a two-position three-way solenoid valve to achieve the same function.
In some embodiments, after the water circulation and thawing unit 100 is installed, the third solenoid valve 33 may be located at a position where the pipe 20 is closest or closer to the ground to facilitate the emptying of water.
In some embodiments, the water circulation thawing unit 100 further comprises a liquid level sensor 341, the liquid level sensor 341 is used for detecting the water level inside the water bath tank 10, and a user can know whether the water level inside the water bath tank 10 is normal or not by checking the liquid level value detected by the liquid level sensor 341, so that the user can make adjustments at any time.
The level sensor 341 may be cooperated with the first and second solenoid valves 31 and 32 to automatically adjust the water level in the water bath tank 10. For example, when the liquid level sensor 341 detects that the liquid level in the water bath tank 10 does not reach the predetermined value, the first electromagnetic valve 31 automatically communicates with the water path according to the detection value of the liquid level sensor 341, so that the water in the external water supply unit enters the pipeline 20; when the liquid level sensor 341 detects that the liquid level in the water bath tank 10 reaches a predetermined value, the first electromagnetic valve 31 automatically closes the water path according to the detection value of the liquid level sensor 341 to stop the water in the external water supply unit from continuously entering the pipeline 20; when the liquid level sensor 341 detects that the liquid level in the water bath tank 10 exceeds the maximum level value, the second electromagnetic valve 32 automatically communicates with the water path according to the detection value of the liquid level sensor 341, so that the water in the pipe 20 is discharged to the external water discharge unit and the water path is closed when the liquid level sensor 341 detects that the liquid level in the water bath tank 10 reaches a predetermined value.
The liquid level sensor 341 may be a contact type liquid level sensor or a non-contact type liquid level sensor, and when the liquid level sensor 341 is a contact type liquid level sensor such as a floating ball type liquid level transmitter, a magnetic liquid level transmitter, a drop type liquid level transmitter, or the like, the liquid level sensor 341 may be disposed in the water bath tank 10; when the liquid level sensor 341 is a non-contact liquid level sensor such as an ultrasonic liquid level transmitter, a radar liquid level transmitter, etc., the liquid level sensor 341 may be disposed inside the water bath tank 10 or outside the water bath tank 10.
In some embodiments, the water circulation thawing unit 100 further includes a temperature sensor 25, the temperature sensor 25 is disposed at the water bath 10, the temperature sensor 25 is used for detecting the temperature of the water in the water bath 10, and the temperature regulator 26 adjusts the temperature of the water in the pipe 20 according to the parameter detected by the temperature sensor 25.
Generally, in an environment where plasma is melted, the temperature inside the water bath 10 is usually kept at 4 ℃ ± 2 ℃, and if the temperature is too high, plasma is precipitated with little or no cryoprecipitate, and if the temperature is too low, other impurity components in the plasma are precipitated too much.
The temperature sensor 25 and the temperature regulator 26 can be matched with each other, the temperature regulator 26 processes data detected by the temperature sensor 25 in real time by using a PID (proportional-Integral-Differential) program, and when the temperature sensor 25 detects that the temperature in the water bath box 10 is too high or too low, the temperature regulator 26 can adaptively adjust the temperature of the water in the pipeline 20 according to the detection value of the temperature sensor 25 in time, so as to change the temperature of the water in the water bath box 10, which is helpful for the temperature regulator 26 to accurately control the temperature of the water in the water bath box 10, and meet the requirement of low temperature and constant temperature in the cold precipitation preparation process.
The temperature sensor 25 may be a contact temperature sensor or a non-contact temperature sensor, and when the temperature sensor 25 is a contact temperature sensor such as a bimetal temperature sensor, a glass liquid temperature sensor, a pressure type temperature sensor, a resistance temperature sensor, a thermistor sensor, or a thermocouple sensor, the temperature sensor 25 may be disposed in the water bath tank 10; when the temperature sensor 25 is a non-contact temperature sensor such as an optical temperature sensor, a radiation temperature sensor, or a colorimetric temperature sensor, the temperature sensor 25 may be disposed inside the water bath 10 or outside the water bath 10.
In some embodiments, the water circulation thawing unit 100 further comprises a filter 35, a first end of the filter 35 is communicated with the external water supply unit through the pipe 20, and a second end of the filter 35 is communicated with the control valve assembly 30 through the pipe 20.
