CN110841122A - Method and device for preparing cryoprecipitate - Google Patents
Method and device for preparing cryoprecipitate Download PDFInfo
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- CN110841122A CN110841122A CN201911054240.9A CN201911054240A CN110841122A CN 110841122 A CN110841122 A CN 110841122A CN 201911054240 A CN201911054240 A CN 201911054240A CN 110841122 A CN110841122 A CN 110841122A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0259—Apparatus for treatment of blood or blood constituents not otherwise provided for
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
Abstract
The embodiment of the application provides a method for preparing cryoprecipitate, which is applied to a preparation system of the cryoprecipitate, and the method comprises the following steps: submerging the first blood bag in the liquid; continuously monitoring the real-time liquid level of the water bath during thawing of the frozen plasma, wherein a dissolved portion of the frozen plasma enters a second blood bag located outside the water bath via siphoning; and removing the first blood bag from the liquid when the real-time liquid level falls within the target liquid level range. By monitoring the liquid level of the water bath tank in the preparation process, whether the preparation of the cryoprecipitate is finished or not can be determined according to whether the real-time liquid level falls into the target liquid level range or not, so that the accuracy of the preparation amount of the cryoprecipitate is improved, and the preparation efficiency of the cryoprecipitate is also improved. The embodiment of the application also provides a device for preparing the cryoprecipitate.
Description
Technical Field
The application relates to the technical field of medical treatment, in particular to a method and a device for preparing cryoprecipitate.
Background
Cryoprecipitate refers to plasma cryoprecipitate containing factor VIII and fibrinogen, and can be used for treating patients who lack factor VIII and fibrinogen and have more bleeding or hemophilia. Wherein the cryoprecipitate is prepared from fresh frozen plasma at 4 deg.C. The preparation is generally carried out by a centrifugal method or a water bath siphon method according to the characteristic that cryoprecipitate is not melted at 4 ℃.
Disclosure of Invention
In view of the above, the present application provides a method and apparatus for preparing cryoprecipitate to improve the above problems.
The embodiment of the application provides a method for preparing cryoprecipitate, which is applied to a preparation system of the cryoprecipitate, the system comprises a water bath and a liquid level sensor arranged on the water bath, the water bath is suitable for containing liquid for unfreezing frozen plasma, the frozen plasma is contained in a first blood bag, the first blood bag is communicated to a second blood bag through a conduit, a height difference exists between the first blood bag and the second blood bag, and the dissolved frozen plasma can flow to the second blood bag through the conduit. The method comprises the following steps: acquiring an initial liquid level of a water bath; submerging the first blood bag in the liquid; continuously monitoring the real-time liquid level of the water bath during thawing of the frozen plasma, wherein a dissolved portion of the frozen plasma enters a second blood bag located outside the water bath via siphoning; and removing the first blood bag from the liquid when the real-time liquid level falls within the target liquid level range.
In some embodiments, prior to submerging the first blood bag in the liquid, the method further comprises: acquiring an initial liquid level of a water bath; determining an empty bag volume of the first blood bag, determining a target volume of the cryoprecipitate; and determining a target liquid level range according to the initial liquid level, the empty bag volume, the target volume and the size information of the water bath.
In some embodiments, continuously monitoring the real-time liquid level of the water bath during frozen plasma thawing comprises: detecting and determining the real-time liquid level of the water bath tank according to the detection data of the liquid level sensor in the unfreezing process of the frozen plasma; and determining a real-time volume of the undissolved portion of frozen plasma from the real-time liquid level, the initial liquid level, the empty bag volume, and the dimensional information of the water bath; the real-time volume of the undissolved portion of the frozen plasma is shown.
In some embodiments, prior to continuously detecting the administration level of the water bath during thawing of the frozen plasma, the method further comprises: acquiring a marking liquid level of a water bath tank after the first blood bag is immersed in liquid; based on the marker level, initial level, empty bag volume, and size information of the water bath, the initial volume of frozen plasma was determined.
