CN105394756B - Compound milk thistle oral disintegrating tablet - Google Patents
Compound milk thistle oral disintegrating tablet Download PDFInfo
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- CN105394756B CN105394756B CN201510854555.7A CN201510854555A CN105394756B CN 105394756 B CN105394756 B CN 105394756B CN 201510854555 A CN201510854555 A CN 201510854555A CN 105394756 B CN105394756 B CN 105394756B
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a kind of compound milk thistle oral disintegrating tablet, is made of 20~28 parts by weight milk thistle honey, 30~35 parts by weight milk thistle pollen, 33~40 parts by weight microcrystalline celluloses, the water-soluble propolis of 1~5 parts by weight, 1~5 parts by weight physiological saline, 0.5~3 parts by weight turmeric, 0.5~2 parts by weight dandelion, 1~1.5 parts by weight aloe, 1~2 parts by weight radix glycyrrhizae.The present invention further simultaneously discloses the preparation method of this compound milk thistle oral disintegrating tablet.Reasonable mixture ratio of the present invention, has good nutritive value and protect liver effect, especially to convalescent hepatopath, has good rehabilitative action；In stable condition, no lamination, in good taste, preparation temperature is not high, it is ensured that color and luster does not change, and is light yellow；Preservative is not added, is a kind of green natural product of health, is beneficial to the health of user.
Description
Technical field
The present invention relates to edible health care product, particularly a kind of compound milk thistle oral disintegrating tablet.
Background technology
Silybum 1 year or biennial catananche, are excellent protect liver plants, originate in West Europe and north African.In
State the provinces such as Shaanxi, Gansu, Heilungkiang and Hebei cultivate, it is adaptable, not tight to soil, moisture requirement, sandy beach, it is saline and alkaline
Ground can plant.Herb is used for early stage of pyogenic infection of skin and erysipelas；Fruit and extract are used for hepatopathy, spleen disease gall stone, jaundice and chronic
Cough.Clearing heat and detoxicating, liver protection, cholagogic, protect brain, anti-X-ray.To acute or chronic hepatitis, hepatic sclerosis, fatty liver, metabolism poisoning
Property hepatic injury, cholelithiasis, the scorching disease of liver, courage such as inflammation has good efficacy around cholangitis and hepatic duct, can make liver patient from
Feel that symptom and some biochemical indexes such as serum bilirubin, white Anhui and ball Anhui coefficient, prothrombing, glutamic-pyruvic transaminase etc. change rapidly
It is kind.Highly finished product of the milk thistle honey as the glucide of milk thistle, the effect such as have blood pressure lowering, protect liver, relieve pain, being not only
Delicious nutriment, and be also treatment a variety of disease, strong body and the medicines promoted longevity.Milk thistle honey is for body
The children for needing high heat and being easy to the food of digestion are also particularly advantageous, it can promote appetite, improve metabolism, make one spirit
It is strong refreshing and full of physical strength, improve resistance of the body to disease.A kind of milk thistle pollen product excellent as milk thistle shape,
Also have effects that suitable.Water-soluble propolis can preferably be absorbed by human body, improve health-care effect.
Turmeric is the rhizome of zingiberaceous plant turmeric, and turmeric is pungent, bitter, temperature, returns spleen, Liver Channel, turmeric energy blood-breaking, and promoting menstruation stops
Bitterly.Turmeric twinges for chest side of body, amenorrhoea, abdominal mass, rheumatism shoulder arm pain, tumbling and swelling.Also, turmeric has reducing blood lipid, antitumor
The effect such as effect, anti-inflammatory and cholagogic.
Dandelion composite family herbaceos perennial.Capitulum, has the bobbles that white pappus is formed on seed, after the flowers are in blossom
Rack and breed new life to new place.Contain taraxol, taraxacin, choline, organic acid, chrysanthemum in dandelion plant
A variety of health-nutrition components such as sugar, there is diuresis, laxative, removing jaundice subcutaneous ulcer, cholagogic and other effects.Dandelion at the same time containing protein, fat,
Carbohydrate, trace element and vitamin etc., there is an abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, are dietotherapeutics
Plant.Dandelion has abundant carrotene and vC and mineral matter, plays the role of improvement to indigestion, constipation.
