CN105395896A - 治疗口腔溃疡的口含药液及制法 - Google Patents
治疗口腔溃疡的口含药液及制法 Download PDFInfo
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Abstract
本发明公开了一种治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成：石斛5-15份，佩兰10-20份，玄明粉3-9份，苹果3-7份，橙子1-5份，冬瓜3-8份，维生素B21-5份，桑叶5-15份，板蓝根4-10份，细辛2-6份，炉甘石1-5份，金银花3-8份。本发明药材药源易得，成本低廉，所选药材多为药性平和之物，长期使用也不会给使用者增加经济和身体上的负担。
Description
技术领域
本发明涉及中医中药领域，特别是涉及一种治疗口腔溃疡的口含药液及制备方法。
背景技术
复发性阿弗他溃疡，又称复发性阿弗他口炎、复发性口腔溃疡、复发性口疮，是口腔黏膜疾病中发病率最高的一种疾病，普通感冒、消化不良、精神紧张、郁闷不乐等情况均能偶然引起该病的发生，好发于唇、颊、舌缘等，在黏膜的任何部位均能出现，但在角化完全的附着龈和硬腭则少见。发病年龄一般在10～30岁之间，女性较多，一年四季均能发生。复发性阿弗他溃疡有自限性，能在10天左右自愈。该病具有周期性、复发性及自限性等特点。现代医学认为，复发性阿弗他溃疡首先与免疫有着很密切的关系。有的患者表现为免疫缺陷，有的患者则表现为自身免疫反应；其次是与遗传有关系，在临床中，复发性阿弗他溃疡的发病，有明显的家族遗传倾向，父母一方或多方若患有复发性阿弗他溃疡，他们的子女就比一般人更容易患病；另外，复发性阿弗他溃疡的发作，还与一些疾病或症状有关，比如消化系统疾病：胃溃疡、十二指肠溃疡、慢性或迁延性肝炎、结肠炎等，另外偏食、消化不良、发热、睡眠不足、过度疲劳、工作压力大、月经周期的改变等等。随着一种或多种因素的活跃、交替出现机体免疫力下降,致使复发性阿弗他溃疡的频繁发作。
1.轻型复发性阿弗他溃疡：初起病变处敏感或出现针尖样大小或稍大的充血区，短期内即形成直径在2～4mm左右，圆形或椭圆形，边界清晰的浅小溃疡。中心微凹陷，表面覆有一层淡黄色假膜，溃疡周围黏膜充血呈红晕状，其底扪之不硬。溃疡数目一般为2～3个左右。溃疡形成后有较剧烈的烧灼痛。经7～10天左右溃疡可逐渐自愈，不留瘢痕。但经长短不一的间歇期后又可复发。患者甚为痛苦。2.疱疹型复发性阿弗他溃疡：亦称口炎型口疮。此型除溃疡小、数目多（可达20～30个）外，其余与轻型复发性阿弗他溃疡表现相似。溃疡散在，分布广泛，黏膜充血明显。有剧烈疼痛及伴有头痛、发热、局部淋巴结肿大等。3.重型复发性阿弗他溃疡：亦称复发性坏死性黏膜腺周围炎或腺周口疮，为各型中最严重的一型。溃疡常单个发生，2个或2个以上者少见。好发于唇内侧及口角区黏膜。初起时溃疡与轻型复发性阿弗他溃疡相同，但其直径逐渐扩大至1～2cm，并向深层发展至黏膜腺。溃疡为紫红色或暗红色，边缘不规则，呈瓣状隆起，中央凹陷，似“弹坑”。底不平、微硬、呈小结节状，溃疡周围红晕，局部有剧烈疼痛及可伴局部淋巴结肿大、发热等。病程常在月余以上。愈后遗留瘢痕，严重者可形成组织缺损或畸形。
在现有的中医药治疗口腔溃疡的方法中，申请公布号CN102038815A（申请号201010600379.1）的专利公开了口腔溃疡散，其特征在于：其原料药为：青黛8-12g、硼砂（煅）8-12g、柿霜16～24g、象牙屑（焙）8-12g、珍珠3-6g、玄明粉8-12g、人指甲（焙）2.4-3.2g、血蝎3-5g、孩儿茶8-10g、马勃1.6-2.4g、露蜂房（炒）2.4-4.2g、枯矾3-5g、西瓜霜8-13g、细辛0.4-0.9g、薄荷脑0.3-0.8g、蛇蜕（炙）1.6-2.4g、象皮（焙）3-9g、龙骨6-10g、牛黄0.6-1g、甜菊素0.6-1g、冰片0.15-0.3g、其制作方法为：将上述药材研磨成能通过250目筛网的细粉，按比例配制即可。授权公告号CN102600365B（申请号201210091494.X）的专利公开了一种治疗口腔溃疡的药剂，其特征在于，它是由下列原料药按重量份计制成：细辛10-20份、挂金灯20-30份、栀子10-30份、薄荷20-50份、白芨5-15份、吴茱萸5-15份、青黛5-10份、黄苓10-20份和马勃10-20份。