In some embodiments, continuously monitoring the real-time liquid level of the water bath during thawing of the frozen plasma comprises determining a dissolved volume of the frozen plasma from the marker liquid level, the real-time liquid level, the empty bag volume, and the dimensional information of the water bath; determining a real-time volume of the undissolved portion of the frozen plasma based on the initial volume of frozen plasma and the dissolved volume of frozen plasma; the real-time volume of the undissolved portion of the frozen plasma is shown.
In some embodiments, displaying the real-time volume of the undissolved portion of frozen plasma comprises scaling the real-time weight of the undissolved portion of frozen plasma based on the real-time volume of the undissolved portion of frozen plasma; the real-time volume of the undissolved portion of frozen plasma and the real-time weight of the undissolved portion of frozen plasma are shown.
In some embodiments, when the real-time liquid level falls within the target liquid level range, after removing the first blood bag from the liquid level, the method comprises: obtaining a current weight of a first blood bag; and if the current weight of the first blood bag does not fall into the preset weight range of the first blood bag, sending a reminding signal.
The embodiment of the application also provides a device for preparing the cryoprecipitate, which comprises a water bath, a liquid level sensor and a processor. The water bath is suitable for containing liquid for unfreezing frozen plasma, the frozen plasma is contained in a first blood bag and unfrozen in the liquid, the first blood bag is communicated to a second blood bag through a conduit, and the frozen plasma with a height difference between the first blood bag and the second blood bag can flow to the second blood bag through the conduit after being dissolved; the liquid level sensor is arranged in the water bath; and a processor connected with the liquid level sensor, the processor being used for executing the above method.
In some embodiments, the device further comprises a weight measurement coupled to the processor, the weight measurement for measuring the weight of the first blood bag removed from the water bath.
In some embodiments, the device further comprises an alarm coupled to the processor for issuing an alarm based on whether the weight of the first blood bag falls within a predetermined range.
In some embodiments, the device further comprises a display coupled to the processor, the display for displaying a real-time volume and/or a real-time weight of the currently undissolved portion of the first blood bag.
The method and the device for preparing the cryoprecipitate can really complete the preparation of the cryoprecipitate according to whether the real-time liquid level falls into the target liquid level range or not by monitoring the liquid level of the water bath tank in the preparation process, improve the precision of preparing the cryoprecipitate weight and also improve the preparation efficiency of the cryoprecipitate.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
Fig. 1 is a schematic flow chart of a method for preparing cryoprecipitate provided in the embodiments of the present application.
Fig. 2 is a schematic flow chart of an implementation method of step S103 of the method shown in fig. 1.
Fig. 3 is a schematic flow chart of another implementation method of step S103 of the method shown in fig. 1.
Fig. 4 is a schematic diagram of an apparatus for preparing cryoprecipitate provided in the embodiments of the present application.
Fig. 5 is a block diagram of a portion of the structure of the apparatus shown in fig. 4.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application.
In the examples of the present application, a water bath siphon method was used to prepare the cryoprecipitate. The process of preparing the cryoprecipitate by the water bath siphon method is to unfreeze fresh frozen plasma in an environment of 4 ℃, and because the cryoprecipitate has the characteristic of being infusible at 4 ℃, the dissolved part and the undissolved part are separated, so that the preparation of the cryoprecipitate can be realized. Because the frozen plasma is unfrozen in the environment of 4 ℃, whether the preparation of the cryoprecipitate is finished or not is difficult to accurately determine, and the preparation efficiency of the cryoprecipitate is influenced.
Based on this, the inventors have conducted extensive and repeated alignments and studies on the preparation process of cryoprecipitate. The inventor further studied how to design a method and a device for realizing the precise monitoring of the cold precipitation in the cold precipitation preparation process, and thereby proposed the scheme of the embodiment of the present application.