A second end of the filter 35 may be in communication with the first solenoid valve 31. The filter 35 is used for filtering impurities of water entering the pipeline 20 from an external water supply unit, so that the impurities such as sand and stone in the water are prevented from entering the water bath box 10, the situation that the blood bag 60 is damaged due to the fact that the impurities collide with the blood bag 60 due to the flowing of the water in the process of melting the blood plasma in the blood bag 60 is avoided, and the situation that the blood plasma leaks from the blood bag 60 is reduced.
In some embodiments, please refer to fig. 5 and 6, the water circulation thawing unit 100 further includes a water storage tank 28, the water storage tank 28 is respectively communicated with the water inlet of the water pump 24 and the water outlet of the water bath tank 10 through the pipeline 20, the water storage tank 28 is respectively communicated with the external water supply unit and the external water discharge unit through the pipeline 20, the control valve assembly 30 is used for controlling the on-off of the water path from the external water supply unit to the water storage tank 28, the control valve assembly 30 is also used for controlling the on-off of the water path from the water outlet of the water bath tank 10 to the water inlet of the water pump 24, the control valve assembly 30 is also used for controlling the on-off of the water path from the water storage tank 28 to the water inlet of the water pump 24, and the control valve assembly 30 is also used for controlling the on-off of the water.
Based on this, during the water inlet process of the water storage tank 28 of the water circulation thawing unit 100, the user can keep the water path between the external water supply unit and the water storage tank 28 connected, the water path between the water storage tank 28 and the external water drainage unit closed, the water path between the water outlet of the water bath box 10 and the water pump 24 closed, the water path between the water storage tank 28 and the water inlet of the water pump 24 closed, the water path between the water storage tank 28 and the water outlet of the water bath box 10 closed, at this time, the water in the external water supply unit enters the pipeline 20 and flows into the water storage tank 28, and when the water amount in the water storage tank 28 is accumulated to a proper position, the user can close the water path between the external water supply unit and. In the water inlet process of the water bath box 10 of the water circulation unfreezing unit 100, the water path between the water outlet of the water storage tank 28 and the water pump 24 is kept communicated, the water path between the water storage tank 28 and the water outlet of the water bath box 10 is kept closed, the water pump 24 is started, water in the water storage tank 28 is conveyed to the temperature regulator 26 for temperature regulation through suction, and the water after temperature regulation is conveyed into the water bath box 10. When the water in the water bath box 10 is accumulated to a proper position, a user can close the water path between the external water supply unit and the water storage tank 28, keep the water path between the water storage tank 28 and the external drainage unit closed, communicate the water path between the water outlet of the water bath box 10 and the water pump 24, close the water path between the water storage tank 28 and the water inlet of the water pump 24, and keep the water path between the water storage tank 28 and the water outlet of the water bath box 10 closed, so that the water outlet of the water bath box 10 is communicated with the water inlet of the water pump 24 through the pipeline 20 to form a closed loop to form a water circulation effect. The direction indicated by the thick arrow in fig. 5 is the flow direction of water.
Generally, after the cryoprecipitate preparation of one blood bag 60 is completed, the water in the water bath 10 is typically drained to prepare the cryoprecipitate of the next blood bag 60. The water circulation thawing unit 100 of the embodiment of the present application collects water discharged from the water bath 10 by providing the water storage tank 28, on the one hand, water for preparing cryoprecipitate at the previous time can be repeatedly used to save water cost, and on the other hand, since parameters (such as temperature, water amount, etc.) of water for preparing cryoprecipitate at the previous time are closer to the conditions for preparing cryoprecipitate than parameters of water flowing into the water bath 10 from a water source again, time consumed for adjusting parameters of water for preparing cryoprecipitate at the next time is saved, and improvement of preparation efficiency of cryoprecipitate is facilitated. In addition, before the water of the last preparation of the cryoprecipitate is recycled, leakage pollution detection needs to be carried out on the water of the last preparation of the cryoprecipitate so as to avoid pollution caused by the next preparation of the cryoprecipitate.