由此可见，中药在治疗口腔溃疡方面占有非常重要的地位，但是专利文献中，没有专门用于治疗口腔溃疡的口含药液。
发明内容
针对现有技术的不足，本发明的目的之一在于提供治疗口腔溃疡的口含药液，本发明药材药源易得，成本低廉，所选药材多为药性平和之物，中药材和水果组合在一起制备成的口含药液，长期使用也不会给使用者增加经济和身体上的负担。
本发明的另一目的就是提供上述口含药液的制备方法。
本发明的技术方案是：
一种治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成：石斛5-15份，佩兰10-20份，玄明粉3-9份，苹果3-7份，橙子1-5份，冬瓜3-8份，维生素B21-5份，桑叶5-15份，板蓝根4-10份，细辛2-6份，炉甘石1-5份，金银花3-8份。
一种治疗口腔溃疡的口含药液，优选的方案为，取下述重量配比的主要原料制备而成：石斛8-13份，佩兰13-18份，玄明粉5-7份，苹果4-6份，橙子2-4份，冬瓜4-7份，维生素B22-4份，桑叶8-13份，板蓝根6-8份，细辛3-5份，炉甘石2-4份，金银花4-7份。
一种治疗口腔溃疡的口含药液，更为优选的方案为，取下述重量配比的主要原料制备而成：石斛10份，佩兰15份，玄明粉6份，苹果5份，橙子3份，冬瓜5.5份，维生素B23份，桑叶10份，板蓝根7份，细辛4份，炉甘石3份，金银花5份。
上述口含药液的制备方法，步骤如下：
（1）将炉甘石置于透明的容器内，加入80-100℃的淡盐水浸泡2-4小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡10-20分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒2-6分钟，研磨成细末过80-120目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2-4倍的黄酒拌匀，浸泡25-45分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的2-4倍，每次煎煮50-70分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖20-40分钟，置于蒸笼上蒸制28-46分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌18-26分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
上述口含药液的制备方法，步骤（1）加入85-95℃的淡盐水浸泡2.5-3.5小时（优选的，加入90℃的淡盐水浸泡3小时）。
上述口含药液的制备方法，步骤（2）将石斛用米醋浸泡13-18分钟（优选的，将石斛用米醋浸泡15分钟）。
上述口含药液的制备方法，步骤（2）反复翻炒3-5分钟，研磨成细末过90-110目筛待用（优选的，反复翻炒4分钟，研磨成细末过100目筛待用）。
上述口含药液的制备方法，步骤（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2.5-3.5倍的黄酒拌匀（优选的，将佩兰、桑叶、板蓝根、细辛和金银花用原料药3倍的黄酒拌匀）。
上述口含药液的制备方法，步骤（3）每次加水量是原料药的2.5-3.5倍，每次煎煮55-65分钟（优选的，每次加水量是原料药的3倍，每次煎煮60分钟）。
上述口含药液的制备方法，步骤（4）用保鲜膜包裹焖25-35分钟，置于蒸笼上蒸制35-38分钟（优选的，用保鲜膜包裹焖30分钟，置于蒸笼上蒸制37分钟）。
最佳使用方法：为使本发明达到最佳的治疗效果，制成的口含药液，每次服用3-5ml，一日数次，每次含2-4分钟。
各原料药的药理功效分别为：
石斛：药用植物，性味甘淡微咸，寒，归胃、肾，肺经。益胃生津，滋阴清热。用于阴伤津亏，口干烦渴，食少干呕，病后虚热，目暗不明。
佩兰：感受暑湿;寒热头痛；湿润内蕴；脘痞不饥；恶心呕吐；口中甜腻；消洵，用于湿浊中阻，脘痞呕恶，口中甜腻，口臭，多涎，暑湿表症，头胀胸闷。