Aloe originates in Mediterranean, Africa, is Eremurus chinensis section herbaceos perennial, is edible, medicinal collection, beauty, sight
Plant nova is appreciated, there is the effects such as sterilization, anti-inflammatory, immune and removing toxic substances.Modern study shows, its leaf rheum officinale containing aloe
Plain, different aloe-emodin and aloe bitter principle etc., pharmacological evaluation has rush down under, antitumaous effect.Chinese aloe flower is cold in nature, bitter and puckery flavor, has clear
Heat, cough-relieving, hemostasia effect, can treat cough, spit blood.
Radix glycyrrhizae is grown in arid, semiarid desert steppe, desert edge and loess hill area more, in irrigation areas
It is also easy to breed in field and flood land, it is adaptable, and resistance is strong.In China, growth of Glycyrrhiza uralensis is in northwest, North, Northeast China
Etc. ground.Radix glycyrrhizae taste is sweet, it is mild-natured and, enter the heart, spleen, lung, stomach four and pass through.It is raw with cooler, can purging intense heat and detonicating, relieving spasm to stop pain；Process with inclined
Temperature, can dissipate exterior cold, tonifying middle-Jiao and Qi.In addition, radix glycyrrhizae is also good at mediation property of medicine, the poison of hundred medicines is solved.
Above material not only can usually be eaten as health products, can also be used as medicinal material, common edible or use
When, it can more mutually promote.Oral disintegrating tablet has and absorbs fast as a kind of new formulation, and bioavilability is high, and enteron aisle residual is few,
Side effect is low and can be to avoid remarkable advantages such as the first pass effects of liver.Therefore, a kind of compound water containing above-mentioned material is researched and developed
Flying Ji oral disintegrating tablet and a kind of preparation method of compound milk thistle oral disintegrating tablet becomes a urgent and important job.
The content of the invention
It is an object of the invention to overcome the shortcoming of above-mentioned existing background technology, and provide a kind of compound milk thistle mouthful
Disintegrating tablet.
The purpose of the present invention is reached by following measure：A kind of compound milk thistle oral disintegrating tablet, by 20~28 weight
Part milk thistle honey, 30~35 parts by weight milk thistle pollen, 33~40 parts by weight microcrystalline celluloses, the water-soluble bee of 1~5 parts by weight
Glue, 1~5 parts by weight physiological saline, 0.5~3 parts by weight turmeric, 0.5~2 parts by weight dandelion, 1~1.5 parts by weight aloe, 1
~2 parts by weight radix glycyrrhizaes are made.
Preferably, it is micro- by 21~25 parts by weight milk thistle honey, 33~35 parts by weight milk thistle pollen, 33~35 parts by weight
Crystalline cellulose, the water-soluble propolis of 1~3 parts by weight, 1~3 parts by weight physiological saline, 0.5~2 parts by weight turmeric, 0.5~1.5 weight
Part dandelion, 1.2~1.5 parts by weight aloes, 1~1.5 parts by weight radix glycyrrhizae are made.
Further, turmeric, dandelion, aloe, the weight ratio of radix glycyrrhizae are 1:1:1:1.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, 12~18h is placed at 25~35 DEG C, obtains mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), be uniformly mixed, at 40~50 DEG C
Place 5~8h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Further, by 23 parts by weight milk thistle honey, 35 parts by weight milk thistle pollen, 34 parts by weight microcrystalline celluloses
Element, the water-soluble propolis of 2 parts by weight, 3 parts by weight physiological saline, 1.5 parts by weight turmerics, 1.5 parts by weight dandelions, 1.5 parts by weight reeds
Luxuriant growth, 1.5 parts by weight radix glycyrrhizaes are made.
Preferably, in step 2), 15h is placed at 30~35 DEG C.
Further, in step 3), 8h is placed at 45 DEG C.
The advantage of the invention is that：
First, reasonable mixture ratio, has good nutritive value and protect liver effect, especially to convalescent hepatopath, tool
There is good rehabilitative action；
Second, in stable condition, no lamination, in good taste, preparation temperature is not high, it is ensured that color and luster does not change,
To be light yellow；
It is a kind of green natural product of health third, not adding preservative, is beneficial to the health of user.
Fourth, the present invention is through being summarized in the bee product dietotherapy operation of nearly 20 years, long-term consumption can strengthen human body and exempt from
Epidemic disease power, and have certain opsonic action to hepatopath, because raw material of the present invention is natural prodcuts, except pollen hypersensitivity constitution person foreign minister
Phase, which eats to have no, has human body any adverse reaction.