In the embodiment where the water circulation thawing unit 100 comprises the water storage tank 28, the control valve assembly 30 further comprises a fourth solenoid valve 34 in addition to a first solenoid valve 31, a second solenoid valve 32 and a third solenoid valve 33, wherein a first end of the first solenoid valve 31 is communicated with the external water supply unit through the pipeline 20, a second end of the first solenoid valve 31 is communicated with the water inlet of the water storage tank 28 through the pipeline 20, a first end of the second solenoid valve 32 is communicated with the external water drainage unit through the pipeline 20, and a second end of the second solenoid valve 32 is communicated with the water outlet of the water storage tank 28 through the pipeline 20; the water outlet of the water storage tank 28 is communicated with a first end of a fourth electromagnetic valve 34 through a pipeline 20, a second end of the fourth electromagnetic valve 34 is communicated with the water inlet of the water pump 24 through the pipeline 20, a second end of the fourth electromagnetic valve 34 is also communicated with a first end of a third electromagnetic valve 33 through the pipeline 20, and a second end of the third electromagnetic valve 33 is communicated with the water outlet of the water bath tank 10 through the pipeline 20.
The first solenoid valve 31, the second solenoid valve 32, the third solenoid valve 33 and the fourth solenoid valve 34 cooperate with each other, for example, during the water inlet process of the water storage tank 28 of the water circulation thawing unit 100, the first solenoid valve 31 communicates with the water path, the second solenoid valve 32 closes the water path, the fourth solenoid valve 34 closes the water path, and when the water amount in the water storage tank 28 is accumulated to a proper position, the first solenoid valve 31 closes the water path. In the water inlet process of the water bath box 10 of the water circulation thawing unit 100, the fourth electromagnetic valve 34 is communicated with the water path, the third electromagnetic valve 33 is closed, and when the water amount in the water bath box 10 is accumulated to a proper position, the fourth electromagnetic valve 34 is closed. In the water circulation process of the water circulation thawing unit 100, the first solenoid valve 31, the second solenoid valve 32 and the fourth solenoid valve 34 are all closed, and the third solenoid valve 33 is communicated with the water path. In the process of draining the water bath tank of the water circulation thawing unit 100, the first electromagnetic valve 31 and the second electromagnetic valve 32 close the water path, the third electromagnetic valve 33 and the fourth electromagnetic valve 34 are communicated with the water path, and the water is drained into the water storage tank 28 for storage. When the circulation is used for a plurality of times, the second electromagnetic valve 32 is communicated with the waterway to discharge the water in the water storage tank 28.
The first solenoid valve 31, the second solenoid valve 32, the third solenoid valve 33 and the fourth solenoid valve 34 may all be solenoid valves of the same type, and the types of the solenoid valves refer to the above-described embodiment, wherein the two solenoid valves, i.e., the first solenoid valve 31 and the third solenoid valve 33, may be replaced by a two-position three-way solenoid valve, so as to achieve the same function.
In the embodiment where the water circulation thawing unit 100 comprises the water storage tank 28, the water circulation thawing unit 100 may further comprise a liquid level sensor 342 disposed on the water storage tank 28 to detect the condition of the liquid level in the water storage tank 28, and the type of the liquid level sensor 342 is referred to the type of the liquid level sensor 341 of the water bath 10 in the above-described embodiment.
The liquid level sensor 342 can cooperate with the first solenoid valve 31 and the second solenoid valve 32, and the first solenoid valve 31 controls the liquid level in the storage tank 28 by communicating or closing the water inlet path of the storage tank 28. For example, when the liquid level sensor 342 detects that the liquid level of the water storage tank 28 does not reach a predetermined value, the first solenoid valve 31 communicates with the water inlet passage according to the detection value of the liquid level sensor 342 so that the water in the water source flows into the water storage tank 28; when the liquid level sensor 342 detects that the liquid level of the water storage tank 28 reaches a predetermined value, the first electromagnetic valve 31 closes the water path according to the detection value of the liquid level sensor 342 to stop the water from entering the water storage tank 28.
In embodiments where the water circulation defrost unit 100 includes a water storage tank 28, the second solenoid valve 32 is disposed at the bottom of the water storage tank 28. When the user detects that the water in the water storage tank 28 is not satisfactory, for example, plasma in the blood bag 60 has leaked from the last preparation of cryoprecipitation, the user may open the second solenoid valve 32 to communicate the water storage tank 28 with an external drain unit to drain the water. In addition, the second solenoid valve 32 can be further cooperated with the liquid level sensor 342, and when the liquid level sensor 342 detects that the liquid level of the water storage tank 28 exceeds the maximum predetermined value, the second solenoid valve 32 communicates with the water path according to the detection value of the liquid level sensor 342 to discharge a part of water to the external drain unit.