玄明粉：主要成分为无水硫酸钠Na2SO4。是朴硝(Na2SO4.10H2O)脱水制成，由于产地及提炼方法不同，所含夹杂物亦异，常见者为硫酸钙(CaSO4)，硫酸铁Fe2(SO4)3，硫酸钾(K2SO4)。具有泻热通便；软坚散结；清热解毒；清肺解暑；消积和胃的功效。主要治疗实热积滞；大便不通；目赤肿痛；咽肿口疮；痈疽肿毒。
苹果：降低胆固醇：保持血糖的稳定，还能有效降低胆固醇。防癌抗癌：减少肺癌的危险，预防铅中毒，原花青素能预防结肠癌。血管清理剂：改善呼吸系统和肺功能，保护肺部免受污染和烟尘的影响。促进胃肠蠕动：协助人体排出废物，减少有害物质对皮肤的危害。维持酸碱平衡：苹果是碱性食品，吃苹果可迅速中和体内过多的酸性物质(包括运动(运动食品)产生的酸及鱼、肉、蛋等酸性食物在体内产生的酸性代谢产物)，增强体力和抗病能力。减肥：苹果会增加饱腹感，饭前吃能减少进食量，达到减肥目的。苹果的性味温和，含有丰富的碳水化合物、维生素和微量元素，有糖类、有机酸、果胶、蛋白质、钙、磷、钾、铁、维生素A、维生素B、维生素C和膳食纤维，另含有苹果酸，酒石酸，胡萝卜素。
橙子：味甘、酸，性微凉。能生津止渴，助消化，和胃。含柠檬酸、苹果酸、琥珀酸、糖类、果胶、维生素C等成分。用于胃阴不足，口渴心烦，饮酒过度；消化不良，胃气不和，恶心呕逆。
冬瓜：冬瓜营养十分丰富。每500克含蛋白质2克、碳水化合物9克、粗纤维3克、钙95毫克、铁2毫克、胡萝卜素0.15毫克、抗坏血酸75毫克。冬瓜含有较多的蛋白质、糖以及少量的钙、磷、铁等矿物质和维生素B1、B2、C及尼克酸，其中维生素B1可促使体内的淀粉、糖转化为热能，而不变成脂肪，冬瓜与其他瓜菜不同的是它不含脂肪，含钠量、热量都很低。冬瓜味甘、性寒，有消热、利水、消肿的功效。冬瓜含钠量较低，对动脉硬化症、肝硬化腹水、冠心病、高血压、肾炎、水肿膨胀等疾病有良好的辅助治疗作用。
维生素B2：核黄素还与人的性生活质量有关，当人体缺少核黄素，尤其是严重缺乏时，人体腔道的粘膜层就会出现问题，引起粘膜病变，造成性欲减退、性冷淡。含维生素B2的食物核黄素的保健新功效：1、利尿消肿；2、防治肿瘤；3、降低心脑血管病的发生。
桑叶：有清肺润燥、止咳、去热、化痰、治盗汗;补肝、清肝明目、治疗头晕眼花、失眠、消除眼部疲劳;消肿、清血‘治疗痢疾、腹痛、减肥、除脚气、利大、小肠;抗应激、凉血、降血压、降血脂、预防心肌梗塞、脑溢血、祛头痛、长发;降血糖、抗糖病等。
板蓝根：板蓝根分为北板蓝根和南板蓝根，北板蓝根来源为十字花科植物菘蓝（IsatistinctoriaL.）的根；南板蓝根为爵床科植物马蓝（Baphicacanthuscusia(Nees)Brem.）的根茎及根。其性寒，味先微甜后苦涩，具有清热解毒、预防感冒、利咽之功效。主要用于治疗温毒发斑、舌绛紫暗、烂喉丹痧等疾病。
细辛：性温，有小毒。归心、肺、肾经。有祛风，散寒，温肺、行水，开窍的作用。治风寒头痛，鼻渊，齿痛，痰饮咳逆，风湿痹痛。此外，细辛还具有抗炎免疫、局部麻醉、提高新陈代谢、抗菌作用，亦可用于肿瘤患者化疗和放疗所致的白细胞减少。
炉甘石：为不溶于水的天然碳酸锌，广用于皮肤科，作为中度的防腐、收敛、保护剂治疗皮肤炎症或表面创伤。一般用5-10%水混悬液（洗剂），亦有用油膏者。外用可抑制局部葡萄球菌生长。能部分吸收创面分泌液，有收敛、保护作用；尚能抑制局部葡萄球菌的生长。止血，消肿毒，生肌，明目，去翳退赤，收湿除烂。
金银花：现代研究证明，金银花含有绿原酸、木犀草素苷等药理活性成分，对溶血性链球菌、金黄葡萄球菌等多种致病菌及上呼吸道感染致病病毒等有较强的抑制力，另外还可增强免疫力、抗早孕、护肝、抗肿瘤、消炎、解热、止血（凝血）、抑制肠道吸收胆固醇等，其临床用途非常广泛，可与其它药物配伍用于治疗呼吸道感染、菌痢、急性泌尿系统感染、高血压等40余种病症。
本发明口含药液“注重整体”，既可治疗口腔溃疡，又可改善食欲，最主要的是将中药材与水果组合在一起，这是有别于药物治疗的一大特点，本口含药液完全根据中医中药原理制备而成，更加安全可靠，无任何毒副作用，对基体无任何刺激。
具体实施方式
下面结合实施例和实验例详细说明本发明的技术方案，但保护范围不被此限制。
实施例1治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成（每份取10g）：石斛5份，佩兰10份，玄明粉3份，苹果3份，橙子1份，冬瓜3份，维生素B21份，桑叶5份，板蓝根4份，细辛2份，炉甘石1份，金银花3份。