Every 2 grams of compound milk thistle oral disintegrating tablet of the present invention.Take once in the morning and once at night, to take before the meal.
Embodiment
With reference to the embodiment performance that the present invention will be described in detail, but they do not form limitation of the invention,
It is only for example.At the same time by illustrating that advantages of the present invention will become clearer and be readily appreciated that.
A kind of compound milk thistle oral disintegrating tablet, by 20~28 parts by weight milk thistle honey, 30~35 parts by weight milk thistle pollen,
33~40 parts by weight microcrystalline celluloses, the water-soluble propolis of 1~5 parts by weight, 1~5 parts by weight physiological saline, 0.5~3 parts by weight ginger
Huang, 0.5~2 parts by weight dandelion, 1~1.5 parts by weight aloe, 1~2 parts by weight radix glycyrrhizae are made.
Preferably, it is micro- by 21~25 parts by weight milk thistle honey, 33~35 parts by weight milk thistle pollen, 33~35 parts by weight
Crystalline cellulose, the water-soluble propolis of 1~3 parts by weight, 1~3 parts by weight physiological saline, 0.5~2 parts by weight turmeric, 0.5~1.5 weight
Part dandelion, 1.2~1.5 parts by weight aloes, 1~1.5 parts by weight radix glycyrrhizae are made.
Further, turmeric, dandelion, aloe, the weight ratio of radix glycyrrhizae are 1:1:1:1.
Further, by 23 parts by weight milk thistle honey, 35 parts by weight milk thistle pollen, 34 parts by weight microcrystalline celluloses
Element, the water-soluble propolis of 2 parts by weight, 3 parts by weight physiological saline, 1.5 parts by weight turmerics, 1.5 parts by weight dandelions, 1.5 parts by weight reeds
Luxuriant growth, 1.5 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, 12~18h is placed at 25~35 DEG C, obtains mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), be uniformly mixed, at 40~50 DEG C
Place 5~8h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Preferably, in step 2), 15h is placed at 30~35 DEG C.
Further, in step 3), 8h is placed at 45 DEG C.
Embodiment 1
Compound milk thistle oral disintegrating tablet, by 23 parts by weight milk thistle honey, 35 parts by weight milk thistle pollen, 34 parts by weight crystallites
Cellulose, the water-soluble propolis of 2 parts by weight, 3 parts by weight physiological saline, 1.5 parts by weight turmerics, 1.5 parts by weight dandelions, 1.5 weight
Part aloe, 1.5 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 15h at 35 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 45 DEG C
8h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Embodiment 2
Compound milk thistle oral disintegrating tablet, by 28 parts by weight milk thistle honey, 30 parts by weight milk thistle pollen, 35 parts by weight crystallites
Cellulose, the water-soluble propolis of 1 parts by weight, 2 parts by weight physiological saline, 1.3 parts by weight turmerics, 1.3 parts by weight dandelions, 1.3 weight
Part aloe, 1.3 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 12h at 30 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 48 DEG C
5h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Embodiment 3
Compound milk thistle oral disintegrating tablet, by 28 parts by weight milk thistle honey, 30 parts by weight milk thistle pollen, 35 parts by weight crystallites
Cellulose, the water-soluble propolis of 1 parts by weight, 2 parts by weight physiological saline, 0.5 parts by weight turmeric, 2 parts by weight dandelions, 1 parts by weight reed
Luxuriant growth, 2 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 12h at 30 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 48 DEG C
5h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Embodiment 4
Compound milk thistle oral disintegrating tablet, by 25 parts by weight milk thistle honey, 33 parts by weight milk thistle pollen, 33 parts by weight crystallites
Cellulose, the water-soluble propolis of 3 parts by weight, 1 parts by weight physiological saline, 3 parts by weight turmerics, 0.5 parts by weight dandelion, 1.2 parts by weight
Aloe, 1 parts by weight radix glycyrrhizae are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 18h at 33 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 50 DEG C
6h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Embodiment 5
Compound milk thistle oral disintegrating tablet, by 20 parts by weight milk thistle honey, 32 parts by weight milk thistle pollen, 38 parts by weight crystallites
Cellulose, the water-soluble propolis of 5 parts by weight, 4 parts by weight physiological saline, 2 parts by weight turmerics, 1 parts by weight dandelion, 1.4 parts by weight reeds
Luxuriant growth, 1.2 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 16h at 25 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 43 DEG C
7h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Embodiment 6
Compound milk thistle oral disintegrating tablet, by 21 parts by weight milk thistle honey, 31 parts by weight milk thistle pollen, 40 parts by weight crystallites