The bottom of the storage tank 28 is at a relative position, which represents the position where the storage tank 28 is closest to or closer to the ground when the water circulation thawing unit 100 is installed, such as the posture of the water circulation thawing unit 100 in normal use shown in fig. 5, the second solenoid valve 32 is located at the bottom of the storage tank 28, and the second solenoid valve 32 located at the bottom of the storage tank 28 facilitates the water in the storage tank 28 to be emptied.
In some embodiments, the temperature regulator 26 is a semiconductor refrigerator, which can convert the cooling and heating more quickly than a compressor, and can regulate the temperature without using a refrigerant, and the semiconductor refrigerator has less working power, and is more suitable for the case where the water bath 10 melts one blood bag 60.
Referring to fig. 7 and 8, in the embodiment of the present application, a water circulation thawing system 200 is provided, the water circulation thawing system 200 includes a plurality of water circulation thawing units 100 according to any of the above embodiments, the plurality of water circulation thawing units 100 are independent from each other.
The term "plurality" in the present application means two or more, for example, the number of the water circulation thawing units 100 may be two or three or four or five or more, the number of the water circulation thawing units 100 is six in the example shown in fig. 7, and the number of the water circulation thawing units 100 is twelve in the example shown in fig. 8.
The plurality of water circulation/thawing units 100 are independent of each other, in which the environmental conditions (for example, the amount and temperature of water in the water bath 10, the temperature and flow rate in the pipe 20, and the like) in any one of the water circulation/thawing units 100 are not affected by the other water circulation/thawing units 100, and water in any one of the water circulation/thawing units 100 does not enter the other water circulation/thawing units 100. The plurality of water circulation thawing units 100 may be arranged at intervals, and may also be closely offset to improve the space utilization of the water circulation thawing system 200.
In the water circulation thawing system 200 of the embodiment of the application, the blood bag 60 is placed in the water bath box 10 for thawing, the water circulation control device 101 is connected with the water bath box 10 to form a closed water path circulation, and the temperature of the water can be controlled to be kept stable so as to promote the thawing of the blood bag 60, because the water bath box 10 contains one blood bag 60 at most, compared with other modes of thawing a plurality of blood bags 60 in the same water bath box 10 at the same time, the plasma leakage caused by the damage of one blood bag 60 is avoided, and then the condition of cross contamination between the blood bags 60 is caused, and the safety of cryoprecipitation is improved.
Referring to fig. 9, the present embodiment provides a cryoprecipitate preparing apparatus 300, wherein the cryoprecipitate preparing apparatus 300 includes the water circulation thawing system 200 according to any one of the above embodiments.
In the cryoprecipitation preparation appearance 300 of the embodiment of the application, the blood bag 60 that is equipped with fresh frozen plasma is placed and is melted in water bath 10, water circulation controlling means 101 is connected with water bath 10 and is formed a confined water route circulation, and can control the temperature of water and remain stable in order to promote melting of blood bag 60, because water bath 10 holds a blood bag 60 at most, compare in other mode of melting a plurality of blood bags 60 simultaneously in same water bath 10, avoided taking place the plasma seepage because of one of them blood bag 60 is damaged, and then make the condition of taking place cross contamination between the blood bag 60, the security that has improved the cryoprecipitation.
The cryoprecipitation preparation apparatus 300 further includes a plurality of placing units 40 and a plurality of air discharging units 50, and the placing units 40 are trays or hooks for placing empty bags in the duplex bags. The placing units 40 are in one-to-one correspondence with the water bath boxes 10 to form a height difference, the height of the water bath boxes 10 from the ground is higher than that of the placing units 40 from the ground, each exhaust unit 50 is arranged between each water bath box 10 and each placing unit 40, the exhaust units 50 are used for clamping a conduit to perform peristalsis, air in the blood bag 60 filled with fresh frozen plasma in the external duplex bag is exhausted to an empty bag through the conduit, and siphoning can be performed after the air is exhausted.
The exhaust unit 50 may be a peristaltic pump, and since a certain height drop is formed between the placing unit 40 and the water bath 10, after the exhaust unit 50 exhausts the air in the conduit, the cryoprecipitate preparing apparatus 300 can discharge the plasma in the blood bag 60 in the water bath 10 into an empty bag by using a siphon effect, so that the cryoprecipitate preparing apparatus 300 can prepare the cryoprecipitate by using a water bath siphon method.