上述口含药液的制备方法，制备步骤如下：
（1）将炉甘石置于透明的容器内，加入80℃的淡盐水浸泡2小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡10分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒2分钟，研磨成细末过80目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2倍的黄酒拌匀，浸泡25分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的2倍，每次煎煮50分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖20分钟，置于蒸笼上蒸制28分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌18分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
典型病例一：王XX，男，3岁，是济南人，患儿一周前因感冒突然发烧，并服用退烧药、阿莫西林等药物治疗，4天前口腔内开始出现多个溃疡，下唇部出现多个成簇小水疱，
就诊时患儿已退烧，但口内溃疡疼痛明显，影响进食与说话，遂来就诊，口内检查：硬腭、上下唇内侧黏膜、舌腹等部位可见数十个大小不等的溃疡，较小者约0.2cm×0.2cm，较大溃疡形状不规则，约0.8cm×0.5cm，表面有伪膜，周围黏膜充血明显。牙龈红肿，尤其以前牙明显，探诊易出血，下唇唇红部与口周皮肤交界处未见明显水疱，可见一约0.5cm×0.3cm糜烂面，表面有黄色结痂，医生建议使用本发明所得治疗口腔溃疡的口含药液。
使用本实施例1所得口含药液，各临床症状明显好转，用药1天后，口腔溃疡面积减小，继续使用1天，痊愈。
实施例2：治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成（每份取5g）：石斛15份，佩兰20份，玄明粉9份，苹果7份，橙子5份，冬瓜8份，维生素B25份，桑叶15份，板蓝根10份，细辛6份，炉甘石5份，金银花8份。
上述口含药液的制备方法，制备步骤如下：
（1）将炉甘石置于透明的容器内，加入100℃的淡盐水浸泡4小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡20分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒6分钟，研磨成细末过120目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药4倍的黄酒拌匀，浸泡45分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的4倍，每次煎煮70分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖40分钟，置于蒸笼上蒸制46分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌26分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
实施例3：治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成（每份取15g）：石斛8份，佩兰13份，玄明粉5份，苹果4份，橙子2份，冬瓜4份，维生素B22份，桑叶8份，板蓝根6份，细辛3份，炉甘石2份，金银花4份。
述口含药液的制备方法，制备步骤如下：
（1）将炉甘石置于透明的容器内，加入85℃的淡盐水浸泡2.5小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡13分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒3分钟，研磨成细末过90目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2.5倍的黄酒拌匀，浸泡30分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的2.5倍，每次煎煮55分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖25分钟，置于蒸笼上蒸制35分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌20分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