Referring to fig. 1, a method for preparing cryoprecipitate according to an embodiment of the present application is shown, and the method is applied to a preparation system of cryoprecipitate, the system includes a water bath adapted to contain a liquid for thawing frozen plasma, wherein the frozen plasma is contained in a first blood bag, the first blood bag is communicated to a second blood bag through a conduit, a height difference exists between the first blood bag and the second blood bag, and the dissolved frozen plasma can flow to the second blood bag through the conduit. The method can accurately determine whether the preparation of the cryoprecipitate is finished or not so as to improve the preparation efficiency of the cryoprecipitate. Specifically, the method may include steps S101 to S107.
Step S101: submerging the first blood bag in the liquid.
In the embodiment of the present application, in order to create a temperature environment for cryoprecipitation preparation, such as a thawing environment maintained at 4 ℃, a liquid at 4 ℃ is stored in the water bath tank in advance, and may be purified water, sterile water, or the like. At the beginning of the cryoprecipitate preparation, the first blood bag needs to be immersed in a liquid to create a temperature environment for the cryoprecipitate preparation.
Further, a portion of the liquid is pre-existing in the water bath before the first blood bag is submerged in the liquid. At this point, an initial level of the water bath is obtained for use in identifying a pre-existing volume of liquid within the water bath.
Step S103: during thawing of frozen plasma, the real-time liquid level of the water bath was continuously monitored.
In the embodiment of the present application, the frozen plasma in the first blood bag is dissolved in the water bath, and due to the height difference between the first blood bag and the second blood bag, the dissolved part in the first blood bag enters the second blood bag outside the water bath through siphon action, and the liquid level in the water bath is changed. Thus, the remaining amount of frozen plasma in the first blood bag, i.e. the prepared amount of cryoprecipitate, may be obtained by continuously monitoring the change in the level of the water bath.
Further, a target preparation amount of cryoprecipitate may be predetermined, such as a target preparation amount of cryoprecipitate prepared with 150ml and 200ml of fresh frozen plasma, typically 40ml to 50 ml. Therefore, the target liquid level range can be determined by acquiring the size information of the water bath and according to the initial liquid level, the size information of the water bath and the target preparation amount of the cryoprecipitate.
Alternatively, the target preparation amount of cryoprecipitate is the target volume of cryoprecipitate, which in turn may be obtained from the initial volume of frozen plasma. For example, the empty bag volume of the first blood bag is known, the initial volume of frozen plasma can be obtained by direct measurement, and the target volume of cryoprecipitate is determined as a percentage of the initial volume of frozen plasma. Further, a target level range of the water bath may be obtained from the initial level, the empty bag volume, the target volume of the frozen plasma, and the dimensional information of the water bath (e.g., the bottom area dimension or cross-sectional dimension of the water bath, etc.).
In some embodiments, the target preparation amount of the cryoprecipitate may also be the weight of the cryoprecipitate, and the target weight of the cryoprecipitate may be obtained according to the initial weight of the frozen plasma and then converted according to the target weight of the cryoprecipitate to obtain the target liquid level range of the water bath.
In some embodiments, referring to fig. 2, step S103 may include steps S1031 to S1035, specifically:
step S1031: and in the frozen plasma thawing process, detecting and determining the real-time liquid level of the water bath according to the detection data of the liquid level sensor.
Wherein, the real-time liquid level of the water bath can be detected and determined through the detection data of the liquid level sensor. Alternatively, the liquid level sensor may be of the contact type, including single flange static pressure/double flange differential pressure liquid level transmitter, float ball type liquid level transmitter, magnetic liquid level transmitter, drop-in type liquid level transmitter, electric inner float ball type liquid level transmitter, electric float bowl type liquid level transmitter, capacitive type liquid level transmitter, magnetostrictive type liquid level transmitter, servo liquid level transmitter, etc. The liquid level sensor can also be in a non-contact type, and is classified into an ultrasonic liquid level transmitter, a radar liquid level transmitter and the like.
Step S1033: the real-time volume of the undissolved portion of frozen plasma is determined from the real-time liquid level, the initial liquid level, the empty bag volume, and the dimensional information of the water bath.