The above embodiments are only used to illustrate the technical solutions of the present application, and not to limit the same; although the present application has been described in detail with reference to the foregoing embodiments, it should be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not substantially depart from the spirit and scope of the embodiments of the present application and are intended to be included within the scope of the present application.
Claims (13)
1. A water circulation defrosting unit characterized by comprising:
a water bath for containing only one blood bag; and
and the water circulation control device is connected with the water bath tank.
2. The water circulation unfreezing unit according to claim 1, wherein the water circulation control device comprises a water pump, a temperature regulator and a plurality of pipelines, the water inlet of the water bath tank is communicated with an external water supply unit through the pipelines, the water outlet of the water bath tank is communicated with an external drainage unit through the pipelines, the water outlet of the water bath tank is also communicated with the water inlet of the water bath tank through the pipelines to form water circulation, the water pump is arranged between the water outlet of the water bath tank and the water inlet of the water bath tank through the pipelines to provide power for the water circulation, and the temperature regulator is arranged between the water outlet of the water bath tank and the water inlet of the water bath tank through the pipelines to control the temperature of water in a water channel.
3. The water circulation thawing unit according to claim 2, wherein the water inlet of the water pump is communicated with the external water supply unit through the pipeline, the water outlet of the water pump is communicated with the water inlet of the water bath tank through the pipeline, the water outlet of the water bath tank is communicated with the external drainage unit through the pipeline, and the water outlet of the water bath tank is also communicated with the water inlet of the water pump through the pipeline to form water circulation.
4. The water circulation thawing unit according to claim 2, wherein the water inlet of the temperature regulator is communicated with the external water supply unit through the pipeline, the water outlet of the temperature regulator is communicated with the water inlet of the water bath tank, the water outlet of the water bath tank is communicated with the external drainage unit through the pipeline, and the water outlet of the water bath tank is also communicated with the water inlet of the temperature regulator through the pipeline to form a water circulation.
5. The water circulation unfreezing unit according to any one of claims 2 to 4, wherein the water circulation control device further comprises a control valve assembly, the control valve assembly is arranged among the plurality of pipelines and is used for controlling the on-off of a water path from the external water supply unit to the water inlet of the water bath tank and controlling the on-off of the water path from the water outlet of the water bath tank to the external water drainage unit.
6. The water circulation unfreezing unit according to claim 3, wherein the water circulation control device further comprises a control valve assembly, the control valve assembly is arranged among the plurality of pipelines and is used for controlling the on-off of a water path from the external water supply unit to the water inlet of the water bath tank, controlling the on-off of a water path from the water outlet of the water bath tank to the external drainage unit and controlling the on-off of a water path from the water outlet of the water bath tank to the water inlet of the water pump.
7. The water circulation defrosting unit of claim 1, wherein the water circulation control means comprises: the temperature control device comprises a water pump, a temperature regulator, a control valve assembly and a plurality of pipelines, wherein the temperature regulator is used for controlling the temperature of water in a waterway;
the water inlet of the temperature regulator is communicated with an external water supply unit through the pipeline, the water outlet of the temperature regulator is communicated with the water inlet of the water bath tank, the water outlet of the water bath tank is communicated with an external drainage unit through the pipeline, the water outlet of the water bath tank is also communicated with the water inlet of the temperature regulator through the pipeline to form water circulation, and the water pump is arranged between the water outlet of the water bath tank and the water inlet of the temperature regulator through the pipeline to provide power for the water circulation;
the control valve assembly is arranged among the pipelines and used for controlling the on-off of a water path from the external water supply unit to the water inlet of the temperature regulator, controlling the on-off of a water path from the water outlet of the water bath box to the external drainage unit and controlling the on-off of a water path from the water outlet of the water bath box to the water inlet of the temperature regulator.