实施例4：治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成（每份取20g）：石斛13份，佩兰18份，玄明粉7份，苹果6份，橙子4份，冬瓜7份，维生素B24份，桑叶13份，板蓝根8份，细辛5份，炉甘石4份，金银花7份。
上述口含药液的制备方法，制备步骤如下：
（1）将炉甘石置于透明的容器内，加入95℃的淡盐水浸泡3.5小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡18分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒5分钟，研磨成细末过110目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药3.5倍的黄酒拌匀，浸泡40分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的3.5倍，每次煎煮65分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖35分钟，置于蒸笼上蒸制38分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌24分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
典型病例二：黄XX，女，35岁，山东济南人士，因口腔反复长溃疡8年，再发3天来就诊。8年来，患者反复出现口腔溃疡。初起时数月发作1次，一般3～5天即愈，近来发作次数明显增加，间隔时间很短，甚至此起彼伏，发作时口水多，颌下有时也肿胀疼痛，甚感痛苦。曾到多家医院就诊，按口腔溃疡给予维生素、强的松口服，并用过多种口腔膜、溃疡膏、冰硼散、西瓜霜润喉片等，最初有效，但最近一段时间，效果不佳。每次发病时总在口腔，而皮肤、眼睛及外阴部无异常，所以医生建议使用本发明所得治疗口腔溃疡的口含药液。
使用本实施例4所得口含药液，2天后，疼痛等临床症状消失，又继续服用5天，自感痊愈。
实施例5：治疗口腔溃疡的口含药液，取下述重量配比的主要原料制备而成（每份取30g）：石斛10份，佩兰15份，玄明粉6份，苹果5份，橙子3份，冬瓜5.5份，维生素B23份，桑叶10份，板蓝根7份，细辛4份，炉甘石3份，金银花5份。
上述口含药液的制备方法，制备步骤如下：
（1）将炉甘石置于透明的容器内，加入90℃的淡盐水浸泡3小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡15分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒4分钟，研磨成细末过100目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药3倍的黄酒拌匀，浸泡35分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的3倍，每次煎煮60分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖30分钟，置于蒸笼上蒸制37分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌22分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
试验例1实施例5所得治疗口腔溃疡的口含药液的临床应用：在4所医院筛选100例患者，试验之前2天，对该人群进行连续观察，记录症状及变化，随机分为两组，实验组及对照组，实验组使用实施例5所得产品，对照组使用其它药品。