Optionally, the empty bag volume and the real-time volume of the undissolved portion of the frozen plasma are determined by obtaining a first liquid level difference between the real-time liquid level and the initial liquid level and based on the first liquid level difference and the dimensional information of the water bath. The real-time volume of the undissolved portion of the frozen plasma is then determined based on the volume of the first blood bag. The real-time volume of the undissolved portion of the frozen plasma may refer to the remaining volume of frozen plasma in the first blood bag, since the dissolved portion of frozen plasma has entered the second blood bag via siphoning.
Step S1035: the real-time volume of the undissolved portion of the frozen plasma is shown.
In the embodiment of the application, the real-time volume of the undissolved part of the frozen plasma can be displayed by arranging a display device such as a display panel, so that a person can observe and know the progress of the preparation process more intuitively.
Further, whether the real-time volume of the undissolved portion of the frozen plasma is the target volume is judged according to the real-time volume of the undissolved portion of the frozen plasma. Due to the corresponding relation between the volume and the liquid level of the water bath, if the real-time volume of the undissolved part of the frozen plasma is the target volume, the real-time liquid level of the water bath falls into the target liquid level range, and a reminding signal can be sent to remind personnel that the current preparation process is finished. Alternatively, the reminding signal can be an alarm signal sent by an alarm, a light signal sent by an indicator lamp and the like.
As an embodiment, when the real-time volume of the undissolved portion of frozen plasma is displayed, the real-time weight of the undissolved portion of frozen plasma may be converted according to the real-time volume of the undissolved portion of frozen plasma, and the real-time volume of the undissolved portion of frozen plasma and the real-time weight of the undissolved portion of frozen plasma are displayed, so that the preparation amount of the cryoprecipitate is determined by the real-time volume of the undissolved portion of frozen plasma and the weight of the undissolved portion of frozen plasma, so that a person can know the progress of the current preparation process.
In some embodiments, referring to fig. 3, step S1061 to step S1063 may be performed before step S103, and step S1065 to step S1067 may be used instead of step S103.
Step S1061: and acquiring the marking liquid level of the water bath after the first blood bag is immersed in the liquid.
After the first blood bag is immersed in the liquid, the volume of the liquid can be changed, so that the liquid level of the water bath tank is changed, and the liquid level is recorded as a marking liquid level after the liquid level of the water bath tank is stabilized. The marker level is used to identify a level within the water bath after the first blood bag is submerged in liquid.
Step S1063: an initial volume of frozen plasma is determined based on the marker level, the initial level, the empty bag volume, and the dimensional information of the water bath.
Wherein the initial volume of frozen plasma may be determined based on the initial liquid level, the marker level, the empty bag volume, and the dimensional information of the water bath. First, the volume of the first blood bag and the initial volume of frozen plasma may be determined from the second liquid level difference and the dimensional information of the water bath by obtaining the second liquid level difference of the initial liquid level and the marker liquid level. Wherein the volume of the first blood bag is known and the initial volume of frozen plasma can be determined by comparing the volume of the first blood bag with the determined volume of the first blood bag (i.e., the empty bag volume) and the initial volume of frozen plasma.
Step S1065: the dissolved volume of frozen plasma is determined from the marker level, the real-time level, the empty bag volume, and the dimensional information of the water bath.
Optionally, the dissolved volume of plasma is determined from the third liquid level difference and the dimensional information of the water bath by obtaining a third liquid level difference between the real-time liquid level and the marker liquid level. Wherein, the obtaining manner of the real-time liquid level refers to step S1031, which is not described herein again
Step S1067: the real-time volume of the undissolved portion of frozen plasma is determined from the initial volume of frozen plasma and the dissolved volume of frozen plasma.
Wherein the initial volume of frozen plasma is equal to the sum of the volume of dissolved frozen plasma and the volume of undissolved portion of frozen plasma, and the real-time volume of undissolved portion of frozen plasma can be determined when both the initial volume of frozen plasma and the volume of dissolved frozen plasma are known.
Optionally, the real-time volume of the undissolved portion of the frozen plasma is also displayed at this time (see step S1035) to facilitate the progress of the current manufacturing process.