Cellulose, the water-soluble propolis of 4 parts by weight, 5 parts by weight physiological saline, 2.5 parts by weight turmerics, 1.3 parts by weight dandelions, 1.3 weight
Part aloe, 1.8 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into paste
Thing, removes slag, and is dried into crystalline solid, cooling, obtains compounding crystal；
2) by weight by the milk thistle pollen ground, physiological saline, water-soluble propolis and the compounding crystal obtained by step 1)
It is uniformly mixed, places 14h at 28 DEG C, obtain mixed material；
3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, is placed at 40 DEG C
6.5h；
4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；
6) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 5) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Comparative example 1
Compound milk thistle oral disintegrating tablet is contrasted, by 23 parts by weight milk thistle honey, 35 parts by weight milk thistle pollen, 34 parts by weight
Microcrystalline cellulose, the water-soluble propolis of 2 parts by weight, 3 parts by weight physiological saline, 1.5 parts by weight turmerics, 1.5 parts by weight dandelions, 1.5
Parts by weight aloe, 1.5 parts by weight radix glycyrrhizaes are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) the milk thistle pollen ground, physiological saline, water-soluble propolis are uniformly mixed by weight, are placed at 35 DEG C
15h, obtains mixed material；
2) the milk thistle honey of parts by weight is added into mixed material obtained by step 1), is uniformly mixed, is placed at 45 DEG C
8h；
3) mixed material containing milk thistle honey obtained by step 2) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
4) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 3) by weight, be uniformly mixed, dehydration；
5) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 4) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
Comparative example 2
Compound milk thistle oral disintegrating tablet is contrasted, by 28 parts by weight milk thistle honey, 30 parts by weight milk thistle pollen, 35 parts by weight
Microcrystalline cellulose, the water-soluble propolis of 1 parts by weight, 2 parts by weight physiological saline are made.
The method for preparing above-mentioned compound milk thistle oral disintegrating tablet, includes the following steps：
1) the milk thistle pollen ground, physiological saline, water-soluble propolis are uniformly mixed by weight, are placed at 30 DEG C
12h, obtains mixed material；
2) the milk thistle honey of parts by weight is added into mixed material obtained by step 1), is uniformly mixed, is placed at 48 DEG C
5h；
3) mixed material containing milk thistle honey obtained by step 2) is filtered, particulate matter is removed, up to compound fine grinding
Ji cream；
4) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 3) by weight, be uniformly mixed, dehydration；
5) cylindrical mouth disintegrating tablet is made in the dewatered compound milk thistle cream of step 4) with tablet press machine, up to compound milk thistle
Oral disintegrating tablet.
To 500 hepatitis recovery phase patient tests, wherein male 282 people, 218 people of female is the oldest 65 years old, 27 years old minimum.
It can not drink during taking, it is impossible to eat maror, it is impossible to eat greasy food, it is necessary to based on light, the hepatitis illness phase
For 1 year to 5 years.
Not take compound milk thistle oral disintegrating tablet Related product, other respectively take one again sooner or later daily respectively for blank control
Square milk thistle oral disintegrating tablet, acquired results are as follows：
1 embodiment of table and comparative example effect
| Hepatitis recurrence rate (%) | Evaluation | |
| Embodiment 1 | 7.6 | Protect liver effect is fine |
| Embodiment 2 | 8.3 | Protect liver effect is fine |
| Embodiment 3 | 11.9 | Protect liver effect is good |
| Embodiment 4 | 19.3 | Protect liver effect is good |
| Embodiment 5 | 16.3 | Protect liver effect is good |
| Embodiment 6 | 14.7 | Protect liver effect is good |
| Comparative example 1 | 25.8 | Protect liver effect is general |
| Comparative example 2 | 31.3 | Protect liver effect is general |
| Blank control | 50 | - |
In upper table, hepatitis recurrence rate is considered as that protect liver effect is fine, and hepatitis recurrence rate is in 10%-20% for less than 10%
Between to be considered as protect liver effect good, it is general that hepatitis recurrence rate less than 40% is considered as protect liver effect.As can be seen from the above table, addition contains
The compound milk thistle oral disintegrating tablet of compounding crystal for having turmeric, dandelion, aloe, radix glycyrrhizae has more preferable protect liver effect；It is and multiple
With in crystal, turmeric, dandelion, aloe, the weight ratio of radix glycyrrhizae are 1:1:1:When 1, the shield of the compound milk thistle oral disintegrating tablet of gained
Liver effect is best.
