CN105395678A - 一种护肝药物 - Google Patents

一种护肝药物 Download PDF

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CN105395678A
CN105395678A CN201510834535.3A CN201510834535A CN105395678A CN 105395678 A CN105395678 A CN 105395678A CN 201510834535 A CN201510834535 A CN 201510834535A CN 105395678 A CN105395678 A CN 105395678A
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liver
radix
liver protection
protection medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

本发明涉及一种护肝药物，是由下列质量比例的原料组成：黄芪10-20份、丹参15-30份、白芍10-20份、五味子20-30份、川芎20-40份、三七10-20份。本发明具有清肝利胆、活血化淤、降酶退黄等作用，无明显毒副作用。

Description

一种护肝药物
技术领域
本发明属于生物医药领域，具体涉及一种护肝药物。
背景技术
肝脏是机体重要的代谢器官，它在糖、脂类、蛋白质、维生素、激素、胆色素等物质代谢中均有重要作用，同时肝脏还有分泌、排泄、生物转化等方面的功能。肝细胞中含有丰富的酶，并合成许多酶和各种凝血因子，储存和释放造血因子，参与血液凝固和造血过程。肝脏也是机体的屏障器官，其解毒和吞噬功能对机体有重要的保护作用。当肝功能受损伤时则代谢障碍，并影响其他脏器功能，严重则危及生命。肝脏具有肝动脉和门静脉的双重血液供应，并拥有大量血窦，肝细胞膜直接与血液接触，同时肝细胞膜的通透性较大，故肝细胞与血液间经常进行活跃有效的物质交换。
病毒、药物及有毒物质、自身免疫性肝炎等均可引起肝细胞坏死。研究表明，在肝细胞坏死而剩余肝细胞再生的情况下，则往往伴有肝间质增生，即导致肝纤维化以及肝硬化。在肝硬化时静脉血流受阻，导致肝静脉和门脉高压，促进肝内动静脉吻合支的形成，致使肝细胞供血减少，进而发生肝细胞变性和坏死，纤维增生，肝硬化更加严重，造成恶性循环。当肝严重损伤时，代偿能力显著减弱，则出现严重肝功能障碍，进一步发展为肝功衰竭，并进而引起中枢神经系统功能障碍，出现肝昏迷。各种有害因子和物质，如病毒，药物，酒精等均可以激发肝细胞发生损伤，产生一系列介质，造成肝细胞坏死、炎症、纤维化的病变过程，最终导致各种肝脏疾病。
研究发现冬虫夏草具有保护肝脏的作用，可以防止肝细胞点状坏死和局灶性坏死。黄芪可以使大鼠肝纤维化程度明显降低，减少总胶原I、III、IV型胶原在肝内的沉积。丹参是一种很有前途的抗肝损伤中药，其作用机制是多方面的，如改善肝内微循环，抑制脂质过氧化，保护肝细胞，促进沉积的胶原降解和重吸收等。三七具有活血化淤的功效，能抑制肝内成纤维细胞和Ito细胞的活性，减少胶原纤维的产生。此外，甘草、茯苓、五味子、柴胡、红花、垂盆草、水飞蓟等中药的抗肝损伤作用在实验研究中也得到了证实。
发明内容
综合本领域现有技术以及存在的问题，本发明的目的在于提供一种护肝药物，本发明为纯中药制剂，具有清肝利胆、活血化淤、降酶退黄等作用，无明显毒副作用。
为达到上述目的，本发明是由下列质量比例的原料组成：黄芪10-20份、丹参15-30份、白芍10-20份、五味子20-30份、川芎20-40份、三七10-20份。本发明给药剂型优选口服制剂。
具体实施方式
实施例1.本发明由下列质量比例的原料组成：黄芪10份、丹参30份、白芍10份、五味子30份、川芎40份、三七10份。
实施例2.本发明由下列质量比例的原料组成：黄芪20份、丹参15份、白芍20份、五味子20份、川芎20份、三七20份。

Claims (2)

1.一种护肝药物，是由下列质量比例的原料组成：黄芪10-20份、丹参15-30份、白芍10-20份、五味子20-30份、川芎20-40份、三七10-20份。
2.根据权利要求1所述一种护肝药物，其特征在于：所述给药剂型为口服制剂。
CN201510834535.3A 2015-11-25 2015-11-25 一种护肝药物 Pending CN105395678A (zh)

Priority Applications (1)

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Publications (1)

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CN105395678A true CN105395678A (zh) 2016-03-16

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106620473A (zh) * 2016-12-28 2017-05-10 王于法 一种术后养肝的药物及其制备方法
CN108619313A (zh) * 2017-03-22 2018-10-09 赖彦君 一种护肝健肾丸及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
王振华等: "降酶口服液对鼠降血清转氨酶的实验研究", 《长春中医学院学报》 *
董明慧等: "具有保肝作用的临床常用中药", 《中医药导报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106620473A (zh) * 2016-12-28 2017-05-10 王于法 一种术后养肝的药物及其制备方法
CN108619313A (zh) * 2017-03-22 2018-10-09 赖彦君 一种护肝健肾丸及其制备方法

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