Step S105: and when the real-time liquid level falls into the target liquid level range, removing the first blood bag from the liquid.
In the embodiment of the present application, when the real-time liquid level falls within the target liquid level range, the remaining amount of the frozen plasma can be considered to reach the target preparation amount of the cryoprecipitate, and then the first blood bag can be removed from the liquid to complete the preparation of the cryoprecipitate. Wherein the residual amount of the frozen plasma is the amount of the undissolved portion of the frozen plasma.
Target level range further, when the real-time liquid level falls within the target level range, the real-time weight of the undissolved portion of frozen plasma can be considered to reach the target preparation volume, and the first blood bag can then be removed from the liquid to complete the preparation of the cryoprecipitate.
In some embodiments, to ensure the accuracy of the cryoprecipitate preparation volume, the weight of the first blood bag may be rechecked after the first blood bag is removed from the fluid, and the weight of the second blood bag may also be rechecked. For example, the current weight of the first blood bag can be obtained through the weighing device, then the current weight of the first blood bag is compared with the preset weight range of the first blood bag, if the current weight of the first blood bag does not fall into the preset weight range of the first blood bag, it indicates that the prepared cryoprecipitate does not meet the requirements, and a reminding signal can be sent out through the alarm. The preset weight range of the first blood bag can be converted according to the target volume (such as 40-50ml) of the frozen plasma. Optionally, the current weight of the second blood bag may be obtained through the weighing device, and then the current weight of the second blood bag is compared with the preset weight range of the second blood bag, if the current weight of the second blood bag does not fall into the preset weight range of the second blood bag, it indicates that the prepared cryoprecipitate does not meet the requirement, and a warning signal may be sent through the alarm. The preset weight range of the second blood bag can be converted according to the volume of the dissolved part of the frozen plasma (the difference between the initial volume and the target volume of the frozen plasma).
According to the method for preparing the cryoprecipitate, whether the preparation of the cryoprecipitate is finished or not can be determined according to whether the real-time liquid level falls into the target liquid level range or not by monitoring the liquid level of the water bath tank in the preparation process, so that the accuracy of the preparation amount of the cryoprecipitate is improved, and the preparation efficiency of the cryoprecipitate is also improved.
Referring to fig. 4, an apparatus 10 for preparing cryoprecipitate according to an embodiment of the present application is shown, the apparatus 10 including a water bath 110, a level sensor 130 and a processor 150.
In particular, the water bath 110 is adapted to contain a liquid for thawing frozen plasma, which may be thermostated water at 4 ℃, to create an environment that facilitates the preparation of cryoprecipitate. Alternatively, the frozen plasma is contained in the first blood bag 170 and thawed in a liquid, the first blood bag 170 is connected to the second blood bag 190 through a conduit, there is a height difference between the first blood bag 170 and the second blood bag 190, and the frozen plasma can flow to the second blood bag 190 through the conduit after being dissolved. In some embodiments, the frozen plasma may be contained in other containers, such as a cassette, and the like, without limitation.
The level sensor 130 is disposed in the water bath 110 and is configured to monitor changes in the level of the water bath 110. Alternatively, the liquid level sensor may be of the contact type, including single flange static pressure/double flange differential pressure liquid level transmitter, float ball type liquid level transmitter, magnetic liquid level transmitter, drop-in type liquid level transmitter, electric inner float ball type liquid level transmitter, electric float bowl type liquid level transmitter, capacitive type liquid level transmitter, magnetostrictive type liquid level transmitter, servo liquid level transmitter, etc. The liquid level sensor can also be in a non-contact type, and is classified into an ultrasonic liquid level transmitter, a radar liquid level transmitter and the like.