疗效情况判定标准:有效：服用本品后，不适症状消失；无效：服用本品后，身体状况无变化。结果如表1所示。
表1:使用实施例5所得口含药液效果验证
| 实验组 | 对照组 | |
| 例数 | 50 | 50 |
| 显效例数 | 48 | 35 |
| 无效例数 | 2 | 15 |
| 显效率 | 96% | 70% |
治疗效果：显效48例（96%），无效2例（4%），显效率96%，效果明显优于对照组。且无效中的2人在继续使用一段时间后，溃疡面积减小、红肿、疼痛消失，因此不排除因使用时间短而使结果有所偏差，使用期间，无一人出现不适症状或副作用。
Claims (10)
1.一种治疗口腔溃疡的口含药液，其特征在于：取下述重量配比的主要原料制备而成：石斛5-15份，佩兰10-20份，玄明粉3-9份，苹果3-7份，橙子1-5份，冬瓜3-8份，维生素B21-5份，桑叶5-15份，板蓝根4-10份，细辛2-6份，炉甘石1-5份，金银花3-8份。
2.根据权利要求1所述的治疗口腔溃疡的口含药液，其特征在于：取下述重量配比的主要原料制备而成：石斛8-13份，佩兰13-18份，玄明粉5-7份，苹果4-6份，橙子2-4份，冬瓜4-7份，维生素B22-4份，桑叶8-13份，板蓝根6-8份，细辛3-5份，炉甘石2-4份，金银花4-7份。
3.根据权利要求1所述的治疗口腔溃疡的口含药液，其特征在于：取下述重量配比的主要原料制备而成：石斛10份，佩兰15份，玄明粉6份，苹果5份，橙子3份，冬瓜5.5份，维生素B23份，桑叶10份，板蓝根7份，细辛4份，炉甘石3份，金银花5份。
4.根据权利要求1-3任一项所述的治疗口腔溃疡的口含药液的制备方法，其特征在于：步骤如下：
（1）将炉甘石置于透明的容器内，加入80-100℃的淡盐水浸泡2-4小时，锻制酥脆，研磨成细末待用；
（2）将石斛用米醋浸泡10-20分钟，将锅烧干，取适量食物油倒入锅内，待四周起烟时放入浸泡好的石斛，反复翻炒2-6分钟，研磨成细末过80-120目筛待用；
（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2-4倍的黄酒拌匀，浸泡25-45分钟，取出浸泡好的原料药，置于砂锅内，加水煎煮2次，每次加水量是原料药的2-4倍，每次煎煮50-70分钟，过滤，两次滤液合并得混合液；
（4）将苹果、橙子和冬瓜去皮一同切块置于干净的容器内，加入步骤（1）-（2）所得细末、玄明粉和维生素B2，拌匀，用保鲜膜包裹焖20-40分钟，置于蒸笼上蒸制28-46分钟，取出晾凉；
（5）将步骤（4）所得物与步骤（3）所得混合液拌匀，一边煎煮一边搅拌18-26分钟，过滤，滤去残渣，滤液放凉装瓶即得口含药液。
5.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（1）加入85-95℃的淡盐水浸泡2.5-3.5小时（优选的，加入90℃的淡盐水浸泡3小时）。
6.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（2）将石斛用米醋浸泡13-18分钟（优选的，将石斛用米醋浸泡15分钟）。
7.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（2）反复翻炒3-5分钟，研磨成细末过90-110目筛待用（优选的，反复翻炒4分钟，研磨成细末过100目筛待用）。
8.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（3）将佩兰、桑叶、板蓝根、细辛和金银花用原料药2.5-3.5倍的黄酒拌匀（优选的，将佩兰、桑叶、板蓝根、细辛和金银花用原料药3倍的黄酒拌匀）。
9.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（3）每次加水量是原料药的2.5-3.5倍，每次煎煮55-65分钟（优选的，每次加水量是原料药的3倍，每次煎煮60分钟）。
10.根据权利要求4所述的口含药液的制备方法，其特征在于：步骤（4）用保鲜膜包裹焖25-35分钟，置于蒸笼上蒸制35-38分钟（优选的，用保鲜膜包裹焖30分钟，置于蒸笼上蒸制37分钟）。
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