8. The water circulation thaw unit of claim 7, wherein the control valve assembly includes a first solenoid valve, a second solenoid valve, and a third solenoid valve; the first end of the first electromagnetic valve is communicated with the external water supply unit through the pipeline, and the second end of the first electromagnetic valve is communicated with the water inlet of the temperature regulator through the pipeline; the first end of the second electromagnetic valve is communicated with the external drainage unit through the pipeline, the second end of the second electromagnetic valve is communicated with the first end of the third electromagnetic valve through the pipeline, and the second end of the third electromagnetic valve is communicated with the water outlet of the water bath tank through the pipeline; the second end of the first electromagnetic valve is also communicated with the second end of the second electromagnetic valve;
the water pump is installed between the water inlet of the temperature regulator and the external water supply unit through the pipeline, the water inlet of the water pump is communicated with the external water supply unit through the pipeline, the water outlet of the water pump is communicated with the water inlet of the temperature regulator through the pipeline, and the water outlet of the water bath tank is communicated with the water inlet of the water pump through the pipeline to form water circulation.
9. The water circulation defrosting unit of claim 6 or 8 further comprising a water storage tank, the water storage tank is respectively communicated with the water inlet of the water pump and the water outlet of the water bath tank through the pipeline, the water storage tank is respectively communicated with the external water supply unit and the external drainage unit through the pipelines, the control valve assembly is used for controlling the on-off of a water path from the external water supply unit to the water storage tank, controlling the on-off of a water path from the water storage tank to the external drainage unit, controlling the on-off of a water path from the water outlet of the water bath tank to the water inlet of the water pump, controlling the on-off of a water path from the water storage tank to the water inlet of the water pump and controlling the on-off of a water path from the water outlet of the water bath tank to the water storage tank.
10. The water circulation thaw unit of claim 9, wherein the control valve assembly includes a first solenoid valve, a second solenoid valve, a third solenoid valve, and a fourth solenoid valve; the first end of the first electromagnetic valve is communicated with the external water supply unit through the pipeline, and the second end of the first electromagnetic valve is communicated with the water inlet of the water storage tank through the pipeline; the first end of the second electromagnetic valve is communicated with the external drainage unit through the pipeline, and the second end of the second electromagnetic valve is communicated with the water outlet of the water storage tank through the pipeline; the water outlet of the water storage tank is communicated with the first end of the fourth electromagnetic valve through the pipeline, the second end of the fourth electromagnetic valve is communicated with the water inlet of the water pump through the pipeline, the second end of the fourth electromagnetic valve is also communicated with the first end of the third electromagnetic valve through the pipeline, and the second end of the third electromagnetic valve is communicated with the water outlet of the water bath tank through the pipeline.
11. The water circulation defrosting unit of claim 6 or 8 wherein the temperature regulator is a semiconductor refrigerator; and/or
The water circulation unfreezing unit further comprises a liquid level sensor, the liquid level sensor is arranged in the water bath tank, and the liquid level sensor is used for detecting the water level in the water bath tank; and/or
The water circulation unfreezing unit further comprises a temperature sensor, the temperature sensor is arranged in the water bath tank, and the temperature sensor is used for detecting the temperature of water in the water bath tank; and/or
The water circulation thawing unit further comprises a filter, a first end of the filter is communicated with the external water supply unit through the pipeline, and a second end of the filter is communicated with the control valve assembly through the pipeline.
12. A water circulation defrosting system comprising a plurality of water circulation defrosting units according to any one of claims 1 to 11, which are independent of each other.
13. A cryoprecipitation preparation instrument is characterized by comprising:
the water circulation defrosting system of claim 12;
the placing units are used for placing empty bags of external duplex bags, the placing units correspond to the water bath boxes in the water circulation unfreezing system one by one and form a height difference, and the height of the water bath boxes from the ground is higher than the height of the placing units from the ground; and
and the exhaust units are arranged between the water bath tank and the placing unit and used for clamping the conduit of the external duplex bag to exhaust.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| CN114404701A (en) * | 2022-02-18 | 2022-04-29 | 潍坊骏驰电子科技有限公司 | Cold precipitation preparation instrument and preparation method thereof |
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| CN112254407A (en) * | 2020-10-20 | 2021-01-22 | 佛山沃塘医疗科技有限公司 | Full-automatic cryoprecipitation preparation appearance |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025618A (en) * | 1974-09-03 | 1977-05-24 | Baxter Travenol Laboratories, Inc. | Method for separation of cryoprecipitate from blook plasma |
| CN2348844Y (en) * | 1998-08-05 | 1999-11-17 | 苏州市医用仪器厂 | Box for defreezing frozen plasma |
| US20030052065A1 (en) * | 2001-09-14 | 2003-03-20 | Keith Rosiello | Blood product transfer system |
| US6752777B1 (en) * | 1997-06-16 | 2004-06-22 | Terumo Kabushiki Kaisha | Blood component collecting apparatus |
| CN201481889U (en) * | 2009-03-20 | 2010-05-26 | 王继坤 | Water isolation adjustable frozen blood production melting apparatus |
| CN201988403U (en) * | 2011-03-09 | 2011-09-28 | 中国人民解放军第三军医大学第二附属医院 | Water bath box |
| CN102258816A (en) * | 2011-04-20 | 2011-11-30 | 武汉贝索医疗器械有限公司 | Blood plasma thawing apparatus and blood plasma thawing automatic control method |
| CN102389592A (en) * | 2011-11-08 | 2012-03-28 | 山东中保康医疗器具有限公司 | Cryoprecipitation blood coagulation factor preparation instrument |
| CN202198899U (en) * | 2011-08-02 | 2012-04-25 | 董喜春 | Dry blood plasma unfreezing apparatus |
| CN104623748A (en) * | 2015-02-06 | 2015-05-20 | 李智 | Cryoprecipitation preparation instrument |
| CN105399814A (en) * | 2015-11-10 | 2016-03-16 | 卢瑾 | Cryoprecipitated antihemophilic factor preparation instrument and application method thereof |
| CN105461803A (en) * | 2015-12-31 | 2016-04-06 | 山东中保康医疗器具有限公司 | Novel cryoprecipitated antihemophilic factor preparing instrument |
| CN207214507U (en) * | 2017-08-04 | 2018-04-10 | 李智 | A kind of cryoprecipitate preparation facilities with semiconductor refrigerating plate |
-
2019
- 2019-11-27 CN CN201911181994.0A patent/CN110812550A/en active Pending
-
2020
- 2020-09-03 CN CN202010917894.6A patent/CN111870749A/en active Pending
- 2020-09-03 CN CN202021902718.7U patent/CN213608752U/en active Active
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025618A (en) * | 1974-09-03 | 1977-05-24 | Baxter Travenol Laboratories, Inc. | Method for separation of cryoprecipitate from blook plasma |
| US6752777B1 (en) * | 1997-06-16 | 2004-06-22 | Terumo Kabushiki Kaisha | Blood component collecting apparatus |
| CN2348844Y (en) * | 1998-08-05 | 1999-11-17 | 苏州市医用仪器厂 | Box for defreezing frozen plasma |
| US20030052065A1 (en) * | 2001-09-14 | 2003-03-20 | Keith Rosiello | Blood product transfer system |
| CN201481889U (en) * | 2009-03-20 | 2010-05-26 | 王继坤 | Water isolation adjustable frozen blood production melting apparatus |
| CN201988403U (en) * | 2011-03-09 | 2011-09-28 | 中国人民解放军第三军医大学第二附属医院 | Water bath box |
| CN102258816A (en) * | 2011-04-20 | 2011-11-30 | 武汉贝索医疗器械有限公司 | Blood plasma thawing apparatus and blood plasma thawing automatic control method |
| CN202198899U (en) * | 2011-08-02 | 2012-04-25 | 董喜春 | Dry blood plasma unfreezing apparatus |
| CN102389592A (en) * | 2011-11-08 | 2012-03-28 | 山东中保康医疗器具有限公司 | Cryoprecipitation blood coagulation factor preparation instrument |
| CN104623748A (en) * | 2015-02-06 | 2015-05-20 | 李智 | Cryoprecipitation preparation instrument |
| CN105399814A (en) * | 2015-11-10 | 2016-03-16 | 卢瑾 | Cryoprecipitated antihemophilic factor preparation instrument and application method thereof |
| CN105461803A (en) * | 2015-12-31 | 2016-04-06 | 山东中保康医疗器具有限公司 | Novel cryoprecipitated antihemophilic factor preparing instrument |
| CN207214507U (en) * | 2017-08-04 | 2018-04-10 | 李智 | A kind of cryoprecipitate preparation facilities with semiconductor refrigerating plate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114404701A (en) * | 2022-02-18 | 2022-04-29 | 潍坊骏驰电子科技有限公司 | Cold precipitation preparation instrument and preparation method thereof |
| CN114404701B (en) * | 2022-02-18 | 2023-08-15 | 潍坊骏驰电子科技有限公司 | Cold precipitation preparation instrument and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110812550A (en) | 2020-02-21 |
| CN213608752U (en) | 2021-07-06 |
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