In the process of unfreezing the frozen plasma in the liquid, the frozen plasma is dissolved, and meanwhile, the dissolved part of the frozen plasma flows from the first blood bag 170 to the second blood bag 190 through siphonage, so that the liquid level of the water bath 110 is changed, at the moment, the liquid level change of the water bath 110 can be monitored according to the liquid level sensor 130, and the preparation process of the cryoprecipitate is monitored. For the example of FIG. 4, level A is used to indicate an initial level of the water bath 110 when the first blood bag 170 is not submerged in the liquid of the water bath 110; level C is used to indicate an identification level of the water bath 110 when the first blood bag 170 is submerged in the liquid of the water bath 110; level B is used to indicate the real time level of the water bath 110 during the thawing process, as the frozen plasma lyses and flows by siphoning from the first blood bag 170 to the second blood bag 190.
The processor 150 is connected to the level sensor 130, and the processor 150 is configured to perform the method for preparing a cryoprecipitate in the above-described embodiment to remove the first blood bag 170 from the liquid when the level sensor 130 detects that the real-time liquid level of the water bath 110 falls within a target level range.
In some embodiments, the device 10 further comprises a holding device (not shown) for holding the first blood bag 170, determining that preparation of the cryoprecipitate has been completed when the real-time liquid level monitored by the level sensor 130 falls within a target liquid level range, the holding device removing the first blood bag 170 from the liquid in the water bath 110. Alternatively, the removal process may be performed manually by a person.
In some embodiments, referring to fig. 5, the apparatus 10 further comprises a weight measuring unit 151, the weight measuring unit 151 being connected to the processor 150, the weight measuring unit 151 being configured to measure the weight of the first blood bag 170 removed from the water bath 110, i.e., to recheck the weight of the prepared cryoprecipitate to ensure accuracy of the prepared amount of the resulting cryoprecipitate. Optionally, the weight measuring unit 151 may also be used to measure the weight of the second blood bag 190, so as to deduce the weight of the prepared cryoprecipitate from the weight of the second blood bag 190, thereby achieving the rechecking effect.
Further, the apparatus 10 further comprises a display 153 (not shown), wherein the display 153 is a panel with a display function, and is connected to the processor 150 and is used for displaying the liquid level data monitored by the liquid level sensor 130 in real time, so that a person can know the real-time progress of the cryoprecipitate preparation process in time. Optionally, the processor 150 may be further programmed to scale the real-time volume and/or the real-time weight of the undissolved portion of frozen plasma based on the level information and the dimensional information of the water bath 110, and to display the real-time volume and/or the real-time weight of the undissolved portion of frozen plasma on the display 153 in real time.
Optionally, the apparatus 10 further comprises an alarm 155, and the processor 150 may be connected to the alarm 155, and the alarm 155 is configured to issue an alarm according to whether the weight of the first blood bag falls within a preset range, so as to recheck the preparation result of the cryoprecipitate and ensure the accuracy of the preparation amount of the cryoprecipitate. In some embodiments, the alarm 155 may be configured to issue an alarm based on whether the weight of the second blood bag falls within a predetermined range to recheck the preparation result of the cryoprecipitate to ensure the accuracy of the preparation amount of the cryoprecipitate. Alternatively, the alarm 155 may be a buzzer, an indicator lamp, or the like, to remind a person by sound and light.
The device 10 for preparing the cryoprecipitate provided by the embodiment monitors the liquid level of the water bath 110 by arranging the liquid level sensor 130, and can really complete the preparation of the cryoprecipitate according to whether the real-time liquid level falls into the target liquid level range, so that the accuracy of the preparation amount of the cryoprecipitate is improved, and the preparation efficiency of the cryoprecipitate is also improved.