Other parts not being described in detail are the prior art.
Claims (4)
- A kind of 1. compound milk thistle oral disintegrating tablet, it is characterised in that：By 21~25 parts by weight milk thistle honey, 33~35 parts by weight water Fly thistle powder, 33~35 parts by weight microcrystalline celluloses, the water-soluble propolis of 1~3 parts by weight, 1~3 parts by weight physiological saline, 0.5~2 Parts by weight turmeric, 0.5~1.5 parts by weight dandelion, 1.2~1.5 parts by weight aloes, 1~1.5 parts by weight radix glycyrrhizae are made；The turmeric, dandelion, aloe, the weight ratio of radix glycyrrhizae are 1:1:1:1；The method for preparing the compound milk thistle oral disintegrating tablet, includes the following steps：1) by turmeric, dandelion, aloe, radix glycyrrhizae by weight plus water heated in iron pan boil boil 7 it is small when into pastel, go Slag, is dried into crystalline solid, cooling, obtains compounding crystal；2) the milk thistle pollen ground, physiological saline, water-soluble propolis are mixed with the compounding crystal obtained by step 1) by weight Uniformly, 12~18h is placed at 25~35 DEG C, obtains mixed material；3) the milk thistle honey of parts by weight is added into mixed material obtained by step 2), is uniformly mixed, 5 are placed at 40~50 DEG C ~8h；4) mixed material containing milk thistle honey obtained by step 3) is filtered, particulate matter is removed, up to compound milk thistle cream；5) microcrystalline cellulose is added in the compound milk thistle cream obtained by step 4) by weight, be uniformly mixed, dehydration；6) the dewatered compound milk thistle cream of step 5) is made to the cylindrical mouth disintegrating tablet of unified specification with tablet press machine, up to compound Milk thistle oral disintegrating tablet.
- 2. compound milk thistle oral disintegrating tablet according to claim 1, it is characterised in that：By 23 parts by weight milk thistle honey, 35 Parts by weight milk thistle pollen, 34 parts by weight microcrystalline celluloses, the water-soluble propolis of 2 parts by weight, 3 parts by weight physiological saline, 1.5 parts by weight Turmeric, 1.5 parts by weight dandelions, 1.5 parts by weight aloes, 1.5 parts by weight radix glycyrrhizaes are made.
- 3. compound milk thistle mouthful according to claim 1 is collapsed, it is characterised in that：In the step 2), at 30~35 DEG C Place 15h.
- 4. the compound milk thistle oral disintegrating tablet according to claim 1 or 3, it is characterised in that：In the step 3), at 45 DEG C Place 8h.
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| WO1996025056A1 (en) * | 1995-02-15 | 1996-08-22 | Cazaj Jozef | Process for producing a food product based on bee products, and a food product therefrom |
| CN1356060A (en) * | 2001-12-12 | 2002-07-03 | 吴军 | Preparation made of aloe, ganoderma, propolis, melissa pollen and honey |
| CN101856384A (en) * | 2009-04-09 | 2010-10-13 | 李佳柔 | Liver-protecting combination |
| CN103028092A (en) * | 2012-12-28 | 2013-04-10 | 李瀚旻 | Medicine for regulating liver regeneration and preparation method of medicine |
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2015
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996025056A1 (en) * | 1995-02-15 | 1996-08-22 | Cazaj Jozef | Process for producing a food product based on bee products, and a food product therefrom |
| CN1356060A (en) * | 2001-12-12 | 2002-07-03 | 吴军 | Preparation made of aloe, ganoderma, propolis, melissa pollen and honey |
| CN101856384A (en) * | 2009-04-09 | 2010-10-13 | 李佳柔 | Liver-protecting combination |
| CN103028092A (en) * | 2012-12-28 | 2013-04-10 | 李瀚旻 | Medicine for regulating liver regeneration and preparation method of medicine |
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