As used in the specification and in the claims, certain terms are used to refer to particular components. As one skilled in the art will appreciate, various names may be used to refer to a component. The specification and claims do not intend to distinguish between components that differ in name but not function. In the following description and in the claims, the terms "include" and "comprise" are used in an open-ended fashion, and thus should be interpreted to mean "include, but not limited to,"; "substantially" means that a person skilled in the art can solve the technical problem within a certain error range and basically achieve the technical effect.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Claims (11)
1. A method for preparing cryoprecipitate is applied to a preparation system of the cryoprecipitate, the system comprises a water bath and a liquid level sensor arranged on the water bath, the water bath is suitable for containing liquid for unfreezing frozen plasma, the frozen plasma is contained in a first blood bag, the first blood bag is communicated to a second blood bag through a conduit, a height difference exists between the first blood bag and the second blood bag, and the dissolved frozen plasma can flow to the second blood bag through the conduit; the method comprises the following steps:
submerging the first blood bag in the liquid;
continuously monitoring a real-time liquid level of the water bath during thawing of the frozen plasma, wherein a dissolved portion of the frozen plasma enters the second blood bag located outside the water bath via siphoning; and
and when the real-time liquid level falls into a target liquid level range, removing the first blood bag from the liquid.
2. The method of claim 1, wherein prior to said submerging the first blood bag in the liquid, the method further comprises:
acquiring an initial liquid level of the water bath;
determining an empty bag volume of the first blood bag;
determining a target volume of the cryoprecipitate; and
determining the target liquid level range according to the initial liquid level, the empty bag volume, the target volume and the size information of the water bath.
3. The method of claim 2, wherein said continuously monitoring a real-time liquid level of said water bath during said thawing of frozen plasma comprises:
detecting and determining the real-time liquid level of the water bath tank according to the detection data of the liquid level sensor in the frozen plasma thawing process;
determining a real-time volume of the undissolved portion of frozen plasma from the real-time liquid level, the initial liquid level, the empty bag volume, and dimensional information of the water bath; and
real-time volumes of the undissolved portions of the frozen plasma are shown.
4. The method of claim 2, wherein prior to continuously monitoring the real-time liquid level of the water bath during the frozen plasma thawing, the method further comprises:
obtaining a marking liquid level of the water bath after the first blood bag is immersed in the liquid;
determining an initial volume of the frozen plasma from the marker level, the initial level, the empty bag volume, and size information of the water bath.
5. The method of claim 4, wherein said continuously monitoring a real-time liquid level of said water bath during said thawing of frozen plasma comprises:
determining a dissolved volume of the frozen plasma from the marker level, the real-time level, the empty bag volume, and the dimensional information of the water bath;
determining a real-time volume of an undissolved portion of the frozen plasma from the initial volume of the frozen plasma and the dissolved volume of the frozen plasma; and
real-time volumes of the undissolved portions of the frozen plasma are shown.
6. The method of any one of claims 3 or 5, wherein said displaying the real-time volume of the undissolved portion of frozen plasma comprises:
calculating a real-time weight of the undissolved portion of frozen plasma based on the real-time volume of the undissolved portion of frozen plasma;
displaying a real-time volume of the undissolved portion of frozen plasma and a real-time weight of the undissolved portion of frozen plasma.
7. The method of claim 1, wherein after removing the first blood bag from the liquid when the real-time liquid level falls within a target liquid level range, the method further comprises:
obtaining a current weight of the first blood bag;
and if the current weight of the first blood bag does not fall into the preset weight range of the first blood bag, sending a reminding signal.
8. An apparatus for preparing a cryoprecipitate, the apparatus comprising:
a water bath adapted to contain a liquid for thawing frozen plasma, wherein the frozen plasma is contained in a first blood bag and thawed in the liquid, the first blood bag is communicated to a second blood bag through a conduit, there is a height difference between the first blood bag and the second blood bag, and the frozen plasma can flow to the second blood bag through the conduit after being dissolved;
the liquid level sensor is arranged on the water bath; and
a processor connected to the level sensor, the processor being configured to perform the method of any of claims 1-7.
9. The apparatus of claim 8, further comprising a weight measuring device coupled to the processor, the weight measuring device configured to measure the weight of the first blood bag removed from the water bath.
10. The apparatus of claim 9, further comprising an alarm coupled to the processor for generating an alarm based on whether the weight of the first blood bag falls within a predetermined range.
11. The apparatus of claim 8, further comprising a display coupled to the processor, the display for displaying a current real-time volume and/or a current real-time weight of the undissolved portion of the first blood bag.
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